REFERENCES
- Kushner JP, Porter JP, Olivieri NF. Secondary Iron Overload. Hematology Am Soc Hematol Educ Program 2001: 47–61.
- Greenberg PL. Myelodysplastic syndromes: iron overload consequences and current chelating therapies. J Natl Compr Canc Netw 2006; 4: 91–96.
- Walter PB, Fung EB, Killilea DW et al. Oxidative stress and inflammation in iron-overloaded patients with beta-thalassaemia or sickle cell disease. Br J Haematol 2006; 135: 254–263.
- Young IS, Woodside TV Antioxidants in health and disease. J Clin Pathol 2001; 54: 176–186.
- Zanninelli G, Loreal O, Brissot P et al. The labile iron pool of hepatocytes in chronic and acute iron overload and chelator-induced iron deprivation. J Hepatol 2002; 36: 39–46.
- Walter PB, Knutson MD, Paler-Martinez A et al. Iron deficiency and iron excess damage mitochondria and mitochondrial DNA in rats. Proc Nail Acad Sci USA 2002; 99: 2264–2269.
- Atamna H. Heme, iron, and the mitochondrial decay of ageing. Ageing Res Rev 2004; 3: 303–318.
- Welch KD, Davis TZ, Van Eden ME, Aust SD. Deleterious iron-mediated oxidation of biomolecules. Free Radic Biol Med 2002; 32: 577–583.
- Livrea MA, Tesoriere L, Pintaudi AM et al. Oxidative stress and antioxidant status in beta-thalassemia major: iron overload and depletion of lipid-soluble antioxidants. Blood 1996; 88: 3608–3614.
- Walter PB, Fung E, Killilea DW et al. Toxic unbound iron and membrane injury in I3-thalassemia and sickle cell disease: elevated non-transferrin bound iron (NTBI) and malondialdehyde (MDA) [Abstract]. Blood 2004; 104: 3608.
- Chiu D, Vichinsky E, Ho SL, Liu T, Lubin BH. Vitamin C deficiency in patients with sickle cell anemia. Am J Pediatr Hematol Oncol 1990; 12: 262–267.
- Westerman MP, Zhang Y, McConnell JP et al. Ascorbate levels in red blood cells and urine in patients with sickle cell anemia. Am J Hematol 2000; 65: 174–175.
- Tesoriere L, D'Arpa D, Butera D et al. Oral supplements of vitamin E improve measures of oxidative stress in plasma and reduce oxidative damage to LDL and erythrocytes in beta-thalassemia intermedia patients. Free Radic Res 2001; 34: 529–540.
- Kalpravidh RW, Wichit A, Siritanaratkul N, Fucharoen S. Effect of coenzyme Qm as an antioxidant in beta-thalassemia/Hb E patients. Biofactors 2005; 25: 225–234.
- Tesoriere L, Allegra M, Butera D, Gentile C, Livrea MA. Cytoprotective effects of the antioxidant phytochemical indicaxanthin in beta-thalassemia red blood cells. Free Radic Res 2006; 40: 753–761.
- Dissayabutra T, Tosukhowong P, Seksan P. The benefits of vitamin C and vitamin E in children with beta-thalassemia with high oxidative stress. J Med Assoc Thai 2005; 88 (Suppl 4): S317–S321.
- de Franceschi L, Turrini F, Honczarenko M et al. In vivo reduction of erythrocyte oxidant stress in a murine model of beta-thalassemia. Haematologica 2004; 89: 1287–1298.
- Marangon K, Devaraj S, Tirosh O, Packer L, Jialal I. Comparison of the effect of alpha-lipoic acid and alpha-tocopherol supplementation on measures of oxidative stress. Free Radic Biol Med 1999; 27: 1114–1121.
- Killilea DW, Atamna H, Liao C, Ames BN. Iron accumulation during cellular senescence in human fibroblasts in vitro. Antioxid Redox Signal 2003; 5: 507–516.
- Voloboueva LA, Liu J, Suh JH, Ames BN, Miller SS. (R)-alpha-lipoic acid protects retinal pigment epithelial cells from oxidative damage. Invest Ophthalmol Vis Sci 2005; 46: 4302–4310.
- Hagen TM, Liu J, Lykkesfeldt J et al. Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. Proc Nail Acad Sci USA 2002; 99: 1870–1875.
- Eaton JW, Qian M. Molecular bases of cellular iron toxicity. Free Radic Biol Med 2002; 32: 833–840.
- Goralska M, Dackor R, Holley B, McGahan MC. Alpha lipoic acid changes iron uptake and storage in lens epithelial cells. Exp Eye Res 2003; 76: 241–248.
- Moini H, Packer L, Saris NE. Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid. Toxicol Appl Pharmacol 2002; 182: 84–90.
- Pick U, Haramaki N, Constantinescu A et al. Glutathione reductase and lipoamide dehydrogenase have opposite stereospecificities for alpha-lipoic acid enantiomers. Biochem Biophys Res Commun 1995; 206: 724–730.
- Suh JH, Shenvi SV, Dixon BM et al. Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc Nail Acad Sci USA 2004; 101: 3381–3386.
- Hagen TM, Vinarsky V, Wehr CM, Ames BN. (R)-Alpha-lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo. Antioxid Redox Signal 2000; 2: 473–483.
- Coleman MD, Fernandes S, Khanderia L. A preliminary evaluation of a novel method to monitor a triple antioxidant combination (vitamins E, C and a-lipoic acid) in diabetic volunteers using in vitro methaemoglobin formation. Environ Toxicol Pharmacol 2003; 14: 69–75.
- Kwak MK, Wakabayashi N, Itoh K et al. Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keapl—Nrf2 pathway. Identification of novel gene clusters for cell survival. J Biol Chem 2003; 278: 8135–8145.
- Maitra I, Serbinova E, Tritschler HJ, Packer L. Stereospecific effects of R-lipoic acid on buthionine sulfoximine-induced cataract formation in newborn rats. Biochem Biophys Res Commun 1996; 221: 422–429.
- Bast A, Haenen GR. Lipoic acid: a multifunctional antioxidant. Biofactors 2003; 17: 207–213.
- Bonomi F, Cerioli A, Pagani S. Molecular aspects of the removal of ferritin-bound iron by DL-dihydrolipoate. Biochim Biophys Acta 1989; 994: 180–186.
- Yamamoto H, Watanabe T, Mizuno H et al. The antioxidant effect of DL-alpha-lipoic acid on copper-induced acute hepatitis in Long-Evans Cinnamon (LEC) rats. Free Radic Res 2001; 34: 69–80.
- Liu J, Killilea DW, Ames BN. Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-alpha-lipoic acid. Proc Natl Acad Sci USA 2002; 99: 1876–1881.