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Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 36, 2014 - Issue 9
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Efficacy and safety assessment of alteplase in the treatment of stroke — gender differences

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References

  • Appelros P, Stegmayr B, Terént A. Sex differences in stroke epidemiology: a systematic review. Stroke. 2009,40(4):1082–90.
  • Clark WM, Wissman S, Albers GW, Jhamandas JH, Madden KP, Hamilton S. Recombinant tissue-type plasminogen activator (Alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS Study: a randomized controlled trial. Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke. JAMA. 1999;282(21):2019–26.
  • Di Carlo A, Lamassa M, Baldereschi M, Pracucci G, Basile AM, Wolfe CD, et al. Sex differences in the clinical presentation, resource use, and 3-month outcome of acute stroke in Europe: data from a multicenter multinational hospital-based registry. Stroke. 2003;34:1114–9.
  • Elkind MS, Prabhakaran S, Pittman J, Koroshetz W, Jacoby M, Johnston KC. Sex as a predictor of outcomes in patients treated with thrombolysis for acute stroke. Neurology. 2007;68(11):842–8.
  • Förster A, Gass A, Kern R, Wolf ME, Ottomeyer C, Zohsel K, et al. Gender differences in acute ischemic stroke: etiology, stroke patterns and response to thrombolysis. Stroke. 2009;40(7):2428–32.
  • Fukuda M, Kanda T, Kamide N, Akutsu T, Sakai F. Gender differences in long-term functional outcome after first-ever ischemic stroke. Intern Med. 2009;48(12):967–73.
  • Gargano J, Wehner S, Reeves M. Do presenting symptoms explain sex differences in emergency department delays among patients with acute stroke? Stroke. 2009;40:1114–20.
  • Giralt D, Domingues-Montanari S, Mendioroz M, Ortega L, Maisterra O, Perea-Gainza M et al. The gender gap in stroke: a meta-analysis. Acta Neurol Scand. 2012;125(2):83–90.
  • Glader E, Stegmayr B, Norrving B, Terént A, Hulter Åsberg K, Wester PO, et al. Sex differences in management and outcome after stroke: a Swedish national perspective. Stroke. 2003;34(8):1970–5.
  • Hacke W, Kaste M, Fieschi C, Toni D, Lesaffre E, von Kummer R, et al. Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS) JAMA. 1995;274(13):1017–25.
  • Hill M, Buchan A. Canadian Alteplase for Stroke Effectiveness Study (CASES) Investigators. Thrombolysis for acute ischemic stroke: results of the Canadian Alteplase for Stroke Effectiveness Study. CMAJ. 2005;172(10):1307–12.
  • Hill M, Kent D, Hinchey J, Rowley H, Buchan AM, Wechsler LR, et al. Sex-based differences in the effect of intra-arterial treatment of stroke: analysis of the PROACT-2 study. Stroke. 2006;37(9):2322–5.
  • Holroyd-Leduc J, Kapral M, Austin PC, Tu JV. Sex differences and similarities in the management and outcome of stroke patients. Stroke. 2000;31(8):1833–7.
  • Jovanović D, Beslać-Bumbasirević L, Budimkić M, Pekmezović T, Zivković M, Kostić VS; SETIS Investigation Group. Do women benefit more from systemic thrombolysis in acute ischemic stroke? A Serbian experience with thrombolysis in ischemic stroke (SETIS) study. Clin Neurol Neurosurg. 2009,111(9):729–732.
  • Kain K, Carter AM, Bamford JM, Grant PJ, Catto AJ. Gender differences in coagulation and fibrinolysis in white subjects with acute ischemic stroke. J Thromb Haemost. 2003;1:390–2.
  • Kain K, Catto AJ, Carter AM, Young J, Bamford J, Bavington J, et al. Decreased fibrinolytic potential in south Asian women with ischaemic cerebrovascular disease. Br J Haematol. 2001;114:155–61.
  • Kent D, Buchan A, Hill M. The gender effect in stroke thrombolysis: of CASES, controls, and treatment-effect modification. Neurology. 2008;71(14):1080–3.
  • Kent D, Hill M. Differences in response to reperfusion therapies in acute stroke between men and women: mediated by sex or by chance? Stroke. 2006;37(12):2878–9.
  • Kent DM, Price LL, Ringleb P, Hill MD, Selker HP. Sex-based differences in response to recombinant tissue plasminogen activator in acute ischemic stroke: a pooled analysis of randomized clinical trials. Stroke. 2005;36(1):62–5.
  • Lisabeth L, Brown D, Morgenstern L. Barriers to intravenous tissue plasminogen activator for acute stroke therapy in women. Gend Med. 2006;3(4):270–8.
  • Mouradian MS, Senthilselvan A, Jickling G, McCombe JA, Emery DJ, Dean N, et al. Intravenous rt-PA for acute stroke: comparing its effectiveness in younger and older patients J Neurol Neurosurg Psychiatry. 2005;76:1234–7.
  • Niewada M, Kobayashi A, Sandercock PA, Kaminski B, Czlonkowska A. Influence of gender on baseline features and clinical outcomes among 17,370 patients with confirmed ischaemic stroke in the international stroke trial. Neuroepidemiology. 2005;24(3):123–8.
  • Reeves MJ, Bushnell CD, Howard G, Gargano JW, Duncan PW, Lynch G, et al. Sex differences in stroke: epidemiology, clinical presentation, medical care, and outcomes. Lancet Neurol. 2008;7(10):915–26.
  • Roquer J, Campello AR, Gomis M. Sex differences in first-ever acute stroke. Stroke. 2003;34(7):1581–5.
  • Saposnik G, Di Legge S, Webster F, Hachinski V. Predictors of major neurologic improvement after thrombolysis in acute stroke. Neurology. 2005;65(8):1169–74.
  • Savitz SI, Schlaug G, Caplan L, Selim M. Arterial occlusive lesions recanalize more frequently in women than in men after intravenous tissue plasminogen activator administration for acute stroke. Stroke. 2005;36(7):1447–51.
  • Shah S, Liebeskind D, Saver J, Starkman S, Vinuela F, Duckwiler G, et al. Influence of gender on outcomes after intra-arterial thrombolysis for acute ischemic stroke. Neurology. 2006;66(11):1745–6.
  • Smith D, Murphy P, Santos P, Phillips M, Wilde M. Gender differences in the Colorado Stroke Registry. Stroke. 2009;40(4):1078–81.
  • Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med. 1995;333(24):1581–7.
  • Tafreshi G, Raman R, Ernstrom K, Hemmen TM. Gender Differences in Acute Stroke Treatment. The University of California San Diego Experience. Stroke. 2010;41:1755–7.
  • Turtzo LC, McCullough LD. Sex-specific responses to stroke. Future Neurol. 2010;5(1):47–59.

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