Oxidative stress involvement and gene expression in indomethacin-induced gastropathy

REFERENCES

• Wallace JL. Pathogenesis of NSAID-induced gastroduodenal mucosal injury. Best Pract Res Clin Gastroenterol 2001; 15: 691–703.
   PubMed Web of Science ®Google Scholar
• Yoshikawa T, Naito Y. The role of neutrophils and inflammation in gastric mucosal injury. Free Radic Res 2001; 33: 785–794.
   Web of Science ®Google Scholar
• Naito Y, Kuroda M, Mizushima K et al. Transcriptome analysis for cytoprotective actions of rebamipide against indomethacin-induced gastric mucosal injury in rats. Gastroenterology 2006; 130 (Suppl 2): A–271.
   Google Scholar
• Naito Y, Kajikawa H, Mizushima K et al. Rebamipide, a gastro-protective drug, inhibits indomethacin-induced apoptosis in cultured rat gastric mucosal cells: association with the inhibition of growth arrest and DNA damage-induced 45 alpha expression. Dig Dis Sci 2005; 50 (Suppl 1): S 104—S 112.
   Google Scholar
• Yoshikawa T, Naito Y, Kishi A et al. Role of active oxygen, lipid peroxidation, and antioxidants in the pathogenesis of gastric mucosal injury induced by indomethacin in rats. Gut 1993; 34: 732–737.
   PubMed Web of Science ®Google Scholar
• Yoshikawa T, Miyagawa H, Yoshida N, Sugino S, Kondo M. Increase in lipid peroxidation in rat gastric mucosal lesions induced by water-immersion restraint stress. J Clin Biochem Nutr 1986; 1: 271–277.
   Google Scholar
• Yoshikawa T, Yoshida N, Miyagawa H et al. Role of lipid peroxidation in gastric mucosal lesions induced by burn shock in rats. J Clin Biochem Nutr 1987; 2: 163–170.
   Web of Science ®Google Scholar
• Yoshikawa T, Ueda S, Naito Yet al. Role of oxygen-derived free radicals in gastric mucosal injury induced by ischemia or ischemia-reperfusion in rats. Free Radic Res Commun 1989; 7: 285–291.
   PubMed Web of Science ®Google Scholar
• Yoshida N, Sugimoto N, Hirayama F et al. Helicobacter pylori infection potentiates aspirin induced gastric mucosal injury in Mongolian gerbils. Gut 2002; 50: 594–598.
   PubMed Web of Science ®Google Scholar
• Tanaka J, Yuda Y. Lipid peroxidation in gastric mucosal lesions induced by indomethacin in rat. Biol Pharm Bull 1996; 19: 716–720.
   PubMed Web of Science ®Google Scholar
• Alarcon de la Lastra C, Motilva V, Martin MJ et al. Protective effect of melatonin on indomethacin-induced gastric injury in rats. J Pineal Res 1999; 26: 101–107.
   PubMed Web of Science ®Google Scholar
• Joseph RM, Varela V, Kanji VK, Subramony C, Mihas AA. Protective effects of zinc in indomethacin-induced gastric mucosal injury: evidence for a dual mechanism involving lipid peroxidation and nitric oxide. Aliment Pharmacol Ther 1999; 13: 203–208.
   PubMed Web of Science ®Google Scholar
• El-Missiry MA, El-Sayed IH, Othman AT. Protection by metal complexes with SOD-mimetic activity against oxidative gastric injury induced by indomethacin and ethanol in rats. Ann Clin Biochem 2001; 38: 694–700.
   PubMed Web of Science ®Google Scholar
• Nagano Y, Matsui H, Muramatsu M et al. Rebamipide significantly inhibits indomethacin-induced mitochondrial damage, lipid peroxidation, and apoptosis in gastric epithelial RGM-1 cells. Dig Dis Sci 2005; 50 (Suppl 1): S76–S83.
   PubMedGoogle Scholar
• Naito Y, Yoshikawa T, Iinuma S et al. Rebamipide protects against indomethacin-induced gastric mucosal injury in healthy volunteers in a double-blind, placebo-controlled study. Dig Dis Sci 1998; 43: 83S-895.
   Google Scholar
• Yoshikawa T, Naito Y, Nakamura S et al. Effect of rebamipide on lipid peroxidation and gastric mucosal injury induced by indometacin in rats. Arzneimittelforschung 1993; 43: 1327–1330.
   PubMed Web of Science ®Google Scholar
• Naito Y, Yoshikawa T, Kaneko T et al. Role of oxygen radicals in indomethacin-induced gastric mucosal microvascular injury in rats. J Clin Gastroenterol 1993; 17: S99–S103.
   PubMed Web of Science ®Google Scholar
• Suzuki M, Miura S, Mori M et al. Rebamipide, a novel antiulcer agent, attenuates Helicobacter pylori induced gastric mucosal cell injury associated with neutrophil derived oxidants. Gut 1994; 35: 1375–1378.
   PubMed Web of Science ®Google Scholar
• Naito Y, Yoshikawa T, Tanigawa T et al. Hydroxyl radical scavenging by rebamipide and related compounds: electron paramagnetic resonance study. Free Radic Biol Med 1995; 18: 117–123.
   PubMed Web of Science ®Google Scholar
• Hahm KB, Park IS, Kim YS et al. Role of rebamipide on induction of heat-shock proteins and protection against reactive oxygen metabolite-mediated cell damage in cultured gastric mucosal cells. Free Radic Biol Med 1997; 22: 711–716.
   PubMed Web of Science ®Google Scholar
• Aihara M, Azuma A, Takizawa H et al. Molecular analysis of suppression of interleukin-8 production by rebamipide in Helicobacter pylori-stimulated gastric cancer cell lines. Dig Dis Sci 1998; 43: 174S-180S.
   Google Scholar
• Iinuma S, Naito Y, Yoshikawa T et al. In vitro studies indicating antioxidative properties of rebamipide. Dig Dis Sci 1998; 43 (9 Suppl): 35S-39S.
   Google Scholar
• Takeuchi K, Ueshima K, Hironaka Y, Fujioka Y, Matsumoto J, Okabe S. Oxygen free radicals and lipid peroxidation in the pathogenesis of gastric mucosal lesions induced by indomethacin in rats. Digestion 1991; 49: 175–184.
   PubMed Web of Science ®Google Scholar
• Suzuki M, Inauen W, Kvietys PR et al. Superoxide mediated reperfusion-induced leukocyte-endothelial cell interactions. Am J Physiol 1989; 257: H1740–H1745.
   PubMed Web of Science ®Google Scholar
• Sekizuka E, Benoit JN, Grisham MB, Granger DN. Dimethylsulfoxide prevents chemoattractant-induced leukocyte adherence. Am J Physiol 1989; 256: H594–H597.
   PubMed Web of Science ®Google Scholar
• Wallace JL, Keenan CM, Granger DN. Gastric ulceration induced by non-steroidal anti-inflammatory drugs is a neutrophil-dependent process. Am J Physiol 1990; 259: G462–G467.
   PubMed Web of Science ®Google Scholar
• Wallace JL, Arfors KE, McKnight GW. A monoclonal antibody against the CD18 leukocyte adhesion molecule prevents indomethacin-induced gastric damage in the rabbit. Gastroenterology 1991; 100: 878–883.
   PubMed Web of Science ®Google Scholar
• Asako H, Kubes P, Wallace J, Gaginella T, Wolf RE, Granger DN. Indomethacin-induced leukocyte adhesion in mesenteric venules: role of lipoxygenase products. Am J Physiol 1992; 262: G903–G908.
   PubMed Web of Science ®Google Scholar
• Fiorucci S, Santucci L, Gerli R et al. NSAIDs upregulate beta 2-integrin expression on human neutrophils through a calcium-dependent pathway. Aliment Pharmacol Ther 1997; 11: 619–630.
   PubMed Web of Science ®Google Scholar
• Andrews FJ, Malcontenti-Wilson C, O'Brien PE. Effect of nonsteroidal anti-inflammatory drugs on LFA-1 and ICAM-1 expression in gastric mucosa. Am J Physiol 1994; 266: G657–G664.
   PubMed Web of Science ®Google Scholar
• Santucci L, Fiorucci S, Giansanti M, Brunori PM, Di Matte° FM, Morelli A. Pentoxifylline prevents indomethacin induced acute gastric mucosal damage in rats: role of tumour necrosis factor alpha. Gut 1994; 35: 909–915.
   PubMed Web of Science ®Google Scholar
• Naito Y, Mizushima K, Yoshikawa T. Global analysis of gene expression in gastric ischemia-reperfusion: a future therapeutic direction for mucosal protective drugs. Dig Dis Sci 2005; 50 (Suppl 1): S45–S55.
   PubMedGoogle Scholar
• Katada K, Naito Y, Mizushima K et al. Gene expression profiles on hypoxia and reoxygenation in rat gastric epithelial cells: a high-density DNA microarray analysis. Digestion 2006; 73: 89–100.
   PubMed Web of Science ®Google Scholar
• Vaananen PM, Meddings JB, Wallace JL. Role of oxygen-derived free radicals in indomethacin-induced gastric injury. Am J Physiol 1991; 261: G470–G475.
   PubMed Web of Science ®Google Scholar
• Naito Y, Yoshikawa T, Yoshida N, Kondo M. Role of oxygen radical and lipid peroxidation in indomethacin-induced gastric mucosal injury. Dig Dis Sci 1998; 43: 30S-34S.
   Google Scholar
• Chattopadhyay I, Bandyopadhyay U, Biswas K, Maity P, Banerjee RK. Indomethacin inactivates gastric peroxidase to induce reactive-oxygen-mediated gastric mucosal injury and curcumin protects it by preventing peroxidase inactivation and scavenging reactive oxygen. Free Radic Biol Med 2006; 40: 1397–1408.
   PubMed Web of Science ®Google Scholar
• van Lieshout EM, Tiemessen DM, Peters WH, Jansen JB. Effects of nonsteroidal anti-inflammatory drugs on glutathione S-transferases of the rat digestive tract. Carcinogenesis 1997; 18: 485–490.
   PubMed Web of Science ®Google Scholar
• Gionchetti P, Vaira D, Campieri M et al. Enhanced mucosal interleukin-6 and -8 in Helicobacter pylori-positive dyspeptic patients. Am J Gastroenterol 1994; 89: 883–887.
   PubMed Web of Science ®Google Scholar
• Basso D, Scrigner M, Toma A et al. Helicobacter pylori infection enhances mucosal interleukin-1 beta, interleukin-6, and the soluble receptor of interleukin-2. Int J Clin Lab Res 1996; 26: 207–210.
   PubMedGoogle Scholar
• Kusuhara H, Matsuyuki H, Matsuura M, Imayoshi T, Okamoto T, Matsui H. Induction of apoptotic DNA fragmentation by nonsteroidal anti-inflammatory drugs in cultured rat gastric mucosal cells. Eur J Pharmacol 1998; 360: 273–280.
   PubMed Web of Science ®Google Scholar
• Imamine S, Akbar F, Mizukami Y, Matsui H, Onji M. Apoptosis of rat gastric mucosa and of primary cultures of gastric epithelial cells by indomethacin: role of inducible nitric oxide synthase and interleukin-8. Int J Exp Pathol 2001; 82: 221–229.
   PubMed Web of Science ®Google Scholar
• Fujii Y, Matsura T, Kai M, Matsui H, Kawasaki H, Yamada K. Mitochondrial cytochrome c release and caspase-3-like protease activation during indomethacin-induced apoptosis in rat gastric mucosal cells. Proc Soc Exp Biol Med 2000; 224: 102–108.
   PubMed Web of Science ®Google Scholar
• Slomiany BL, Piotrowski J, Slomiany A. Induction of tumor necrosis factor-alpha and apoptosis in gastric mucosal injury by indomethacin: effect of omeprazole and ebrotidine. Scand J Gastroenterol 1997; 32: 638–642.
   PubMed Web of Science ®Google Scholar
• Kusuhara H, Komatsu H, Sumichika H, Sugahara K. Reactive oxygen species are involved in the apoptosis induced by nonsteroidal anti-inflammatory drugs in cultured gastric cells. Eur J Pharmacol 1999; 383: 331–337.
   PubMed Web of Science ®Google Scholar
• Fuji Y, Matsura T, Kai M, Kawasaki H, Yamada K. Protection by polaprezinc, an anti-ulcer drug, against indomethacin-induced apoptosis in rat gastric mucosal cells. Jpn J Phannacol 2000; 84: 63–70.
   PubMed Web of Science ®Google Scholar
• Kim TI, Jin SH, Kim WH et al. Prolonged activation of mitogen-activated protein kinases during NSAID-induced apoptosis in HT-29 colon cancer cells. Int J Colorectal Dis 2001; 16: 167–173.
   PubMed Web of Science ®Google Scholar
• Bradbury CM, Markovina S, Wei SJ et al. Indomethacin-induced radiosensitization and inhibition of ionizing radiation-induced NF-kappaB activation in HeLa cells occur via a mechanism involving p38 MAP kinase. Cancer Res 2001; 61: 7689–7696.
   PubMed Web of Science ®Google Scholar
• Kim TI, Jin SH, Kang EH, Shin SK, Choi KY, Kim WH. The role of mitogen-activated protein kinases and their relationship with NF-kappaB and PPARgamma in indomethacin-Induced apoptosis of colon cancer cells. Ann NY Acad Sci 2002; 973: 241–245.
   PubMed Web of Science ®Google Scholar
• Du K, Herzig S, Kulkarni RN, Montminy M. TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science 2003; 300: 1574–1577.
   PubMed Web of Science ®Google Scholar
• Hanada M, Feng J, Hemmings BA. Structure, regulation and function of PKB/AKT — a major therapeutic target. Biochim Biophys Ada 2004; 1697: 3–16.
   PubMed Web of Science ®Google Scholar
• Liebermann DA, Hoffman B. Myeloid differentiation (MyD) primary response genes in hematopoiesis. Blood Cells Mol Dis 2003; 31: 213–228.
   PubMed Web of Science ®Google Scholar
• Jin S, Antinore MJ, Lung FD et al. The GADD45 inhibition of Cdc2 kinase correlates with GADD45-mediated growth suppression. J Biol Chem 2000; 275: 16602–16608.
   PubMed Web of Science ®Google Scholar
• Sheikh MS, Hollander MC, Fornance AJ Jr. Role of Gadd45 in apoptosis. Biochem Pharmacol 2000; 59: 43–45.
   PubMed Web of Science ®Google Scholar
• Wang XW, Zhan Q, Coursen JD et al. GADD45 induction of a G2/M cell cycle checkpoint. Proc Natl Acad Sci USA 1999; 96: 3706–3711.
   PubMed Web of Science ®Google Scholar
• Takekawa M, Saito H. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. Cell 1998; 95: 521–530.
   PubMed Web of Science ®Google Scholar
• Mita H, Tsutsui J, Takekawa M, Witten EA, Saito H. Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding. Mol Cell Biol 2002; 22: 4541 4555.
   Google Scholar