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Thalassemia

Role of non-invasive assessment in prediction of preclinical cardiac affection in multi-transfused thalassaemia major patients

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References

  • Rund D, Rachmilewitz E. Beta-thalassemia. N Engl J Med. 2005;353:1135–46.
  • McLaren GD. Iron overload disorders: natural history, pathogenesis, diagnosis, and therapy. Crit Rev Clin Lab Sci. 1983;19:205–66.
  • Nemeth E. Hepcidin in β-thalassemia. Ann N Y Acad Sci. 2010;1202:31–5.
  • Aggeli C, Felekos I, Poulidakis E, Aggelis A, Tousoulis D, Stefanadis C. Quantitative analysis of left atrial function in asymptomatic patients with b-thalassemia major using real-time three-dimensional echocardiography. Cardiovas Ultrasound. 2011;9:38.
  • Engle MA, Erlandson M, Smith CH. Late cardiac complications of chronic, sever, refractory anemia. Circulation 1964;30:698–705.
  • Modell B, Khan M, Darlison M. Survival in beta-thalassaemia major in the UK: data from the UK Thalassaemia Register. Lancet. 2000;355:2051–2.
  • Borgna-Pignatti C, Cappellini MD, De Stefano P, Del Vecchio GC, Forni GL, Gamberini MR, et al. Survival and complications in thalassemia. Ann N Y Acad Sci. 2005;1054:40–7.
  • Hahalis G, Manolis AS, Apostolopoulos D, Alexopoulos D, Vagenakis AG, Zoumbos NC. Right ventricular cardiomyopathy in beta-thalassaemia major. Eur Heart J. 2002;23:147–56.
  • Fragasso A, Ciancio A, Mannarella C, Gaudiano C, Scarciolla O, Ottonello C, et al. Myocardial iron overload assessed by magnetic resonance imaging (MRI) T2* in multi-transfused patients with thalassemia and acquired anemias. Eur J Int Med. 2011;1:62–5.
  • Alpendurada F, Carpenter JP, Deac M, Kirk P, Walker JM, Porter JB, et al. Relation of myocardial T2* to right ventricular function in thalassaemia major. Eur Heart J. 2010;31(13):1648–54.
  • Wood JC. Impact of Iron Assessment by MRI. ASH Education book 2011:443–50.
  • Anderson LJ, Holden S, Davis B, Prescott E, Charrier CC, Bunce NH, et al. Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J. 2001;23:2171–79.
  • Fitchett DH, Coltart DJ, Littler WA, Leyland MJ, Trueman T, Gozzard DI, et al. Cardiac involvement in secondary hemochromatosis: a catheter biopsy study and analysis of myocardium. Cardiovasc Res. 1980;14:719–24.
  • Olson LJ, Edwards WD, Holmes DR, Jr, Miller FA, Jr, Nordstrom LA, Baldus WP. Endomyocardial biopsy in hemochromatosis: clinicopathologic correlates in six cases. J Am Coll Cardiol. 1989;13:116–20.
  • Kirk P, He T, Anderson LJ, Roughton M, Tanner MA, Lam WW, et al. International reproducibility of single breath hold T2* MR for cardiac and liver iron assessment among five thalassemia centers. J Magn Reson Imaging. 2010;32:315–19.
  • Borgna-Pignatti C, Rugolotto S, De Stefano P, Zhao H, Cappellini MD, Del Vecchio GC, et al. Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine. Haematologica. 2004;89(10):1187–93.
  • Angelucci E, Barosi G, Camaschella C, Cappellini MD, Cazzola M, Galanello R, Marchetti M, Piga A, Tura S. Italian Society of Hematology practice guidelines for the management of iron overload in thalassemia major and related disorders. Haematologica. 2008;93(5):741–52.
  • Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO, 3rd, Criqui M, et al. Markers of inflammation and cardiovascular disease application to clinical and public health practice: a statement for healthcare professionals from the centers for disease control and prevention and the american heart association. Circulation 2003;107(3):499–511.
  • Cheitlin MD, Armstrong WF, Aurigemma GP, Beller GA, Bierman FZ, Davis JL, et al. Guideline update for the clinical application of echocardiography: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASE Committee to Update the 1997 Guidelines for the Clinical Application of Echocardiography). J Am Coll Cardiol. 2003;42(5):954–70.
  • Hazırolan T, Eldem G, Ünal S, Akpınar B, Gümrük F, Alibek S, et al. Dual-echo TFE MRI for the assessment of myocardial iron overload in beta-thalassemia major patients. Diagn Interv Radiol. 2010;16(1):59–62.
  • Sackett DL, Haynes RB, Guyatt GH, Tugwell P editors. Clinical epidemiology: a basic science for clinical medicine. New York: Little Brown and Co; 1991. p. 51–68.
  • Gardner M, Altman DG. Statistics with confidence: confidence intervals and statistical guidelines. London: BMJ Books; 2000. ISBN 0-7279-1375-1.
  • Pennell DJ. T2* magnetic resonance and myocardial iron in thalassemia. Ann N Y Acad Sci. 2005;1054:373–78.
  • Wood JC, Tyszka JM, Carson S, Nelson MD, Coates TD. Myocardial iron loading in transfusion- dependent thalassemia and sickle cell disease. Blood 2004;103(5):1934–36.
  • Libby P, Bonow RO, Mann DL, Zipes DP editors. Braunwald's heart disease: a textbook of cardiovascular medicine. 8th ed. Philadelphia, PA, USA: Saunders; 2007.
  • Wood JC, Origa R, Agus A, Matta G, Coates TD, Galanella R. Onset of cardiac iron loading in pediatric patients with thalassemia patients. Haematologica. 2008;93:917–20.
  • Nemeth E, Ganz T. Hepcidin and iron loading anemias. Haematologica. 2006;91:727–32.
  • Paricha SR, Frazer DM, Bowden DK, Anderson GJ. Transfusion suppresses erythropoiesis and increases hepcidin in adult patients with beta-thalassemia major: a longitudinal study. Blood. 2013;122(1):124–33.
  • Detterich J, Noetzli L, Dorey F, Bar-Cohen Y, Harmatz P, Coates T, et al. Electrocardiographic consequences of cardiac iron overload in thalassemia major. Am J Hematol. 2012;87:139–44.
  • Beard ME, Necheles TF, Allen DM. Clinical experience with intensive transfusion therapy in Cooley's anemia. Ann N Y Acad Sci. 1969;165:415–22.
  • Kuryshev YA, Brittenham GM, Fujioka H, Kannan P, Shieh CC, Cohen SA, et al. Decreased sodium and increased transient outward potassium currents in iron loaded cardiac myocytes. Implications for the arrhythmogenesis of human siderotic heart disease. Circulation. 1999;100(6):675–83.
  • Kirk P, Roughton M, Porter JB, Walker JM, Tanner MA, Patel J, et al. Cardiac T2* magnetic resonance for prediction of cardiac complications in thalassemia major. Circulation. 2009;120:1961–8.
  • Obejero-Paz CA, Yang T, Dong WQ, Levy MN, Brittenham GM, Kuryshev YA, et al. Deferoxamine promotes survival and prevents electrocardiographic abnormalities in the gerbil model of iron-overload cardiomyopathy. J Lab Clin Med. 2003;141:121–30.
  • Rutjanaprom W, Kanlop N, Charoenkwan P, Sittiwangkul R, Srichairatanakool S, Tantiworawit A, et al. Heart rate variability in beta-thalassemia patients. Eur J Haematol. 2009;83(5):483–9.
  • Kardelen F, Tezcan G, Akcurin G, Ertug H, Yesilipek A. Heart rate variability in patients with thalassemia major. Pediatr Cardiol. 2008;29(5):935–9.
  • Claster S, Wood JC, Noetzli L, Carson SM, Hofstra TC, Khanna R, et al. Nutritional deficiencies in iron overloaded patients with hemoglobinopathies. Am J Hematol. 2009;84(6):344–8.

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