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Redox Report
Communications in Free Radical Research
Volume 21, 2016 - Issue 4
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Original Articles

The antioxidant effect of ubiquinone and combined therapy on mitochondrial function in blood cells in non-proliferative diabetic retinopathy: A randomized, double-blind, phase IIa, placebo-controlled study

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References

  • Moreno A, Lozano M, Salinas P. Diabetic retinopathy. Nutr Hosp 2013;28(2):53–6.
  • Gholamhossein Y, Behrouz H, Asghar Z. Diabetic retinopathy risk factors: plasma erythropoietin as a risk factor for proliferative diabetic retinopathy. Korean J Ophthalmol 2014;28(5):373–8. doi: 10.3341/kjo.2014.28.5.373
  • Antonetti DA, Klein R, Gardner TW. Diabetic retinopathy. N Engl J Med 2012;366(13):1227–1239. doi: 10.1056/NEJMra1005073
  • Fong DS, Aiello L, Gardner TW, King GL, Blankenship G, Cavallerano JD, et al. Retinopathy in diabetes. Diabetes Care 2004;27(1):S84–7. doi: 10.2337/diacare.27.2007.S84
  • Demir M, Oba E, Sensoz H, Ozdal E. Retinal nerve fiber layer and ganglion cell complex thickness in patients with type 2 diabetes mellitus. Indian J Ophthalmol 2014;62(6):719–20. doi: 10.4103/0301-4738.136234
  • Pareja-Ríos A, Serrano-García M, Quijada-Fumero E, Marrero MD, Cabrera-López F, Abreu-Reyes P, et al. Review of the protocol for the treatment of diabetic retinopathy. Arch Soc Esp Oftalmol 2009;84(2):65–74. doi: 10.4321/S0365-66912009000200004
  • Crawford TN, Alfaro DV, Kerrison JB, Jablon EP. Diabetic retinopathy and angiogenesis. Curr Diabetes Rev 2009;5(1):8–13. doi: 10.2174/157339909787314149
  • Gündüz K, Bakri SJ. Management of proliferative diabetic retinopathy. Compr Ophthalmol Update 2007;8(5):245–56.
  • Chen S, Khan Z, Barbin Y, Chakrabarti S. Pro-oxidant role of heme oxigenase in mediating glucose-induced endothelial cell damage. Free Radic Res 2004;38:1301–10. doi: 10.1080/10715760400017228
  • Miranda M, Muriach M, Roma J, Bosch-Morell F, Genovés JM, Barcia J, et al. Oxidative stress in a model of experimental diabetic retinopathy: the utility of peroxynitrite scavengers. Arch Soc Esp Oftalmol 2006;81(1):27–32. doi: 10.4321/S0365-66912006000100007
  • Ates O, Bilen H, Keles S, Alp HH, Keleş MS, Yıldırım K, et al. Plasma coenzyme Q10 levels in type 2 diabetic patients with retinopathy. Int J Ophthalmol 2013;6(5):675–9.
  • Santos JM, Tewari S, Goldberg AF, Kowluru RA. Mitochondrial biogenesis and the development of diabetic retinopathy. Free Radic Biol Med 2011;51(10):1849–60. doi: 10.1016/j.freeradbiomed.2011.08.017
  • Kanwar M, Chan PS, Kern TS, Kowluru RA. Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dismutase. Invest Ophthalmol Vis Sci 2007;48(8):3805–11. doi: 10.1167/iovs.06-1280
  • Eshaq RS, Wright WS, Harris NR. Oxygen delivery, consumption, and conversion to reactive oxygen species in experimental models of diabetic retinopathy. Redox Biol 2014;2:661–6. doi: 10.1016/j.redox.2014.04.006
  • Ostman B, Sjödin A, Michaëlsson K, Byberg L. Coenzyme Q10 supplementation and exercise-induced oxidative stress in humans. Nutrition 2012;28(4):403–17. doi: 10.1016/j.nut.2011.07.010
  • Ernster L, Dallner G. Biochemical, physiological and medical aspects of ubiquinone function. Biochim Biophys Acta 1995;271(1):195–204. doi: 10.1016/0925-4439(95)00028-3
  • Bartlett HE, Eperjesi F. Nutritional supplementation for type 2 diabetes: a systematic review. Ophthalmic Physiol Opt 2008;28(6):503–23. doi: 10.1111/j.1475-1313.2008.00595.x
  • Jurado AS, Almeida LM, Madeira VC. Fluidity of bacterial membrane lipids monitored by intramolecular excimerization of 1,3 di (2-pyrenyl)propane. Biochem Biophys Res Comm 1991;176:356–63. doi: 10.1016/0006-291X(91)90932-W
  • Ortiz GG, Pacheco-Moisés F, El Hafidi M, Jiménez-Delgado A, Macías-Islas MA, Rosales Corral SA, et al. Detection of membrane fluidity in submitochondrial particles of platelets and erythrocyte membranes from Mexican patients with Alzheimer disease by intramolecular excimer formation of 1,3 dipyrenylpropane. Dis Markers 2008;24(3):151–6. doi: 10.1155/2008/642120
  • Baracca A, Barogi S, Carelli V, Lenaz G, Solaini G. Catalytic activities of mitochondrial ATP synthase in patients with mitochondrial DNA T8993G mutation in the ATPase 6 gene encoding subunit a. J Biol Chem 2000;275(6):4177–82. doi: 10.1074/jbc.275.6.4177
  • Drozda JJr, Messer JV, Spertus J, Abramowitz B, Alexander K, Beam CT, et al. ACCF/AHA/AMA-PCPI 2011 performance measures for adults with coronary artery disease and hypertension: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Performance Measures and the American Medical Association-Physician Consortium for Performance Improvement. Circulation 2011;124(2):248–70. doi: 10.1161/CIR.0b013e31821d9ef2
  • Tsuda K. Oxidative stress and membrane fluidity of red blood cells in hypertensive and normotensive men: an electron spin resonance investigation. Int Heart J 2010;51(2):121–4. doi: 10.1536/ihj.51.121
  • Singh M, Shin S. Changes in erythrocyte aggregation and deformability in diabetes mellitus: a brief review. Indian J Exp Biol 2009;47:7–15.
  • Shin S, Ku Y, Babu N, Singh M. Erythrocyte deformability and its variation in diabetes mellitus. Indian J Exp Biol 2007;45:121–8.
  • Saxena S, Srivastava P, Khanna VK. Antioxidant supplementation improves platelet membrane fluidity in idiopathic retinal periphlebitis (Eales’ disease). J Ocul Pharmacol Ther 2010;26(6):623–6. doi: 10.1089/jop.2010.0075
  • Bosch M, Marí M, Herms A, Fernández A, Fajardo A, Kassan A, et al. Caveolin-1 deficiency causes cholesterol-dependent mitochondrial dysfunction and apoptotic susceptibility. Curr Biol 2011;21(8):681–6. doi: 10.1016/j.cub.2011.03.030
  • Martínez-Cano E, Ortiz-Genaro G, Pacheco-Moisés F, Macías-Islas MA, Sánchez-Nieto S, Rosales-Corral SA. Functional disorders of FOF1-ATPase in submitochondrial particles obtained from platelets of patients with a diagnosis of probable Alzheimer's disease. Rev Neurol 2005;40(2):81–5.
  • Littaru GP, Langsjoen P. Coensyme Q10 and statins: biochemical and clinical implications. Mitochondrion 2007;7:S168–74. doi: 10.1016/j.mito.2007.03.002
  • Chinnery P, Majamaa K, Turnbull D, Thorburn D. Treatment for mitochondrial disorders. Cochrane Database Syst Rev 2006;(1):CD004426.