NADPH oxidase in stroke and cerebrovascular disease

References

• Jahan R. Hyperacute therapy of ischemic stroke: intravenous thrombolysis. Tech Vasc Interv Radiol. 2005;8:81–6.
   PubMedGoogle Scholar
• Jahan R. Hyperacute therapy of acute ischemic stroke: intraarterial thrombolysis and mechanical revascularization strategies. Tech Vasc Interv Radiol. 2005;8:87–91.
   PubMedGoogle Scholar
• Kuroda S, Siesjo BK. Reperfusion damage following focal ischemia: pathophysiology and therapeutic windows. Clin Neurosci. 1997;4:199–212.
   PubMedGoogle Scholar
• Aronowski J, Strong R, Grotta JC. Reperfusion injury: demonstration of brain damage produced by reperfusion after transient focal ischemia in rats. J Cereb Blood Flow Metab. 1997;17:1048–56.
   PubMed Web of Science ®Google Scholar
• Chan PH. Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab. 2001;21:2–14.
   PubMed Web of Science ®Google Scholar
• Wang Q, Tang XN, Yenari MA. The inflammatory response in stroke. J Neuroimmunol. 2007;184:53–68.
   PubMed Web of Science ®Google Scholar
• Munzel T, Hink U, Heitzer T, Meinertz T. Role for nadph/nadh oxidase in the modulation of vascular tone. Ann NY Acad Sci. 1999;874:386–400.
   PubMed Web of Science ®Google Scholar
• Lambeth JD. NOX enzymes and the biology of reactive oxygen. Nat Rev Immunol. 2004;4:181–9.
   PubMed Web of Science ®Google Scholar
• Bokoch GM, Knaus UG. Nadph oxidases: not just for leukocytes anymore!Trends Biochem Sci. 2003;28:502–8.
   PubMed Web of Science ®Google Scholar
• Groemping Y, Rittinger K. Activation and assembly of the NADPH oxidase: a structural perspective. Biochem J. 2005;386:401–16.
   PubMed Web of Science ®Google Scholar
• Bedard K, Krause KH. The NOX family of ROS-generating nadph oxidases: physiology and pathophysiology. Physiol Rev. 2007;87:245–313.
   PubMed Web of Science ®Google Scholar
• Anrather J, Racchumi G, Iadecola C. NF-kappaB regulates phagocytic NADPH oxidase by inducing the expression of gp91phox. J Biol Chem. 2006;281:5657–67.
   PubMed Web of Science ®Google Scholar
• Lassegue B, Clempus RE. Vascular NAD(P)H oxidases: specific features, expression, and regulation. Am J Physiol Regul Integr Comp Physiol. 2003;285:R277–97.
   PubMed Web of Science ®Google Scholar
• Suh YA, Arnold RS, Lassegue B, Shi J, Xu X, Sorescu D, et al.. Cell transformation by the superoxide-generating oxidase Mox1. Nature. 1999;401:79–82.
   PubMed Web of Science ®Google Scholar
• Lambeth JD, Cheng G, Arnold RS, Edens WA. Novel homologs of gp91phox. Trends Biochem Sci. 2000;25:459–61.
   PubMed Web of Science ®Google Scholar
• Cheng G, Cao Z, Xu X, van Meir EG, Lambeth JD. Homologs of gp91phox: cloning and tissue expression of NOX3, NOX4, and NOX5. Gene. 2001;269:131–40.
   PubMed Web of Science ®Google Scholar
• Quinn MT, Gauss KA. Structure and regulation of the neutrophil respiratory burst oxidase: omparison with nonphagocyte oxidases. J Leukoc Biol. 2004;76:760–81.
   PubMed Web of Science ®Google Scholar
• Sorce S, Krause KH. Nox enzymes in the central nervous system: from signaling to disease. Antioxid Redox Signal. 2009;11:2481–504.
   PubMed Web of Science ®Google Scholar
• Infanger DW, Sharma RV, Davisson RL. NADPH oxidases of the brain: distribution, regulation, and function. Antioxid Redox Signal. 2006;8:1583–96.
   PubMed Web of Science ®Google Scholar
• Green SP, Cairns B, Rae J, Errett-Baroncini C, Hongo JA, Erickson RW, et al.. Induction of gp91-phox, a component of the phagocyte NADPH oxidase, in microglial cells during central nervous system inflammation. J Cereb Blood Flow Metab. 2001;21:374–84.
   PubMed Web of Science ®Google Scholar
• Tammariello SP, Quinn MT, Estus S. NADPH oxidase contributes directly to oxidative stress and apoptosis in nerve growth factor-deprived sympathetic neurons. J Neurosci. 2000;20:RC53.
   PubMed Web of Science ®Google Scholar
• Serrano F, Kolluri NS, Wientjes FB, Card JP, Klann E. NADPH oxidase immunoreactivity in the mouse brain. Brain Res. 2003;988:193–8.
   PubMed Web of Science ®Google Scholar
• Vallet P, Charnay Y, Steger K, Ogier-Denis E, Kovari E, Herrmann F, et al.. Neuronal expression of the NADPH oxidase NOX4, and its regulation in mouse experimental brain ischemia. Neuroscience. 2005;132:233–8.
   PubMed Web of Science ®Google Scholar
• Lambeth JD. Nox enzymes, ros, and chronic disease: an example of antagonistic pleiotropy. Free Radic Biol Med. 2007;43:332–47.
   PubMed Web of Science ®Google Scholar
• Kim MJ, Shin KS, Chung YB, Jung KW, Cha CI, Shin DH. Immunohistochemical study of p47phox and gp91phox distributions in rat brain. Brain Res. 2005;1040:178–86.
   PubMed Web of Science ®Google Scholar
• Paravicini TM, Chrissobolis S, Drummond GR, Sobey CG. Increased NADPH-oxidase activity and NOX4 expression during chronic hypertension is associated with enhanced cerebral vasodilatation to NADPH in vivo. Stroke. 2004;35:584–9.
   PubMed Web of Science ®Google Scholar
• Miller AA, Drummond GR, Schmidt HH, Sobey CG. Nadph oxidase activity and function are profoundly greater in cerebral versus systemic arteries. Circ Res. 2005;97:1055–62.
   PubMed Web of Science ®Google Scholar
• Tejada-Simon MV, Serrano F, Villasana LE, Kanterewicz BI, Wu GY, Quinn MT, et al.. Synaptic localization of a functional NADPH oxidase in the mouse hippocampus. Mol Cell Neurosci. 2005;29:97–106.
   PubMed Web of Science ®Google Scholar
• Zheng Z, Yenari MA. Post-ischemic inflammation: molecular mechanisms and therapeutic implications. Neurol Res. 2004;26:884–92.
   PubMed Web of Science ®Google Scholar
• Chamorro A, Hallenbeck J. The harms and benefits of inflammatory and immune responses in vascular disease. Stroke. 2006;37:291–3.
   PubMed Web of Science ®Google Scholar
• Kahles T, Luedike P, Endres M, Galla HJ, Steinmetz H, Busse R, et al.. NADPH oxidase plays a central role in blood–brain barrier damage in experimental stroke. Stroke. 2007;38:3000–6.
   PubMed Web of Science ®Google Scholar
• Walder CE, Green SP, Darbonne WC, Mathias J, Rae J, Dinauer MC, et al.. Ischemic stroke injury is reduced in mice lacking a functional NADPH oxidase. Stroke. 1997;28:2252–8.
   PubMed Web of Science ®Google Scholar
• Chen H, Song YS, Chan PH. Inhibition of NADPH oxidase is neuroprotective after ischemia–reperfusion. J Cereb Blood Flow Metab. 2009;29:1262–72.
   PubMed Web of Science ®Google Scholar
• Suh SW, Shin BS, Ma H, van Hoecke M, Brennan AM, Yenari MA, et al.. Glucose and NADPH oxidase drive neuronal superoxide formation in stroke. Ann Neurol. 2008;64:654–63.
   PubMed Web of Science ®Google Scholar
• Brennan AM, Suh SW, Won SJ, Narasimhan P, Kauppinen TM, Lee H, et al.. NADPH oxidase is the primary source of superoxide induced by nmda receptor activation. Nat Neurosci. 2009;12:857–63.
   PubMed Web of Science ®Google Scholar
• Won SJ, Tang XN, Suh SW, Yenari MA, Swanson RA. Hyperglycemia promotes tissue plasminogen activator-induced hemorrhage by increasing superoxide production. Ann Neurol. 2011;70:583–90.
   PubMed Web of Science ®Google Scholar
• Shen J, Bai XY, Qin Y, Jin WW, Zhou JY, Zhou JP, et al.. Interrupted reperfusion reduces the activation of NADPH oxidase after cerebral I/R injury. Free Radic Biol Med. 2011;50:1780–6.
   PubMed Web of Science ®Google Scholar
• Chen H, Kim GS, Okami N, Narasimhan P, Chan PH. NADPH oxidase is involved in post-ischemic brain inflammation. Neurobiol Dis. 2011;42:341–8.
   PubMed Web of Science ®Google Scholar
• Woodfin A, Hu DE, Sarker M, Kurokawa T, Fraser P. Acute nadph oxidase activation potentiates cerebrovascular permeability response to bradykinin in ischemia–reperfusion. Free Radic Biol Med. 2011;50:518–24.
   PubMed Web of Science ®Google Scholar
• Genovese T, Mazzon E, Paterniti I, Esposito E, Bramanti P, Cuzzocrea S. Modulation of nadph oxidase activation in cerebral ischemia/reperfusion injury in rats. Brain Res. 2011;1372:92–102.
   PubMed Web of Science ®Google Scholar
• Tang XN, Zheng Z, Giffard RG, Yenari MA. Significance of marrow-derived nicotinamide adenine dinucleotide phosphate oxidase in experimental ischemic stroke. Ann Neurol. 2011;70:606–15.
   PubMed Web of Science ®Google Scholar
• Kleinschnitz C, Grund H, Wingler K, Armitage ME, Jones E, Mittal M, et al.. Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration. PLoS Biol. 2010;8:e1000479.
   PubMed Web of Science ®Google Scholar
• Stolk J, Hiltermann TJ, Dijkman JH, Verhoeven AJ. Characteristics of the inhibition of nadph oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol. Am J Respir Cell Mol Biol. 1994;11:95–102.
   PubMed Web of Science ®Google Scholar
• Simons JM, Hart BA, Ip Vai Ching TR, van Dijk H, Labadie RP. Metabolic activation of natural phenols into selective oxidative burst agonists by activated human neutrophils. Free Radic Biol Med. 1990;8:251–8.
   PubMed Web of Science ®Google Scholar
• Touyz RM. Apocynin, nadph oxidase, and vascular cells: a complex matter. Hypertension. 2008;51:172–4.
   PubMed Web of Science ®Google Scholar
• Stolk J, Rossie W, Dijkman JH. Apocynin improves the efficacy of secretory leukocyte protease inhibitor in experimental emphysema. Am J Respir Crit Care Med. 1994;150:1628–31.
   PubMed Web of Science ®Google Scholar
• Worm van denE, Beukelman CJ, Berg van denAJ, Kroes BH, Labadie RP, et al.. Effects of methoxylation of apocynin and analogs on the inhibition of reactive oxygen species production by stimulated human neutrophils. Eur J Pharmacol. 2001;433:225–30.
   PubMed Web of Science ®Google Scholar
• Heumuller S, Wind S, Barbosa-Sicard E, Schmidt HH, Busse R, Schroder K, et al.. Apocynin is not an inhibitor of vascular nadph oxidases but an antioxidant. Hypertension. 2008;51:211–7.
   PubMed Web of Science ®Google Scholar
• Vejrazka M, Micek R, Stipek S. Apocynin inhibits nadph oxidase in phagocytes but stimulates ros production in non-phagocytic cells. Biochim Biophys Acta. 2005;1722:143–7.
   PubMed Web of Science ®Google Scholar
• Ximenes VF, Fernandes JR, Bueno VB, Catalani LH, de Oliveira GH, Machado RG. The effect of ph on horseradish peroxidase-catalyzed oxidation of melatonin: production of N1-acetyl-N2-5-methoxykynuramine versus radical-mediated degradation. J Pineal Res. 2007;42:291–6.
   PubMed Web of Science ®Google Scholar
• Tang XN, Cairns B, Cairns N, Yenari MA. Apocynin improves outcome in experimental stroke with a narrow dose range. Neuroscience. 2008;154:556–62.
   PubMed Web of Science ®Google Scholar
• Tang LL, Ye K, Yang XF, Zheng JS. Apocynin attenuates cerebral infarction after transient focal ischaemia in rats. J Int Med Res. 2007;35:517–22.
   PubMed Web of Science ®Google Scholar
• Wang Q, Tompkins KD, Simonyi A, Korthuis RJ, Sun AY, Sun GY. Apocynin protects against global cerebral ischemia–reperfusion-induced oxidative stress and injury in the gerbil hippocampus. Brain Res. 2006;1090:182–9.
   PubMed Web of Science ®Google Scholar
• Pandey A, Kour K, Bani S, Suri KA, Satti NK, Sharma P, et al.. Amelioration of adjuvant induced arthritis by apocynin. Phytother Res. 2009;23:1462–8.
   PubMed Web of Science ®Google Scholar
• Ellis JA, Cross AR, Jones OT. Studies on the electron-transfer mechanism of the human neutrophil NADPH oxidase. Biochem J. 1989;262:575–9.
   PubMed Web of Science ®Google Scholar
• Nagel S, Genius J, Heiland S, Horstmann S, Gardner H, Wagner S. Diphenyleneiodonium and dimethylsulfoxide for treatment of reperfusion injury in cerebral ischemia of the rat. Brain Res. 2007;1132:210–7.
   PubMed Web of Science ®Google Scholar
• Diatchuk V, Lotan O, Koshkin V, Wikstroem P, Pick E. Inhibition of nadph oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds. J Biol Chem. 1997;272:13292–301.
   PubMed Web of Science ®Google Scholar
• Gillibert M, Dehry Z, Terrier M, El Benna J, Lederer F. Another biological effect of tosylphenylalanylchloromethane (TPCK): it prevents p47phox phosphorylation and translocation upon neutrophil stimulation. Biochem J. 2005;386:549–56.
   PubMed Web of Science ®Google Scholar
• Jaquet V, Scapozza L, Clark RA, Krause KH, Lambeth JD. Small-molecule nox inhibitors: ROS-generating nadph oxidases as therapeutic targets. Antioxid Redox Signal. 2009;11:2535–52.
   PubMed Web of Science ®Google Scholar
• Doussiere J, Poinas A, Blais C, Vignais PV. Phenylarsine oxide as an inhibitor of the activation of the neutrophil nadph oxidase — identification of the beta subunit of the flavocytochrome b component of the nadph oxidase as a target site for phenylarsine oxide by photoaffinity labeling and photoinactivation. Eur J Biochem. 1998;251:649–58.
   PubMedGoogle Scholar
• Kutsumi H, Kawai K, Johnston RB, Rokutan K. Evidence for participation of vicinal dithiols in the activation sequence of the respiratory burst of human neutrophils. Blood. 1995;85:2559–69.
   PubMed Web of Science ®Google Scholar
• Yoshida LS, Abe S, Tsunawaki S. Fungal gliotoxin targets the onset of superoxide-generating NADPH oxidase of human neutrophils. Biochem Biophys Res Commun. 2000;268:716–23.
   PubMed Web of Science ®Google Scholar
• Liou KT, Shen YC, Chen CF, Tsao CM, Tsai SK. Honokiol protects rat brain from focal cerebral ischemia–reperfusion injury by inhibiting neutrophil infiltration and reactive oxygen species production. Brain Res. 2003;992:159–66.
   PubMed Web of Science ®Google Scholar
• Chen CM, Liu SH, Lin-Shiau SY. Honokiol, a neuroprotectant against mouse cerebral ischaemia, mediated by preserving Na+, K+-atpase activity and mitochondrial functions. Basic Clin Pharmacol Toxicol. 2007;101:108–16.
   PubMed Web of Science ®Google Scholar
• Ding Y, Chen ZJ, Liu S, Che D, Vetter M, Chang CH. Inhibition of NOX-4 activity by plumbagin, a plant-derived bioactive naphthoquinone. J Pharm Pharmacol. 2005;57:111–6.
   PubMed Web of Science ®Google Scholar
• Barry-Lane PA, Patterson C, Merwe van derM, Hu Z, Holland SM, Yeh ET, et al.. P47phox is required for atherosclerotic lesion progression in ApoE−/− mice. J Clin Invest. 2001;108:1513–22.
   PubMed Web of Science ®Google Scholar
• Shiose A, Kuroda J, Tsuruya K, Hirai M, Hirakata H, Naito S, et al.. A novel superoxide-producing NAD(P)H oxidase in kidney. J Biol Chem. 2001;276:1417–23.
   PubMed Web of Science ®Google Scholar
• Hazra B, Sarkar R, Bhattacharyya S, Ghosh PK, Chel G, Dinda B. Synthesis of plumbagin derivatives and their inhibitory activities against ehrlich ascites carcinoma in vivo and leishmania donovani promastigotes in vitro. Phytother Res. 2002;16:133–7.
   PubMed Web of Science ®Google Scholar
• Parimala R, Sachdanandam P. Effect of plumbagin on some glucose metabolising enzymes studied in rats in experimental hepatoma. Mol Cell Biochem. 1993;125:59–63.
   PubMed Web of Science ®Google Scholar
• Szatrowski TP, Nathan CF. Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res. 1991;51:794–8.
   PubMed Web of Science ®Google Scholar
• Rey FE, Cifuentes ME, Kiarash A, Quinn MT, Pagano PJ. Novel competitive inhibitor of NAD(P)H oxidase assembly attenuates vascular O2− and systolic blood pressure in mice. Circ Res. 2001;89:408–14.
   PubMed Web of Science ®Google Scholar
• Cotgreave IA, Duddy SK, Kass GE, Thompson D, Moldeus P. Studies on the anti-inflammatory activity of ebselen. Ebselen interferes with granulocyte oxidative burst by dual inhibition of nadph oxidase and protein kinase c? Biochem Pharmacol. 1989;38:649–56.
   PubMed Web of Science ®Google Scholar
• Parnham M, Sies H. Ebselen: prospective therapy for cerebral ischaemia. Expert Opin Investig Drugs. 2000;9:607–19.
   PubMed Web of Science ®Google Scholar
• Yamaguchi T, Sano K, Takakura K, Saito I, Shinohara Y, Asano T, et al.. Ebselen in acute ischemic stroke: A placebo-controlled, double-blind clinical trial. Ebselen study group. Stroke. 1998;29:12–7.
   PubMed Web of Science ®Google Scholar
• ten Freyhaus H, Huntgeburth M, Wingler K, Schnitker J, Baumer AT, Vantler M, et al.. Novel NOX inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation. Cardiovasc Res. 2006;71:331–41.
   PubMed Web of Science ®Google Scholar
• Stielow C, Catar RA, Muller G, Wingler K, Scheurer P, Schmidt HH, et al.. Novel NOX inhibitor of OXLDL-induced reactive oxygen species formation in human endothelial cells. Biochem Biophys Res Commun. 2006;344:200–5.
   PubMed Web of Science ®Google Scholar
• Cayatte AJ, Rupin A, Oliver-Krasinski J, Maitland K, Sansilvestri-Morel P, Boussard MF, et al.. S17834, a new inhibitor of cell adhesion and atherosclerosis that targets NADPH oxidase. Arterioscler Thromb Vasc Biol. 2001;21:1577–84.
   PubMed Web of Science ®Google Scholar
• Miller AA, Drummond GR, Sobey CG. Novel isoforms of NADPH-oxidase in cerebral vascular control. Pharmacol Ther. 2006;111:928–48.
   PubMed Web of Science ®Google Scholar
• Warnholtz A, Nickenig G, Schulz E, Macharzina R, Brasen JH, Skatchkov M, et al.. Increased nadh-oxidase-mediated superoxide production in the early stages of atherosclerosis: evidence for involvement of the renin-angiotensin system. Circulation. 1999;99:2027–33.
   PubMed Web of Science ®Google Scholar
• Wagner AH, Kohler T, Ruckschloss U, Just I, Hecker M. Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation. Arterioscler Thromb Vasc Biol. 2000;20:61–9.
   PubMed Web of Science ®Google Scholar