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Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 17, 2014 - Issue 4
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Original Research Papers

Dietary omega-3 deficiency reduces BDNF content and activation NMDA receptor and Fyn in dorsal hippocampus: Implications on persistence of long-term memory in rats

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References

  • Parletta N, Milte CM, Meyer BJ. Nutritional modulation of cognitive function and mental health. J Nutr Biochem 2013;24:5.
  • Karr JE, Alexander JE, Winninghan RG. Omega-3 polyunsaturated fatty acids and cognition throughout lifespan: a review. Nutr Neurosci 2011;14(5):216–25.
  • Innis SM. The role of n-6 and n-3 fatty acids in the developing brain. Dev Neurosci 2000;22(5–6):474–80.
  • Martinez M. Treatment with docosahexaenoic acid favorably modifies the fatty acid composition of erythrocytes in peroxisomal patients. Prog Clin Biol Res 1992;375:389–97.
  • Green P, Glozman S, Kamensky B, Yavin E. Developmental changes in rat brain membrane lipids and fatty acids. The preferential prenatal accumulation of docosahexaenoic acid. J Lipid Res 1999;40:960–6.
  • Su HM. Mechanisms of n-3 fatty acid-mediated development and maintenance of learning memory performance. J Nutr Biochem 2010;21:364–73.
  • Schiefermeier M, Yavin E. n-3 Deficient and docosahexaenoic acid-enriched diets during critical periods of the developing prenatal rat brain. J Lipid Res 2002;43:124–31.
  • Moreira JD, Knorr L, Ganzella M, Thomazi AP, de Souza CG, de Souza DG, et al. Omega-3 fatty acids deprivation affects ontogeny of glutamatergic synapses in rats: relevance for behavior alterations. Neurochem Int 2010;56:753–9.
  • Lim SY, Hoshiba J, Salem N Jr. An extraordinary degree of structural specificity is required in neural phospholipids for optimal brain function: n-6 docosapentaenoic acid substitution for docosahexaenoic acid leads to a loss in spatial task performance. J Neurochem 2005;95:848–57.
  • Moriguchi T, Greiner RS, Salem N Jr. Behavioral deficits associated with dietary induction of decreased brain docosahexaenoic acid concentration. J Neurochem 2000;75:2563–73.
  • Fedorova I, Hussein N, Baumann MH, Di Martino C, Salem N Jr. An n-3 fatty acid deficiency impairs rat spatial learning in the Barnes maze. Behav Neurosci 2009;123:196–205.
  • Moriguchi T, Salem N Jr. Recovery of brain docosahexaenoate leads to recovery of spatial task performance. J Neurochem 2003;87:297–309.
  • Bekinschtein P, Katche C, Slipczuk L, Gonzalez C, Dorman G, Cammarota M, et al. Persistence of long-term memory storage: new insights into molecular signatures in the hippocampus and related structures. Neurotox Res 2010;18:377–85.
  • Medina JH, Bekinschtein P, Cammarota M, Izquierdo I. Do memories consolidate to persist or do they persist to consolidate. Behav Brain Res 2008;192(1):61–9.
  • Collingridge GL, Volianskis A, Bannister N, France G, Hanna L, Mercier M, et al. The NMDA receptor as a target for cognitive enhancement. Neuropharmacology 2013;64:13–26.
  • Bekinschtein P, Cammarota M, Igaz LM, Bevilaqua LR, Izquierdo I, Medina JH. Persistence of long-term memory storage requires a late protein synthesis- and BDNF-dependent phase in the hippocampus. Neuron 2007;53:261–77.
  • Black IB. Trophic regulation of synaptic plasticity. J Neurobiol 1999;41:108–18.
  • Yamada K, Nabeshima T. Brain-derived neurotrophic factor/TrkB signaling in memory process. J Pharmacol Sci 2003;91:267–70.
  • Ali DW, Salter MW. NMDA receptor regulation by Src kinase signaling in excitatory synaptic transmission and plasticity. Curr Opin Neurobiol 2001;11(3):336–42.
  • Salter MW, Kalia LV. Src kinases: a hub for NMDA receptor regulation. Nat Rev Neurosci 2004;5:317–28.
  • Kloda A, Martinac B, Adams DJ. Polymodal regulation of NMDA receptor channels. Channels 2007;1(5):334–43.
  • Grant SG, O'Dell TJ, Karl KA, Stein PL, Soriano P, Kandel ER. Impaired long-term potentiation, special memory, and hippocampal development in Fyn mutant mice. Science 1992;258(5090):1903–10.
  • Kojima N, Sakamoto T, Endo S, Niki H. Impairment of conditional freezing to tone, but not to context, in Fyn-transgenic mice: relationship to NMDA receptor subunit 2B function. Eur J Neurosci 2005;21(5):1359–69.
  • Kojima N, Wang J, Mansuy IM, Grant SG, Mayford M, Kandel ER. Rescuing impairment of long-term potentiation in Fyn-deficient mice by introducing Fyn transgene. Proc Natl Acad Sci USA 1997;94(9):4761–5.
  • Lu YF, Kojima N, Tomizawa K, Moriwaki A, Matsushita M, Obata K, et al. Enhanced synaptic transmission and reduced threshold for LTP induction in Fyn-transgenic mice. Eur J Neurosci 1999;11(1):75–82.
  • Kojima N, Ishibashi H, Obata K, Kandel ER. Higher seizure susceptibility and enhanced tyrosine phosphorilation of N-methyl-d-aspartate receptor subunit 2B in Fyn transgenic mice. Learn Mem 1998;5(6):429–45.
  • Bevilaqua LR, Rossato JI, Medina JH, Izquierdo I, Cammarota M. Src kinase activity is required for avoidance memory formation and recall. Behav Pharmacol 2003;14:649–52.
  • Mizuno M, Yamada K, He J, Nakajima A, Nabeshima T. Involvement of BDNF receptor TrkB in spatial memory formation. Learn Mem 2003;10:108–15.
  • Isosaka T, Hattori K, Kida S, Kohno T, Nakazawa T, Yamamoto T, et al. Activation of Fyn tyrosine kinase in the mouse dorsal hippocampus is essential for contextual fear conditioning. Eur J Neurosci 2008;28:973–81.
  • Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959;37(8):911–7.
  • Hartman L, Lago RC. Rapid preparation of fatty acids methyl esters from lipids. Lab Pract 1973;22(6):475–6.
  • Muller AP, Gnoatto J, Moreira JD, Zimmer ER, Haas CB, Lulhier F, et al. Exercise increase insulin signaling in the hippocampus: physiological effects and pharmacological impact of intracerebroventricular insulin administration in mice. Hippocampus 2011;21(10):1082–92.
  • Miyazawa D, Yasui Y, Yamada K, Ohara N, Okuyama H. Regional differences of the mouse brain in response to an alpha-linolenic acid-restricted diet: Neurotrophin content and protein kinase activity. Life Sci 2010;87:490–4.
  • Aïd S, Vancassel S, Poumès-Ballihaut C, Chalon S, Guesnet P, Lavialle M. Effect of a diet-induced n-3 PUFA depletion on cholinergic parameters in the rat hippocampus. J Lipid Res 2003;44:1545–51.
  • Chung WL, Chen JJ, Su HM. Fish oil supplementation of control and (n-3) fatty acid-deficient male rats enhances reference and working memory performance and increases brain regional docosahexaenoic acid levels. J Nutr 2008;138:1165–71.
  • Mathieu G, Denis S, Lavialle M, Vancassel S. Synergistic effects of stress and omega-3 fatty acid deprivation on emotional response and brain lipid composition in adult rats. Prostaglandins Leukot Essent Fatty Acids 2008;78:391–401.
  • García-Calatayud S, Redondo C, Martín E, Ruiz JI, García-Fuentes M, Sanjurjo P. Brain docosahexaenoic acid status and learning in young rats submitted to dietary long-chain polyunsaturated fatty acid deficiency and supplementation limited to lactation. Pediatr Res 2005;57:719–23.
  • Cao D, Kevala K, Kim J, Moon HS, Jun SB, Lovinger D, et al. Docosahexaenoic acid promotes hippocampal neuronal development and synaptic function. J Neurochem 2009;111:510–21.
  • Izquierdo I, Medina JH. Memory formation: the sequence of biochemical events in the hippocampus and its connection to activity in other brain structures. Neurobiol Learn Mem 1997;68:285–316.
  • Bevilaqua LR, da Silva WN, Medina JH, Izquierdo I, Cammarota M. Extinction and reacquisition of a fear-motivated memory require activity of the Src family of tyrosine kinases in the CA1 region of the hippocampus. Pharmacol Biochem Behav 2005;81:139–45.
  • Rossato JI, Bevilaqua LR, Izquierdo I, Medina JH, Cammarota M. Dopamine controls persistence of long-term memory storage. Science 2009;325:1017–20.
  • Suen PC, Wu K, Levine ES, Mount HT, Xu JL, Lin SY, et al. Brain-derived neurotrophic factor rapidly enhances phosphorylation of the postsynaptic N-methyl-d-aspartate receptor subunit 1. Proc Natl Acad Sci USA 1997;94:8191–5.
  • Xu F, Plummer MR, Len GW, Nakazawa T, Yamamoto T, Black IB, et al. Brain-derived neurotrophic factor rapidly increases NMDA receptor channel activity through Fyn-mediated phosphorylation. Brain Res 2006;1121:22–34.
  • Nakazawa T, Komai S, Tezuka T, Hisatsune C, Umemori H, Semba K, et al. Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-d-aspartate receptor. J Biol Chem 2001;276:693–9.
  • Nakazawa T, Tezuka T, Yamamoto T. Regulation of NMDA receptor function by Fyn-mediated tyrosine phosphorylation. Nihon Shinkei SeishinYakurigaku Zasshi 2002;22(5):165–7.
  • Bekinschtein P, Cammarota M, Katche C, Slipczuk L, Rossato JI, Goldin A, et al. BDNF is essential to promote persistence of long-term memory storage. Proc Natl Acad Sci USA 2008;105:2711–6.
  • Rao JS, Ertley RN, Lee HJ, DeMar JC Jr, Arnold JT, Rapoport SI, et al. n-3 polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism. Mol Psychiatry 2007;12:36–46.
  • Bousquet M, Gibrat C, Saint-Pierre M, Julien C, Calon F, Cicchetti F. Modulation of brain-derived neurotrophic factor as a potential neuroprotective mechanism of action of omega-3 fatty acids in a parkinsonian animal model. Prog Neuropsychopharmacol Biol Psychiatry 2009;33:1401–8.
  • Young C, Gean PW, Wu SP, Lin CH, Shen YZ. Cancellation of low-frequency stimulation-induced long-term depression by docosahexaenoic acid in the rat hippocampus. Neurosci Lett 1998;247(2–3):198–200.
  • Itokazu N, Ikegaya Y, Nishikawa M, Matsuki N. Bidirectional actions of docosahexaenoic acid on hippocampal neurotransmissions in vivo. Brain Res 2000;862(1–2):211–6.
  • Mirnikjoo B, Brown SE, Kim HF, Marangell LB, Sweatt JD, Weeber EJ. Protein kinase inhibition by omega-3 fatty acids. J Biol Chem 2001;276(14):10888–96.

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