Coenzyme Q10 supplementation ameliorates inflammatory markers in patients with multiple sclerosis: a double blind, placebo, controlled randomized clinical trial

References

• Fernandes KS, Brum DG, Palei AC, Sandrim VC, Guerreiro CT, Tanus-Santos JE, et al. Functional MMP-9 polymorphisms modulate plasma MMP-9 levels in multiple sclerosis patients. J Neuroimmunol 2012;249(1–2):56–9.
   PubMed Web of Science ®Google Scholar
• Furlan R, Bergami A, Lang R, Brambilla E, Franciotta D, Martinelli V, et al. Interferon-beta treatment in multiple sclerosis patients decreases the number of circulating T cells producing interferon-gamma and interleukin-4. J Neuroimmunol 2000;111(1–2):86–92.
   PubMed Web of Science ®Google Scholar
• van Horssen J, Witte ME, Schreibelt G, de Vries HE. Radical changes in multiple sclerosis pathogenesis. Biochim Biophys Acta (BBA)-Mol Basis Dis 2011;1812(2):141–50.
   PubMed Web of Science ®Google Scholar
• Larochelle C, Alvarez JI, Prat A. How do immune cells overcome the blood–brain barrier in multiple sclerosis? FEBS Lett 2011;585(23):3770–80.
   PubMed Web of Science ®Google Scholar
• Miller A, Shapiro S, Gershtein R, Kinarty A, Rawashdeh H, Honigman S, et al. Treatment of multiple sclerosis with copolymer-1 (Copaxone): implicating mechanisms of Th1 to Th2/Th3 immune-deviation. J Neuroimmunol 1998;92(1–2):113–21.
   PubMed Web of Science ®Google Scholar
• Spooren A, Kolmus K, Laureys G, Clinckers R, De Keyser J, Haegeman G, et al. Interleukin-6, a mental cytokine. Brain Res Rev 2011;67(1):157–83.
   PubMedGoogle Scholar
• Choi HK, Pokharel YR, Lim SC, Han HK, Ryu CS, Kim SK, et al. Inhibition of liver fibrosis by solubilized coenzyme Q10: role of Nrf2 activation in inhibiting transforming growth factor-β1 expression. Toxicol Appl Pharmacol 2009;240(3):377–84.
   PubMed Web of Science ®Google Scholar
• Dai YL, Luk TH, Yiu KH, Wang M, Yip P, Lee SWL, et al. Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: a randomized controlled trial. Atherosclerosis 2011;216(2):395–401.
   PubMed Web of Science ®Google Scholar
• Lee BJ, Huang YC, Chen SJ, Lin PT. Effects of coenzyme Q10 supplementation on inflammatory markers (high-sensitivity C-reactive protein, interleukin-6, and homocysteine) in patients with coronary artery disease. Nutrition 2012;28(7–8):767–72.
   PubMed Web of Science ®Google Scholar
• Kumar A, Kaur H, Devi P, Mohan V. Role of coenzyme Q10 (CoQ10) in cardiac disease, hypertension and Meniere-like syndrome. Pharmacol Therapeutics 2009;124(3):259–68.
   PubMed Web of Science ®Google Scholar
• Fuller B, Smith D, Howerton A, Kern D. Anti-inflammatory effects of CoQ10 and colorless carotenoids. J Cosmet Dermatol 2006;5(1):30–8.
   PubMedGoogle Scholar
• Matthews RT, Yang L, Browne S, Baik M, Beal MF. Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proc Natl Acad Sci 1998;95(15):8892–7.
   PubMed Web of Science ®Google Scholar
• Schmelzer C, Lorenz G, Rimbach G, Döring F. In vitro effects of the reduced form of coenzyme Q10 on secretion levels of TNF-α and chemokines in response to LPS in the human monocytic cell line THP-1. J Clin Biochem Nutr 2009;44(1):62.
   PubMed Web of Science ®Google Scholar
• Fouad AA, Jresat I. Hepatoprotective effect of coenzyme Q10 in rats with acetaminophen toxicity. Environ Toxicol Pharmacol 2012;33(2):158–67.
   PubMed Web of Science ®Google Scholar
• Mancuso M, Orsucci D, Calsolaro V, Choub A, Siciliano G. Coenzyme Q10 and neurological diseases. Pharmaceuticals 2009;2(3):134–49.
   Google Scholar
• Bahar M, Khaghani S, Pasalar P, Paknejad M, Khorramizadeh MR, Mirmiranpour H, et al. Exogenous coenzyme Q10 modulates MMP-2 activity in MCF-7 cell line as a breast cancer cellular model. Nutr J 2010;9(62):1475–2891.
   Google Scholar
• Besler HİT, Çomoğlu SÇ, OkÇu Zİ. Serum levels of antioxidant vitamins and lipid peroxidation in multiple sclerosis. Nutr Neurosci 2002;5(3):215–20.
   PubMed Web of Science ®Google Scholar
• Jimenez-Jimenez FJ, Molina JA, de Bustos F, Garcia-Redondo A, Gomez-Escalonilla C, Martinez-Salio A, et al. Serum levels of coenzyme Q10 in patients with Parkinson's disease. J Neural Transm 2000;107(2):177–81.
   PubMed Web of Science ®Google Scholar
• Sanoobar M, Eghtesadi S, Azimi A, Khalili M, Jazayeri S, Gohari MR. Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with relapsing-remitting multiple sclerosis. Int J Neurosci 2013;123(11):776–82.
   PubMed Web of Science ®Google Scholar
• Khalili M, Eghtesadi S, Mirshafiey A, Eskandari G, Sanoobar M, Sahraian MA, et al. Effect of lipoic acid consumption on oxidative stress among multiple sclerosis patients: a randomized controlled clinical trial. Nutr Neurosci 2013;0:23485514.
   Google Scholar
• Khalili M, Izadi V, Eghtesadi S, Mirshafiey A, Sahraian MA, Motevalian A, et al. Is the lipoic acid consumption affect on the cytokine profile in the multiple sclerosis patients: a double blind, placebo, controlled randomized clinical trial. Neuroimmunomodulation 2013; DOI: 356145.
   Web of Science ®Google Scholar
• McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 2001;50(1):121–7.
   PubMed Web of Science ®Google Scholar
• Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis results of an international survey. Neurology 1996;46(4):907–11.
   PubMed Web of Science ®Google Scholar
• Singh RB, Shinde SN, Chopra RK, Niaz MA, Thakur AS, Onouchi Z. Effect of coenzyme Q10 on experimental atherosclerosis and chemical composition and quality of atheroma in rabbits. Atherosclerosis 2000;148(2):275.
   PubMed Web of Science ®Google Scholar
• Dhib-Jalbut S, Arnold DL, Cleveland DW, Fisher M, Friedlander RM, Mouradian MM, et al. Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases. J Neuroimmunol. 2006;176(1):198–215.
   PubMed Web of Science ®Google Scholar
• Muzio L, Martino G, Furlan R. Multifaceted aspects of inflammation in multiple sclerosis: the role of microglia. J Neuroimmunol 2007;191(1):39–44.
   PubMed Web of Science ®Google Scholar
• Silber E, Sharief MK. Axonal degeneration in the pathogenesis of multiple sclerosis. J Neurol Sci 1999;170(1):11–18.
   PubMed Web of Science ®Google Scholar
• Bessler H, Bergman M, Blumberger N, Djaldetti M, Salman H. Coenzyme Q10 secreases TNF-ALPHA. and IL-2 secretion by human peripheral blood mononuclear cells. J Nutr Sci Vitaminol 2010;56(1):77–81.
   PubMed Web of Science ®Google Scholar
• Carmona MC, Lefebvre P, Lefebvre B, Galinier A, Bénani A, Jeanson Y, et al. Coadministration of coenzyme Q prevents rosiglitazone-induced adipogenesis in ob/ob mice. Int J Obes 2009;33(2):204–11.
   Web of Science ®Google Scholar
• Fouad AA, Al-Sultan AI, Refaie SM, Yacoubi MT. Coenzyme Q10 treatment ameliorates acute cisplatin nephrotoxicity in mice. Toxicology 2010;274(1):49–56.
   PubMed Web of Science ®Google Scholar
• Martino G, Furlan R, Brambilla E, Bergami A, Ruffini F, Gironi M, et al. Cytokines and immunity in multiple sclerosis: the dual signal hypothesis. J Neuroimmunol 2000;109(1):3–9.
   PubMed Web of Science ®Google Scholar
• Sohet FM, Neyrinck AM, Pachikian BD, de Backer FC, Bindels LB, Niklowitz P, et al. Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation associated with diet-induced obesity in mice. Biochem Pharmacol 2009;78(11):1391–400.
   PubMed Web of Science ®Google Scholar
• Inui M, Ooe M, Fujii K, Matsunaka H, Yoshida M, Ichihashi M. Mechanisms of inhibitory effects of CoQ10 on UVB-induced wrinkle formation in vitro and in vivo. Biofactors 2008;32(1–4):237–43.
   PubMed Web of Science ®Google Scholar
• Premkumar VG, Yuvaraj S, Sathish S, Shanthi P, Sachdanandam P. Anti-angiogenic potential of Coenzyme Q10, riboflavin and niacin in breast cancer patients undergoing tamoxifen therapy. Vasc Pharmacol 2008;48(4):191–201.
   PubMed Web of Science ®Google Scholar
• Gokbel H, Gergerlioglu HS, Okudan N, Gul I, Buyukbas S, Belviranli M. Effects of coenzyme Q10 supplementation on plasma adiponectin, interleukin-6, and tumor necrosis factor-alpha levels in men. J Med Food 2010;13(1):216–18.
   PubMed Web of Science ®Google Scholar
• Imitola J, Chitnis T, Khoury SJ. Cytokines in multiple sclerosis: from bench to bedside. Pharmacol Therapeutics 2005;106(2):163–77.
   PubMed Web of Science ®Google Scholar
• Meoli EM, Oh U, Grant CW, Jacobson S. TGF-beta signaling is altered in the peripheral blood of subjects with multiple sclerosis. J Neuroimmunol 2011;230(1–2):164–8.
   PubMed Web of Science ®Google Scholar
• Losy J, Michałowska-Wender G. In vivo effect of interferon-β 1a on interleukin-12 and TGF-β1 cytokines in patients with relapsing–remitting multiple sclerosis. Acta Neurol Scand 2002;106(1):44–6.
   PubMed Web of Science ®Google Scholar
• Kandhare AD, Ghosh P, Ghule AE, Bodhankar SL. Elucidation of molecular mechanism involved in neuroprotective effect of Coenzyme Q10 in alcohol-induced neuropathic pain. Fundam Clin Pharmacol 2013;27(6):603–22.
   PubMed Web of Science ®Google Scholar
• Hohnoki K, Inoue A, Koh CS. Elevated serum levels of IFN-gamma, IL-4 and TNF-alpha/unelevated serum levels of IL-10 in patients with demyelinating diseases during the acute stage. J Neuroimmunol 1998;87(1–2):27–32.
   PubMed Web of Science ®Google Scholar
• Yubero-Serrano EM, Gonzalez-Guardia L, Rangel-Zuniga O, Delgado-Lista J, Gutierrez-Mariscal FM, Perez-Martinez P, et al. Mediterranean diet supplemented with coenzyme Q10 modifies the expression of proinflammatory and endoplasmic reticulum stress-related genes in elderly men and women. J Gerontol A Biol Sci Med Sci 2012;67(1):3–10.
   PubMed Web of Science ®Google Scholar
• Leppert D, Lindberg RL, Kappos L, Leib SL. Matrix metalloproteinases: multifunctional effectors of inflammation in multiple sclerosis and bacterial meningitis. Brain Res Brain Res Rev 2001;36(2–3):249–57.
   PubMedGoogle Scholar