Association between leptin receptor (LEPR) and brain-derived neurotrophic factor (BDNF) gene variants and obesity: a case-control study

References

• WHO/FAO Expert Consultation 2003. Report of the joint WHO/FAO expert consultation on diet, nutrition and the prevention of chronic diseases. Geneva: WHO, 2003.
   Google Scholar
• Bell CG, Walley AJ, Froguel P. The genetics of human obesity. Nat Genet Rev 2005; 6: 221–235.
   PubMed Web of Science ®Google Scholar
• Farooqi IS, O’Rahilly S. Genetics of obesity in humans. Endocr Rev 2006; 22: 221–226.
   Google Scholar
• Martinez-Hernández A, Enriquez L, Moreno-Moreno MJ, Marti A. Genetics of obesity. Public Health Nutr 2007; 10: 1138–1144.
   PubMed Web of Science ®Google Scholar
• Seeley RJ, Drazen DL, Clegg DJ. The critical role of the melanocortin system in the control of energy intake. Annu Rev Nutr 2004; 24: 133–149.
   PubMed Web of Science ®Google Scholar
• Farooqi IS, Keogh JM, Yeo GSH, et al. Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med 2003; 348: 1085–1095.
   PubMed Web of Science ®Google Scholar
• Farooqi IS, Wangensteen T, Collins S, et al. Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor. N Engl J Med 2007; 356: 237–247.
   PubMed Web of Science ®Google Scholar
• Paracchini V, Pedotti P, Taioli E. Genetics of leptin and obesity: a HuGE review. Am J Epidemiol 2005; 162: 101–114.
   PubMed Web of Science ®Google Scholar
• De Krom M, van der Schouw YT, Hendriks J, et al. Common genetic variations in CCK, leptin, and leptin receptor genes are associated with specific human eating patterns. Diabetes 2007; 56: 276–280.
   PubMed Web of Science ®Google Scholar
• Loos RJ, Lindgren CM, Li S, et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008; 40: 768–775.
   PubMed Web of Science ®Google Scholar
• Xu B, Goulding EH, Zang K, et al. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci 2003; 6: 736–742.
   PubMed Web of Science ®Google Scholar
• Froguel P, Blakemore AIF. The power of the extreme in elucidating obesity. N Engl J Med 2008; 359: 891–893.
   PubMed Web of Science ®Google Scholar
• Unger TJ, Calderon GA, Bradley LC, et al. Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity. J Neurosci 2007; 27: 14265–14274.
   PubMed Web of Science ®Google Scholar
• Gray J, Yeo GS, Cox JJ, et al. Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene. Diabetes 2006; 55: 3366–3371.
   PubMed Web of Science ®Google Scholar
• Yeo GS, Connie Hung CC, Rochford J, et al. A de novo mutation affecting human TrkB associated with severe obesity and developmental delay. Nat Neurosci 2004; 7: 1187–1189.
   PubMed Web of Science ®Google Scholar
• Han JC, Liu QR, Jones MP, et al. Brain-derived neurotrophic factor in the WAGR syndrome. N Engl J Med 2008; 359: 918–927.
   PubMed Web of Science ®Google Scholar
• Martinez JA, Corbalán MS, Sánchez-Villegas A, et al. Obesity risk is associated with carbohydrate intake in women carrying the Gln27Glu beta2-adrenoceptor polymorphism. J Nutr 2003; 133: 2549–2554.
   PubMed Web of Science ®Google Scholar
• Maisonpierre PC, Le Beau MM, Espinosa R, et al. Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. Genomics 1991; 10: 558–568.
   PubMed Web of Science ®Google Scholar
• De Cid R, Fonseca F, Gratacos M, et al. BDNF variability in opioid addicts and response to methadone treatment: preliminary findings. Genes Brain Behav 2008; 7: 512–522.
   Google Scholar
• Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21: 263–265.
   Google Scholar
• Dudbridge F. Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data. Hum Hered 2008; 66: 87–98.
   PubMed Web of Science ®Google Scholar
• Marti A, Berraondo B, Martinez JA. Leptin: physiological actions. J Physiol Biochem 1999; 55: 43–49.
   Google Scholar
• Ochoa MC, Azcona C, Biebermann H, et al. A novel mutation Thr162Arg of the melanocortin 4 receptor gene in a Spanish children and adolescent population. Clin Endocrinol 2007; 66: 652–658.
   PubMed Web of Science ®Google Scholar
• Ranadive SA, Vaisse C. Lessons from extreme human obesity: monogenic disorders. Endocrinol Metab Clin North Am 2008; 37: 733–751.
   PubMed Web of Science ®Google Scholar
• Heo M, Leibel RL, Fontaine KR, et al. A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference. Int J Obes 2002; 26: 640–646.
   Web of Science ®Google Scholar
• Friedel S, Horro FF, Wermter AK, et al. Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 2005; 5: 96–99.
   Google Scholar
• Beckers S, Peeters A, Zegers D, et al. Association of the BDNF Val66Met variation with obesity in women. Mol Genet Metab 2008; 95: 110–112.
   PubMed Web of Science ®Google Scholar
• Gunstad J, Schofield P, Paul RH, et al. BDNF Val66Met polymorphism is associated with body mass index in healthy adults. Neuropsychobiology 2006; 53: 153–156.
   PubMed Web of Science ®Google Scholar
• Ribasés M, Gratacos M, Armengol L, et al. Met66 in the brain- derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type. Mol Psychiatry 2003; 8: 745–751.
   PubMed Web of Science ®Google Scholar
• Ribasés M, Gratacos M, Fernandez-Aranda F, et al. Association of BDNF with restricting anorexia nervosa and minimum body mass index: a family-based association study of eight European populations. Eur J Hum Genet 2005; 13: 428–434.
   PubMed Web of Science ®Google Scholar
• Marti A, Martinez-González MA, Martinez JA. Interaction between genes and lifestyle factors on obesity. Proc Nutr Soc 2008; 67: 1–8.
   PubMed Web of Science ®Google Scholar
• Thorleifsson G, Walters GB, Gudbjartsson DF, et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 2009; 41: 18–24.
   PubMed Web of Science ®Google Scholar
• Akey J, Jin L, Xiong M. Haplotypes vs single marker linkage disequilibrium tests: what do we gain? Eur J Hum Genet 2001; 9: 291–300.
   PubMed Web of Science ®Google Scholar
• Souren NY, Paulussen AD, Steyls A, et al. Common SNPs in LEP and LEPR associated with birth weight and type 2 diabetes-related metabolic risk factors in twins. Int J Obes 2008; 32: 1233–1239.
   PubMed Web of Science ®Google Scholar
• van Rossum CT, Hoebee B, van Baak MA, et al. Genetic variation in the leptin receptor gene, leptin, and weight gain in young Dutch adults. Obes Res 2003; 11: 377–386.
   PubMedGoogle Scholar