Oil palm phenolics confer neuroprotective effects involving cognitive and motor functions in mice

References

• Young IS, Woodside JV. Antioxidants in health and disease. J Clin Pathol 2001;54:176–86.
   PubMed Web of Science ®Google Scholar
• Lau FC, Shukitt-Hale B, Joseph JA. The beneficial effects of fruit polyphenols on brain aging. Neurobiol Aging 2005;26(Suppl. 1):128–32.
   PubMed Web of Science ®Google Scholar
• Youdim KA, Shukitt-Hale B, Joseph JA. Flavonoids and the brain: interactions at the blood-brain barrier and their physiological effects on the central nervous system. Free Radic Biol Med 2004;37:1683–93.
   PubMed Web of Science ®Google Scholar
• Shukitt-Hale B, Carey AN, Jenkins D, Rabin BM, Joseph JA. Beneficial effects of fruit extracts on neuronal function and behavior in a rodent model of accelerated aging. Neurobiol Aging 2007;28:1187–94.
   PubMed Web of Science ®Google Scholar
• Topic B, Tani E, Tsiakitzis K, Kourounakis PN, Dere E, Hasenohrl RU, et al. Enhanced maze performance and reduced oxidative stress by combined extracts of Zingiber officinale and Ginkgo biloba in the aged rat. Neurobiol Aging 2002;23:135–43.
   PubMed Web of Science ®Google Scholar
• Rogers EJ, Milhalik S, Orthiz D, Shea TB. Apple juice prevents oxidative stress and impaired cognitive performance caused by genetic and dietary deficiencies in mice. J Nutr Health Aging 2004;8:92–7.
   PubMedGoogle Scholar
• Joseph JA, Shukitt-Hale B, Casadesus G. Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds. Am J Clin Nutr 2005;81:313S–6S.
   PubMed Web of Science ®Google Scholar
• Haque AM, Hashimoto M, Katakura M, Tanabe Y, Hara Y, Shido O. Long-term administration of green tea catechins improves spatial cognition learning ability in rats. J Nutr 2006;136:1043–7.
   PubMed Web of Science ®Google Scholar
• van Praag H, Lucero MJ, Yeo GW, Stecker K, Heivand N, Zhao C, et al. Plant-derived flavanol (−)epicatechin enhances angiogenesis and retention of spatial memory in mice. J Neurosci 2007;27:5869–78.
   PubMed Web of Science ®Google Scholar
• Wang J, Ho L, Zhao Z, Seror I, Humala N, Dickstein DL, et al. Moderate consumption of Cabernet Sauvignon attenuates Abeta neuropathology in a mouse model of Alzheimer's disease. Faseb J 2006;20:2313–20.
   PubMed Web of Science ®Google Scholar
• Hartman RE, Shah A, Fagan AM, Schwetye KE, Parsadanian M, Schulman RN, et al. Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer's disease. Neurobiol Dis 2006;24:506–15.
   PubMed Web of Science ®Google Scholar
• Williams RJ, Spencer JP, Rice-Evans C. Flavonoids: antioxidants or signalling molecules? Free Radic Biol Med 2004;36:838–49.
   PubMed Web of Science ®Google Scholar
• Spencer JP. The impact of flavonoids on memory: physiological and molecular considerations. Chem Soc Rev 2009;38:1152–61.
   PubMed Web of Science ®Google Scholar
• Williams CM, El Mohsen MA, Vauzour D, Rendeiro C, Butler LT, Ellis JA, et al. Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels. Free Radic Biol Med 2008;45:295–305.
   PubMed Web of Science ®Google Scholar
• Sambanthamurthi R, Tan YA, Sundram K, inventors; Malaysian Palm Oil Board, assignee. Treatment of vegetation liquors derived from oil-bearing fruit. United States patent US 7,387,802 B2; 2008.
   Google Scholar
• Sambanthamurthi R, Tan YA, Sundram K, Abeywardena M, Sambandan TG, Rha C, et al. Oil palm vegetation liquor: a new source of phenolic bioactives. Br J Nutr 2011;106:1655–63.
   PubMed Web of Science ®Google Scholar
• Sekaran SD, Leow SS, Abobaker N, Tee KK, Sundram K, Sambanthamurthi R, et al. Effects of oil palm phenolics on tumor cells in vitro and in vivo. Afr J Food Sci 2010;4:495–502.
   Google Scholar
• Sambanthamurthi R, Tan YA, Sundram K, Hayes KC, Abeywardena M, Leow SS, et al. Positive outcomes of oil palm phenolics on degenerative diseases in animal models. Br J Nutr 2011;106:1664–75.
   PubMed Web of Science ®Google Scholar
• Leow SS, Sekaran SD, Sundram K, Tan YA, Sambanthamurthi R. Differential transcriptomic profiles effected by oil palm phenolics indicate novel health outcomes. BMC Genomics 2011;12:432.
   PubMed Web of Science ®Google Scholar
• Leow SS, Sekaran SD, Sundram K, Tan YA, Sambanthamurthi R. Oil palm phenolics attenuate changes caused by an atherogenic diet in mice. Eur J Nutr. 2012; Published online DOI 10.1007/s00394-012-0346-0
   PubMed Web of Science ®Google Scholar
• Reagan-Shaw S, Nihal M, Ahmad N. Dose translation from animal to human studies revisited. FASEB J 2008;22:659–61.
   PubMed Web of Science ®Google Scholar
• Vorhees CV, Williams MT. Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc 2006;1:848–58.
   PubMed Web of Science ®Google Scholar
• Edgar R, Domrachev M, Lash AE. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 2002;30:207–10.
   PubMed Web of Science ®Google Scholar
• Saeed AI, Sharov V, White J, Li J, Liang W, Bhagabati N, et al. TM4: A free, open-source system for microarray data management and analysis. Biotechniques 2003;34:374–8.
   PubMed Web of Science ®Google Scholar
• Novak JP, Miller MC, Bell DA. Variation in fiberoptic bead-based oligonucleotide microarrays: dispersion characteristics among hybridization and biological replicate samples. Biol Direct 2006;1:18.
   PubMed Web of Science ®Google Scholar
• Dahlquist KD, Salomonis N, Vranizan K, Lawlor SC, Conklin BR. GenMAPP, a new tool for viewing and analyzing microarray data on biological pathways. Nat Genet 2002;31:19–20.
   PubMed Web of Science ®Google Scholar
• Doniger SW, Salomonis N, Dahlquist KD, Vranizan K, Lawlor SC, Conklin BR. MAPPFinder: using Gene Ontology and GenMAPP to create a global gene-expression profile from microarray data. Genome Biol 2003;4:R7.
   PubMed Web of Science ®Google Scholar
• Bustin SA, Nolan T. Pitfalls of quantitative real-time reverse-transcription polymerase chain reaction. J Biomol Tech 2004;15:155–66.
   PubMedGoogle Scholar
• Nolan T, Hands RE, Bustin SA. Quantification of mRNA using real-time RT-PCR. Nat Protoc 2006;1:1559–82.
   PubMed Web of Science ®Google Scholar
• Hellemans J, Mortier G, De Paepe A, Speleman F, Vandesompele J. qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data. Genome Biol 2007;8:R19.
   PubMed Web of Science ®Google Scholar
• Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 2002;3: RESEARCH0034.
   PubMed Web of Science ®Google Scholar
• Farina M, Franco JL, Ribas CM, Meotti FC, Missau FC, Pizzolatti MG, et al. Protective effects of Polygala paniculata extract against methylmercury-induced neurotoxicity in mice. J Pharm Pharmacol 2005;57:1503–8.
   PubMed Web of Science ®Google Scholar
• Mohanasundari M, Srinivasan MS, Sethupathy S, Sabesan M. Enhanced neuroprotective effect by combination of bromocriptine and Hypericum perforatum extract against MPTP-induced neurotoxicity in mice. J Neurol Sci 2006;249:140–4.
   PubMed Web of Science ®Google Scholar
• Raskin I, Ripoll C. Can an apple a day keep the doctor away? Curr Pharm Des 2004;10:3419–29.
   PubMed Web of Science ®Google Scholar
• de Boer VC, van Schothorst EM, Dihal AA, van der Woude H, Arts IC, Rietjens IM, et al. Chronic quercetin exposure affects fatty acid catabolism in rat lung. Cell Mol Life Sci 2006;63:2847–58.
   PubMed Web of Science ®Google Scholar
• Kaliora AC, Dedoussis GV, Schmidt H. Dietary antioxidants in preventing atherogenesis. Atherosclerosis 2006;187:1–17.
   PubMed Web of Science ®Google Scholar
• Iida K, Nishimura I. Gene expression profiling by DNA microarray technology. Crit Rev Oral Biol Med 2002;13:35–50.
   PubMedGoogle Scholar
• Gohil K, Chakraborty AA. Applications of microarray and bioinformatics tools to dissect molecular responses of the central nervous system to antioxidant micronutrients. Nutrition 2004;20:50–5.
   PubMed Web of Science ®Google Scholar
• Watanabe CM, Wolffram S, Ader P, Rimbach G, Packer L, Maguire JJ, et al. The in vivo neuromodulatory effects of the herbal medicine Ginkgo biloba. Proc Natl Acad Sci USA 2001;98:6577–80.
   PubMed Web of Science ®Google Scholar
• Yin Y, Edelman GM, Vanderklish PW. The brain-derived neurotrophic factor enhances synthesis of Arc in synaptoneurosomes. Proc Natl Acad Sci USA 2002;99:2368–73.
   PubMed Web of Science ®Google Scholar
• Binder DK, Scharfman HE. Brain-derived neurotrophic factor. Growth Factors 2004;22:123–31.
   PubMed Web of Science ®Google Scholar
• Li L, Carter J, Gao X, Whitehead J, Tourtellotte WG. The neuroplasticity-associated arc gene is a direct transcriptional target of early growth response (Egr) transcription factors. Mol Cell Biol 2005;25:10286–300.
   PubMed Web of Science ®Google Scholar
• Tohda C, Kuboyama T, Komatsu K. Search for natural products related to regeneration of the neuronal network. Neurosignals 2005;14:34–45.
   PubMed Web of Science ®Google Scholar
• Ng TB, Wang HX, Liu F, Xia LX. Plants beneficial to the aging brain. Neuroembryol Aging 2005;3:136–41.
   Google Scholar
• Schaffer S, Podstawa M, Visioli F, Bogani P, Muller WE, Eckert GP. Hydroxytyrosol-rich olive mill wastewater extract protects brain cells in vitro and ex vivo. J Agric Food Chem 2007;55:5043–9.
   PubMed Web of Science ®Google Scholar
• Steinman L, Zamvil S. Transcriptional analysis of targets in multiple sclerosis. Nat Rev Immunol 2003;3:483–92.
   PubMed Web of Science ®Google Scholar
• Ray A, Ray BK. Persistent expression of serum amyloid A during experimentally induced chronic inflammatory condition in rabbit involves differential activation of SAF, NF-kappa B, and C/EBP transcription factors. J Immunol 1999;163:2143–50.
   PubMed Web of Science ®Google Scholar
• Lee CK, Weindruch R, Prolla TA. Gene-expression profile of the ageing brain in mice. Nat Genet 2000;25:294–7.
   PubMed Web of Science ®Google Scholar
• Blalock EM, Chen KC, Sharrow K, Herman JP, Porter NM, Foster TC, et al. Gene microarrays in hippocampal aging: Statistical profiling identifies novel processes correlated with cognitive impairment. J Neurosci 2003;23:3807–19.
   PubMed Web of Science ®Google Scholar
• Kim JM, Lee KH, Jeon YJ, Oh JH, Jeong SY, Song IS, et al. Identification of genes related to Parkinson's disease using expressed sequence tags. DNA Res 2006;13:275–86.
   PubMed Web of Science ®Google Scholar
• Deshane J, Chaves L, Sarikonda KV, Isbell S, Wilson L, Kirk M, et al. Proteomics analysis of rat brain protein modulations by grape seed extract. J Agric Food Chem 2004;52:7872–83.
   PubMed Web of Science ®Google Scholar
• Ramassamy C. Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets. Eur J Pharmacol 2006;545:51–64.
   PubMed Web of Science ®Google Scholar
• Blalock EM, Geddes JW, Chen KC, Porter NM, Markesbery WR, Landfield PW. Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses. Proc Natl Acad Sci USA 2004;101:2173–8.
   PubMed Web of Science ®Google Scholar