The olive leaf extract oleuropein exerts protective effects against oxidant-induced cell death, concurrently displaying pro-oxidant activity in human hepatocarcinoma cells

References

• Filik L , Ozyilkan O . Olive-oil consumption and cancer risk. Eur J Clin Nutr 2003;57(1):191.
   PubMed Web of Science ®Google Scholar
• Cristina F . Mediterranean diet health benefits may be due to a synergistic combination of phytochemicals and fatty-acids. BMJ 2005;331(7508):E366.
   PubMedGoogle Scholar
• Topalovic DZ , Zivkovic L , Cabarkapa A , Djelic N , Bajic V , Dekanski D , et al. Dry olive leaf extract counteracts l-thyroxine-induced genotoxicity in human peripheral blood leukocytes in vitro. Oxid Med Cell Longev 2015;2015:762192.
   PubMed Web of Science ®Google Scholar
• Turkez H , Togar B , Polat E . Olive leaf extract modulates permethrin induced genetic and oxidative damage in rats. Cytotechnology 2012;64(4):459–64.
   PubMed Web of Science ®Google Scholar
• de Bock M , Thorstensen EB , Derraik JG , Henderson HV , Hofman PL , Cutfield WS . Human absorption and metabolism of oleuropein and hydroxytyrosol ingested as olive (Olea europaea L.) leaf extract. Mol Nutr Food Res 2013;57(11):2079–85.
   PubMed Web of Science ®Google Scholar
• Tan HW , Tuck KL , Stupans I , Hayball PJ . Simultaneous determination of oleuropein and hydroxytyrosol in rat plasma using liquid chromatography with fluorescence detection. J Chromatogr B Analyt Technol Biomed Life Sci 2003;785(1):187–91.
   PubMed Web of Science ®Google Scholar
• Vissers MN , Zock PL , Roodenburg AJ , Leenen R , Katan MB . Olive oil phenols are absorbed in humans. J Nutr 2002;132(3):409–17.
   PubMed Web of Science ®Google Scholar
• Corona G , Tzounis X , Assunta Dessi M , Deiana M , Debnam ES , Visioli F , et al. The fate of olive oil polyphenols in the gastrointestinal tract: implications of gastric and colonic microflora-dependent biotransformation. Free Radic Res 2006;40(6):647–58.
   PubMed Web of Science ®Google Scholar
• Bonanome A , Pagnan A , Caruso D , Toia A , Xamin A , Fedeli E , et al. Evidence of postprandial absorption of olive oil phenols in humans. Nutr Metab Cardiovasc Dis 2000;10(3):111–20.
   PubMed Web of Science ®Google Scholar
• Domitrovic R , Jakovac H , Marchesi VV , Sain I , Romic Z , Rahelic D . Preventive and therapeutic effects of oleuropein against carbon tetrachloride-induced liver damage in mice. Pharmacol Res 2012;65(4):451–64.
   PubMed Web of Science ®Google Scholar
• Cardeno A , Sanchez-Hidalgo M , Rosillo MA , de la Lastra CA . Oleuropein, a secoiridoid derived from olive tree, inhibits the proliferation of human colorectal cancer cell through downregulation of HIF-1alpha. Nutr Cancer 2013;65(1):147–56.
   PubMed Web of Science ®Google Scholar
• Bulotta S , Corradino R , Celano M , Maiuolo J , D'Agostino M , Oliverio M , et al. Antioxidant and antigrowth action of peracetylated oleuropein in thyroid cancer cells. J Mol Endocrinol 2013;51(1):181–9.
   PubMed Web of Science ®Google Scholar
• Jemai H , Bouaziz M , Fki I , El Feki A , Sayadi S . Hypolipidimic and antioxidant activities of oleuropein and its hydrolysis derivative-rich extracts from Chemlali olive leaves. Chem Biol Interact 2008;176(2–3):88–98.
   PubMed Web of Science ®Google Scholar
• Anter J , Fernandez-Bedmar Z , Villatoro-Pulido M , Demyda-Peyras S , Moreno-Millan M , Alonso-Moraga A , et al. A pilot study on the DNA-protective, cytotoxic, and apoptosis-inducing properties of olive-leaf extracts. Mutat Res 2011;723(2):165–70.
   PubMed Web of Science ®Google Scholar
• Acquaviva R , Di Giacomo C , Sorrenti V , Galvano F , Santangelo R , Cardile V , et al. Antiproliferative effect of oleuropein in prostate cell lines. Int J Oncol 2012;41(1):31–8.
   PubMed Web of Science ®Google Scholar
• Yao J , Wu J , Yang X , Yang J , Zhang Y , Du L . Oleuropein induced apoptosis in HeLa cells via a mitochondrial apoptotic cascade associated with activation of the c-Jun NH2-terminal kinase. J Pharmacol Sci 2014;125(3):300–11.
   PubMed Web of Science ®Google Scholar
• Fabiani R , Rosignoli P , De Bartolomeo A , Fuccelli R , Servili M , Montedoro GF , et al. Oxidative DNA damage is prevented by extracts of olive oil, hydroxytyrosol, and other olive phenolic compounds in human blood mononuclear cells and HL60 cells. J Nutr 2008;138(8):1411–6.
   PubMed Web of Science ®Google Scholar
• Hur W , Kim SW , Lee YK , Choi JE , Hong SW , Song MJ , et al. Oleuropein reduces free fatty acid-induced lipogenesis via lowered extracellular signal-regulated kinase activation in hepatocytes. Nutr Res 2012;32(10):778–86.
   PubMed Web of Science ®Google Scholar
• Katsoulieris E , Mabley JG , Samai M , Sharpe MA , Green IC , Chatterjee PK . Lipotoxicity in renal proximal tubular cells: relationship between endoplasmic reticulum stress and oxidative stress pathways. Free Radic Biol Med 2010;48(12):1654–62.
   PubMed Web of Science ®Google Scholar
• Halliwell B , Grootveld M , Gutteridge JM . Methods for the measurement of hydroxyl radicals in biomedical systems: deoxyribose degradation and aromatic hydroxylation. Methods Biochem Anal 1988;33:59–90.
   PubMedGoogle Scholar
• Sozo F , O'Day L , Maritz G , Kenna K , Stacy V , Brew N , et al. Repeated ethanol exposure during late gestation alters the maturation and innate immune status of the ovine fetal lung. Am J Physiol Lung Cell Mol Physiol 2009;296(3):L510–8.
   PubMed Web of Science ®Google Scholar
• Kim H , Lee SW , Baek KM , Park JS , Min JH . Continuous hypoxia attenuates paraquat-induced cytotoxicity in the human A549 lung carcinoma cell line. Exp Mol Med 2011;43(9):494–500.
   PubMed Web of Science ®Google Scholar
• Li WD , Zhao YZ , Chou IN . Paraquat-induced cytoskeletal injury in cultured cells. Toxicol Appl Pharmacol 1987;91(1):96–106.
   PubMed Web of Science ®Google Scholar
• Kamada S , Kikkawa U , Tsujimoto Y , Hunter T . Nuclear translocation of caspase-3 is dependent on its proteolytic activation and recognition of a substrate-like protein(s). J Biol Chem 2005;280(2):857–60.
   PubMed Web of Science ®Google Scholar
• Zhivotovsky B , Samali A , Gahm A , Orrenius S . Caspases: their intracellular localization and translocation during apoptosis. Cell Death Differ 1999;6(7):644–51.
   PubMed Web of Science ®Google Scholar
• Niquet J , Allen SG , Baldwin RA , Wasterlain CG . Evidence of caspase-3 activation in hyposmotic stress-induced necrosis. Neurosci Lett 2004;356(3):225–7.
   PubMed Web of Science ®Google Scholar
• Herceg Z , Wang ZQ . Failure of poly(ADP-ribose) polymerase cleavage by caspases leads to induction of necrosis and enhanced apoptosis. Mol Cell Biol 1999;19(7):5124–33.
   PubMed Web of Science ®Google Scholar
• Odiatou EM , Skaltsounis AL , Constantinou AI . Identification of the factors responsible for the in vitro pro-oxidant and cytotoxic activities of the olive polyphenols oleuropein and hydroxytyrosol. Cancer Lett 2013;330(1):113–21.
   PubMed Web of Science ®Google Scholar
• Sakihama Y , Cohen MF , Grace SC , Yamasaki H . Plant phenolic antioxidant and prooxidant activities: phenolics-induced oxidative damage mediated by metals in plants. Toxicology 2002;177(1):67–80.
   PubMed Web of Science ®Google Scholar
• Visioli F , Bellomo G , Galli C . Free radical-scavenging properties of olive oil polyphenols. Biochem Biophys Res Commun 1998;247(1):60–4.
   PubMed Web of Science ®Google Scholar
• Gutierrez VR , de la Puerta R , Catala A . The effect of tyrosol, hydroxytyrosol and oleuropein on the non-enzymatic lipid peroxidation of rat liver microsomes. Mol Cell Biochem 2001;217(1–2):35–41.
   PubMed Web of Science ®Google Scholar
• Fabiani R , Fuccelli R , Pieravanti F , De Bartolomeo A , Morozzi G . Production of hydrogen peroxide is responsible for the induction of apoptosis by hydroxytyrosol on HL60 cells. Mol Nutr Food Res 2009;53(7):887–96.
   PubMed Web of Science ®Google Scholar
• Elamin MH , Daghestani MH , Omer SA , Elobeid MA , Virk P , Al-Olayan EM , et al. Olive oil oleuropein has anti-breast cancer properties with higher efficiency on ER-negative cells. Food Chem Toxicol 2013;53:310–6.
   PubMed Web of Science ®Google Scholar
• Goya L , Mateos R , Bravo L . Effect of the olive oil phenol hydroxytyrosol on human hepatoma HepG2 cells. Protection against oxidative stress induced by tert-butylhydroperoxide. Eur J Nutr 2007;46(2):70–8.
   PubMed Web of Science ®Google Scholar
• Ahmad I , Shukla S , Kumar A , Singh BK , Kumar V , Chauhan AK , et al. Biochemical and molecular mechanisms of N-acetyl cysteine and silymarin-mediated protection against maneb- and paraquat-induced hepatotoxicity in rats. Chem Biol Interact 2013;201(1–3):9–18.
   PubMed Web of Science ®Google Scholar
• Han J , Talorete TP , Yamada P , Isoda H . Anti-proliferative and apoptotic effects of oleuropein and hydroxytyrosol on human breast cancer MCF-7 cells. Cytotechnology 2009;59(1):45–53.
   PubMed Web of Science ®Google Scholar
• Hassan ZK , Elamin MH , Omer SA , Daghestani MH , Al-Olayan ES , Elobeid MA , et al. Oleuropein induces apoptosis via the p53 pathway in breast cancer cells. Asian Pac J Cancer Prev 2014;14(11):6739–42.
   PubMedGoogle Scholar
• Valko M , Izakovic M , Mazur M , Rhodes CJ , Telser J . Role of oxygen radicals in DNA damage and cancer incidence. Mol Cell Biochem 2004;266(1–2):37–56.
   PubMed Web of Science ®Google Scholar
• Halliwell B . Oxidative stress and cancer: have we moved forward? Biochem J 2007;401(1):1–11.
   PubMed Web of Science ®Google Scholar