High-level cerebellar expression of cytokines and adhesion molecules in fatal, paediatric, cerebral malaria

REFERENCES

• Aikawa, M., Brown, A., Smith, C. D., Tegoshi, T., Howard, R. J., Hasler, T. H., Ito, Y., Perry, G., Collins, W. E. & Webster, K. (1992). A primate model for human cerebral malaria: Plasmodium coatneyi-infected rhesus monkeys. American Journal of Tropical Medicine and Hygiene, 46, 391–397.
   PubMed Web of Science ®Google Scholar
• Artavanis-Tsakonas, K., Tongren, J. E. & Riley, E. M. (2003). The war between the malaria parasite and the immune system: immunity, immunoregulation and immunopathology. Clinical and Experimental Immunology, 133, 145–152.
   PubMed Web of Science ®Google Scholar
• Belnoue, E., Kayibanda, M., Deschemin, J. C., Viguier, M., Mack, M., Kuziel, W. A. & Renia, L. (2003). CCR5 deficiency decreases susceptibility to experi-mental cerebral malaria. Blood, 101, 4253–4259.
   PubMed Web of Science ®Google Scholar
• Bitsch, A., Trostdorf, F., Bruck, W., Schmidt H., Fischer F. R. & Nau, R. (1997). Central nervous system TNF-alpha mRNA expression during rabbit experimental pneumococcal meningitis. Neuroscience Letters, 237,105–108.
   PubMed Web of Science ®Google Scholar
• Boivin, M. J. (2002). Effects of early cerebral malaria on cognitive ability in Senegalese children. Journal of Developmental Behaviour and Paediatrics, 23,353–364.
   PubMed Web of Science ®Google Scholar
• Brown, H., Turner, G., Rogerson, S., Tembo, M., Mwenechanya, J., Molyneux, M. & Taylor, T. (1999). Cytokine expression in the brain in human cerebral malaria. Journal of Infectious Diseases, 180, 1742–1746.
   PubMed Web of Science ®Google Scholar
• Brown, H. C., Chau, T. T., Mai, N. T., Day, N. P., Sinh, D. X., White, N. J., Hien, T. T., Farrar, J. & Turner, G. D. (2000). Blood—brain barrier function in cerebral malaria and CNS infections in Vietnam. Neurology, 55,104–111.
   PubMed Web of Science ®Google Scholar
• Deininger, M. H., Kremsner, P. G., Meyermann, R. & Schluesener, H. J. (2000). Differential cellular accumulation of transforming growth factor-131, -132, and -133 in brains of patients who died with cerebral malaria. Journal of Infectious Diseases, 181, 2111–2115.
   PubMed Web of Science ®Google Scholar
• Engwerda, C. R., Mynott, T. L., Sawhney, S., de Souza J. B., Bickle Q. D. & Kaye P. M. (2002). Locally up-regulated lymphotoxin alpha, not systemic tumour necrosis factor alpha, is the principal mediator of murine cerebral malaria. Journal of Experimental Medicine, 195, 1371–1377.
   PubMed Web of Science ®Google Scholar
• Flanders, K. C., Ren, R. F. & Lippa, C. F. (1998). Transforming growth factor-betas in neurodegenera-tive disease. Progress in Neurobiology, 54,71–85.
   PubMed Web of Science ®Google Scholar
• Gahring, L. C., Carlson, N. G., Kulmar, R. A. & Rogers, S. W. (1996). Neuronal expression of tumour necrosis factor alpha in the murine brain. Neuroimmunomodulation, 3,289–303.
   PubMed Web of Science ®Google Scholar
• Garcia, I., Araki, K., Miyazaki, Y., Araki, M., Juillard, P., Grau, G. E., Milon, G., Belkaid, Y., Montini, C., Lesslauer, W. & Vassalli, P. (1995). Transgenic mice expressing soluble TNE-R1-IgG3 molecules are protected from lethal septic shock and cerebral malaria, and are highly sensitive to Listeria monocytogenes and Leishmania major infections. European Journal of Immunology, 25,2401–2407.
   PubMed Web of Science ®Google Scholar
• Grau, G. E. & de Kossodo, S. (1994). Cerebral malaria: mediators, mechanical obstruction and more? Parasitology Today, 10, 408–409.
   PubMedGoogle Scholar
• Grau, G. E., Mackenzie, C. D., Carr, R. A., Redard, M., Pizzolato, G., Allasia, C., Cataldo, C., Taylor, T. E. & Molyneux, M. E. (2003). Platelet accumulation in brain microvessels in fatal paediatric cerebral malaria. Journal of Infectious Diseases, 187, 461–466.
   Google Scholar
• Holding, P. A., Stevenson, J., Peshu, N. & Marsh, K. (1999). Cognitive sequelae of severe malaria with impaired consciousness. Transactions of the Royal Society of Tropical Medicine and Hygiene, 93, 529–534.
   PubMed Web of Science ®Google Scholar
• Hunt, N. H. & Grau, G. E. (2003). Cytokines: accelerators and brakes in the pathogenesis of cerebral malaria. Trends in Immunology, 24,491–499.
   PubMed Web of Science ®Google Scholar
• Johnson, M. D. & Gold, L. I. (1996). Distribution of transforming growth factor-beta isoforms in HIV-1 encephalitis. Human Pathology, 27,643–649
   PubMed Web of Science ®Google Scholar
• Kwiatkowski, D., Hill, A. V., Sambou, I., Twumasi, P., Castracane, J., Manogue, K. R., Cerami, A., Brewster, D. R. & Greenwood, B. M. (1990). TNF concentration in fatal cerebral, non-fatal cerebral and uncomplicated Plasmodium falciparum malaria. Lancet, 336, 1201–1204.
   PubMed Web of Science ®Google Scholar
• Lou, J., Donati, Y. R. A., Juillard, P., Giroud, C., Vesin, C., Mili, N. & Grau, G. E. (1997). Platelets play an important role in TNF-induced microvascu-lar endothelial cell pathology. American Journal of Pathology, 151, 1397–1405.
   PubMed Web of Science ®Google Scholar
• Lou, J., Lucas, R. & Grau, G. E. (2001). Pathogenesis of cerebral malaria: recent experimental data and possible applications for humans. Clinical Microbiology Reviews, 14, 810–820.
   PubMed Web of Science ®Google Scholar
• Lucas, R., Juillard, P., Decoster, E., Redard, M., Burger, D., Donati, Y., Giroud, C., Monsohinard, C., DeKesel, T., Buurman, W. A., Moore, M. W., Dayer, J. M., Fiers, W., Bluethmann, H. & Grau, G. E. (1997). Crucial role of tumor necrosis factor (TNF) receptor 2 and membrane-bound TNF in experimental cerebral malaria. European Journal of Immunology, 27,1719–1725.
   PubMed Web of Science ®Google Scholar
• MacPherson, G. G., Warrell, M. J., White, N. J., Looareesuwan, S. & Warrell, D. A. (1985). Human cerebral malaria: a quantitative ultrastructural analy-sis of parasitized erythrocyte sequestration. American Journal of Pathology, 119, 385–401.
   PubMed Web of Science ®Google Scholar
• Mazier, D., Nitcheu, J. & Idrissa-Boubou, M. (2000). Cerebral malaria and immunogenetics. Parasite Immunology, 22,613–623.
   PubMed Web of Science ®Google Scholar
• Medana, I. M., Hunt, N. H. & Chaudhri, G. (1997). TNF-a expression in the brain during fatal murine cerebral malaria: evidence for production by micro-glia and astrocytes. American Journal of Pathology, 150, 1473–1483.
   PubMed Web of Science ®Google Scholar
• Newton, C. R. J. C. & Krishna, S. (1998). Severe falciparum malaria in children: current understanding of pathophysiology and supportive treatment. Pharmacology and Therapeutics, 79, 1–53.
   PubMed Web of Science ®Google Scholar
• Nitcheu, J., Bonduelle, O., Combadiere, C., Tefit, M., Seilhean, D., Mazier, D. & Combadiere, B. (2003). Perforin-dependent brain-infiltrating cytotoxic CD8 + T lymphocytes mediate experimental cere-bral malaria. Journal of Immunology, 170, 2221–2228.
   PubMed Web of Science ®Google Scholar
• Ockenhouse, C. F., Ho, M., Tandon, N. N., van Seventer, G. A., Shaw, S., White, N. J., Jamieson, G. A., Chulay, J. D. & Webster, H. K. (1991). Molecular basis of sequestration in severe and uncomplicated Plasmodium falciparum malaria: differ-ential adhesion of infected erythrocytes to CD36 and ICAM-1. Journal of Infectious Diseases, 164, 163–169.
   PubMed Web of Science ®Google Scholar
• Ockenhouse, C., Tegoshi, T., Maeno, Y., Benjamin, C., Ho, M., Kan, K., Thway, Y., Win, K., Aikawa, M. & Lobb, R (1992). Human vascular endothelial cell adhesion receptors for Plasmodium falciparum infected erythrocytes: roles for endothelial leukocytes adhesion molecule-1 and vascular cell adhesion molecule-1. Journal of Experimental Medicine, 176, 1183–1189.
   PubMed Web of Science ®Google Scholar
• Omer, F. M. & Riley, E. M. (1998). Transforming growth factor beta production is inversely correlated with severity of murine malaria infection. Journal of Experimental Medicine, 188, 39–48.
   PubMed Web of Science ®Google Scholar
• Oo, M. M., Aikawa, M., Than, T., Aye, T. M., Myint, P. T., Igarashi, I. & Schoene, W. C. (1987). Human cerebral malaria: a pathological study. Journal of Neuropathology and Experimental Neurology, 46, 223–231.
   PubMed Web of Science ®Google Scholar
• Patnaik, J. K., Das, B. S., Mishra, S. K., Mohanty, S., Satpathy, S. K. & Mohanty, D. (1994). Vascular clogging, mononuclear cell margination and enhanced vascular permeability in the pathogenesis of human cerebral malaria. American Journal of Tropical Medicine and Hygiene, 51, 642–647.
   PubMed Web of Science ®Google Scholar
• Polder, T. W., Eling, W. M., Kubat, K. & Jerusalem, C. R. (1988). Histochemistry of cerebral lesions in mice infected with Plasmodium berghei. Tropical Medicine and Parasitology, 39, 277–283.
   PubMedGoogle Scholar
• Polder, T. W., Eling, W. M., Jerusalem, C. R. & Wijers-Rouw, M. (1991a). A cytochemical study of cerebrovascular lesions in mice infected with Plasmodium berghei. Journal of Neurological Science, 101, 24–34.
   PubMed Web of Science ®Google Scholar
• Polder, T. W., Jerusalem, C. R. & Eling, W. M. (1991b). Morphological characteristics of intracer-ebral arterioles in clinical (Plasmodium falciparum) and experimental (Plasmodium berghei) cerebral malaria. Journal of Neurological Science, 101, 35–46.
   PubMed Web of Science ®Google Scholar
• Pongponratn E., Riganti M., Punpoowong, B. & Aikawa M. (1991). Microvascular sequestration of parasitized erythrocytes in human falciparum malaria: a pathological study. American Journal of Tropical Medicine and Hygiene, 44,168–175.
   PubMed Web of Science ®Google Scholar
• Pongponratn, E., Turner, G. D. H., Day, N. P. J., Phu, N. H., Simpson, J. A., Stepniewska, K., Mai, N. T. H., Viriyavejakul, P., Looareesuwan, S., Hien, T. T., Ferguson, D. J. P. & White, N. J. (2003). An ultrastructural study of the brain in fatal Plasmodium falciparum malaria. American Journal of Tropical Medicine and Hygiene, 69, 345–359.
   PubMed Web of Science ®Google Scholar
• Porta, J., Carota, A., Pizzolato, G. P., Wildi, E., Widmer, M. C., Margairaz, C. & Grau, G. E. (1993). Immunopathological changes in human cerebral malaria. Clinical Neuropathology, 12, 142–146.
   PubMed Web of Science ®Google Scholar
• Raja, R. N. (1922). Postmortem examination in cerebral malaria: a new simple method of demon-strating parasites in the capillaries of the brain. Indian Medical Gazette, 57, 298–299.
   Google Scholar
• Rogerson, S. J., Tembenu, R., Dobano, C., Plitt, S., Taylor, T. E. & Molyneux, M. E. (1999). Cytoadherence characteristics of Plasmodium falci-parum-infected erythrocytes from Malawian children with severe and uncomplicated malaria. American Journal of Tropical Medicine and Hygiene, 61, 467–472.
   PubMed Web of Science ®Google Scholar
• Rothwell, N. J. & Strijbos, P. J. (1995). Cytokines in neurodegeneration and repair. International Journal of Developmental Neuroscience, 13, 179–185.
   PubMed Web of Science ®Google Scholar
• Rudin, W., Eugster, H. P., Bordmann, G., Bonato, J., Muller, M., Yamage, M. & Ryffel, B. (1997). Resistance to cerebral malaria in tumor necrosis factor-alpha/beta-deficient mice is associated with a reduction of intercellular adhesion molecule-1 up-regulation and T helper type 1 response. American Journal of Pathology, 150, 257–266.
   PubMed Web of Science ®Google Scholar
• Sarfo, B. Y., Singh, S., Lillard, J. W., Quarshie, A., Gyasi, R. K., Armah, H., Adjei, A. A., Jolly, P. & Stiles, J. K. (2004). The cerebral-malaria-associated expression of RANTES, CCR3 and CCR5 in postmortem tissue samples. Annals of Tropical Medicine and Parasitology, 98, 297–303.
   PubMed Web of Science ®Google Scholar
• Schmahmann, J. D. (1991). An emerging concept: the cerebellar contribution to higher function. Archives of Neurology, 48, 1178–1187.
   PubMed Web of Science ®Google Scholar
• Sein, K. K., Brown, A. E., Maeno Y., Smith C. D., Corcoran, K. D., Hansukjariya, P., Webster, H. K. & Aikawa M. (1993a). Sequestration pattern of para-sitized erythrocytes in cerebrum, mid-brain and cerebellum of Plasmodium coatneyi-infected rhesus monkeys (Macaca mulatta). American Journal of Tropical Medicine and Hygiene, 49, 513–519.
   PubMed Web of Science ®Google Scholar
• Sein, K. K., Maeno, Y., Thuc, H. V., Anh T. K. & Aikawa, M. (1993b). Differential sequestration pat-tern of parasitized erythrocytes in the cerebrum and cerebellum in human cerebral malaria. American Journal of Tropical Medicine and Hygiene, 48, 504–511.
   PubMed Web of Science ®Google Scholar
• Silamut, K., Phu, N. H., Whitty, C., Turner, G. D., Louwrier, K., Mai, N. T., Simpson, J. A., Hien, T. T. & White, N. J. (1999). A quantitative analysis of the microvascular sequestration of malaria parasites in the human brain. American Journal of Pathology, 155, 395–410.
   PubMed Web of Science ®Google Scholar
• Smith, C. D., Brown, A. E., Nakazawa, S., Fujioka, H. & Aikawa, M. (1996). Multi-organ erythrocyte sequestration and ligand expression in rhesus mon-keys infected with Plasmodium coatneyi malaria. American Journal of Tropical Medicine and Hygiene, 55, 379–383.
   PubMed Web of Science ®Google Scholar
• Tongren, J. E., Yang, C., Collins, W. E., Sullivan, J. S., Lal, A. A. & Xiao, L. (2000). Expression of proinflammatory cytokines in four regions of the brain in Macaque mulatta (rhesus) monkeys infected with Plasmodium coatneyi. American Journal of Tropical Medicine and Hygiene, 62, 530–534.
   PubMed Web of Science ®Google Scholar
• Turner, G. D. H., Morrison, H., Jones, M., Davis, T. M. E., Looareesuwan, S., Buley, I. D., Gatter, K. C., Newbold, C. I., Pukrittayakamee, S., Nagachinta, B., White N. J. & Berendt, A. R. (1994). An immunohistochemical study of the pathology of fatal malaria: evidence for systemic endothelial activation. American Journal of Pathology, 145, 1057–1069.
   PubMed Web of Science ®Google Scholar
• Turner, G. D., Ly, V. C., Nguyen, T. H., Tran, T. H., Nguyen, H. P., Bethell, D., Wyllie, S., Louwrier, K., Fox, S. B., Gatter, K. C., Day, N. P., Tran, T. H., White, N. J. & Berendt, A. R. (1998). Systemic endothelial activation in both mild and severe malaria: correlating dermal microvascular endothelial cell phenotype and soluble cell adhesion molecules with disease severity. American Journal of Pathology, 152, 1477–1487.
   PubMed Web of Science ®Google Scholar
• Udomsangpetch, R., Chivapat, S., Viriyavejakul, P., Riganti, M., Wilairatana, P., Pongpontatn, E., & Looaresuwan, S. (1997). Involvement of cytokines in the histopathology of malaria. American Journal of Tropical Medicine and Hygiene, 57, 501–506.
   PubMed Web of Science ®Google Scholar
• Wassmer, S. C., Coltel, N., Combes, V. & Grau, G. E. (2003a). Pathogenesis of cerebral malaria: facts and hypotheses. Médecine Tropicale, 63, 254–257.
   PubMedGoogle Scholar
• Wassmer, S. C., Combes, V. & Grau, G. E. (2003b). Pathophysiology of cerebral malaria: role of host cells in the modulation of cytoadhesion. Annals of the New York Academy of Science, 992, 30–38.
   PubMed Web of Science ®Google Scholar
• Wassmer, S. C., Lepolard, C., Traore, B., Pouvelle, B., Gysin, J. & Grau, G. E. (2004). Platelets reorient Plasmodium falciparum-infected erythrocyte cytoadhe-sion activated endothelial cells. Journal of Infectious Diseases, 189, 180–189.
   PubMed Web of Science ®Google Scholar
• Weber, C., Negrescu, E., Erl, W., Pietsch, A., Frankenberger, M., Ziegler-Heitbrock, H. W., Siess, W. & Weber, P. C. (1995). Inhibitors of protein tyrosine kinase suppress TNF-stimulated induction of endothelial cell adhesion molecules. Journal of Immunology, 155, 445–451.
   PubMed Web of Science ®Google Scholar
• World Health Organization (1998). Tropical Research, 7th Program Report. Geneva: WHO.
   Google Scholar
• World Health Organization (2000). Severe falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 94 (Suppl. 1), 1–90.
   Google Scholar