855
Views
8
CrossRef citations to date
0
Altmetric
HEMOSTASIS AND THROMBOSIS

Acquired factor V inhibitor associated with life-threatening bleeding and a mixing test result that indicated coagulation factor deficiency

, , , , , , , , , , , , , , , , , , & show all
Pages 300-304 | Published online: 15 Nov 2013

References

  • Knobl P, Lechner K. Acquired factor V inhibitors. Baillieres Clin Haematol. 1998;11:305–18.
  • Zehnder JL, Leung LL. Development of antibodies to thrombin and factor V with recurrent bleeding in a patient exposed to topical bovine thrombin. Blood 1990;76:2011–6.
  • Streiff MB, Ness PM. Acquired FV inhibitors: a needless iatrogenic complication of bovine thrombin exposure. Transfusion 2002;42:18–26.
  • Stenbjerg S, Husted S, Mygind K. A circulating factor V inhibitor: possible side effect of treatment with streptomycin. Scand J Haematol. 1975;14:280–5.
  • Endo H, Kawauchi K, Tomimatsu M, Iga D, Ogasawara T, Yasuyama M, et al. Acquired factor V inhibitor responsive to corticosteroids in a patient with double cancers. Intern Med. 2007;46:621–5.
  • Koyama T, Saito T, Kusano T, Hirosawa S. Factor V inhibitor associated with Sjogren's syndrome. Br J Haematol. 1995;89:893–6.
  • Franchini M, Lippi G. Acquired factor V inhibitors: a systematic review. J Thromb Thrombolysis 2011;31:449–57.
  • Ang AL, Kuperan P, Ng CH, Ng HJ. Acquired factor V inhibitor. A problem-based systematic review. Thromb Haemost. 2009;101:852–9.
  • Kamal AH, Tefferi A, Pruthi RK. How to interpret and pursue an abnormal prothrombin time, activated partial thromboplastin time, and bleeding time in adults. Mayo Clin Proc. 2007;82:864–73.
  • Ortel TL, Quinn-Allen MA, Charles LA, Devore-Carter D, Kane WH. Characterization of an acquired inhibitor to coagulation factor V. Antibody binding to the second C-type domain of factor V inhibits the binding of factor V to phosphatidylserine and neutralizes procoagulant activity. J Clin Invest. 1992;90:2340–7.
  • Coots MC, Muhleman AF, Glueck HI. Hemorrhagic death associated with a high titer factor V inhibitor. Am J Hematol. 1978;4:193–206.
  • Gartrell B. Acquired factor V inhibitor complicating warfarin therapy. Am J Hematol. 2011;86:710–2.
  • Lipshitz J, Chelliah T, Aledort L. A case of factor V inhibitor with complete correction of the PT and aPTT upon mixing. Am J Hematol. 2012;87:313–5.
  • Fu YX, Kaufman R, Rudolph AE, Collum SE, Blinder MA. Multimodality therapy of an acquired factor V inhibitor. Am J Hematol. 1996;51:315–8.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.