Publication Cover
Redox Report
Communications in Free Radical Research
Volume 8, 2003 - Issue 5
189
Views
7
CrossRef citations to date
0
Altmetric
Articles

Iron chelators as drugs against malaria pose a potential risk

, , , &
Pages 268-271 | Published online: 02 Dec 2013

REFERENCES

  • Loyevsky M, Gordeuk VR. Iron chelators. In: Rosenthal PJ. (ed) Antimalarial Chemotherapy. Totowa, New Jersey: Humana, 2001; 307–324.
  • Le NTV, Richardson DR. The role of iron in cell cycle progression and the proliferation of neoplastic cells. Biochim Biophys Acta 2002; 1603: 31–46.
  • Nappi AJ, Vass E. Interactions of iron with reactive intermediates of oxygen and nitrogen. Dev Neurosci 2002; 24: 134–142.
  • Greene BT, Thorbum J, Willingham MC et al. Activation of caspase pathways during iron chelator-mediated apoptosis. J Biol Chem 2002; 277: 25568–25575.
  • Cabantchik ZI, Glickstein H, Golenser J, Loyevsky M, Tsafack A. Iron chelators: mode of action as antimalarials. Ada Haematol 1996; 95: 70–77.
  • Loyevsky M, Lytton SD, Mester B, Libman J, Shanzer A, Cabantchik ZI. The antimalarial action of desferal involves a direct access route to erythrocytic (P. falciparum) parasites. J Clin Invest 1993; 91: 218–224.
  • Golenser J, Tsafack A, Libman J, Amichai I, Shanzer A, Cabantchik ZI. The antimalarial action of hydroxamate-based iron chelators. Effects of drug combinations. Antimicrob Agents Chemother 1995; 39: 61–69.
  • Postma NS, Boerman OC, Oyen WJ, Zuidema J, Storm G. Absorption and biodistribution of mindium-labelled desferri-oxamine (“In-DFO) after subcutaneous injection of “In-DFO liposomes. J Control Release 1999; 58: 51–60.
  • Golenser J, Domb A, Teomim D et al. The treatment of animal models of malaria with iron chelators using a novel polymeric device for slow drug release. J Pharmacol Exp Ther 1997; 281: 1127–1135.
  • Golenser J, Miller J, Spira DT, Navok T, Chevion M. Inhibitory effect of a Fava bean component on the in vitro development of P. fakiparum in normal and G-6-PD deficient erythrocytes. Blood 1983; 61: 507–510.
  • Sanni LA, Rae C, Maitland A, Stocker R, Hunt NH. Is ischemia involved in the pathogenesis of murine cerebral malaria? Am J Pathol 2001; 159: 1105-1112.
  • Schwarzer E, Kuhn H, Valente E, Arese P. Malaria-parasitized erythrocytes and hemozoin nonenzymatically generate large amounts of hydroxy fatty acids that inhibit monocyte functions. Blood 2003; 101: 722–728.
  • Nathan DG, Weatheralk DJ. Academic freedom in clinical research. N Engl J Med 2002; 347: 1368–1371.
  • Forge A, Li L. Apoptotic death of hair cells in mammalian vestibular sensory epithelia. Hear Res 2000; 139: 97–115.
  • Thuma PE, Mabeza GF, Biemba G et al. Effect of iron chelation therapy on mortality in Zambian children with cerebral malaria. Trans R Soc Trop Med Hyg 1998; 92: 214–218.
  • Mohanty D, Shosh K, Pathare AV, Kamad D. Deferiprone (L1) as an adjuvant therapy for P. falciparum malaria. Indian J Med Res 2002; 115: 17–21.
  • Simonart T, Boelaert JR, Van Hooren JP. Enhancement of classic Kaposi's sarcoma growth after intralesional injections of DFO. Dermatology 2002; 202: 290–292.
  • Andersen O, Aaseth J. Molecular mechanisms of in vivo metal chelation: implications for clinical treatment of metal intoxications. Environ Health Perspect 2002; 110: 887–890.
  • Liu DY, Liu ZD, Hider RC. Oral iron chelators - development and application. Best Pract Res Clin Haematol 2002; 15: 369–84.
  • Scholz M, Blaheta RA, Henrich D et al. Immunomodulatory properties of the metal chelators desferrioxamine and diethylenetriamine penta-acetic acid in vitro. Transplantation 1996; 62: 1371–1374.
  • Weiss G, Thuma PE, Mabeza G, Werner ER, Herold M, Gordeuk VR. Modulatory potential of iron chelation on nitric oxide formation in cerebral malaria. J Infect Dis 1997; 175: 226–230.
  • Moorman AM, Hossler PA, Meshnick SR. DFO effects on P. fakiparum gene expression. Mol Biochem Parasitol 1999; 98: 279–283.
  • Lucas R, Lou J, Morel DR, Ricou B, Suter PM, Grau GE. TNF receptors in the microvascular pathology of acute respiratory distress syndrome and cerebral malaria. J Leukoc Biol 1997; 6: 551–558.
  • Postma NS, Hermsen CC, Crommelin DJ, Zuidema J, Eling WM. Treatment with recombinant human tumour necrosis factor-alpha reduces parasitaemia and prevents Plasmodium berghei K173- induced experimental cerebral malaria in mice. Parasitology 1999; 118: 7–15.
  • Luty AJ, Perkins DJ, Lell B et al. Low interleukin-12 activity in severe Plasmodium falciparum malaria. Infect Immun 2000; 68: 3909–3915.
  • Yang J, Jones SP, Suhara T et al. Endothelial cell overexpression of FasL attenuates ischemia-reperfusion injury in the heart. J Biol Chem 2003; 278: 15185–15191.
  • Yoon G, Kim HJ, Yoon YS, Cho H, Lim IK, Lee JH. Iron chelation-induced senescence-like growth arrest in hepatocyte cell lines: association of transforming growth factor betal (TGF-betal)-mediated p27Kip 1 expression. Biochem J 2002; 366: 613–621.
  • Chaston TB, Lovejoy DB, Watts RN, Richardson DR. Examination of the antiproliferative activity of iron chelators: multiple cellular targets and the different mechanism of action of triapine compared with desferrioxamine and the potent pyridoxal isonicotinoyl hydrazone analogue 311. Clin Cancer Res 2003; 9: 402–414.
  • Prada J, Kremsner PG. Reactive nitrogen intermediates and cerebral malaria. Trans R Soc Trop Med Hyg 1997; 91: 92–93.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.