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Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 16, 2013 - Issue 4
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Original research papers

Low docosahexaenoic acid status is associated with reduced indices in cortical integrity in the anterior cingulate of healthy male children: A 1H MRS Study

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Pages 183-190 | Published online: 19 Jul 2013

References

  • Carver JD, Benford VJ, Han B, Cantor AB. The relationship between age and the fatty acid composition of cerebral cortex and erythrocytes in human subjects. Brain Res Bull 2001;56:79–85.
  • McNamara RK, Liu Y, Jandacek R, Rider T, Tso P. The aging human orbitofrontal cortex: decreasing polyunsaturated fatty acid composition and associated increases in lipogenic gene expression and stearoyl-CoA desaturase activity. Prostaglandins Leukot Essent Fatty Acids 2008;78:293–304.
  • Clandinin MT, Chappell JE, Leong S, Heim T, Swyer PR, Chance GW. Intrauterine fatty acid accretion rates in human brain: implications for fatty acid requirements. Early Hum Dev 1980a;4:121–9.
  • Martínez M, Mougan I. Fatty acid composition of human brain phospholipids during normal development. J Neurochem 1998;71:2528–33.
  • Clandinin MT, Chappell JE, Leong S, Heim T, Swyer PR, Chance GW. Extrauterine fatty acid accretion in infant brain: implications for fatty acid requirements. Early Hum Dev 1980b;4:131–8.
  • Giedd JN, Lalonde FM, Celano MJ, White SL, Wallace GL, Lee NR, et al. Anatomical brain magnetic resonance imaging of typically developing children and adolescents. J Am Acad Child Adolesc Psychiatry 2009;48:465–47.
  • Boucher O, Burden MJ, Muckle G, Saint-Amour D, Ayotte P, Dewailly E, et al. Neurophysiologic and neurobehavioral evidence of beneficial effects of prenatal omega-3 fatty acid intake on memory function at school age. Am J Clin Nutr 2011;93:1025–37.
  • Carlson SE. Early determinants of development: a lipid perspective. Am J Clin Nutr 2009;89:1523S–9S.
  • Drover JR, Hoffman DR, Castañeda YS, Morale SE, Garfield S, Wheaton DH, et al. Cognitive function in 18-month-old term infants of the DIAMOND study: a randomized, controlled clinical trial with multiple dietary levels of docosahexaenoic acid. Early Hum Dev 2011;87:223–30.
  • McNamara RK, Carlson SE. Role of omega-3 fatty acids in brain development and function: potential implications for the pathogenesis and prevention of psychopathology. Prostaglandins Leukot Essent Fatty Acids 2006;75:329–49.
  • Ryan AS, Astwood JD, Gautier S, Kuratko CN, Nelson EB, Salem N Effects of long-chain polyunsaturated fatty acid supplementation on neurodevelopment in childhood: a review of human studies. Prostaglandins Leukot Essent Fatty Acids 2010;82:305–14.
  • Helland IB, Smith L, Saarem K, Saugstad OD, Drevon CA. Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children's IQ at 4 years of age. Pediatrics 2003;111:39–44.
  • Karr JE, Alexander JE, Winningham RG. Omega-3 polyunsaturated fatty acids and cognition throughout the lifespan: a review. Nutr Neurosci 2011;14:216–25.
  • Kohlboeck G, Glaser C, Tiesler C, Demmelmair H, Standl M, Romanos M, et al. LISAplus Study Group. Effect of fatty acid status in cord blood serum on children's behavioral difficulties at 10 y of age: results from the LISAplus Study. Am J Clin Nutr 2011;94:1592–9.
  • Brand A, Richter-Landsberg C, Leibfritz D. Multinuclear NMR studies on the energy metabolism of glial and neuronal cells. Dev Neurosci 1993;15:289–98.
  • Griffin JL, Bollard M, Nicholson JK, Bhakoo K. Spectral profiles of cultured neuronal and glial cells derived from HRMAS (1)H NMR spectroscopy. NMR Biomed 2002;15:375–84.
  • Bates TE, Strangward M, Keelan J, Davey GP, Munro PM, Clark JB. Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo. Neuroreport 1996;7:1397–400.
  • Ciccarelli O, Toosy AT, De Stefano N, Wheeler-Kingshott CA, Miller DH, Thompson AJ. Assessing neuronal metabolism in vivo by modeling imaging measures. J Neurosci 2010;30:15030–3.
  • McNamara RK, Able JA, Jandacek R, Rider T, Tso P, Lindquist DM. Perinatal omega-3 fatty acid deficiency selectively reduces myo-inositol levels in the adult rat prefrontal cortex: an in vivo 1H-MRS study. J Lipid Res 2009;50:405–11.
  • McNamara RK. Deciphering the role of docosahexaenoic acid in brain maturation and pathology with magnetic resonance imaging. Prostaglandins Leukot Essent Fatty Acids 2012; [Epub ahead of print].
  • Cao J, Schwichtenberg KA, Hanson NQ, Tsai MY. Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipids. Clin Chem 2006;52:2265–72.
  • Fekete K, Marosvölgyi T, Jakobik V, Decsi T. Methods of assessment of n-3 long-chain polyunsaturated fatty acid status in humans: a systematic review. Am J Clin Nutr 2009;89:2070–84.
  • Sands SA, Reid KJ, Windsor SL, Harris WS. The impact of age, body mass index, and fish intake on the EPA and DHA content of human erythrocytes. Lipids 2005;40:343–7.
  • Connor WE, Neuringer M, Lin DS. Dietary effects on brain fatty acid composition: the reversibility of n-3 fatty acid deficiency and turnover of docosahexaenoic acid in the brain, erythrocytes, and plasma of rhesus monkeys. J Lipid Res 1990;31:237–47.
  • McNamara RK, Sullivan J, Richtand NM. Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult mice: prevention by chronic lithium treatment. J Psychiatr Res 2008;42:458–68.
  • Fristad MA, Glickman AR, Verducci JS, Teare M, Weller EB, Weller RA. Study V: Children's Interview for Psychiatric Syndromes (ChIPS): psychometrics in two community samples. J Child Adolesc Psychopharmacol 1998;8:237–45.
  • Crovitz HF, Zener K. A group-test for assessing hand- and eye-dominance. Am J Psychol 1962;75:271–6.
  • Benisek D, Bailey-Hall E, Oken H, Masayesva S, Arterburn L. Validation of a simple food frequency questionnaire as an indicator of long chain omega-3 intake. 93rd Annual AOCS Meeting, Montreal, Quebec, Canada, 2002. p. S96.
  • Adler CM, Sax KW, Holland SK, Schmithorst V, Rosenberg L, Strakowski SM. Changes in neuronal activation with increasing attention demand in healthy volunteers: an fMRI study. Synapse 2001;42:266–72.
  • McNamara RK, Able JA, Jandacek R, Rider T, Tso P, Eliassen J, et al. Docosahexaenoic acid supplementation increases prefrontal cortex activation during sustained attention in healthy boys: a placebo-controlled, dose-ranging, functional magnetic resonance imaging study. Am J Clin Nutr 2010;91:1060–7.
  • Kaufman AS, Kaufman NL. Kaufman brief intelligence test. 1st ed. Circle Pines, MN: American Guidance Service; 1990.
  • McNamara RK, Jandacek R, Rider T, Tso P, Dwivedi Y, Pandey GN. Selective deficits in erythrocyte docosahexaenoic acid composition in adult patients with bipolar disorder and major depressive disorder. J Affect Disord 2010;126:303–11.
  • Metcalfe LD, Schmitz AA, Pelka JR. Rapid preparation of fatty acid esters from lipids for gas chromatographic analysis. Anal Chem 1966;38:514–5.
  • Lee J-H, Garwood M, Menon R, Adriany G, Andersen P, Truwit CL, et al. High contrast and fast three-dimensional magnetic resonance imaging at high fields. Magn Reson Med 1995;34:308–12.
  • Gruetter R, Boesch C. Fast, noniterative shimming of spatially localized signals. In vivo analysis of the magnetic field along axes. J Magn Reson 1992;96:323–34.
  • Tkac I, Staruck Z, Choi IY, Gruetter R. In vivo 1H NMR spectroscopy of rat brain at 1 ms echo time. Magn Reson Med 1999;41:649–56.
  • Provincher SW. Estimation of metabolite concentration from localized in vivo proton NMR spectra. Magn Reson Med 1993;30:672–9.
  • Hetherington HP, Mason GF, Pan JW, Ponder SL, Vaughan JT, Twieg DB, et al. Evaluation of cerebral gray and white matter metabolite differences by spectroscopic imaging at 4.1 T. Magn Reson Med 1994;32:565–71.
  • Casey BJ, Trainor R, Giedd J, Vauss Y, Vaituzis CK, Hamburger S, et al. The role of the anterior cingulate in automatic and controlled processes: a developmental neuroanatomical study. Dev Psychobiol 1997;30:61–9.
  • Naito E, Kinomura S, Geyer S, Kawashima R, Roland PE, Zilles K. Fast reaction to different sensory modalities activates common fields in the motor areas, but the anterior cingulate cortex is involved in the speed of reaction. J Neurophysiol 2000;83:1701–9.
  • Paus T. Primate anterior cingulate cortex: where motor control, drive and cognition interface. Nat Rev Neurosci 2001;2:417–24.
  • Itomura M, Fujioka S, Hamazaki K, Kobayashi K, Nagasawa T, Sawazaki S, et al. Factors influencing EPA+DHA levels in red blood cells in Japan. In Vivo 2008;22:131–5.
  • Chen JR, Hsu SF, Hsu CD, Hwang LH, Yang SC. Dietary patterns and blood fatty acid composition in children with attention-deficit hyperactivity disorder in Taiwan. J Nutr Biochem 2004;15:467–72.
  • Colter AL, Cutler C, Meckling KA. Fatty acid status and behavioural symptoms of attention deficit hyperactivity disorder in adolescents: a case-control study. Nutr J 2008;7:8.
  • Stevens LJ, Zentall SS, Deck JL, Abate ML, Watkins BA, Lipp SR, et al. Essential fatty acid metabolism in boys with attention-deficit hyperactivity disorder. Am J Clin Nutr 1995;62:761–8.
  • Brenna JT, Salem N, Sinclair AJ, Cunnane SC, International Society for the Study of Fatty Acids and Lipids, ISSFAL. Alpha-linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans. Prostaglandins Leukot Essent Fatty Acids 2009;80:85–91.
  • Joardar A, Sen AK, Das S. Docosahexaenoic acid facilitates cell maturation and beta-adrenergic transmission in astrocytes. J Lipid Res 2006;47:571–81.
  • Pifferi F, Roux F, Langelier B, Alessandri JM, Vancassel S, Jouin M, et al. (n-3) polyunsaturated fatty acid deficiency reduces the expression of both isoforms of the brain glucose transporter GLUT1 in rats. J Nutr 2005;135:2241–6.
  • Ximenes da Silva A, Lavialle F, Gendrot G, Guesnet P, Alessandri JM, Lavialle M. Glucose transport and utilization are altered in the brain of rats deficient in n-3 polyunsaturated fatty acids. J Neurochem 2002;81:1328–37.
  • Bjartmar C, Kidd G, Mörk S, Rudick R, Trapp BD. Neurological disability correlates with spinal cord axonal loss and reduced N-acetyl aspartate in chronic multiple sclerosis patients. Ann Neurol 2000;48:893–901.
  • Demougeot C, Marie C, Giroud M, Beley A. N-acetylaspartate: a literature review of animal research on brain ischaemia. J Neurochem 2004;90:776–83.
  • Malisza KL, Kozlowski P, Peeling J. A review of in vivo 1H magnetic resonance spectroscopy of cerebral ischemia in rats. Biochem Cell Biol 1998;76:487–96.
  • Woo CW, Lee BS, Kim ST, Kim KS. Correlation between lactate and neuronal cell damage in the rat brain after focal ischemia: an in vivo 1H magnetic resonance spectroscopic (1H-MRS) study. Acta Radiol 2010;51:344–50.
  • Belayev L, Khoutorova L, Atkins KD, Bazan NG. Robust docosahexaenoic acid-mediated neuroprotection in a rat model of transient, focal cerebral ischemia. Stroke 2009;40:3121–6.
  • Blondeau N, Widmann C, Lazdunski M, Heurteaux C. Polyunsaturated fatty acids induce ischemic and epileptic tolerance. Neuroscience 2002;109:231–41.
  • Duijn JH, Matson GB, Maudsley AA, Hugg JW, Weiner MW. Human brain infarction: proton MR spectroscopy. Radiology 1992;183:711–8.
  • Lanfermann H, Kugel H, Heindel W, Herholz K, Heiss WD, Lackner K. Metabolic changes in acute and subacute cerebral infarctions: findings at proton MR spectroscopic imaging. Radiology 1995;196:203–10.
  • Federico F, Simone IL, Lucivero V, Giannini P, Laddomada G, Mezzapesa DM, et al. Prognostic value of proton magnetic resonance spectroscopy in ischemic stroke. Arch Neurol 1998;55:489–94.
  • Conklin SM, Gianaros PJ, Brown SM, Yao JK, Hariri AR, Manuck SB, et al. Long-chain omega-3 fatty acid intake is associated positively with corticolimbic gray matter volume in healthy adults. Neurosci Lett 2007;421:209–12.
  • Semrud-Clikeman M, Pliszka SR, Lancaster J, Liotti M. Volumetric MRI differences in treatment-naive vs. chronically treated children with ADHD. Neurology 2006;67:1023–7.
  • Bush G, Frazier JA, Rauch SL, Seidman LJ, Whalen PJ, Jenike MA, et al. Anterior cingulate cortex dysfunction in attention-deficit/hyperactivity disorder revealed by fMRI and the counting stroop. Biol Psychiatry 1999;45:1542–52.
  • Smith AB, Taylor E, Brammer M, Halari R, Rubia K. Reduced activation in right lateral prefrontal cortex and anterior cingulate gyrus in medication-naïve adolescents with attention deficit hyperactivity disorder during time discrimination. J Child Psychol Psychiatry 2008;49:977–85.
  • Tamm L, Menon V, Ringel J, Reiss AL. Event-related FMRI evidence of frontotemporal involvement in aberrant response inhibition and task switching in attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 2004;43:1430–40.
  • Epstein JN, Hwang ME, Antonini T, Langberg JM, Altaye M, Arnold LE. Examining predictors of reaction times in children with ADHD and normal controls. J Int Neuropsychol Soc 2010;16:138–47.
  • Conklin SM, Runyan CA, Leonard S, Reddy RD, Muldoon MF, Yao JK. Age-related changes of n-3 and n-6 polyunsaturated fatty acids in the anterior cingulate cortex of individuals with major depressive disorder. Prostaglandins Leukot Essent Fatty Acids 2010;82:111–9.
  • Järnum H, Eskildsen SF, Steffensen EG, Lundbye-Christensen S, Simonsen CW, Thomsen IS, et al. Longitudinal MRI study of cortical thickness, perfusion, and metabolite levels in major depressive disorder. Acta Psychiatr Scand 2011;124:435–46.
  • Halari R, Simic M, Pariante CM, Papadopoulos A, Cleare A, Brammer M, et al. Reduced activation in lateral prefrontal cortex and anterior cingulate during attention and cognitive control functions in medication-naïve adolescents with depression compared to controls. J Child Psychol Psychiatry 2009;50:307–16.

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