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Redox Report
Communications in Free Radical Research
Volume 7, 2002 - Issue 3
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Research Articles

Protective effects of green tea polyphenols and their major component, (–)-epigallocatechin-3-gallate (EGCG), on 6-hydroxydopamine-induced apoptosis in PC12 cells

Guangjun NieLaboratory of Visual Information Processing Department of Molecular and Cell Biophysics, Institute of Biophysics, Academia Sinica, Beijing , China
,
Yuanlin CaoLaboratory of Visual Information Processing Department of Molecular and Cell Biophysics, Institute of Biophysics, Academia Sinica, Beijing , China
&
Baolu ZhaoLaboratory of Visual Information Processing Department of Molecular and Cell Biophysics, Institute of Biophysics, Academia Sinica, Beijing , China
Pages 171-177 | Published online: 19 Jul 2013

  • Hirsch EC, Faucheux B, Damier P, Mouatt-Prigent A, Agid Y. Neuronal vulnerability in Parkinson's disease. J Neural Transm Suppl1997; 50: 79-88.
  • Mochizuki H, Goto K, Mori H, Mizuno Y. Histochemical detection of apoptosis in Parkinson's disease. J Neurol Sci 1996; 137: 120–123.
  • Anglade P. Vyas S, Javoy-Agid F et al. Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease. Histol Histopathol 1997; 12: 25–31.
  • Tompkins MM, Basgall EJ, Zamrini E, Hill WD. Apoptotic-like changes in Lewy-body-associated disorders and normal aging in substantia nigra neurons. Am J Pathol 1997; 150: 119–131.
  • Halliwall B. Reactive oxygen species and the central nervous system. J Neurochem 1992; 59: 1609–1623.
  • Jenner P, Olanow CW. Understanding cell death in Parkinson's disease. Ann Neurol 1998; 44 (Supp. 11): 572-884.
  • Ungerstedt U. 6-hydroxydopamine induced degeneration of central monoamine neurons. Eur J Pharmacol 1968; 5: 107–110.
  • Jonnson G, Sachs C. Effects of 6-hydroxydopamine on the uptake and storage of noradrenaline in sympathetic adrenergic neurons. Eur J Phannacol 1970; 9: 141–155.
  • Ljungdahl A, Hökfelf T, Jonsson G, Sachs C. Autoradiographic demonstration of uptake and accumulation of 3H-6-hydroxy-dopamine in adrenergic nerves. Experientia 1977;27: 297–299.
  • Glinka Y, Gassen M, Youdim MB. Mechanism of 6-hydroxy-dopamine neurotoxicity. J Neural Transm Suppl 1997; 50: 55–66.
  • Soto-Otero R, Mendez-Alvarez E, Hermida-Ameijeiras Mufioz-Patillo AM, Labaneira-Garcia JL. Autoxidation and neurotoxicity of 6-hydrodopamine in the presence of some antioxidants:potential implication in relation to the pathogenesis of Parkinson's disease. J Neurochem 2000; 74: 1605–1612.
  • Graham D, Tiffany SM, Bell Jr WR, Gutknecht WF. Autoxidation versus covalent binding of quinines as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells in vitro. Mol Pharmacol 1978; 14: 644–653.
  • Mukhtar H, Wang ZY, Katiyar SK, Agarwal R. Tea components: antimutagenic and anticarcinogenic effects. Prey Med 1992; 21: 351–360.
  • Wang ZY, Cheng SJ, Zhou ZC et al. Antimutagenic activity of green tea polyphenols. Mutat Res 1989; 223: 273–289.
  • Dong ZG, Ma WY, Huang CS, Yang CS. Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (-)-epigallocatechin gallate and theaflavins. Cancer Res 1997; 57: 4414–4419.
  • Nanjo F, Goto K, Seto R, Suzuki M, Sakai M,Hara Y. Scavenging effect of tea catechins and their derivatives on 1,1-dipheny1-2-picrylhydrazyl radical. Free Radic Biol Med 1996; 21: 895–902.
  • Sichel G, Corsaro M, Scalia M, DiBilio AJ, Bonomo RP. In vitro scavenger activity of some flavonoids and metanins against 02`. Free Radic Biol Med 1991; 11: 1–8.
  • Guo Q, Zhao BL, Li MF, Shen SR, Xin WJ. Studies on protective mechanisms of four components of green tea polyphenols against lipid peroxidation in synaptosomes. Biochim Biophys Acta 1996; 1304: 210–222.
  • Inanami 0, Watanabe Y, Syuto B, Nakano M, Tsuji M, Kuwabara M. Oral administration of (-)-catechin protects against ischemia-reperfusion-induced neuronal death in the gerbil. Free Radic Res 1998; 29: 359–365.
  • Yoneda T, Hiramatsu M, Skamoto N, Togasaki K, Komatsu M, Yamaguchi K. Antioxidant effects of `13-catechin'. Biochem Mol Biol Int 1995;35: 995–1008.
  • Harada J, Sugimoto M. Polyamines prevent apoptotic cell death in cultured granule neurons. Brain Res 1997; 753: 251–259.
  • Harfield PJ, Mayne GC, Murray AW. Ceramide induced apoptosis in PC12 cells. FEB S Lett 1997; 401: 148–152.
  • Migheli R, Godani C, Sciola L, Delogu R, Serra PA. Enhancing effect of manganese on L-DOPA-induced apoptosis in PC12 cells: role of oxidative stress. J Neurochem 1999; 73: 1155–1163.
  • Guo Q, Zhao BL, Hou JW, Xin WJ. ESR study on the structure-antioxidant activity relationship of tea catechins and their epimers. Biochim Biophys Acta 1999; 1427: 13–23.
  • Choi WS, Young SY, Oh TH, Choi EJ, Oalley KL, Oh Y. Two distinct mechanisms are involved in 6-hydroxydopamine- and MPPtinduced dopaminergic neuronal cell death: role of caspases, ROS, and JNK. J Neurosci Res 1999; 57: 86–94.
  • Yu R, Jiao JJ, Duh JL, Gudehithlu K, Tan TH, Kong AT. Activation of mitogen-activated protein kinases by green tea polyphenols: potential signalling pathway in the regulation of antioxidant-responsive element-mediated phase 11 enzyme gene expression. Carcinogenesis 1997; 18: 451–455.
  • Chen C, Yu R, Owuor ED, Kong ANT. Activation of antioxidant-response element (ARE), mitogen-activated protein kinases (MAPKS) and caspases by major green tea polyphenols during cell survival and death. Arch Phann Res 2000; 23: 605–612.
  • Nakagawa K, Miyazawa T. Chemiluminescence-high-performance liquid chromatographic determination of tea catechin, (—)-epicatechin 3-gallate, at picomole levels in rat and human plasma. Anal Biochem 1997; 248: 41–49.
  • Nakagawa K, Miyazawa, T. Absorption and distribution of tea catechin, (—)-epicatechin 3-gallate, in the rat. J Nutr Sci Vitaminol 1997;43: 679–684.
  • Inanami 0, Asanuma T, Inukai N et al. The suppression of age-related accumulation of lipid peroxides in rat brain by administration of rooibos tea. Neurosci Lett 1995; 196: 85–88.
  • Levites Y, Weinreb 0, Maor G, Youdim M, Mandel S. Green tea polyphenol (—)-epigallocatechin-3-gallate prevents N-methy1-4-pheny1-1,2,3,6-tetrahydropyidine-induced dopaminergic neurodegeneration. J Neurochem 2001;78: 1073–1082.
  • Salah N, Miller NJ, Paganga G, Tijburg L, Bowell GP, Rice-Evans C. Polyphenolicflavonols as scavengers of aqueous phase radicals and as chain-breaking antioxidants. Arch Biochem Biophys 1995; 322: 339–346.

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