250
Views
4
CrossRef citations to date
0
Altmetric
Short Refereed Papers

Analysis of HNE metabolism in CNS models

, , , &
Pages 16-19 | Published online: 19 Jul 2013

REFERENCES

  • Picklo MJ, Montine TJ, Amamath V, Neely MD. Carbonyl toxicology and Alzheimer's disease. Toxicol Appl Phannacol 2002; 184: 187–197.
  • Zarkovic K. 4-Hydroxynonenal and neurodegenerative diseases. Mol Aspects Med 2003; 24: 293–303.
  • Petersen DR, Doom JA. Reactions of 4-hydroxynonenal with proteins and cellular targets. Free Radic Biol Med 2004; 37: 937–945.
  • Mattson MP, Fu W, Waeg G, Uchida K. 4-Hydroxynonenal, a product of lipid peroxidation, inhibits dephosphorylation of the microtubule-associated protein tau. Neuroreport 1997; 8: 2275–2281.
  • Keller JN, Pang Z, Geddes JW et al. Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: role of the lipid peroxidation product 4-hydroxynonenaL J Neurochem 1997; 69: 273-284.
  • Srivastava S, Conklin DJ, Liu S et al. Identification of biochemical pathways for the metabolism of oxidized low-density lipoprotein derived aldehyde-4-hydroxy trans-2-nonenal in vascular smooth muscle cells. Atherosclerosis 2001; 158: 339–350.
  • Mitchell DY, Petersen DR Inhibition of rat hepatic mitochondrial aldehyde dehydrogenase-mediated acetylaldehyde oxidation by trans-4-hydroxy-2-nonenaL Hepatology 1991; 13: 728-734.
  • Tjalkens RB, Cook LW, Petersen DR. Formation and export of the glutathione conjugate of 4-hydroxy-2,3-E-nonenal (4-LINE) in hepatoma cells. Arch Biochem Biophys 1999; 361: 113–119.
  • Kunstmann S, Mertsch K, Blasig IE, Grune T. High metabolic rates of 4-hydroxynonenal in brain capillary endothelial cells during hypoxia/reoxygenation. Brain Res 1996; 740: 353–355.
  • Picklo MJ, Amamath V, McIntyre JO, Graham DG, Montine TJ. 4-Hydroxy-2(E)-nonenal inhibits CNS mitochondrial respiration at multiple sites. J Neurochem 1999; 72: 1617–1624.
  • Meyer MJ, Mosely DE, Amamath V, Picklo MJSr. Metabolism of 4-hydroxy-trans-2-nonenal by central nervous system mitochondria is dependent on age and NAIL)* availability. Chem Res Toxicol 2004; 17: 1272–1279.
  • Ullrich O, Grune T, Henke W, Esterbauer H, Siems WG. Identification of metabolic pathways of the lipid peroxidation product 4-hydroxynonenal by mitochondria isolated from rat kidney cortex. FEBS Lett 1994; 352: 84–86.
  • Murphy TC, Amamath V, Gibson KM, Picklo MJSr. Oxidation of 4-hydroxy-2-nonenal by succinic semialdehyde dehydrogenase (ALDH5A). J Neurochem 2003; 86: 298–305.
  • Hiratsuka A, Saito H, Hirose K, Watabe T. Marked expression of glutathione 5-transferase A4-4 detoxifying 4-hydroxy-2(E)-nonenal in the skin of rats irradiated by ultraviolet B-band light (UVB). Biochem Biophys Res Commun 1999; 260: 740–746.
  • Hiratsuka A, Tobita K, Saito H et al. (S)-preferential detoxification of 4-hydroxy-2(E)-nonenal enantiomers by hepatic glutathione 5-transferase isoforms in guinea-pigs and rats. Biochem J2001; 355: 237–244.
  • Hashimoto M, Sibata T, Wasada H, Toyokuni S, Uchida K. Structural basis of protein-bound endogenous aldehydes. Chemical and immunochemical characterizations of configurational isomers of a 4-hydroxy-2-nonenal-histidine adduct J Biol Chem 2003; 278: 5044–5051.
  • Honzatko A, Brichac J, Murphy TC et al. Enantioselective metabolism of trans-4-hydroxy-2-nonenal by brain mitochondria. Free Radic Biol Med 2005; 39: 913–924.
  • Leiphon LJ, Picklo MJSr. Inhibition of aldehyde detoxification in CNS mitochondria by fungicides. Neurotoxicology 2007; In press.
  • Kubatova A, Murphy TC, Combs C, Picklo MJSr. Astrocytic biotransformation of trans-4-hydroxy-2-nonenal is dose-dependent Chem Res Toxicol 2006; 19: 844-851.
  • Dick RA, Kwak MK, Sutter TR Kensler TW. Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase. A new role for leukotrieneB4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase. JBiol Chem 2001; 276: 40803–40810.
  • Picklo MJ, Olson SJ, Markesbery WR, Montine TJ. Expression and activities of aldo-keto oxidoreductases in Alzheimer disease. J Neuropathol Exp Neurol 2001; 60: 686–695.
  • Sidell KR, Montine KS, Picklo Sr MJ, Olsen SJ, Amamath V, Montine TJ. Mercapturate metabolism of 4-hydroxy-2-nonenal in rat and human cerebrum. J Neuropathol Exp Neun912003; 62: 146-153.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.