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Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 35, 2013 - Issue 8
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Original Article

Injection of specific amyloid-beta oligomers (beta1-40:beta1-42 = 10:1) into rat medial septum impairs memory retention without inducing hippocampal apoptosis

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Pages 798-803 | Published online: 03 Dec 2013

References

  • Clark DL, Boutros NN The brain and behavior: an introduction to behavioral neroanatomy. Oxford: Blackwell Science; 1999. pp.178–179, 181–182, 184–185.
  • Dragoi G, Carpi D, Recce M, Csicsvari J, Buzsa G. Interactions between hippocampus and medial septum during sharp waves and theta oscillation in the behaving rat. J Neurosci. 1999;19(14):6191–9.
  • Amaral DG, Kurz J. An analysis of the origins of the cholinergic and noncholinergic septal projections to the hippocampal formation of the rat. J Comp Neurol. 1985;240:37–59.
  • Abe E, Casamenti F, Giovannelli L, Scali C. Administration of amyloid beta-peptides into the medial septum of rats decreases acetylcholine release from hippocampus in vivo. Brain Res. 1994;636(1):162–4.
  • Bartus RT, Dean RL, Beer B, Lippa AS. The cholinergic hypothesis of geriatric memory dysfunction. Science. 1982;217:408–14.
  • Bartus RT, Flicker C, Dean RL, Pontecorvo M, Figueiredo JC, Fisher SK. Selective memory loss following nucleus basalis lesions: long term behavioral recovery despite persistent cholinergic deficiencies. Pharmacol Biochem Behav 1985;23:125–35.
  • Bigl V, Woolf NJ, Butcher LL. Cholinergic projections from the basal forebrain to frontal, parietal, temporal, occipital, and cingulate cortices: a combined flourescent tracer and acetylcholinesterase analysis. Brain Res Bull. 1982;8:727–49.
  • Crooks R, Jackson J, Bland BH. Dissociable pathways facilitate theta and non-theta states in the median raphe septohippocampal circuit. Hippocampus. 2011. 22(7):1567–76.
  • DeKosky ST, Scheff SW, Markesbery WR. Laminar organization of cholinergic circuits in human frontal cortex in Alzheimer’s disease and aging. Neurology. 1985;35:1425–31.
  • Mesulam M, Mufson EJ, Wagner BH, Levey AI. Central cholinergic pathways in the rat: an overveiw based on an alternative nomenclature. Neuroscience. 1983;10:11815–21201.
  • Stanley EM, Fadel J. Aging-related deficits in orexin/hypocretin modulation of the septohippocampal cholinergic system. Synapse. 2012;66(5):445–52.
  • Redish AD, Touretzky DS. The role of the hippocampus in solving the Morris water maze. Neural Comput. 1998;10:73–111.
  • Paxinos G, Watson C. The rat brain in streotaxic coordinates. 4th ed. Waltham, MA: Academic Press; 1998.
  • Walsh DM, Klyubin I, Fadeeva JV, Rowan MJ, Selkoe DJ. Amyloid-β oligomers: their production, toxicity and therapeutic inhibition. Biochem Soc Trans. 2002;30:552–7.
  • Westerman MA, Cooper-Blacketer D, Mariash A, Kotilinek L, Kawarabayashi T, Younkin LH, et al.. The relationship between Aβ and memory in the Tg2576 mouse model of Alzheimer’s disease. J Neurosci. 2002;22:1858–67.
  • Yoshiike Y, Chui DH, Akagi T, Tanaka N, Takashima A. Specific compositions of amyloid -β peptides as the determinant of toxic β-aggregation, J Biol Chem. 2003;278(26):23648–55.
  • Antonova E, Parslow D, Brammer M, Simmons A, Williams S, Dawson GR, et al.. Scopolamine disrupts hippocampal activity during allocentric spatial memory in humans: an fMRI study using a virtual reality analogue of the Morris water maze. J Psychopharmacol. 2011;25(9):1256–65.
  • Atkinson RC, Shiffrin RM. The control of short-term memory. Sci Am. 1971;255:82–90.
  • Colom LV, Castaneda MT, Hernandez S, Perry G, Jaime S, Touhami A. Intrahippocampal amyloid-β1-40 injections injure medial septal neurons in rats. Curr Alzheimer Res. 2011;8(8): 832–40.
  • Sheedan T, Numan M. The septal region and social behavior. In: , Numan R (ed.), The behavioral neuroscience of septal region. New York: Spiringer-Verlag; 2000. pp. 175–209.
  • Swanson LW, Köhler C, Björklund A. The septohippocampal system. In: , Hökfelt T, Björklund A, Swanson LW, (eds.), Handbook of chemical neuroanatomy. Vol. 5. Part 1. Amsterdam: Elsevier; 1987. pp. 125–277.
  • Swanson LW, Risold PY. On the basic architecture of the septal region. In: , Numan R (ed.), The behavioral neuroscience of septal region. New York: Spiringer-Verlag; 2000. pp. 1–14.
  • Brady JV, Nauta WHJ. Subcortical mechanism in emotional behavior: affective changes following septal forebrain lesions in the albino rat. J Comp Physiol Psychol. 1953;46:339–46.
  • Apartis E, Poindessous-Jazat F, Lamour YA, Bassant MH. Loss of rhythmically bursting neurons in rat medial septum following selective lesion of septohippocampal cholinergic system. J Neurophysiol. 1998;79:1633–42.
  • Leutgeb S, Mizumori SJ. Excitotoxic septal lesions result in spatial memory deficit and altered flexibility of hippocampal single-unit representation J Neurosci. 1999;19:6661–72.
  • Numan R. Septal modulation of the working memory for voluntary behavior. In: , Numan R (ed.), The behavioral neuroscience of septal region. New York: Spiringer-Verlag; 2000. pp. 298–326.
  • Perry EK, Perry RH, Blessed G, Tomlinson BE. Changes in the brain cholinesterases in senile demantia of the Alzheimer type. Neuropathol Appl Neurobiol. 1978;4:272–7.
  • Perry EK, Tomlinson BE, Blessed G, Bergmann K, Gibson PH, Perry RH. Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile demantia. Br Med J. 1978;2:1457–9.
  • Hasselmo ME. Septal modulation of hippocampal dynamics: what is the function of the theta rhythm? In: , Numan R (ed.), The behavioral neuroscience of septal region. New York: Spiringer-Verlag; 2000. pp. 92–114.
  • Feder R, Ranck JB. Studies on single neurons in dorsal hippocampal formation and septum in unrestrained rats. II. Hippocampal slow waves and theta cell firing during bar pressing and other behaviors. Exp Neurol. 1973;41:532–55.
  • Hirase H, Leinekugel X, Csicsvari J, Czurko A, Buzsaki G. Behavior dependent states of the hippocampal network affect functional clustering of neurons. J. Neurosci. 2001;21:RC145.
  • King C, Recce M, O’Keffe C. The rhythmicity of cells of the medial septum/diagonal band of Broca in the awake freely moving rat: relationships with behaviour and hippocampal theta. J Neurosci. 1998;10:464–77.
  • Oddie SD, Bland BH. Hippocampal formation theta activity and movement selection. Neurosci Biobehav Rev. 1998;22:221–31.
  • Shin J, Talnov A. A single trial analysis of hippocampal theta frequency during nonsteady wheel running in rats. Brain Res. 2001;897:217–21.

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