Meningioma 1 (MN1) expression: Refined risk stratification in acute myeloid leukemia with normal cytogenetics (CN-AML)

References

• Byrd JC, Mrózek K, Dodge RK, Carroll AJ, Edwards CG, Arthur DC, et al. Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461). Blood 2002;100:4325–36.
   PubMed Web of Science ®Google Scholar
• Mrozek K, Heerema NA, Bloomfield CD. Cytogenetics in acute leukemia. Blood Rev. 2004;18:115–36.
   PubMed Web of Science ®Google Scholar
• Mrózek K, Marcucci G, Paschka P, Whitman SP, Bloomfield CD. Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification? Blood 2007;109:431–48.
   PubMed Web of Science ®Google Scholar
• Baldus CD, Mrozek K, Marcucci G, Bloomfield CD. Clinical outcome of de novo acute myeloid leukaemia patients with normal cytogenetics is affected by molecular genetic alterations: a concise review. Br J Haematol. 2007;137:387–400.
   PubMed Web of Science ®Google Scholar
• Van Wely KHM, Molijn AC, Buijs A, Meester-Smoor MA, Aarnoudse AJ, Hellemons A, et al. The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription. Oncogene 2003;22:699–709.
   PubMed Web of Science ®Google Scholar
• Sutton ALM, Zhang X, Ellison TI, Macdonald PN. The 1,25(OH)2D3-regulated transcription factor MN1 stimulates vitamin D receptor-mediated transcription and inhibits osteoblastic cell proliferation. Mol Endocrinol. 2005;19:2234–44.
   PubMed Web of Science ®Google Scholar
• Deprez RHL, Riegman PHJ, Groen NA, Warringa UL, van Biezen NA, Molijn AC, et al. Cloning and characterization of MN1, a gene from chromosome 22q11, which is disrupted by a balanced translocation in a meningioma. Oncogene 1995;10:1521–8.
   PubMed Web of Science ®Google Scholar
• Buijs A, Sherr S, van Baal S, van Bezouw S, van der Plas D, Geurts van Kessel A, et al. Translocation (12;22)(p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q1. Oncogene 1995;10:1511–9.
   PubMed Web of Science ®Google Scholar
• Du Y, Jenkins NA, Copeland NG. Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells. Blood 2005;106:3932–9.
   PubMed Web of Science ®Google Scholar
• Barjesteh van Waalwijk van Doorn-Khosrovani S, Erpelinck C, van Putten WL, Valk PJ, van der Poel-van de Luytgaarde S, Hack R, et al. High EVI1 expression predicts poor survival in acute myeloid leukemia: a study of 319 de novo AML patients 3. Blood 2003;101:837–45.
   PubMed Web of Science ®Google Scholar
• Carella C, Bonten J, Sirma S, Kranenburg TA, Terranova S, Klein-Geltink R, et al. MN1 overexpression is an important step in the development of inv(16) AML. Leukemia 2007;21:1679–90.
   PubMed Web of Science ®Google Scholar
• Heuser M, Argiropoulos B, Kuchenbauer F, Yung E, Piper J, Fung S, et al. MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in AML patients. Blood 2007;110:1639–47.
   PubMed Web of Science ®Google Scholar
• O'Kelly J, Hisatake J, Hisatake Y, Bishop J, Norman A, Koeffler HP. Normal myelopoiesis but abnormal T lymphocyte responses in vitamin D receptor knockout mice. J Clin Invest. 2002;109:1091–9.
   PubMed Web of Science ®Google Scholar
• Meester-Smoor MA, Molijn AC, Zhao Y, Groen NA, Groffen CA, Boogaard M, et al. The MN1 oncoprotein activates transcription of the IGFBP5 promoter through a CACCC-rich consensus sequence. J Mol Endocrinol. 2007;38:113–25.
   PubMed Web of Science ®Google Scholar
• Heuser M, Yun H, Berg T, Yung E, Argiropoulos B, Kuchenbauer F, et al. Cell of origin in AML: susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complex. Cancer Cell 2011;20(1):39–52.
   PubMed Web of Science ®Google Scholar
• Sakhinia E, Farahangpour M, Tholouli E, Liu Yin JA, Hoyland JA, Byers RJ. Comparison of gene expression profiles in parallel bone marrow and peripheral blood samples in acute myeloid leukemia by real time polymerase chain reaction. J Clin Pathol. 2006;59(10):1059–65.
   PubMed Web of Science ®Google Scholar
• Greer J, Baer M, Kinnery M. Acute myelogenous leukemia. In: , Lee G, Foester J, Leukens J, Pareskerva F, Greer J, Rogers G (eds.) Wintrobe's clinical hematology. 12th ed. Philadelphia: Lippincott Williams and Wilkins; 2009. p. 2045–62.
   Google Scholar
• Michael W. Pfaffl. Quantification strategies in real-time PCR. A–Z of quantitative PCR 2004;3:87–112.
   Google Scholar
• Liu T, Jankovic D, Brault L, Ehret S, Baty F, Stavropoulou V, et al. Functional characterization of high levels of meningioma 1 as collaborating oncogene in acute leukemia. Leukemia 2010;24:601–12.
   PubMed Web of Science ®Google Scholar
• Valk PJ, Verhaak RG, Beijen MA, Erpelinck CA, Barjesteh van Waalwijk van Doorn-Khosrovani S, Boer JM, et al. Prognostically useful gene-expression profiles in acute myeloid leukemia. N Engl J Med. 2004;350:1617–28.
   PubMed Web of Science ®Google Scholar
• Kawagoe H, Grosveld GC. Conditional MN1-TEL knock-in mice develop acute myeloid leukemia in conjunction with over expression of HOXA9 13. Blood 2005;106:4269–77.
   PubMed Web of Science ®Google Scholar
• Sun HM, Qian SX, Li JY. Advance of study on MN1 gene in acute myeloid leukemia. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009;17:504–8.
   PubMedGoogle Scholar
• Rosenbauer F, Tenen DG. Transcription factors in myeloid development: balancing differentiation with transformation. Nat Rev Immunol. 2007;7:105–17.
   PubMed Web of Science ®Google Scholar
• Verhaak RG, Goudswaard CS, van Putten W, Bijl MA, Sanders MA, Hugens W, et al. Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance. Blood 2005;106:3747–54.
   PubMed Web of Science ®Google Scholar
• Heuser M, Beutel G, Krauter J, Döhner K, von Neuhoff N, Schlegelberger B, et al. High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogenetics. Blood 2006;108:3898–905.
   PubMed Web of Science ®Google Scholar
• Grosveld GC. MN1, a novel player in human AML. Blood Cells Mol Dis. 2007;39:336–9.
   PubMed Web of Science ®Google Scholar
• Schwind S, Marcucci G, Kohlschmidt J, Radmacher MD, Mrózek K, Maharry K, et al. Low expression of MN1 associates with better treatment response in older patients with de novo cytogenetically normal acute myeloid leukemia. Blood 2011;118:4188–98.
   PubMed Web of Science ®Google Scholar
• Langer C, Marcucci G, Holland KB, Radmacher MD, Maharry K, Paschka P, et al. Prognostic importance of MN1 transcript levels, and biologic insights from MN1-associated gene and microRNA expression signatures in cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study. J Clin Oncol. 2009;27:3198–204.
   PubMed Web of Science ®Google Scholar
• Junghanss C, Waak M, Knopp A, Kleine HD, Kundt G, Leithäuser M, et al. Multivariate analyses of prognostic factors in acute myeloid leukemia: relevance of cytogenetic abnormalities and CD34 expression. Neoplasma 2005;52:402–10.
   PubMed Web of Science ®Google Scholar
• Damm F, Heuser M, Morgan M, Wagner K, Görlich K, Grosshennig A, et al. Integrative prognostic risk score in acute myeloid leukemia with normal karyotype. Blood 2011;117:4561–8.
   PubMed Web of Science ®Google Scholar
• Baldus CD, Thiede C, Soucek S, Bloomfield CD, Thiel E, Ehninger G. BAALC expression and FLT3 internal tandem duplication mutations in acute myeloid leukemia patients with normal cytogenetics: prognostic implications. J Clin Oncol. 2006;24(5):790–7.
   Google Scholar
• Bienz M, Ludwig M, Leibundgut EO, Mueller BU, Ratschiller D, Solenthaler M, et al. Risk assessment in patients with acute myeloid leukemia and a normal karyotype. Clin Cancer Res. 2005;11(4):1416–24.
   Google Scholar