Predictors of the failure of treatment with chloroquine in children with acute, uncomplicated, Plasmodium falciparum malaria, in an area with high and increasing incidences of chloroquine resistance

REFERENCES

• Anon. (1994). Epi Info Version 6. A Word Processing Data Base and Statistics Program for Public Health on IBM-compatible Microcomputers. Atlanta, GA: Centers for Disease Control and Prevention.
   Google Scholar
• Anon. (1999). SPSS for Windows Release 10.01 (Standard Version). Chicago, IL: SPSS Inc.
   Google Scholar
• Anon. (2004). National Antimalarial Treatment Policy. Abuja, Nigeria: Federal Ministry of Health.
   Google Scholar
• Bonnet, S., Gouagna, L. C., Paul, R E., Safeukui, I., Meunier, J.-Y. & Boudin, C. (2003). Estimation of malaria transmission from humans in two neighbour-ing villages in south Cameroon: evaluation and comparison of several indices. Transactions of the Royal Society of Tropical Medicine and Hygiene, 97, 53–59.
   PubMed Web of Science ®Google Scholar
• Dorsey, G., Kamya, M. R., Ndeezi, G., Barbiye, J. N., Phares, C. R, Olson, J. E., Katabira, E. T. & Rosenthal, P. J. (2000). Predictors of chloroquine treatment failure in children and adults with falci-parum malaria in Kampala, Uganda. American Journal of Tropical Medicine and Hygiene, 62, 686–692.
   PubMed Web of Science ®Google Scholar
• Ezeilo, G. C. (1971). Neutropenia in Africans. Tropical and Geographical Medicine, 23, 264–267.
   PubMedGoogle Scholar
• Fontanet, A. L. & Walker, A. M. (1993). Predictors of treatment failure in multiple drug-resistant falci-parum malaria: results from a 42-day follow-up of 224 patients in eastern Thailand. American Journal of Tropical Medicine and Hygiene, 49, 465–472.
   PubMed Web of Science ®Google Scholar
• Githeko, A. K., Brandling-Bennet, A. D., Beier, M., Atieli, F., Owaga, M. & Collins, F. H. (1992). The reservoir of Plasmodium falciparum malaria in a holoendemic area of western Kenya. Transactions of the Royal Society of Tropical Medicine and Hygiene, 86, 355–358.
   PubMed Web of Science ®Google Scholar
• Hamer, D. H., Macleod, W. B., Addo-Yobo, E., Duggan, C. P., Estrella, B., Fawzi, W. W., Konde-Lule, J. K., Mwanakasale, V., Premji, Z. G., Sempértegui, F., Ssengooba, F. P., Yeboa-Antwi, K. & Simon, J. L. (2003). Age, temperature, and parasitaemia predict chloroquine treatment failure and anaemia in children with uncomplicated Plasmodium falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 97, 422–428.
   PubMed Web of Science ®Google Scholar
• Handunnetti, S. M., Gunewardena, D. M., Pathirana, P. P. S. L., Ekanayake, K., Weerasinghe, S. & Mendis, K. N. (1996). Features of recrudescent chloroquine-resistant Plasmodium falciparum infec-tions confer a survival advantage on parasites and have implications for disease control. Transactions of the Royal Society of Tropical Medicine and Hygiene, 90, 563–567.
   PubMed Web of Science ®Google Scholar
• Happi, T. C., Thomas, S. M., Gbotosho, G. O., Falade, C. O., Akinboye, D. O., Gerena, L., Hudson, T., Sowunmi, A., Kyle, D. E., Milhous, W., Wirth, D. F. & Oduola, A. M. J. (2003). Point mutations in the pfcrt and pfmdr-1 genes of Plasmodium falciparum and clinical response to chloroquine, among malaria patients from Nigeria. Annals of Tropical Medicine and Parasitology, 97, 439–451.
   PubMed Web of Science ®Google Scholar
• Happi, T. C., Gbotosho, G. O., Sowunmi, A., Falade, C. O., Akinboye, D. O., Gerena, L., Kyle, D. E., Milhous, W., Wirth, D. F. & Oduola, A. M. J. (2004). Molecular analysis of Plasmodium falciparum recrudescent malaria infections in children treated with chloroquine in Nigeria. American Journal of Tropical Medicine and Hygiene, 70, 20–26.
   PubMed Web of Science ®Google Scholar
• Hess, F. I., Iannuzzi, A., Leafasia, J., Cowdrey, D., Nothdurft, H. D., von Sonnenburg, F., Loscher, T. & Rieckmann, K. H. (1996). Risk factors of chloroquine resistance in Plasmodium falciparum. Acta Tropica, 61, 293–306.
   PubMed Web of Science ®Google Scholar
• Ittarat, W., Pickard, A. L., Rattanasinganchan, P., Wilairatana, P., Looareesuwan, S., Emery, K., Low, J., Udomsangpetch, R. & Meshnick, S. R. (2003). Recrudescence in artesunate-treated patients with falciparum malaria is dependent on parasite burden not on parasite factor. American Journal of Tropical Medicine and Hygiene, 68, 147–152.
   PubMed Web of Science ®Google Scholar
• Robert, V., Molez, J.-F. & Trape, J.-F. (1996). Gametocytes, chloroquine pressure, and the relative parasite survival advantage of resistant strains of falciparum malaria in West Africa. American Journal of Tropical Medicine and Hygiene, 55,350–351.
   PubMed Web of Science ®Google Scholar
• Salako, L. A. & Aderounmu, A. F. (1987). In vitro chloroquine and mefloquine-resistant Plasmodium falciparum malaria in Nigeria. Lancet, i, 572-573. Salako, L. A., Ajayi, F. O., Sowunmi, A. & Walker, O. (1990). Malaria in Nigeria: a revisit. Annals of Tropical Medicine and Parasitology, 84, 435–445.
   Google Scholar
• Shaper, A. G. & Lewis, P. (1971). Genetic neutropenia in people of African origin. Lancet, ii, 1021-1023. Singhasivanon, V., Chongsuphajasiddhi, T., Sabchareon, A., Attanath, P., Webster, H. K., Wernsdorfer, W. H., Sheth, U. K. & Djaja Lika, I. (1992). Pharmacokinetics of mefloquine in children aged 6 to 24 months. European Journal of Drug Metabolism and Pharmacokinetics, 17, 275–279.
   Google Scholar
• Sowunmi, A. (2002). A randomized comparison of chloroquine, amodiaquine and their combination with pyrimethamine-sulfadoxine in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children. Annals of Tropical Medicine and Parasitology, 96, 227–238.
   PubMed Web of Science ®Google Scholar
• Sowunmi, A. (2003). A randomized comparison of chloroquine and chloroquine plus ketotifen, in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children. Annals of Tropical Medicine and Parasitology, 97,103–117.
   PubMed Web of Science ®Google Scholar
• Sowunmi, A. & Fateye, B. A. (2003a). Asymptomatic, recrudescent, chloroquine-resistant, Plasmodium fal-ciparum infections in Nigerian children: clinical and parasitological characteristics and implications for transmission of drug-resistant infections. Annals of Tropical Medicine and Parasitology, 97,469–479.
   PubMed Web of Science ®Google Scholar
• Sowunmi, A. & Fateye, B. A. (2003b). Gametocyte sex ratio in children with asymptomatic, recrudescent, pyrimethamine-sulfadoxine-resistant Plasmodium fal-ciparum malaria. Annals of Tropical Medicine and Parasitology, 97,671–682.
   PubMed Web of Science ®Google Scholar
• Sowunmi, A. & Oduola, A. M. J. (1995). Open comparison of mefloquine, mefloquine/sulfadoxine/ pyrimethamine and chloroquine in acute uncompli-cated falciparum malaria in children. Transactions of the Royal Society of Tropical Medicine and Hygiene, 89, 303–305.
   PubMed Web of Science ®Google Scholar
• Sowunmi, A. & Salako, L. A. (1992). Evaluation of the relative efficacy of various antimalarial drugs in Nigerian children under five years of age suffering from acute uncomplicated falciparum malaria. Annals of Tropical Medicine and Parasitology, 86,1–8.
   PubMed Web of Science ®Google Scholar
• Sowunmi, A., Oduola, A. M. J., Ogundahunsi, O. A. T. Falade, C. O., Gbotosho, G. O. & Salako, L. A. (1997). Enhanced efficacy of chloroquine-chlorphe-niramine combination in acute uncomplicated falci-parum malaria in children. Transactions of the Royal Society of Tropical Medicine and Hygiene, 91, 63–67.
   PubMed Web of Science ®Google Scholar
• Sowunmi, A., Oduola, A. M. J., Ogundahunsi, O. A. T. & Salako, L. A. (1998). Enhancement of the antimalarial effect of chloroquine by chlorphenira-mine in vivo. Tropical Medicine and International Health, 3, 177–183.
   PubMed Web of Science ®Google Scholar
• Sowunmi, A., Ayede, A. I., Falade, A. G., Ndikum, V. N., Sowunmi, C. O., Adedeji, A. A., Falade, C. O., Happi, T. C. & Oduola, A. M. J. (2001). Randomized comparison of chloroquine and amo-diaquine in the treatment of acute, uncomplicated, Plasmodium falciparum malaria children. Annals of Tropical Medicine and Parasitology, 95,549–558.
   PubMed Web of Science ®Google Scholar
• Sowunmi, A., Fateye, B. A., Adedeji, A. A. & Babalola, C. P. (2004a). Plasmodium falciparum hyperparasi-taemia in children: risk factors, treatment outcomes, and gametocytaemia following treatment. Parasite, 11, 317–323.
   PubMed Web of Science ®Google Scholar
• Sowunmi, A., Fateye, B. A., Adedeji, A. A., Fehintola, F. A. & Happi, T. C. (2004b). Risk factors for gametocyte carriage in uncomplicated falciparum malaria in children. Parasitology, 129, 255–262.
   PubMed Web of Science ®Google Scholar
• Ter Kuile, F. O., Luxemburger, C., Nosten, F., Thwai, K. L., Chongsuphajasiddhi, T. & White, N. J. (1995). Predictors of mefloquine treatment failure: a prospective study of 1590 patients with uncompli-cated falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 89, 660–664.
   PubMed Web of Science ®Google Scholar
• Terlouw, D. J., Courval, J. M., Kolczac, M. S., Rosenberg, O. S., Oloo, A. J., Kager, P. A., Lal, A. A, Nahlen, B. L. & Ter Kuile, F. O. (2003). Treatment history and treatment dose are important determinants of sulfadoxine-pyrimethamine efficacy in children with uncomplicated malaria in western Kenya. Journal of Infectious Diseases, 187, 467–476.
   PubMed Web of Science ®Google Scholar
• Trape, J-.F. (2001). The public health impact of chloroquine resistance in Africa. American Journal of Tropical Medicine and Hygiene, 64 (Suppl.), 12–17.
   Google Scholar
• Trape, J.-F., Pison, G., Preziosi, M.-P., Enel, C., du Lou, A. D., Delaunay, V., Samb, B., Lagarde, E., Molez, J.-F. & Simondon, F. (1998). Impact of chloroqunine resistance on malaria mortality. Life Sciences, 321, 689–697.
   Google Scholar
• Von Seidlein, L., Drakeley, C., Greenwood, B., Walraven, G. & Targett, G. (2001). Risk factors for gametocyte carriage in Gambian children. American Journal of Tropical Medicine and Hygiene, 65, 523–526.
   PubMed Web of Science ®Google Scholar
• Walker, O., Dawodu, A. H., Adeyokunnu, A. A., Salako, L. A. & Alván, G. (1983). Plasma chlor-oquine and desthylchloroquine concentrations in children during and after chloroquine treatment for malaria. British Journal of Clinical Pharmacology, 16, 701–705.
   PubMed Web of Science ®Google Scholar
• Walker, O., Salako, L. A., Alván, G., Ericsson, Ö. & Sjöqvist, F. (1987). The disposition of chloroquine in healthy Nigerians after single intravenous and oral doses. British Journal of Clinical Pharmacology, 23, 295–301.
   PubMed Web of Science ®Google Scholar
• White, N. J. (1998). Why is it that antimalarial drug treatments do not always work? Annals of Tropical Medicine and Parasitology, 92,449–458.
   PubMed Web of Science ®Google Scholar
• World Health Organization (1973). Chemotherapy of Malaria and Resistance to Antimalarials. Technical Report Series No. 529. Geneva: WHO.
   Google Scholar
• World Health Organization (2000). Severe falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 94 (Suppl. 1), 1–90.
   Google Scholar
• World Health Organization (2001a). The Use of Antimalarial Drugs. Report of a WHO Informal Consultation. Document WHO/CDS/RBM/2001.33. Geneva: WHO.
   Google Scholar
• World Health Organization (2001b). The Use of Antimalarial Drugs. Report of a WHO Informal Consultation. Document WHO/CDS/RBM/2001.35. Geneva: WHO.
   Google Scholar