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Redox Report
Communications in Free Radical Research
Volume 8, 2003 - Issue 5
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Articles

Mechanisms of in situ activation for peroxidic antimalarials

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Pages 284-288 | Published online: 19 Jul 2013

REFERENCES

  • Klayman DL. Qinghaosu (artemisinin): an antimalarial drug from China. Science 1985; 228: 1049–1055.
  • Wesche DL, DeCoster MA, TorteIla FC, Brewer TG. Neurotoxicity of artemisinin analogs in vitro. Antimicrob Agents Chemother 1994; 38: 1813–1819.
  • Genovese RF, Newman DB, Brewer TG. Behavioral and neural toxicity of the artemisinin antimalarial, arteether, but not artesunate and artelinate, in rats. Pharmacol Biochem Behav 2000; 67: 37–44.
  • Dong Y, Vennerstrom JL. Peroxidic antimalarials. Expert Opin Ther Pat 2001; 11: 1753–1760.
  • Dong Y. Synthesis and antimalarial activity of 1,2,4,5-tetraoxanes. Minirev Med Chem 2002; 2: 113–123.
  • Banedee R, Goldberg DE. The Plasmodium food vacuole. In: Rosenthal PJ. (ed) Antimalarial Chemotherapy. Mechanisms of Action, Resistance, and New Directions in Drug Discovery. Totowa: Humana, 2001; 43–63.
  • Cumming JN, Ploypradith P. Posner GH. Antimalarial activity of artemisinin (qinghaosu) and related trioxanes: mechanism(s) of action. Adv Pharmacol 1997; 37: 253–297.
  • Wu WM, Wu Y, Wu YL et al. Unified mechanistic framework for the Fe(II)-induced cleavage of qinghaosu and derivatives/analogues. The first spin-trapping evidence for the previously postulated secondary C-4 radical. J Am Chem Soc 1998; 120: 3316–3325.
  • Jefford CW. Why artemisinin and certain synthetic peroxides are potent antimalarials. Implications for the mode of action. Curr Med Chem 2001; 8: 1803–1826.
  • Robert A, Dechy-Cabaret O, Cazelles J, Meunier B. From mechanistic studies on artemisinin derivatives to new modular antimalarial drugs. Acc Chem Res 2002; 35: 167–174.
  • Robert A, Cazelles J, Meunier B. Characterization of the alkylation product of heme by the antimalarial drug artemisinin. Angew Chem Int Edn 2001; 40: 1954–1957.
  • Robert A, Coppel Y, Meunier B. Alkylation of heme by the antimalarial drug artemisinin. Chem Commun 2002; 414–415.
  • Cazelles J, Robert A, Meunier B. Alkylating capacity and reaction products of antimalarial trioxanes after activation by a heme model. J Org Chem 2002; 67: 609–619.
  • Pandey AV, Tekwani BL, Singh RL, Chauhan VS. Artemisinin, an endoperoxide antimalarial, disrupts the hemoglobin catabolism and heme detoxification systems in malarial parasite. J Biol Chem 1999; 274: 19383–19388.
  • Meshnick SR. Artemisinin: mechanisms of action, resistance and toxicity. Int J Parasitol 2002; 32: 1655–1660.
  • Wu Y. How might qinghaosu (artemisinin) and related compounds kill the intraerythrocytic malaria parasite? A chemist's view. Acc Chem Res 2002; 35: 255–259.
  • Wu Y, Yue ZY, Wu YL. Interaction of qinghaosu (artemisinin) with cysteine sulfhydryl mediated by traces of non-heme iron. Angew Chem Int Edn 1999; 38: 2580–2582.
  • Wang DY, Wu YL, Wu Y, Liang J, Li Y. Further evidence for the participation of primary carbon-centered free radicals in the antimalarial action of the qinghaosu (artemisinin) series of compounds. J Chem Soc Perkin Trans 1 2001; 605-609.
  • Wang DY, Wu YL. A possible antimalarial action of mode of qinghaosu (artemisinin) series compounds. Alkylation of reduced glutathione by C-centered primary radicals produced from antimalarial compound qinghaosu and 12-(2,4-dimethoxy-pheny1)-12-deoxoqinghaosu. Chem Commun 2000; 2193-2194.

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