Publication Cover
Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 35, 2013 - Issue 9
288
Views
32
CrossRef citations to date
0
Altmetric
Original Article

Lipoxin A4 ameliorates cerebral ischaemia/reperfusion injury through upregulation of nuclear factor erythroid 2-related factor 2

, , , , , , , & show all
Pages 968-975 | Published online: 18 Nov 2013

References

  • Chan PH. Role of oxidants in ischemic brain damage. Stroke. 1996;27:1124–9.
  • Lipton P. Ischemic cell death in brain neurons. Physiol Rev. 1999;79:1431–568.
  • Aztatzi-Santillán E, Nares-López FE, Márquez-Valadez B, Aguilera P, Chánez-Cárdenas ME. The protective role of heme oxygenase-1 in cerebral ischemia. Cent Nerv Syst Agents Med Chem. 2010;10:310–6.
  • Moi P, Chan K, Asunis I, Cao A, Kan YW. Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region. Proc Natl Acad Sci USA. 1994;91:9926–30.
  • Ishii T, Itoh K, Takahashi S, Sato H, Yanagawa T, Katoh Y, et al.. Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem. 2000;275:16023–9.
  • Satoh T, Okamoto SI, Cui J, Watanabe Y, Furuta K, Suzuki M, et al.. Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophillic phase II inducers. Proc Natl Acad Sci. 2006;103:768–73.
  • Shih AY, Li P, Murphy TH. A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo. J Neurosci. 2005;25:10321–35.
  • Kam KY, Yu SJ, Jeong N, Hong JH, Jalin AM, Lee S, et al.. P-Hydroxybenzyl alcohol prevents brain injury and behavioral impairment by activating Nrf2, PDI, and neurotrophic factor genes in a rat model of brain ischemia. Mol Cells. 2011;31:209–15.
  • Ping Z, Liu W, Kang Z, Cai J, Wang Q, Cheng N, et al.. Sulforaphane protects brains against hypoxic–ischemic injury through induction of Nrf2-dependent phase 2 enzyme. Brain Res. 2010;1343:178–85.
  • Yang CH, Zhang XJ, Fan HG, Liu Y. Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia. Brain Res. 2009;1282:133–41.
  • Serhan CN, Hamberg M, Samuelsson B. Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes. Proc Natl Acad Sci USA. 1984;81:5335–9.
  • Chiang N, Fierro IM, Gronert K, Serhan CN. Activation of lipoxin A(4) receptors by aspirin-triggered lipoxins and select peptides evokes ligand-specific responses in inflammation. J Exp Med. 2000;191:1197–208.
  • Sobrado M, Pereira MP, Ballesteros I, Hurtado O, Fernandez-Lopez D, Pradillo JM, et al.. Synthesis of lipoxin A4 by 5-lipoxygenase mediates PPARgamma-dependent, neuroprotective effects of rosiglitazone in experimental stroke. J Neurosci. 2009;29:3875–84.
  • Wu L, Miao S, Zou LB, Wu P, Hao H, Tang K, et al.. Lipoxin A4 inhibits 5-lipoxygenase translocation and leukotrienes biosynthesis to exert a neuroprotective effect in cerebral ischemia/reperfusion injury. J Mol Neurosci. 2012;48:185–200.
  • Longa EZ, Weinstein PR, Carlson S. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 1989;20:84–91.
  • Hunter AJ, Hatcher J, Virley D, Nelson P, Irving E, Hadingham SJ, et al.. Functional assessments in mice and rats after focal stroke. Neuropharmacology. 2000;39:806–16.
  • Williams AJ, Berti R, Dave JR. Delayed treatment of ischemia/reperfusion brain injury extended therapeutic window with the proteosome inhibitor MLN519. Stroke. 2004;35:1186–91.
  • Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem. 1969;27:502–22.
  • Wang F, Wang Y, Geng X, Asmaro K, Peng C, Sullivan JM, et al.. Neuroprotective effect of acute ethanol administration in a rat with transient cerebral ischemia. Stroke. 2012;43:205–10.
  • Maderna P, Godson C. Taking insult from injury: lipoxins and lipoxin receptor agonists and phagocytosis of apoptotic cells. Prostaglandins Leukot Essent Fatty Acids. 2005;73:179–87.
  • Vannucci RC, Connor JR, Mauger DT, Palmer C, Smith MB, Towfighi J, et al.. Rat model of perinatal hypoxic–ischemic brain damage. J Neurosci Res. 1999;55:158–63.
  • Prieto P, Cuenca J, Través PG, Fernández-Velasco M, Martín-Sanz P, Bosca L. Lipoxin A4 impairment of apoptotic signaling in macrophages: implication of the PI3K/Akt and the ERK/Nrf-2 defense pathways. Cell Death Differ. 2010;17:1179–88.
  • Maines MD. Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. FASEB J. 1988;2:2557–68.
  • Stocker R, Yamamoto Y, McDonagh AF, Glazer AN, Ames BN. Bilirubin is an antioxidant of possible physiological importance. Science. 1987;235:1043–6.
  • Nascimento-Silva V, Arruda MA, Barja-Fidalgo C, Villela CG, Fierro IM. Novel lipid mediator aspirin-triggered lipoxin A4 induces heme oxygenase-1 in endothelial cells. Am J Physiol Cell Physiol. 2005;289:557–63.
  • Halliwell B, Gutteridge JMC. Free radicals in biology and medicine, 3rd edn. Oxford, UK: Oxford University Press; 1999.
  • Gotoh O, Yamamoto M, Tamura A, Sano K. Effect of YM737, a new glutathione analogue, on ischemic brain edema. Acta Neurochir Suppl. 1994;60:318–20.
  • Dickinson DA, Levonen AL, Moellering DR, Arnold EK, Zhang H, Darley Usmar VM, et al.. Human glutamate cysteine ligase gene regulation through the electrophile response element. Free Rad Biol Med. 2004;37:1152–9.
  • Burdo J, Schubert D, Maher P. Glutathione production is regulated via distinct pathways in stressed and non-stressed cortical neurons. Brain Res. 2008;1189:12–22.
  • Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N, Katoh Y, et al.. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci USA. 2002;99:11908–13.
  • Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, et al.. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol. 2010;12:213–23.
  • Shibata T, Ohta T, Tong KI, Kokubu A, Odogawa R, Tsuta K, et al.. Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy. Proc Natl Acad Sci USA. 2008;105:13568–73.
  • Inami Y, Waguri S, Sakamoto A, Kouno T, Nakada K, Hino O, et al.. Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells. J Cell Biol. 2011;193:275–84.
  • Kosaka K, Mimura J, Itoh K, Satoh T, Shimojo Y, Kitajima C, et al.. Role of Nrf2 and p62/ZIP in the neurite outgrowth by carnosic acid in PC12h cells. J Biochem. 2010;147:73–81.
  • Liu Y, Kern JT, Walker JR, Johnson JA, Schultz PG, Luesch H. A genomic screen for activators of the antioxidant response element. Proc Natl Acad Sci USA. 2007;104:5205–10.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.