Publication Cover
Redox Report
Communications in Free Radical Research
Volume 21, 2016 - Issue 4
2,237
Views
32
CrossRef citations to date
0
Altmetric
Research article

The effect of ubiquinone and combined antioxidant therapy on oxidative stress markers in non-proliferative diabetic retinopathy: A phase IIa, randomized, double-blind, and placebo-controlled study

, , , , , & show all

References

  • Engerman R, Kern T. Hyperglucemia as a cause of retinopathy. Metabolism 1986;35:20–23. doi: 10.1016/0026-0495(86)90182-4
  • Zhou ZJ, McCall MA. Retinal ganglion cells in diabetes. AM J Physiol 2008;586:4343–45. doi: 10.1113/jphysiol.2008.160838
  • Kern TS, Tang J, Mizutani M, Kowluru RA, Nagaraj RH, Tomeo G, et al. Response of capillary cell death to aminoguanidine predicts the development of retinopathy comparison of diabetes and galactosemia. Invest Ophthalmol Vis Sci 2000;41:3972–78.
  • Lorenzi M. The polyol pathway as a mechanism for diabetic retinopathy: attractive elusive, and resilient. Exp Diabetes Res 2007;2007:1–10. doi: 10.1155/2007/61038
  • El-Asrar AM. Role of inflammation in the pathogenesis of diabetic retinopathy. Middle East Afr J Ophthalmol 2012;19(1):70–74. doi: 10.4103/0974-9233.92118
  • Tiwari B, Pandey K, Abidi A, Rizvi S. Markers of oxidative stress during Diabetes mellitus. J Biomarkers 2013:1–8.
  • Rodriguez A, Castellanos J, Martínez E, Miller G, Pacheco F, Miranda A, et al. Oxidants, antioxidants and mitochondrial function in non-proliferative diabetic retinopathy. J Diab 2014;6(2):167–75. doi: 10.1111/1753-0407.12076
  • Guichardant M, Chantegrel B, Deshayes C, Doutheau A, Moliere P, Lagarde M. Specific markers of lipid peroxidation issued from n-3 and n-6 fatty acids. Biochem Soc Trans 2004;32(1):139–40. doi: 10.1042/bst0320139
  • Kowluru R, Pooi-See C. Oxidative stress and diabetic retinopathy. Exp Diabetes Res 2007;2007:1–12.
  • Wong T, Gillies M, Mohamed Q. Management of diabetic retinopathy a systematic review. JAMA 2007;298(8):902–16. doi: 10.1001/jama.298.8.902
  • Claramunt J. Retinopatía diabetic. Rev Med Clin CONDES 2009;20(5):670–9.
  • Bonakdar R, Guarneri E. Coenzyme Q10. Am Fam Physician 2005;72(6):1065–70.
  • Crane F. Biochemical functions of coenzyme Q10. J Am Coll Nutr 2001;20(6):591–8. doi: 10.1080/07315724.2001.10719063
  • Kieburtz K. A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease. Neurology 2007;68:20–28. doi: 10.1212/01.wnl.0000250355.28474.8e
  • Potgleter M, Pretorius E, Pepper M. Primary and secondary coenzyme Q10 deficiency: the role of therapeutic suplementation. Nutr Rev 2013;7(3):180–8. doi: 10.1111/nure.12011
  • Mancuso M, Orsucci D, Volpi L, Calsolaro V, Siciliano G. Coenzyme Q10 in neuromuscular and neurodegenerative disorders. Curr Drug Targets 2010;11(1):111–21. doi: 10.2174/138945010790031018
  • Parisi V, Tedeschi M, Gallinaro G, Varano M, Saviano S, Piermarocchi S, CARMIS Study Group. Carotenoids and antioxidants in age-related maculopathy Italian study: multifocal electroretinogram modifications after 1 year. Ophthalmology 2008;115(2):324–33. doi: 10.1016/j.ophtha.2007.05.029
  • Hernández-Ojeda J, Cardona-Muñoz EG, Román-Pintos LM, Troyo-Sanromán R, Ortiz-Lazareno PC, Cárdenas-Meza MA, et al. The effect of ubiquinone in diabetic polyneuropathy: a randomized double-blind placebo-controlled study. J Diab Complicat 2012;26(4):352–8. doi: 10.1016/j.jdiacomp.2012.04.004
  • Piermarocchi S, Saviano S, Parisi V, Tedeschi M, Panozzo G, Scarpa G, et al. Carmis Study Group. Carotenoids in age-related maculopathy Italian Study (CARMIS): two-year results of a randomized study. Eur J Ophthalmol 2012;22(2):216–25. doi: 10.5301/ejo.5000069
  • Standards of medical care in diabetes 2012. Diabetes Care 2012;35(1):S11–S63.
  • Drozda J,Jr, Messer JV, Spertus J, Abramowitz B, Alexander K, Beam CT, et al. ACCF/AHA/AMA-PCPI 2011 performance measures for adults with coronary artery disease and hypertension: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Performance Measures and the American Medical Association-Physician Consortium for Performance Improvement. Circulation 2011;124(2):248–70. doi: 10.1161/CIR.0b013e31821d9ef2
  • Wilkinson CP, Ferris FL, III, Klein RE, Lee PP, Agardh CD, Davis M, et al. Global Diabetic Retinopathy Project Group. Proposed international diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology 2003;110:1677–82. doi: 10.1016/S0161-6420(03)00475-5
  • Lima V. Retinopatía diabética simplificada: la escala clínica internacional. Rev Hosp Jua Mex 2006;73(4):170–4.
  • Early Treatment Diabetic Retinopathy Study Research Group. ETDRS report no. 3: Techniques for scatter and focal photocoagulation treatment of diabetic retinopathy. Int Ophthalmol Clin 1987;274:254–64.
  • Asghar Ghasemi A, HedayatiII M, Biabani H. Protein precipitation methods evaluated for determination of serum nitric oxide end products by the Griess assay. JMSR 2007;2:29–32.
  • Standards of Medical Care in Diabetes 2012. Diabetes Care 2012;35(1):S11–63.
  • Park CY, Park SE, Bae JC, Kim WJ, Park SW, Ha MM, et al. Prevalence of and risk factors for diabetic retinopathy in Koreans with type II diabetes: baseline characteristics of Seoul Metropolitan City-Diabetes Prevention Program (SMC-DPP) participants. Br J Ophthalmol 2012;96:151–5. doi: 10.1136/bjo.2010.198275
  • Brauner H, Lüthje P, Grünler J, Ekberg NR, Dallner G, Brismar K, et al. Markers of innate immune activity in patients with type 1 and type 2 diabetes mellitus and the effect of the anti-oxidant coenzyme Q10 on inflammatory activity. Clin Exp Immunol 2014;177(2):478–82. doi: 10.1111/cei.12316
  • Eriksson JG, Forsén TJ, Mortensen SA, Rohde M. The effect of coenzyme Q10 administration on metabolic control in patients with type 2 diabetes mellitus. Biofactors 1999;9(2–4):315–8. doi: 10.1002/biof.5520090229
  • Monnier L, Colette C, Owens DR. Glycemic variability: the third component of the dysglycemia in diabetes. Is it important? How to measure it? J Diabetes Sci Technol 2008;2(6):1094–1100. doi: 10.1177/193229680800200618
  • Gupta M, Chari S. Lipid peroxidation and antioxidant status in patients with diabetic retinopathy. Indian J Physiol Pharmacol 2005;49(2):187–92.
  • Guichardant M, Chantegrel B, Deshayes C, Doutheau A, Moliere P, Lagarde M. Specific markers of lipid peroxidation issued from n-3 and n-6 fatty acids. Biochem Soc Trans 2004;32(1):139–40. doi: 10.1042/bst0320139
  • Esterbauer H, Schaur RJ, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 1991;11(1):81–128. doi: 10.1016/0891-5849(91)90192-6
  • Njie-Mbye YF, Kulkarni-Chitnis M, Opere CA, Barrett A, Ohia SE. Lipid peroxidation: pathophysiological and pharmacological implications in the eye. Front Physiol 2013;4:366. doi: 10.3389/fphys.2013.00366
  • Mancino R, Di Pierro D, Varesi C, Cerulli A, Feraco A, Cedrone C, et al. Lipid peroxidation and total antioxidant capacity in vitreous, aqueous humor, and blood samples from patients with diabetic retinopathy. Mol Vis 2011;17:1298–304.
  • Izumi N, Nagaoka T, Mori F, Sato E, Takahashi A, Yoshida A. Relation between plasma nitric oxide levels and diabetic retinopathy. Jpn J Ophthalmol 2006;50:465–8. doi: 10.1007/s10384-006-0344-y
  • Doganay S, Evereklioglu C, Er H, Türköz Y, Sevinç A, Mehmet N, et al. Comparison of serum NO, TNF-alpha, IL-1 beta, sIL-2R, IL-6 and IL-8 levels with grades of retinopathy in patients with diabetes mellitus. Eye 2002;16:163–70. doi: 10.1038/sj/eye/6700095
  • Castilho Á, Aveleira CA, Leal EC, Simões NF, Fernandes CR, Meirinhos RI, et al. Heme oxygenase-1 protects retinal endothelial cells against high glucose- and oxidative/nitrosative stress-induced toxicity. PLoS One 2012;7(8):e42428. doi: 10.1371/journal.pone.0042428
  • Leal EC, Manivannan A, Hosoya K, Terasaki T, Cunha-Vaz J, Ambrósio AF, et al. Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy. Invest Ophthalmol Vis Sci 2007;48(11):5257–65. doi: 10.1167/iovs.07-0112
  • Beyazyıldız E, Cankaya AB, Ergan E, Anayol MA, Ozdamar Y, Sezer S, et al. Changes of total antioxidant capacity and total oxidant status of aqueous humor in diabetes patients and correlations with diabetic retinopathy. Int J Ophthalmol 2013;6(4):531–6.
  • Valabhji J, McColl AJ, Richmond W, Schachter M, Rubens MB, Elkeles RS. Total antioxidant status and coronary artery calcification in type 1 diabetes. Diabetes Care 2001;24(9):1608–13. doi: 10.2337/diacare.24.9.1608
  • Astaneie F, Afshari M, Mojtahedi A, Mostafalou S, Zamani MJ, Larijani B, et al. Total antioxidant capacity and levels of epidermal growth factor and nitric oxide in blood and saliva of insulin-dependent diabetic patients. Arch Med Res 2005;36(4):376–81. doi: 10.1016/j.arcmed.2005.03.007