The flavonoid morin restores blood pressure and lipid metabolism in DOCA-salt hypertensive rats

References

• World Health Organization. Available from http://www.who.int/mediacentre/factsheets/fs317/en/ [accessed 31 January 2011].
   Google Scholar
• Chapman MJ, Sposito AC. Hypertension and dyslipidemia in obesity and insulin resistance: pathophysiology, impact on atherosclerotic disease and pharmacotherapy. Pharmacol Ther 2008;117:354–73.
   PubMed Web of Science ®Google Scholar
• Wong ND, Lopez V, Tang S, Williams GR. Prevalence, treatment, and control of combined hypertension and hypercholesterolemia in the United States. Am J Cardiol 2006;98:204–8.
   PubMed Web of Science ®Google Scholar
• Kwon HM, Sangiorgi G, Ritman EL. Enhanced coronary vasa vasorum neovascularization in experimental hypercholesterolemia. J Clinic Invest 1998;101:1551–6.
   PubMed Web of Science ®Google Scholar
• Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, et al. Seventh report of the Joint National Committee on prevention, detection, evaluation, treatment of high blood pressure. Hypertens 2003;42:1206–52.
   Google Scholar
• Jagla A, Schrezenmeir J. Postprandial triglycerides and endothelial function. Exp Clin Endocrinol Diabetes 2001;109:533–47.
   PubMed Web of Science ®Google Scholar
• Palmieri VO, Grattagliano I, Portincasa P. Systemic oxidative alterations are associated with visceral adiposity and liver steatosis in patients with metabolic syndrome. J Nutr 2006;136:3022–6.
   PubMed Web of Science ®Google Scholar
• Harborne JB, Williams CA. Advances in flavonoid research since 1992. Phytochemistry 2000;55:481–504.
   PubMed Web of Science ®Google Scholar
• Hou YC, Chao PDL, Ho HJ. Profound difference in pharmacokinetics between morin and its isomer quercetin in rats. J Pharm Pharmacol 2003;55:199–203.
   PubMed Web of Science ®Google Scholar
• Retelny VS, Neuendorf A, Roth JL. Nutrition protocols for the prevention of cardiovascular disease. Nutr Clin Pract 2008;23:468–76.
   PubMed Web of Science ®Google Scholar
• Rattanachaikunsopon P, Phumkhachorn P. Contents and antibacterial activity of flavonoids extracted from leaves of Psidium quajava. J Med Plants Res 2010;4:393–6.
   Web of Science ®Google Scholar
• Lotito SB, Frei B. Consumption of flavonoid rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon. Free Radic Biol Med 2006;41:1727–46.
   PubMed Web of Science ®Google Scholar
• Subash S, Subramanian P. Morin a flavonoid exerts antioxidant potential in chronic hyperammonemic rats: a biochemical and histopathological study. Mol Cell Biochem 2009;32:153–61.
   Google Scholar
• Francis AR, Shetty TK, Bhattacharya RK. Modifying role of dietary factors on the mutagenicity of aflatoxin B1: in vitro effect of plant flavonoids. Mutat Res 1989;222:393–401.
   PubMed Web of Science ®Google Scholar
• Sivaramakrishnan V, Shilpa P, Kumar V, Niranjali Devaraj S. Attenuation of N-nitrosodiethylamine-induced hepatocellular carcinogenesis by a novel favonol-morin. Chem Biol Inter 2008;171:79–88.
   PubMed Web of Science ®Google Scholar
• Sivaramakrishnan V, Devaraj SN. Morin regulates the expression of NF-kB-p65, COX-2 and matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma. Chem Biol Inter 2009;180:353–9.
   PubMed Web of Science ®Google Scholar
• Prahalathan P, Kumar S, Raja B. Effect of morin, a flavonoid against DOCA-salt hypertensive rats: a dose dependent study. Asian Pac J Trop Biomed 2012;2:443–8.
   PubMedGoogle Scholar
• Prahalathan P, Kumar S, Raja B. Morin attenuates blood pressure and oxidative stress in deoxycorticosterone acetate -salt hypertensive rats: a biochemical and histopathological evaluation. Metabolism 2012; doi:10.1016/j.metabol.2011.12.012 (In press).
   PubMed Web of Science ®Google Scholar
• Abishek I, Andrew F, Junxian L, Giang T, Robert C, Maria A. Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats. Brit J Pharmacol 2010;159:1408–17.
   PubMed Web of Science ®Google Scholar
• Vincent C, Andrew F, Abishek I, Andrew H, Lindsay B. Resveratrol improves cardiovascular function in DOCA-salt hypertensive rats. Curr Pharm Biotechnol 2011;12:429–36.
   PubMed Web of Science ®Google Scholar
• Karthik Kumar V, Vennila S, Nalini N. Inhibitory effect of morin on DMH-induced biochemical changes and aberrant crypt foci formation in experimental colon carcinogenesis. Environ Toxicol Phar 2010;29:50–7.
   PubMed Web of Science ®Google Scholar
• Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248–54.
   PubMed Web of Science ®Google Scholar
• Folch J, Lees M, Sloane SGH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 1957;226:497–509.
   PubMed Web of Science ®Google Scholar
• Zlatkis A, Zak B, Boyle AJ. A new method for the direct determination of serum cholesterol. J Lab Clin Med 1953;41:486–92.
   PubMed Web of Science ®Google Scholar
• Fossati P, Prencipe L. Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clin Chem 1982;28:2077–80.
   PubMed Web of Science ®Google Scholar
• Falholt K, Lund B, Falholt W. An easy colorimetric micromethod for routine determination of free fatty acids in plasma. Clin Chim Acta 1973;46:105–1.
   PubMed Web of Science ®Google Scholar
• Zilversmit DB, Davis AK. Microdetermination of plasma phospholipids by trichloroacetic acid precipitation. J Lab Clin Med 1950;35:155–60.
   PubMed Web of Science ®Google Scholar
• Philipp B, Shapiro DJ. Improved methods for the assay and activation of 3-hydroxy-3-methyl glutaryl coenzyme A reductase. J Lipid Res 1970;20:588–93.
   Google Scholar
• Hitz J, Steinmetz G Siest. Plasma lecithin: cholesterol acyltransferasereference values and effects of xenobiotics. Clin Chim Acta 1983;133:85–96.
   PubMed Web of Science ®Google Scholar
• Sesso HD, Gaziano JM, Liu S, Buring JE. Flavonoid intake and the risk of cardiovascular disease in women. Am J Clin Nutr 2003;77:1400–8.
   PubMed Web of Science ®Google Scholar
• Rosario J, Rocio Lopez S, Maria K. Polyphenols restore endothelial function in DOCA-salt hypertension: role of endothelin-1 and NADPH oxidase. Free Radic Biol Med 2007;43:462–73.
   PubMed Web of Science ®Google Scholar
• Friedwald WT, Levy RJ, Fredricken DS. Estimation of the concentration of LDL-cholesterol in the plasma without the use of preparative ultracentrifuge. Clin Chem 1972;18:499–502.
   PubMed Web of Science ®Google Scholar
• Salter AM, White DA. Effects of dietary fat on cholesterol metabolism: regulation of plasma LDL concentrations. Nutr Res 1996;9:241–57.
   Web of Science ®Google Scholar
• McKenney JM. Pharmacotherapy of dyslipidemia. Cardiovasc Drugs Ther 2001;15:413–22.
   PubMed Web of Science ®Google Scholar
• Austin MA, Hokanson JE, Edwards KL. Hypertriglyceridemia as a cardiovascular risk factor. Am J Cardiol 1998;81:7–12.
   PubMed Web of Science ®Google Scholar
• Ohara Y, Peterson TE, Harrison DG. Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest 1993;91:2546–51.
   PubMed Web of Science ®Google Scholar
• Goldstein JL, Brown MS. Progress in understanding the LDL receptor and HMG-CoA reductase, two membrane proteins that regulate the plasma cholesterol. J Lipid Res 1984;25:1450–61.
   PubMed Web of Science ®Google Scholar
• Miller NE, Thelle DS, Forde OH. The Tromso heart-study. HDL and coronary heart-disease: a prospective case control-study. Lancet 1977;1:965–8.
   PubMed Web of Science ®Google Scholar
• Easterbauer H, Gebick J, Phal H. The role of lipidperoxidation and antioxidants in the oxidative modifications of LDL. Free Radic Biol Med 1992;13:341–90.
   PubMed Web of Science ®Google Scholar
• Kok DL, Wong YP, Wu TW, Chan HC, Kwok TT, Fung KP. Morin hydrate a potential antioxidant in minimizing the free radicals-mediated damage to cardiovascular cells by anti-tumor drug. Life Sci 2000;67:91–9.
   PubMed Web of Science ®Google Scholar