Ursodeoxycholic acid in primary biliary cirrhosis improves glutathione status but fails to reduce lipid peroxidation

References

• Poupon RE, Balkau B, Eschwege E, Poupon R. A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis. N Engl J Med 1991; 324: 1548–1554.
   PubMed Web of Science ®Google Scholar
• Goulis J, Leandro G, Burroughs AK. Randomised controlled trials of ursodeoxycholic-acid therapy for primary biliary cirrhosis: a meta-analysis. Lancet 1999; 354: 1053–1060.
   PubMed Web of Science ®Google Scholar
• Corpechot C, Carrat F, Bahr A, Chretien Y, Poupon RE, Poupon R. The effect of ursodeoxycholic acid therapy on the natural course of primary biliary cirrhosis. Gastroenterology 2005; 128: 297–303.
   PubMed Web of Science ®Google Scholar
• Schmucker DL, Ohta M, Kanai S, Sato Y, Kitani K. Hepatic injury induced by bile salts: correlation between biochemical and morphological events. Hepatology 1990; 12: 1216–1221.
   PubMed Web of Science ®Google Scholar
• Trauner M, Graziadei IW. Mechanisms of action and therapeuticapplications of ursodeoxycholic acid in chronic liver diseases. Aliment Pharmacol Ther 1999; 13: 979–996.
   PubMed Web of Science ®Google Scholar
• Lazaridis KN, Gores GJ, Lindor KD. Ursodeoxycholic acid ‘mechanisms of action and clinical use in hepatobiliary disorders’. J Hepatol 2001; 35: 134–146.
   PubMed Web of Science ®Google Scholar
• Marteau P, Chazouilleres O, Myara A, Ran R, Rambaud JC, Poupon R. Effect of chronic administration of ursodeoxycholic acid on the ileal absorption of endogenous bile acids in man. Hepatology 1990; 12: 1206–1208.
   PubMed Web of Science ®Google Scholar
• Rodrigues CM, Steer CJ. Mitochondrial membrane perturbations in cholestasis. J Hepatol 2000; 32: 135–141.
   PubMed Web of Science ®Google Scholar
• Calmus Y, Gane P, Rouger P, Poupon R. Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: effect of ursodeoxycholic acid. Hepatology 1990; 11: 12–15.
   PubMed Web of Science ®Google Scholar
• Sokol RJ, Straka MS, Dahl R et al. Role of oxidant stress in the permeability transition induced in rat hepatic mitochondria by hydrophobic bile acids. Pediatr Res 2001; 49: 519–531.
   PubMed Web of Science ®Google Scholar
• Yerushalmi B, Dahl R, Devereaux MW, Gumpricht E, Sokol RJ. Bile acid-induced rat hepatocyte apoptosis is inhibited by antioxidants and blockers of the mitochondrial permeability transition. Hepatology 2001; 33: 616–626.
   PubMed Web of Science ®Google Scholar
• Ljubuncic P, Fuhrman B, Oiknine J, Aviram M, Bomzon A. Effect of deoxycholic acid and ursodeoxycholic acid on lipid peroxidation in cultured macrophages. Gut 1996; 39: 475–478.
   PubMed Web of Science ®Google Scholar
• Sreejayan N, von Ritter C. Effect of bile acids on lipid peroxidation: the role of iron. Free Radic Biol Med 1998; 25: 50–56.
   PubMed Web of Science ®Google Scholar
• Lapenna D, Ciofani G, Festi D et al. Antioxidant properties of ursodeoxycholic acid. Biochem Phannacol 2002; 64: 1661–1667.
   PubMed Web of Science ®Google Scholar
• Parola M, Robino G. Oxidative stress-related molecules and liver fibrosis. J Hepatol 2001; 35: 297–306.
   PubMed Web of Science ®Google Scholar
• Jain SK, Pemberton PW, Smith A et al. Oxidative stress in chronic hepatitis C: not just a feature of late stage disease. J Hepatol 2002; 36: 805–811.
   PubMed Web of Science ®Google Scholar
• Pemberton PW, Aboutwerat A, Smith A, Burrows PC, McMahon RF, Warnes TW. Oxidant stress in type I autoimmune hepatitis: the link between necroinflammation and fibrogenesis? Biochim Biophys Acta 2004; 1689: 182–189.
   PubMed Web of Science ®Google Scholar
• Pemberton PW, Smith A, Warnes TW. Non-invasive monitoring of oxidant stress in alcoholic liver disease. Scand J Gastroenterol 2005; 40: 1102–1108.
   PubMed Web of Science ®Google Scholar
• Aboutwerat A, Pemberton PW, Smith A et al. Oxidant stress is a significant feature of primary biliary cirrhosis. Biochim Biophys Acta 2003; 1637: 142–150.
   PubMed Web of Science ®Google Scholar
• Warnes TW, Smith A, Lee Fl, Haboubi NY, Johnson PJ, Hunt L. A controlled trial of colchicine in primary biliary cirrhosis. J Hepatol 1987; 5: 1–7.
   PubMed Web of Science ®Google Scholar
• Shapiro JM, Smith H, Schaffner F. Serum bilirubin: a prognostic factor in primary biliary cirrhosis. Gut 1979; 20: 137–140.
   PubMed Web of Science ®Google Scholar
• Pugh RN, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973; 60: 646–649.
   PubMed Web of Science ®Google Scholar
• Whitehead TP, Thorpe GH, Maxwell SR. Enhanced chemiluminescent assay for antioxidant capacity in biological fluids. Anal Chim Acta 1992; 266: 265–277.
   Web of Science ®Google Scholar
• Sies H, Akerboom TP. Glutathione disulfide (GSSG) efflux from cells and tissues. Methods Enzymol 1984; 105: 445–451.
   PubMed Web of Science ®Google Scholar
• Babbs C, Smith A, Hunt LP, Rowan BP, Haboubi NY, Warnes TW. Type III procollagen peptide: a marker of disease activity and prognosis in primary biliary cirrhosis. Lancet 1988; 1: 1021–1024.
   PubMed Web of Science ®Google Scholar
• Serviddio G, Pereda J, Pallardo FV et al. Ursodeoxycholic acid protects against secondary biliary cirrhosis in rats by preventing mitochondrial oxidative stress. Hepatology 2004; 39: 711–720.
   PubMed Web of Science ®Google Scholar
• Mato JM, Camara J, Fernandez de Paz J et al. 5-adenosyl-methionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J Hepatol 1999; 30: 1081–1089.
   PubMed Web of Science ®Google Scholar
• Akerboom TP, Sies H. Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples. Methods Enzymol 1981; 77: 373–382.
   PubMedGoogle Scholar
• Lu SC. Regulation of hepatic glutathione synthesis: current concepts and controversies. FASEB J1999; 13: 1169-1183.
   Google Scholar
• Rodriguez-Ortigosa CM, Cincu RN, Sanz S, Ruiz F, Quiroga J, Prieto J. Effect of ursodeoxycholic acid on methionine adenyltransferase activity and hepatic glutathione metabolism in rats. Gut 2002; 50: 701–706.
   PubMed Web of Science ®Google Scholar
• Mitsuyoshi H, Nakashima T, Sumida Yet al. Ursodeoxycholic acid protects hepatocytes against oxidative injury via induction of antioxidants. Biochem Biophys Res Commun 1999; 263: 537–542.
   PubMed Web of Science ®Google Scholar
• Hirata E, Inoue M, Morino Y. Mechanism of biliary secretion of membranous enzymes: bile acids are important factors for biliary occurrence of gamma-glutamyltransferase and other hydrolases. J Biochem (Tokyo) 1984; 96: 289–297.
   PubMed Web of Science ®Google Scholar
• Mates JM, Perez-Gomez C, Blanca M. Chemical and biological activity of free radical ‘scavengers’ in allergic disease. Clin Chim Acta 2000; 296: 1–15.
   PubMed Web of Science ®Google Scholar
• Roberts LJ, Morrow JD. The generation and actions of isoprostanes. Biochim Biophys Acta 1997; 1345: 121–135.
   PubMed Web of Science ®Google Scholar
• van Hoogstraten HJ, Hansen BE, van Buuren HR, ten Kate F, van Berge-Henegouwen GP, Schalm SW. Prognostic factors and long-term effects of ursodeoxycholic acid on liver biochemical parameters in patients with primary biliary cirrhosis. J Hepatol 1999; 31: 256–262.
   PubMed Web of Science ®Google Scholar
• Poli G. Pathogenesis of liver fibrosis: role of oxidative stress. Mol Aspects Med 2000; 21: 49–98.
   PubMedGoogle Scholar
• Lee KS, Buck M, Houglum K, Chojkier M. Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression. J Clin Invest 1995; 96: 2461–2468.
   PubMed Web of Science ®Google Scholar
• Gluud C, Christensen E. Ursodeoxycholic acid for primary biliary cirrhosis. Cochrane Database Syst Rev 2002; 1: CD000551.
   PubMedGoogle Scholar
• Corpechot C, Carrat F, Bonnand AM, Poupon RE, Poupon R. The effect of ursodeoxycholic acid therapy on liver fibrosis progression in primary biliary cirrhosis. Hepatology 2000; 32: 1196–1199.
   PubMed Web of Science ®Google Scholar