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Redox Report
Communications in Free Radical Research
Volume 20, 2015 - Issue 3
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Research Articles

Effect of N-acetylcysteine plus deferoxamine on oxidative stress and inflammation in dystrophic muscle cells

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References

  • Engel AG,, Yamamoto M, Fischbeck KH. Dystrophinopathies. In: Engel AG, Franzini-Armstrong C, (eds.) Myology. New York: McGraw-Hill Inc; 1994. p. 1133–87.
  • Grounds MD, Torrisi J. Anti-TNFalpha (Remicade) therapy protects dystrophic skeletal muscle from necrosis. FASEB J 2004;18(6):676–82.
  • Hodgetts S, Radley H, Davies M, Grounds MD. Reduced necrosis of dystrophic muscle by depletion of host neutrophils, or blocking TNF alpha function with Etanercept in mdx mice. Neuromuscul Disord 2006;16(9–10):591–602.
  • Tidball JG. Inflammatory processes in muscle injury and repair. Am J Physiol Regul Integr Comp Physiol 2005;288(2):R345–53.
  • Prosser BL, Khairallah RJ, Ziman AP, Ward CW, Lederer WJ. X-ROS signaling in the heart and skeletal muscle: stretch-dependent local ROS regulates [Ca2 + ](i). J Mol Cell Cardiol 2013;58:172–81.
  • Rando TA, Disatnik MH, Yu Y, Franco A. Muscle cells from mdx mice have an increased susceptibility to oxidative stress. Neuromuscular Disord 1998;8(1):14–21.
  • de Senzi Moraes Pinto R, Ferretti R, Moraes LH, Neto HS, Marques MJ, Minatel E. N-acetylcysteine treatment reduces TNF-alpha levels and myonecrosis in diaphragm muscle of mdx mice. Clin Nutr 2013;32(3):472–5.
  • Fogagnolo Mauricio A, Minatel E, Santo Neto H, Marques MJ. Effects of fish oil containing eicosapentaenoic acid and docosahexaenoic acid on dystrophic mdx mice. Clin Nutr 2013;32(4):636–42.
  • Tonon E, Ferretti R, Shiratori JH, Santo Neto H, Marques MJ, Minatel E. Ascorbic acid protects the diaphragm muscle against myonecrosis in mdx mice. Nutrition 2012;28(6):686–90.
  • Terrill JR, Radley-Crabb HG, Grounds MD, Arthur PG. N-Acetylcysteine treatment of dystrophic mdx mice results in protein thiol modifications and inhibition of exercise induced myofibre necrosis. Neuromuscul Disord 2012;22(5):427–34.
  • Arent CO, Reus GZ, Abelaira HM, Ribeiro KF, Steckert AV, Mina F, et al. Synergist effects of N-acetylcysteine and deferoxamine treatment on behavioral and oxidative parameters induced by chronic mild stress in rats. Neurochem Int 2012;61(7):1072–80.
  • Di-Pietro PB, Dias ML, Scaini G, Burigo M, Constantino L, Machado RA, et al. Inhibition of brain creatine kinase activity after renal ischemia is attenuated by N-acetylcysteine and deferoxamine administration. Neurosci Lett 2008;434(1):139–43.
  • Ritter C, Andrades ME, Reinke A, Menna-Barreto S, Moreira JMF, Dal-Pizzol F. Treatment with N-acetylcysteine plus deferoxamine protects rats against oxidative stress and improves survival in sepsis. Crit Care Med 2004;32(2):342–9.
  • Ritter C, da Cunha AA, Echer IC, Andrades M, Reinke A, Lucchiari N, et al. Effects of N-acetylcysteine plus deferoxamine in lipopolysaccharide-induced acute lung injury in the rat. Crit Care Med 2006;34(2):471–7.
  • Valvassori SS, Petronilho FC, Reus GZ, Steckert AV, Oliveira VBM, Boeck CR, et al. Effect of N-acetylcysteine and/or deferoxamine on oxidative stress and hyperactivity in an animal model of mania. Prog Neuropsychopharmacol Biol Psychiatry 2008;32(4):1064–8.
  • Halliwell B. Use of desferrioxamine as a ‘probe‘ for iron-dependent formation of hydroxyl radicals. Evidence for a direct reaction between desferal and the superoxide radical. Biochem Pharmacol 1985;34(2):229–33.
  • Halliwell B. Protection against tissue-damage in vivo by desferrioxamine – what is its mechanism of action. Free Radical Bio Med 1989;7(6):645–51.
  • Bornman L, Rossouw H, Gericke GS, Polla BS. Effects of iron deprivation on the pathology and stress protein expression in murine X-linked muscular dystrophy. Biochem Pharmacol 1998;56(6):751–7.
  • Whitehead NP, Yeung EW, Allen DG. Muscle damage in mdx (dystrophic) mice: role of calcium and reactive oxygen species. Clin Exp Pharmacol Physiol 2006;33(7):657–62.
  • Kumar A, Boriek AM. Mechanical stress activates the nuclear factor-kappaB pathway in skeletal muscle fibers: a possible role in Duchenne muscular dystrophy. FASEB J 2003;17(3):386–96.
  • Rando TA, Blau HM. Primary mouse myoblast purification, characterization, and transplantation for cell-mediated gene therapy. J Cell Biol 1994;125(6):1275–87.
  • Bani C, Lagrota-Candido J, Pinheiro DF, Leite PE, Salimena MC, Henriques-Pons A, et al. Pattern of metalloprotease activity and myofiber regeneration in skeletal muscles of mdx mice. Muscle Nerve 2008;37(5):583–92.
  • Bartelt-Kirbach B, Golenhofen N. Reaction of small heat-shock proteins to different kinds of cellular stress in cultured rat hippocampal neurons. Cell Stress Chaperones 2014;19(1):145–53.
  • Aldini G, Dalle-Donne I, Vistoli G, Maffei Facino R, Carini M. Covalent modification of actin by 4-hydroxy-trans-2-nonenal (HNE): LC-ESI-MS/MS evidence for Cys374 Michael adduction. J Mass Spectrom 2005;40(7):946–54.
  • Patel VB, Spencer CH, Young TA, Lively MO, Cunningham CC. Effects of 4-hydroxynonenal on mitochondrial 3-hydroxy-3-methylglutaryl (HMG-CoA) synthase. Free Radic Biol Med 2007;43(11):1499–507.
  • Culligan K, Banville N, Dowling P, Ohlendieck K. Drastic reduction of calsequestrin-like proteins and impaired calcium binding in dystrophic mdx muscle. J Appl Physiol 2002;92(2):435–45.
  • Whitehead NP, Pham C, Gervasio OL, Allen DG. N-acetylcysteine ameliorates skeletal muscle pathophysiology in mdx mice. J Physiol 2008;586(7):2003–14.
  • Williams IA, Allen DG. The role of reactive oxygen species in the hearts of dystrophin-deficient mdx mice. Am J Physiol-Heart Circ Physiol 2007;293(3):H1969–77.
  • Dycus DL, Au AY, Grzanna MW, Wardlaw JL, Frondoza CG. Modulation of inflammation and oxidative stress in canine chondrocytes. Am J Vet Res 2013;74(7):983–9.
  • Mata M, Morcillo E, Gimeno C, Cortijo J. N-acetyl-L-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type II epithelial cells infected with influenza virus A and B and with respiratory syncytial virus (RSV). Biochem Pharmacol 2011;82(5):548–55.
  • Valko M, Leibfritz D, Moncol J, Cronin MTD, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell B 2007;39(1):44–84.
  • Teixeira KC, Soares FS, Rocha LG, Silveira PC, Silva LA, Valenca SS, et al. Attenuation of bleomycin-induced lung injury and oxidative stress by N-acetylcysteine plus deferoxamine. Pulm Pharmacol Ther 2008;21(2):309–16.
  • Blackwell TS, Blackwell TR, Holden EP, Christman BW, Christman JW. In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutrophilic lung inflammation. J Immunol 1996;157(4):1630–7.
  • Palacio JR, Markert UR, Martinez P. Anti-inflammatory properties of N-acetylcysteine on lipopolysaccharide-activated macrophages. Inflamm Res 2011;60(7):695–704.
  • Vlahakos D, Arkadopoulos N, Kostopanagiotou G, Siasiakou S, Kaklamanis L, Degiannis D, et al. Deferoxamine attenuates lipid peroxidation, blocks interleukin-6 production, ameliorates sepsis inflammatory response syndrome, and confers renoprotection after acute hepatic ischemia in pigs. Artif Organs 2012;36(4):400–8.
  • Messina S, Bitto A, Aguennouz M, Minutoli L, Monici MC, Altavilla D, et al. Nuclear factor kappa-B blockade reduces skeletal muscle degeneration and enhances muscle function in Mdx mice. Exp Neurol 2006;198(1):234–41.
  • Fraga CM, Tomasi CD, Biff D, Topanotti MFL, Felisberto F, Vuolo F, et al. The effects of N-acetylcysteine and deferoxamine on plasma cytokine and oxidative damage parameters in critically ill patients with prolonged hypotension: a randomized controlled trial. J Clin Pharmacol 2012;52(9):1365–72.

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