Maternal obesity affects gene expression and cellular development in fetal brains

References

• Flegal KM, Carroll MD, Ogden CL, Curtin LR. Prevalence and trends in obesity among US adults 1999–2008. JAMA 2010;303:235–41.
   PubMed Web of Science ®Google Scholar
• Barker DJ. Intrauterine programming of adult disease. Mol Med Today 1995;1:418–23.
   PubMedGoogle Scholar
• Fernandez-Twinn DS, Ozanne SE. Early life nutrition and metabolic programming. Ann New York Acad Sci 2010;1212:78–96.
   PubMed Web of Science ®Google Scholar
• Li M, Sloboda DM, Vickers MH. Maternal obesity and developmental programming of metabolic disorders in offspring: evidence from animal models. Exp Diabetes Res 2011;2011:592408.
   PubMedGoogle Scholar
• Grove KL, Allen S, Grayson BE, Smith MS. Postnatal development of the hypothalamic neuropeptide Y system. Neuroscience 2003;116:393–406.
   PubMed Web of Science ®Google Scholar
• Bouret SG. Early life origins of obesity: role of hypothalamic programming. J Pediatr Gastroenterol Nutr 2009;48 (Suppl. 1):S31–8.
   PubMed Web of Science ®Google Scholar
• Patel MS, Srinivasan M. Metabolic programming in the immediate postnatal life. Ann Nutr Metab 2011;58 (Suppl. 2):18–28.
   PubMed Web of Science ®Google Scholar
• Srinivasan M, Dodds C, Ghanim H, Gao T, Ross PJ, Browne RW, et al. Maternal obesity and fetal programming: effects of a high-carbohydrate nutritional modification in the immediate postnatal life of female rats. Am J Physiol Endocrinol Metab 2008;295:E895–903.
   PubMed Web of Science ®Google Scholar
• Chang GQ, Gaysinskaya V, Karatayev O, Leibowitz SF. Maternal high-fat diet and fetal programming: increased proliferation of hypothalamic peptide-producing neurons that increase risk for overeating and obesity. J Neurosci 2008;28:12107–19.
   PubMed Web of Science ®Google Scholar
• Tozuka Y, Wada E, Wada K. ‘Bio-communication’ between mother and offspring: lessons from animals and new perspectives for brain science. J Pharmacol Sci 2009;110:127–32.
   PubMed Web of Science ®Google Scholar
• Huang da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009;4:44–57.
   PubMed Web of Science ®Google Scholar
• Stachowiak EK, Roy I, Lee YW, Capacchietti M, Aletta JM, Prasad PN, et al. Targeting novel integrative nuclear FGFR1 signaling by nanoparticle-mediated gene transfer stimulates neurogenesis in the adult brain. Integr Biol: Quant Biosci from Nano to Macro. 2009;1:394–403.
   Google Scholar
• Vadlamudi S, Kalhan SC, Patel MS. Persistence of metabolic consequences in the progeny of rats fed a HC formula in their early postnatal life. Am J Physiol Endocrinol Metab 1999;269:E731–8.
   Google Scholar
• Gordon MN, Kumar S, Espinosa de los Monteros A, Scully S, Zhang MS, Huber J, et al. Developmental regulation of myelin-associated genes in the normal and the myelin deficient mutant rat. Adv Exp Med Biol 1990;265:11–22.
   PubMedGoogle Scholar
• Coman I, Aigrot MS, Seilhean D, Reynolds R, Girault JA, Zalc B, et al. Nodal, paranodal and juxtaparanodal axonal proteins during demyelination and remyelination in multiple sclerosis. Brain 2006;129:3186–95.
   PubMed Web of Science ®Google Scholar
• Helgeson SC, Schmutz SM. Genetic variation in the pro-melanin-concentrating hormone gene affects carcass traits in Bos taurus cattle. Anim Genet 2008;39:310–5.
   PubMed Web of Science ®Google Scholar
• Remaury A, Vita N, Gendreau S, Jung M, Arnone M, Poncelet M, et al. Targeted inactivation of the neurotensin type 1 receptor reveals its role in body temperature control and feeding behavior but not in analgesia. Brain Res 2002;953:63–72.
   PubMed Web of Science ®Google Scholar
• Reue K, Zhang P. The lipin protein family: dual roles in lipid biosynthesis and gene expression. FEBS Lett 2008;582:90–6.
   PubMed Web of Science ®Google Scholar
• Li M, Ren D, Iseki M, Takaki S, Rui L. Differential role of SH2-B and APS in regulating energy and glucose homeostasis. Endocrinology 2006;147:2163–70.
   PubMed Web of Science ®Google Scholar
• Carroll K, Gomez C, Shapiro L. Tubby proteins: the plot thickens. Nat Rev 2004;5:55–63.
   Google Scholar
• Fine R, Lehman W, Head J, Blitz A. Troponin C in brain. Nature 1975;258:260–7.
   PubMed Web of Science ®Google Scholar
• Kimura N, Nakashima K, Ueno M, Kiyama H, Taga T. A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain. Brain Res: Dev Brain Res 1999;115:183–93.
   PubMedGoogle Scholar
• Adhihetty PJ, Beal MF. Creatine and its potential therapeutic value for targeting cellular energy impairment in neurodegenerative diseases. Neuromol Med 2008;10:275–90.
   PubMed Web of Science ®Google Scholar
• Tozuka Y, Kumon M, Wada E, Onodera M, Mochizuki H, Wada K. Maternal obesity impairs hippocampal BDNF production and spatial learning performance in young mouse offspring. Neurochem Int 2010;57:235–47.
   PubMed Web of Science ®Google Scholar
• Niculescu MD, Lupu DS. High fat diet-induced maternal obesity alters fetal hippocampal development. Int J Dev Neurosci 2009;27:627–33.
   PubMed Web of Science ®Google Scholar
• Chiu SL, Cline HT. Insulin receptor signaling in the development of neuronal structure and function. Neural Dev 2010;5:7.
   PubMed Web of Science ®Google Scholar
• Steen E, Terry BM, Rivera EJ, Cannon JL, Neely TR, Tavares R, et al. Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease–is this type 3 diabetes? J Alzheimers Dis 2005;7:63–80.
   PubMed Web of Science ®Google Scholar
• Wertheimer E, Lu SP, Backeljauw PF, Davenport ML, Taylor SI. Homozygous deletion of the human insulin receptor gene results in leprechaunism. Nat Gen 1993;5:71–3.
   PubMed Web of Science ®Google Scholar
• LaFever L, Drummond-Barbosa D. Direct control of germline stem cell division and cyst growth by neural insulin in Drosophila. Science 2005;309:1071–3.
   PubMed Web of Science ®Google Scholar
• Desai M, Li T, Ross MG. Hypothalamic neurosphere progenitor cells in low birth-weight rat newborns: neurotrophic effects of leptin and insulin. Brain Res 2011;1378:29–42.
   PubMed Web of Science ®Google Scholar
• Plagemann A, Harder T, Rake A, Voits M, Fink H, Rohde W, et al. Perinatal elevation of hypothalamic insulin, acquired malformation of hypothalamic galaninergic neurons, and syndrome x-like alterations in adulthood of neonatally overfed rats. Brain Res 1999;836:146–55.
   PubMed Web of Science ®Google Scholar
• Udagawa J, Hatta T, Hashimoto R, Otani H. Roles of leptin in prenatal and perinatal brain development. Congenit Anom (Kyoto) 2007;47:77–83.
   PubMedGoogle Scholar
• Bouret SG, Draper SJ, Simerly RB. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 2004;304:108–10.
   PubMed Web of Science ®Google Scholar
• Krakowiak P, Walker CK, Bremer AA, Baker AS, Ozonoff S, Hansen RL, et al. Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders. Pediatrics 2012;129:e1121–8.
   PubMed Web of Science ®Google Scholar
• Rodriguez JS, Rodriguez-Gonzalez GL, Reyes-Castro LA, Ibanez C, Ramirez A, Chavira R, et al. Maternal obesity in the rat programs male offspring exploratory, learning and motivation behavior: prevention by dietary intervention pre-gestation or in gestation. Int J Dev Neurosci 2012;30:75–81.
   PubMed Web of Science ®Google Scholar