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Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 36, 2014 - Issue 12
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Review

Involuntary movements due to vitamin B12 deficiency

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References

  • Sharieff AZ, Raffel J, Zee DS. Vitamin B12 deficiency with bilateral globus pallidus abnormalities. Arch Neurol. 2012;69(6):769–72.
  • Addison T. Anaemia: disease of the suprarenal capsules. Lond Med Gaz. 1849;43:517–8; (Quoted in ref. 23).
  • Lichtheim H. Zur Kenntniss der perniciosen Anamie. Munchen Med Med Wchnschr. 1887;34:301; (Quoted in ref. 23).
  • Russell JDR, Batten FE, Collier J. Subacute combined degeneration of the spinal cord. Brain. 1900;23:39–110.
  • Healton EB, Savage DG, Brust JC, Garrett TJ, Lindenbaum J. Neurologic aspects of cobalamin deficiency. Medicine (Baltimore). 1991;70:229–45.
  • Kumar S. Recurrent seizures: an unusual manifestation of vitamin B12 deficiency. Neurol India. 2004;52:122–3.
  • Shyambabu C, Sinha S, Taly AB, Vijayan J, Kovoor JME. Serum vitamin B12 deficiency and hyperhomocysteinemia: a reversible cause of acute chorea, cerebellar ataxia in an adult with cerebral ischemia. J Neurol Sci. 2008;273:152–4.
  • Katsaros VK, Glocker FX, Hemmer B, Schumacher M. MRI of spinal cord and brain lesions in subacute combined degeneration. Neuroradiology. 1988;40:716–9.
  • Jadhav M, Webb JKG, Vaishnava S, Baker SJ. Vitamin B12 deficiency in Indian infants. Lancet. 1962;2:903–7.
  • Alawneh H, Batayneh A, Jaafreh M. Infantile dyskinesia and vitamin B12 deficiency. Middle East J Fam Med. 2006;4(5):42–3.
  • Citak FE, Citak EC. Severe vitamin B12 deficiency in a breast fed infant with pancytopenia. J Trop Pediatr. 2011;57(1):69–70.
  • Brennan MJ, van der Westhuyzen J, Kramer S, Metz J. Neurotoxicity of folates: implications for vitamin B12 deficiency and Huntington's chorea. Med Hypotheses. 1981;7:919–29.
  • Rachmel A, Steinberg T, Ashkenazi S, Sela BA. Cobalamin deficiency in a breast-fed infant of a vegetarian mother. Isr Med Assoc J. 2003;5:534–6.
  • Carmen KB, Belgeman T, Yis U. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Pediatr Emer Care. 2013;29:1223–4.
  • Patiroglu T, Unal E, Yildrim S. Infantile tremor syndrome associated with cobalamin therapy: a case report. Clin Neurol Neurosurg. 2013;115:1903–5.
  • Özdemir Ö, Baytan B, Gunes AM, Okan M. Involuntary movements during vitamin B12 treatment. J Child Neurol. 2010;25:227–30.
  • Zanus C, Alberini E, Costa C, Colonna F, Zennaro F, Carrozzi M. Involuntary movements after correction of vitamin B12 deficiency: a video-case report. Epileptic Disord. 2012;14(2):174–80.
  • Chalouhi C, Faesch S, Anthoine-Milhomme MC, Fulla Y, Dulac O, Cheron G. Neurological consequences of vitamin B12 deficiency and its treatment. Pediatr Emer Care. 2008;24(8):538–41.
  • Ozer EA, Turker M, Bakiler AR, Yaprak I, Ozturk C. Involuntary movements in infantile cobalamin deficiency appearing after treatment. Pediatr Neurol. 2001;25:81–3.
  • Avci Z, Turul T, Aysun S, Ünal I. Involuntary movements and magnetic resonance imaging findings in infantile cobalamin (vitamin B12) deficiency. Pediatrics. 2003;112(3):684–6.
  • Casella EB, Valente M, Medeiros de Navarro J, Kok F. Vitamin B12 deficiency in infancy as a cause of developmental regression. Brain Dev. 2005;27:592–4.
  • Emery ES, Homans AC. Vitamin B12 deficiency: a cause of abnormal movements in infants. Pediatrics. 1997;99:255–6.
  • Grattan-Smith PJ, Wilcken B, Procopis PG, Wise GA. The neurological syndrome of infantile cobalamin deficiency: developmental regression and involuntary movements. Mov Disord. 1997;12(1):39–46.
  • Ahn TB, Cho JW, Jeon BS. Unusual neurological presentations of vitamin B12 deficiency. Eur J Neurol. 2004;11:339–41.
  • Müller T, Woitalla D, Hunsdiek A, Kuhn W. Elevated plasma levels of homocysteine in dystonia. Acta Neurol Scand. 2000;101:388–90.
  • Kumar S. Vitamin B12 deficiency presenting with an acute reversible extrapyramidal syndrome. Neurol India. 2004;52:507–9.
  • Pacchetti C, Cristina S, Nappi G. Reversible chorea and focal dystonia in vitamin B12 deficiency. N Engl J Med. 2002;347:295.
  • Celik M, Barkut IK, Oncel C, Forta H. Involuntary movements associated with vitamin B12 deficiency. Parkinsonism Relat Disord. 2003;10:55–7.
  • Edvardsson B, Persson S. Blepharospasm and vitamin B12 deficiency. Neurol India. 2010;58:320–1.
  • Benito-Leon J, Porta-Etessam J. Shaky-leg syndrome and vitamin B12 deficiency. N Engl J Med. 2000;342(13):981.
  • Edvardsson B, Persson S. Chorea associated with vitamin B12 deficiency. Eur J Neurol. 2011;18:e138–9.
  • Sachdev HPS, Shah D. Vitamin B12 (cobalamin). In: Kliegman RM, Stanton BF, St. Geme JW, Schor NF, Behrman RE, editors. Nelson’s textbook of paediatrics, 19th edn. Philadelphia: Elsevier; 2011. p. 197–8.
  • Rasmussen SA, Fernhoff PM, Scanlon KS. Vitamin B12 deficiency in children and adolescents. J Pediatr. 2001;138:10–7.
  • Samuels MA. Neurological effects of malabsorption and vitamin deficiency. In: Samuels MA, Feske S, editors. Office practice of neurology. New York, NY: Churchill Livingstone; 1996. p. 1280.
  • von Schenck U, Bender-Gotze C, Koletzko B. Persistence of neurological damage induced by dietary vitamin B-12 deficiency in infancy. Arch Dis Child. 1997;77:137–9.
  • Allen LH. Vitamin B12 metabolism and status during pregnancy, lactation and infancy. In: Allen LH, King J, Lonnerdal B, editors. Nutrient regulation during pregnancy, lactation, and infant growth. New York: Plenum Press; 1994. p. 173–86.
  • Graham SM, Arvela OM, Wise GA. Long-term neurologic consequences of nutritional vitamin B 12 deficiency in infants. J Pediatr. 1992;121:710–4.
  • Casterline JE, Allen LH, Ruel MT. Vitamin B12 deficiency is very prevalent in lactating Guatemalan women and their infants at three months postpartum. J Nutr. 1997;127:1966–72.
  • Taskesen M, Yaramis A, Katar S, Gozu Pirincioglu A, Soker M. Neurological presentations of nutritional vitamin B12 deficiency in 42 breastfed infants in Southeast Turkey. Turkish J Med Sci. 2011;41(6):1091–6.
  • Baldessarini RJ. Neuropharmacology of s-adenosyl-l-methionine. Am J Med. 1987;83(Suppl 5A):95–103.
  • Surtees R, Leonard J, Austin S. Association of demyelination with deficiency of cerebrospinal-fluid-S-adenosylmethionine in inborn errors of methyl-transfer pathway. Lancet. 1991;338:1550–4.
  • Garewal G, Narang A, Das KC. Infantile tremor syndrome: a vitamin B12 deficiency syndrome in infants. J Trop Pediatr. 1988;34(4):174–8.
  • Fenton WA, Rosenberg L. Disorders of propionate and methylmalonate metabolism. In: Scriver CR, Beaudet AL, Sly WS, Valle D, editors. The metabolic and molecular bases of inherited disease, 7th edn. New York: McGraw-Hill; 1995, p. 1423–50.
  • Hall CA. Function of vitamin B12 in the central nervous system as revealed by congenital defects. Am J Hematol. 1990;34:121–7.
  • Clayton PT, Smith I, Harding B. Subacute combined degeneration of the cord, dementia and Parkinsonism due to an inborn error of folate metabolism. J Neurol Neurosurg Psychiatry. 1986;49:920–7.
  • Hyland K, Smith I, Bottiglieri T. Demyelination and decreased s-adenosylmethionine in 5,10-methylenetetrahydrofolate reductase deficiency. Neurology. 1988;38:459–62.
  • Codazzi D, Sala F, Parini R. Coma and respiratory failure in a child with severe vitamin B12 deficiency. Pediatr Crit Care Med. 2005;6:483–5.
  • Bottiglieri T. Folate, vitamin B12, and neuropsychiatric disorders. Nutr Rev. 1996;54:382–90.
  • Refsum H, Ueland PM, Nygard O, Vollset SE. Homocysteine and cardiovascular disease. Annu Rev Med. 1998;49:31–62.
  • Herrmann W. Significance of hyperhomocysteinemia. Clin Lab. 2006;52(7–8):367–74.
  • Berardelli A, Thompson PD, Zaccagnini M. Two sisters with generalized dystonia associated with homocystinuria. Mov Dis. 1991;6:163–5.
  • Kempster PA, Brenton DP, Gale AN, Stern GM. Dystonia in homocystinuria. J Neurol Neurosurg Psychiatry. 1988;51:859–62.
  • Vitek JL, Chokkan V, Zhang JY. Neuronal activity in basal ganglia with generalized dystonia and hemiballismus. Ann Neurol. 1999;46:22–35.
  • Zoccolella S, Martino D, Defazio G, Lamberti P, Livrea P. Hyperhomocysteinemia in movement disorders: current evidence and hypotheses. Curr Vasc Pharmacol. 2013;4(3):237–43.
  • Boutell JM, Wood JD, Harper PS, Jones AL. Huntingtin interacts with cystathionine b-synthase. Hum Mol Genet. 1998;7(3):371–8.
  • Choi DW. Glutamate neurotoxicity and diseases of the nervous system. Neuron. 1988;1:623–34.
  • Ankarcrona M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA, et al. Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron. 1995;15:961–73.
  • Andrich J, Saft C, Arz A, Schneider B, Agelink MW, Kraus PH, et al. Hyperhomocysteinaemia in treated patients with Huntington's disease. Mov Disord. 2004;19(2):226–8.
  • Ruck A, Kramer S, Metz J, Brennan MJ. Methyltetrahydrofolate is a potent and selective agonist for kainic acid receptors. Nature. 1980;287:852–3.
  • Larnaout A, Mongalgi MA, Kaabachi N, Khiari D, Debbabi A, Mebazza A. Methylmalonic acidaemia with bilateral globus pallidus involvement: a neuropathological study. J Inherit Metab Dis. 1998;21:639–44.
  • Higginbottom MC, Sweetman L, Nyhan WL. A syndrome of methylmalonic aciduria, homocystinuria, megaloblastic anemia and neurologic abnormalities in a vitamin B12-deficient breastfed infant of a strict vegetarian. N Engl J Med. 1978;299(7):317–23.
  • Kuhne T, Bubl R, Baumgartner R. Maternal vegan diet causing a serious infantile neurological disorder due to vitamin B12 deficiency. Eur J Pediatr. 1991;150(3):205–8.
  • Biancheri R, Cerone R, Schiaffino MC. Cobalamin (Cbl) C/D deficiency: clinical, neurophysiological and neuroradiological findings in 14 cases. Neuropediatrics. 2001;32:14–22.
  • Hamosh A, Johnston MV, Valle D. Non-ketotic hyperglycinemia. In: Scriver CR, Beaudet AL, Sly WS, Valle D, editors. The metabolic and molecular bases of inherited disease, 7th edn. New York, NY: McGraw-Hill; 1995. p. 1337–46.
  • Frazier DM, Summer GK, Chamberlin HR. Hyperglycinuria and hyperglycinemia in two siblings with mild developmental delays. Am J Dis Child. 1978;132(8):777–81.
  • May PC, Gray PN. l-Homocysteic acid as an alternative cytotoxin for studying glutamate-induced cellular degeneration of Huntington’s disease and normal skin fibroblasts. Life Sci. 1985;37:1483–9.
  • Skovby F, Kraus JP, Rosenberg LE. Biosynthesis and proteolytic activation of cystathionine b-synthase in rat liver. J Biol Chem. 1984;259:588.
  • Kang SS, Wong PWK. Genetic and nongenetic factors for moderate hyperhomocyst(e)inemia. Atherosclerosis. 1996;119:135–8.
  • Stollhoff K, Schulte FJ. Vitamin B12 and brain development. Eur J Pediatr. 1987;146:201–5.
  • Grasbeck R. Correspondence on “involuntary movements during vitamin B12 treatment”: was cyanocobalamin perhaps responsible? J Child Neurol. 2010;25:794–5.
  • Rowland LP, Pedley TA. Merritt’s neurology, 12th edn. Philadelphia: Lippincott Williams & Wilkins; 2010.
  • Chanarin I, Metz J. Diagnosis of cobalamin deficiency: the old and the new. Br J Haematol. 1997;97:695–700.
  • Incecik F, Herguner MO, Altunbasak S, Leblebisatan G. Neurologic findings of nutritional vitamin B12 deficiency in children. Turkish J Pediatr. 2010;52:17–21.
  • Chandra J, Jain V, Narayan S, Sharma S, Singh V, Batra S, et al. Tremors and thrombocytosis during treatment of megaloblastic anaemia. Ann Trop Paediatr. 2006;26:101–5.
  • Katar S, Ozbek MN, Yaramis A, Ecer S. Nutritional megaloblastic anemia in young Turkish children is associated with vitamin B12 deficiency and psychomotor retardation. J Pediatr Hematol Oncol. 2006;28:559–62.
  • Yavuz H. Vitamin B12 deficiency, seizure, involuntary movements. Seizure. 2008;17:748–9.
  • McPhee AJ, Davidson GP, Leahay M, Beare T. Vitamin B12 deficiency in a breast fed infant. Arch Dis Child. 1988;63:921–3

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