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Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 36, 2014 - Issue 7
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Original Research Papers

Knockdown of CDK2AP1 by RNA interference inhibits cell growth and tumorigenesis of human glioma

Yonggang XuDepartment of Minimally Invasive NeurosurgeryThe Fourth Affiliated Hospital of Harbin Medical University, China
,
Jie WangHarbin Veterinary Research InstituteChinese Academy of Agricultural Sciences, China
,
Songbin FuLaboratory of Medical Genetics of Harbin Medical University, China
&
Zhi WangDepartment of Minimally Invasive NeurosurgeryThe Fourth Affiliated Hospital of Harbin Medical University, ChinaCorrespondence[email protected]
Pages 659-665 | Published online: 19 Dec 2013

References

  • Goodenberger ML, Jenkins RB. Genetics of adult glioma. Cancer Genet. 2012;205(12):613–21.
  • Ajeawung NF, Wang HY, Gould P, Kamnasaran D. Advances in molecular targets for the treatment of medulloblastomas. Clin Invest Med. 2012;35(5):E246.
  • Marumoto T, Saya H. Molecular biology of glioma. Adv Exp Med Biol. 2012;746:2–11.
  • Todd R, McBride J, Tsuji T, Donoff RB, Nagai M, Chou MY, et al. Deleted in oral cancer-1 (doc-1), a novel oral tumor suppressor gene. FASEB J. 1995;9(13):1362–70.
  • Daigo Y, Suzuki K, Maruyama O, Miyoshi Y, Yasuda T, Kabuto T, et al. Isolation, mapping and mutation analysis of a human cDNA homologous to the doc-1 gene of the Chinese hamster, a candidate tumor suppressor for oral cancer. Genes Chromosomes Cancer. 1997;20(2):204–7.
  • Shintani S, Ohyama H, Zhang X, McBride J, Matsuo K, Tsuji T, et al. p12(DOC-1) is a novel cyclin-dependent kinase 2-associated protein. Mol Cell Biol. 2000;20(17):6300–7.
  • Tsuji T, Duh FM, Latif F, Popescu NC, Zimonjic DB, McBride J, et al. Cloning, mapping, expression, function, and mutation analyses of the human ortholog of the hamster putative tumor suppressor gene Doc-1. J Biol Chem. 1998;273(12):6704–9.
  • Matsuo K, Shintani S, Tsuji T, Nagata E, Lerman M, McBride J, et al. p12(DOC-1), a growth suppressor, associates with DNA polymerase alpha/primase. FASEB J. 2000;14(10):1318–24.
  • Wong DT, Kim JJ, Khalid O, Sun HH, Kim Y. Double edge: CDK2AP1 in cell-cycle regulation and epigenetic regulation. J Dent Res. 2012;91(3):235–41.
  • Sun M, Jiang R, Wang G, Zhang C, Li J, Jin C, et al. Cyclin-dependent kinase 2-associated protein 1 suppresses growth and tumorigenesis of lung cancer. Int J Oncol. 2013;42(4):1376–82.
  • Hiyoshi Y, Watanabe M, Hirashima K, Karashima R, Sato N, Imamura Y, et al. p12CDK2-AP1 is associated with tumor progression and a poor prognosis in esophageal squamous cell carcinoma. Oncol Rep. 2009;22(1):35–9.
  • Tsuji T, Ibaragi S, Shima K, Hu MG, Katsurano M, Sasaki A, et al. Epithelial–mesenchymal transition induced by growth suppressor p12CDK2-AP1 promotes tumor cell local invasion but suppresses distant colony growth. Cancer Res. 2008;68(24):10377–86.
  • Peng H, Shintani S, Kim Y, Wong DT. Loss of p12CDK2-AP1 expression in human oral squamous cell carcinoma with disrupted transforming growth factor-beta-Smad signaling pathway. Neoplasia. 2006;8(12):1028–36.
  • Stewart SA, Dykxhoorn DM, Palliser D, Mizuno H, Yu EY, An DS, et al. Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA. 2003;9(4):493–501.
  • Pastori C, Magistri M, Napoli S, Carbone GM, Catapano CV. Small RNA-directed transcriptional control: new insights into mechanisms and therapeutic applications. Cell Cycle. 2010;9(12):2353–62.
  • Figueiredo ML, Kim Y, St John MA, Wong DT. p12CDK2-AP1 gene therapy strategy inhibits tumor growth in an in vivo mouse model of head and neck cancer. Clin Cancer Res. 2005;11(10):3939–48.
  • Shintani S, Mihara M, Terakado N, Nakahara Y, Matsumura T, Kohno Y, et al. Reduction of p12DOC-1 expression is a negative prognostic indicator in patients with surgically resected oral squamous cell carcinoma. Clin Cancer Res. 2001;7(9):2776–82.
  • Zolochevska O, Figueiredo ML. Cell cycle regulator cdk2ap1 inhibits prostate cancer cell growth and modifies androgen-responsive pathway function. Prostate. 2009;69(14):1586–97.
  • Wu LC, Chen YL, Wu WR, Li CF, Huang HY, Lee SW, et al. Expression of cyclin-dependent kinase 2-associated protein 1 confers an independent prognosticator in nasopharyngeal carcinoma: a cohort study. J Clin Pathol. 2012;65(9):795–801.
  • Zolochevska O, Figueiredo ML. Novel tumor growth inhibition mechanism by cell cycle regulator cdk2ap1 involves antiangiogenesis modulation. Microvasc Res. 2010;80(3):324–31.
  • Choi MG, Sohn TS, Park SB, Paik YH, Noh JH, Kim KM, et al. Decreased expression of p12 is associated with more advanced tumor invasion in human gastric cancer tissues. Eur Surg Res. 2009;42(4):223–9.
  • Yuan Z, Gaba AG, Kent TS, Bennett A, Miller A, Weber TK. Modulation of CDK2-AP1 (p12(DOC-1)) expression in human colorectal cancer. Oncogene. 2005;24(22):3657–68.
  • Elstein KH, Zucker RM. Comparison of cellular and nuclear flow cytometric techniques for discriminating apoptotic subpopulations. Exp Cell Res. 1994;211(2):322–31.
  • Riccardi C, Nicoletti I. Analysis of apoptosis by propidium iodide staining and flow cytometry. Nat Protoc. 2006;1(3):1458–61.
  • Barisic K, Petrik J, Rumora L. Biochemistry of apoptotic cell death. Acta Pharm. 2003;53(3):151–64.
  • Kim Y, Ohyama H, Patel V, Figueiredo M, Wong DT. Mutation of Cys105 inhibits dimerization of p12CDK2-AP1 and its growth suppressor effect. J Biol Chem. 2005;280(24):23273–9.

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