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Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 35, 2013 - Issue 8
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Original Article

Effects of luteolin on spatial memory, cell proliferation, and neuroblast differentiation in the hippocampal dentate gyrus in a scopolamine-induced amnesia model

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Pages 813-820 | Published online: 03 Dec 2013

References

  • Gross CG. Neurogenesis in the adult brain: death of a dogma. Nat Rev Neurosci. 2000;1:67–73.
  • Dayer AG, Ford AA, Cleaver KM, Yassaee M, Cameron HA. Short-term and long-term survival of new neurons in the rat dentate gyrus. J Comp Neurol. 2003;460:563–72.
  • Deng W, Aimone JB, Gage FH. New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nat Rev Neurosci. 2010;11:339–50.
  • Gage FH. Mammalian neural stem cells. Science. 2000;287:1433–8.
  • Cooper-Kuhn CM, Winkler J, Kuhn HG. Decreased neurogenesis after cholinergic forebrain lesion in the adult rat. J Neurosci Res. 2004;77:155–65.
  • Kotani S, Yamauchi T, Teramoto T, Ogura H. Donepezil, an acetylcholinesterase inhibitor, enhances adult hippocampal neurogenesis. Chem Biol Interact. 2008;175:227–30.
  • Mohapel P, Leanza G, Kokaia M, Lindvall O. Forebrain acetylcholine regulates adult hippocampal neurogenesis and learning. Neurobiol Aging. 2005;26:939–46.
  • Kotani S, Yamauchi T, Teramoto T, Ogura H. Pharmacological evidence of cholinergic involvement in adult hippocampal neurogenesis in rats. Neuroscience. 2006;142:505–14.
  • Van der Borght K, Mulder J, Keijser JN, Eggen BJ, Luiten PG, Van der Zee EA. Input from the medial septum regulates adult hippocampal neurogenesis. Brain Res Bull. 2005;67:117–25.
  • Misane I, Ogren SO. Selective 5-HT1A antagonists WAY 100635 and NAD-299 attenuate the impairment of passive avoidance caused by scopolamine in the rat. Neuropsychopharmacology. 2003;28:253–64.
  • Shimoi K, Masuda S, Furugori M, Esaki S, Kinae N. Radioprotective effect of antioxidative flavonoids in gamma-ray irradiated mice. Carcinogenesis. 1994;15:2669–72.
  • Lin Y, Shi R, Wang X, Shen HM. Luteolin, a flavonoid with potential for cancer prevention and therapy. Curr Cancer Drug Targets. 2008;8:634–46.
  • Xu B, Li XX, He GR, Hu JJ, Mu X, Tian S, et al.. Luteolin promotes long-term potentiation and improves cognitive functions in chronic cerebral hypoperfused rats. Eur J Pharmacol. 2010;627:99–105.
  • Zhu LH, Bi W, Qi RB, Wang HD, Wang ZG, Zeng Q, et al.. Luteolin reduces primary hippocampal neurons death induced by neuroinflammation. Neurol Res. 2011;33:927–934.
  • Coleta M, Campos MG, Cotrim MD, Lima TC, Cunha AP. Assessment of luteolin (3′,4′,5,7-tetrahydroxyflavone) neuropharmacological activity. Behav Brain Res. 2008;189:75–82.
  • Dajas F, Rivera-Megret F, Blasina F, Arredondo F, Abin-Carriquiry JA, Costa G, et al.. Neuroprotection by flavonoids. Braz J Med Biol Res. 2003;36:1613–20.
  • Qiao H, Dong L, Zhang X, Zhu C, Zhang X, Wang L, et al.. Protective effect of luteolin in experimental ischemic stroke: upregulated SOD1, CAT, Bcl-2 and claudin-5, down-regulated MDA and Bax expression. Neurochem Res. 2012;37:2014–24.
  • Francis F, Koulakoff A, Boucher D, Chafey P, Schaar B, Vinet MC, et al.. Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons. Neuron. 1999;23:247–56.
  • Gleeson JG, Lin PT, Flanagan LA, Walsh CA. Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons. Neuron. 1999;23:257–71.
  • Jin K, Xie L, Mao XO, Greenberg DA. Alzheimer’s disease drugs promote neurogenesis. Brain Res. 2006;1085:183–88.
  • Foyet HS, Hritcu L, Ciobica A, Stefan M, Kamtchouing P, Cojocaru D. Methanolic extract of Hibiscus asper leaves improves spatial memory deficits in the 6-hydroxydopamine-lesion rodent model of Parkinson’s disease. J Ethnopharmacol. 2011;133:773–9.
  • Brown J, Cooper-Kuhn CM, Kempermann G, Van Praag H, Winkler J, Gage FH, et al.. Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis. Eur J Neurosci. 2003;17:2042–6.
  • Couillard-Despres S, Winner B, Schaubeck S, Aigner R, Vroemen M, Weidner N, et al.. Doublecortin expression levels in adult brain reflect neurogenesis. Eur J Neurosci. 2005;21:1–14.
  • Paxinos G, Watson C. The rat brain in stereotaxic coordinates. Amsterdam: Elsevier; 2007.
  • Ellman GL, Courtney DK, Andres V, Featherstone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol. 1961;7:88–95.
  • Bruel-Jungerman E, Lucassen PJ, Francis F. Cholinergic influences on cortical development and adult neurogenesis. Behav Brain Res. 2011;221:379–88.
  • Gold PE. Acetylcholine modulation of neural systems involved in learning and memory. Neurobiol Learn Mem. 2003;80:194–210.
  • Hasselmo ME. The role of acetylcholine in learning and memory. Curr Opin Neurobiol. 2006;16:710–5.
  • Power AE, Vazdarjanova A, McGaugh JL. Muscarinic cholinergic influences in memory consolidation. Neurobiol Learn Mem. 2003;80:178–93.
  • Blank T, Nijholt I, Spiess J. Molecular determinants mediating effects of acute stress on hippocampus-dependent synaptic plasticity and learning. Mol Neurobiol. 2004;29:131–38.
  • Yusuf S, Adelaiye BA, Agunu A. Effect of Ziziphus mauritiania (L.) seed extracts on spatial recognition memory of rats as measured by the Y-maze test. J Nat Prod. 2009;2:31–9.
  • Jang S, Dilger RN, Johnson RW. Luteolin inhibits microglia and alters hippocampal-dependent spatial working memory in aged mice. J Nutr. 2010;140:1892–8.
  • Yoo DY, Kim W, Yoo KY, Lee CH, Choi JH, Kang IJ, et al.. Effects of Nelumbo nucifera rhizome extract on cell proliferation and neuroblast differentiation in the hippocampal dentate gyrus in a scopolamine-induced amnesia animal model. Phytother Res. 2011;25:809–15.
  • Yoo DY, Woo YJ, Kim W, Nam SM, Lee BH, Yeun GH, et al.. Effects of a new synthetic butyrylcholinesterase inhibitor, HBU-39, on cell proliferation and neuroblast differentiation in the hippocampal dentate gyrus in a scopolamine-induced amnesia animal model. Neurochem Int. 2011;59:722–8.
  • Lee S, Kim DH, Lee DH, Jeon SJ, Lee CH, Son KH, et al.. Oroxylin A, a flavonoid, stimulates adult neurogenesis in the hippocampal dentate gyrus region of mice. Neurochem Res. 2010;35:1725–32.
  • Yoo KY, Choi JH, Hwang IK, Lee CH, Lee SO, Han SM, et al.. (−)-Epigallocatechin-3-gallate increases cell proliferation and neuroblasts in the subgranular zone of the dentate gyrus in adult mice. Phytother Res. 2010;24:1065–70.
  • Liu R, Gao M, Qiang GF, Zhang TT, Lan X, Ying J, et al.. The anti-amnesic effects of luteolin against amyloid β25–35 peptide-induced toxicity in mice involve the protection of neurovascular unit. Neuroscience. 2009;162:1232–43.
  • Palmer AM. The activity of the pentose phosphate pathway is increased in response to oxidative stress in Alzheimer’s disease. J Neural Transm. 1999;106:317–28.
  • El-Sherbiny DA, Khalifa AE, Attia AS, Eel-D Eldenshary. Hypericum perforatum extract demonstrates antioxidant properties against elevated rat brain oxidative status induced by amnestic dose of scopolamine. Pharmacol Biochem Behav. 2003;76:525–33.
  • Tsai FS, Cheng HY, Hsieh MT, Wu CR, Lin YC, Peng WH. The ameliorating effects of luteolin on beta-amyloid-induced impairment of water maze performance and passive avoidance in rats. Am J Chin Med. 2010;38:279–91.
  • Bibel M, Barde YA. Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. Genes Dev. 2000;14:2919–37.
  • Ward NL, Hagg T. BDNF is needed for postnatal maturation of basal forebrain and neostriatum cholinergic neurons in vivo. Exp Neurol. 2000; 162:297–310.
  • Gustafsson E, Lindvall O, Kokaia Z. Intraventricular infusion of TrkB-Fc fusion protein promotes ischemia-induced neurogenesis in adult rat dentate gyrus. Stroke. 2003;34:2710–15.
  • Sairanen M, Lucas G, Ernfors P, Castrén M, Castrén E. Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus. J Neurosci. 2005;25:1089–94.
  • Scharfman H, Goodman J, Macleod A, Phani S, Antonelli C, Croll S. Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats. Exp Neurol. 2005;192:348–56.
  • Berchtold NC, Kesslak JP, Cotman CW. Hippocampal brain-derived neurotrophic factor gene regulation by exercise and the medial septum. J Neurosci Res. 2002;68:511–21.
  • Lapchak PA, Araujo DM, Hefti F. Cholinergic regulation of hippocampal brain-derived neurotrophic factor mRNA expression: evidence from lesion and chronic cholinergic drug treatment studies. Neuroscience. 1993;52:575–85.
  • Gil-Bea FJ, Solas M, Mateos L, Winblad B, Ramírez MJ, Cedazo-Mínguez A. Cholinergic hypofunction impairs memory acquisition possibly through hippocampal Arc and BDNF downregulation. Hippocampus. 2011;21:999–1009.

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