REFERENCES
- Floyd RA. Antioxidants, oxidative stress, and degenerative neuro-logical disorders. Proc Soc Exp Biol Med 1999; 222: 236–245.
- Bishop GM, Robinson SR, Liu Q, Perry G, Atwood CS, Smith MA. Iron: a pathological mediator of Alzheimer disease? Dev Neurosci 2002; 24: 184–187.
- Drugas GT, Paidas CN, Yahanda AM, Ferguson D, Clemens MG. Conjugated desferoxamine attenuates hepatic microvascular injury following ischemia/reperfusion. Circ Shock 1991; 34: 278–283.
- Sarco DP, Becker J, Palmer C, Sheldon RA, Ferriero DM. The neuroprotective effect of deferoxamine in the hypoxic-ischemic immature mouse brain. Neurosci Lett 2000; 282: 113–116.
- Moos T, Morgan EH. Transferrin and transferrin receptor function in brain barrier systems. Cell Mol Neurobiol 2000; 20: 77–95.
- Smith MA, Harris PL, Sayre LM, Perry G. Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. Proc Natl Acad Sci USA 1997; 94: 9866–9868.
- Sayre LM, Perry G, Harris PL, Liu Y, Schubert KA, Smith MA. In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: a central role for bound transition metals. J Neurochem 2000; 74: 270–279.
- Castellani RJ, Harris PL, Sayre LM et al. Active glycation in neurofibrillary pathology of Alzheimer disease: N(epsilon)-(carboxymethyl) lysine and hexitol-lysine. Free Radic Biol Med 2001; 31: 175–180.
- Stemberger LA, Stemberger NH. The unlabeled antibody method: comparison of peroxidase-antiperoxidase with avidin-biotin complex by a new method of quantification. J Histochem Cytochem 1986; 34: 599–605.
- Paxinos G, Franldin KBJ. The Mouse Brain in Stereotaxic Coordinates, 2nd edn. San Diego, CA: Academic Press; 2001.
- Moos T, Mollgard K. A sensitive post-DAB enhancement technique for demonstration of iron in the central nervous system. Histochemistly 1993; 99: 471–475.
- Leung PS, Srai SK, Mascarenhas M, Churchill LJ, Debnam ES. Increased duodenal iron uptake and transfer in a rat model of chronic hypoxia is accompanied by reduced hepcidin expression. Gut 2005; 54: 1391–1395.
- Laftah AH, Simpson RJ, Beaumont N, Bahram S, Schumann K, Srai SK. Hypoxic response of iron absorption is not affected by the Hfe gene knock-out in mice. Br J Haematol 2003; 123: 170–172.
- Raja KB, Pippard MJ, Simpson RJ, Peters TJ. Relationship between erythropoiesis and the enhanced intestinal uptake of ferric iron in hypoxia in the mouse. Br J Haematol 1986; 64: 587–593.
- O'Riordan DK, Debnam ES, Sharp PA, Simpson RJ, Taylor EM, Srai SK. Mechanisms involved in increased iron uptake across rat duodenal brush-border membrane during hypoxia. J Physiol 1997; 500: 379–384.
- Toth I, Yuan L, Rogers JT, Boyce H, Bridges KR. Hypoxia alters iron-regulatory protein-1 binding capacity and modulates cellular iron homeostasis in human hepatoma and erythroleukemia cells. J Biol Chem 1999; 274: 4467–4473.
- Borch-Iohnsen B, Myhre K, Norheim G. Hypoxia and deposition of iron in liver and spleen of mice given iron supplement. Eur J Haematol 1990; 44: 56–62.
- Hershko C, Link G, Pinson A. Modification of iron uptake and lipid peroxidation by hypoxia, ascorbic acid, and alpha-tocopherol in iron-loaded rat myocardial cell cultures. J Lab Clin Med 1987; 110: 355–361.
- Kaur C, Ling EA. Increased expression of transferrin receptors and iron in amoeboid microglial cells in postnatal rats following an exposure to hypoxia. Neurosci Lett 1999; 262: 183–186.
- Palmer C, Menzies SL, Roberts RU, Pavlick G, Connor JR. Changes in iron histochemistry after hypoxic-ischemic brain injury in the neonatal rat. J Neurosci Res 1999; 56: 60–71.
- Niknahad H, Khan S, O'Brien PJ. Hepatocyte injury resulting from the inhibition of mitochondrial respiration at low oxygen concentrations involves reductive stress and oxygen activation. Chem Biol Interact 1995; 98: 27–44.
- Baliga R, Ueda N, Shah SV. Increase in bleomycin-detectable iron in ischaemia/reperfusion injury to rat kidneys. Biochem J 1993; 291: 901–905.
- Khan S, O'Brien PJ. Modulating hypoxia-induced hepatocyte injury by affecting intracellular redox state. Biochim Biophys Acta 1995; 1269: 153–161.
- Kakhlon O, Cabantchik ZI. The labile iron pool: characterization, measurement, and participation in cellular processes (1). Free Radic Biol Med 2002; 33: 1037–1046.
- Yamagami K, Yamamoto Y, Toyokuni S, Hata K, Yamaoka Y. Heat shock preconditioning reduces the formation of 8-hydroxy-2'-deoxyguanosine and 4-hydroxy-2-nonenal modified proteins in ischemia-reperfused liver of rats. Free Radic Res 2002; 36: 169–176.
- Englander EW, Greeley Jr GH, Wang G, Perez-Polo JR, Lee HM. Hypoxia-induced mitochondrial and nuclear DNA damage in the rat brain. J Neurosci Res 1999; 58: 262–269.
- Imai H, Masayasu H, Dewar D, Graham DI, Macrae IM. Ebselen protects both gray and white matter in a rodent model of focal cerebral ischemia. Stroke 2001; 32: 2149–2154.
- Lee EJ, Lee MY, Chen HY et al. Melatonin attenuates gray and white matter damage in a mouse model of transient focal cerebral ischemia. J Pineal Res 2005; 38: 42–52.