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Articles

Mechanisms of peripheral neuropathic pain: implications for musculoskeletal physiotherapy

Pages 313-323 | Published online: 19 Jul 2013

References

  • Campbell J, Meyer R. Mechanisms of neuropathic pain. Neuron 2006;52:77–92
  • Devor M. Sodium channels and mechanisms of neuropathic pain. J Pain 2006;7:S3–S12
  • Klein T, Magerl W, Rolke R, Treede R-D. Human surrogate models of neuropathic pain. Pain 2005;115:227–233
  • Devor M. Cellular processes associated with ectopia. Eur J Pain 2007;11:S10 (23)
  • Amir R, Argoff C, Bennett G, et al. The role of sodium channels in chronic inflammatory and neuropathic pain. J Pain 2006;7:S1–S29
  • Abrahams M. Neuropathic pain in soft tissue complaints. Best Pract Res Clin Rheumatol 2007;21:223–244
  • Cherny N. The treatment of neuropathic pain: from hubris to humility. Pain 2007;132:225–226
  • Hansson P. Difficulties in stratifying neuropathic pain by mechanisms. Eur J Pain 2003;7:353–357
  • Bennett G. Can we distinguish between inflammatory and neuropathic pain? Pain Res Manage 2006;11:11A–15A
  • Marchettini P, Lacerenza M, Mauri E, Marangoni C. Painful peripheral neuropathies. Curr Neuropharmacol 2006;4:175–181
  • Cousins M. Persistent pain: a disease entity. J Pain Symptom Manage 2007;33:S4–S10
  • Kehlet H, Jensen T, Woolf C. Persistent postsurgical pain: risk factors and prevention. Lancet 2006;367:1618–1625
  • Greening J. Workshop: clinical implications for clinicians treating patients with non-specific arm pain, whiplash and carpal tunnel syndrome. Man Ther 2006;11:171–172
  • Schwartzman R, Grothusen J. Brachial plexus traction injury: quantification of sensory abnormalities. Pain Med 2008;9:950–957.
  • Sterling M. Neuropathic components of acute whiplash pain. Eur J Pain 2007;11:S94 (214)
  • Butler D. The Sensitive Nervous System. Adelaide: Noigroup Publications 2000
  • Elvey R. Physical evaluation of the peripheral nervous system in disorders of pain and dysfunction. J Hand Ther 1997;10:122–129
  • Shacklock M. Improving application of neurodynamic (neural tension) testing and treatments: a message to researchers and clinicians. Man Ther 2005;10:175–179
  • Grieve’s Modern Manual Therapy: the Vertebral Column, (2nd ed) 2004; Edinburgh: Churchill Livingstone
  • Loeser JD. Review: Complementary therapies in rehabilitation, Davis CM (ed), Slack Inc. ISBN 1–55642–281–4. APS Bull 1997; 7(4):July/August.
  • Ochoa J, Torebjork E. Sensations evoked by intraneural microstimulation of single mechanoreceptor units innervating the human hand. J Physiol (London) 1983;342:633–654
  • Rasmussen P, Sindrup S, Jenesn T, Bach F. Symptoms and signs in patients with suspected neuropathic pain. Pain 2004;110:461–469
  • Bennett M, Attal N, Backonja M, et al. Using screening tools to identify neuropathic pain. Pain 2007;127:199–203
  • Rolke R, Baron R, Maier C, et al. Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values. Pain 2006a;123:231–243
  • Hansson P, Backonja M, Bouhassira D. Usefulness and limitations of quantitative sensory testing: Clinical and research application in neuropathic pain states. Pain 2007;129:256–259
  • Rolke R, Magerl W, Campbell K, et al. Quantitative sensory testing: a comprehensive protocol for clinical trials. Eur J Pain 2006b;10:77–88
  • Liu X, Eschenfelder S, Blenk K, et al. Spontaneous activity of axotomised afferent neurons after L5 spinal nerve injury in rats. Pain 2000;84:309–318
  • Michaelis M, Liu X, Janig W. Axotomised and intact muscle afferents but not skin afferents develop ongoing discharges of dorsal root ganglion origin after peripheral nerve lesion. J Neurosci 2000;20:2742–2748
  • Woolf C. Dissecting out mechanisms responsible for peripheral neuropathic pain: implications for diagnosis and therapy. Life Sci 2004a;74:2605–2610
  • Noguchi K, Kawai Y, Fukuoka T, et al. Substance P induced by peripheral nerve injury in primary afferent sensory neurons and its effect on dorsal column nucleus neurons. J Neurosci 1995;15:7633–7643
  • Allen B, Menning P, Rogers S, et al. Primary afferent fibers that contribute to increased substance P receptor internalization in the spinal cord after injury. J Neurophysiol 1999;81:1379–1390.
  • Klede M, Handwerker H, Schmelz M. Central origin of secondary Mechanical Hyperalgesia. J Neurophysiol 2003;90:353–359
  • Woolf C. Pain: moving from symptom control toward mechanism-specific pharmacologic management. Annals Int Med 2004b;140:441–451
  • Sun H, Ren K, Zhong C, et al. Nerve injury-induced tactile allodynia is mediated via ascending spinal dorsal column projections. Pain 2001;90:105–111
  • Hall T, Elvey R. Nerve trunk pain: physical diagnosis and treatment. Man Ther 1999;4:63–73
  • Sterling M, Treleaven J, Jull G. Responses to a clinical test of mechanical provocation of nerve tissue in whiplash associated disorders. Man Ther 2002;7:89–94
  • Linderoth B, Foreman R. Mechanisms of spinal cord stimulation in painful syndromes: role of animal models. Pain Med 2006;7:S14–S26
  • Ossipov M, Porreca F. Descending excitatory systems. Handbook Clin Neurol, Pain 2006;81:193–210
  • Serra J. Ectopic discharges in C-nociceptors as a cause of neuropathic pain. Eur J Pain 2007;11:S9 (21)
  • Gold M, Weinreich D, Kim C-S, et al. Redistribution of Nav 1.8 in uninjured axons enables neuropathic pain. J Neurosci 2003;23;158–166
  • Djouhri L, Koutsikou S, Fang X, et al. Spontaneous pain, both neuropathic and inflammatory, is related to frequency of spontaneous firing in intact C-fiber nociceptors. J Neurosci 2006;26:1281–1292
  • Uceyler N, Sommer C. Wallerian degeneration and neuropathic pain. Drug Disc Today: Dis Mechan 2006;3:351–256
  • Eliav E, Benoliel R, Tal M. Inflammation with no axonal damage of the rat saphenous nerve trunk induces ectopic discharge and mechanosensitivity in myelinated axons. Neurosci Lett 2001;311:49–52
  • Greening J. How inflammation and minor nerve injury contribute to pain in nerve root and peripheral neuropathies. In: Boyling J, Jull G (Eds) Grieve’s Modern Manual Therapy: the Vertebral Column, (3rd ed) 2004; Edinburgh: Churchill Livingstone pp 205–214
  • Hall T, Elvey R. Management of mechanosensitivity of the nervous system in spinal pain syndromes. In: Boyling J, Jull G (Eds) Grieve’s Modern Manual Therapy: the Vertebral Column, (3rd ed) 2004; Edinburgh: Churchill Livingstone pp 413–433
  • Vicenzino B, Wright A. Physical treatments. In: Strong J, Unrah A, Wright A, Baxter G (Eds) Pain: A Textbook for Therapists, 2002, Edinburgh: Churchill Livingstone pp 187–206.
  • Zusman M. Cognitive-behavioural components ofmusculoskeletal physiotherapy: the role of control. Phys Ther Rev 2005;10:89–98
  • Zusman M. Associative memory for movement-evoked chronic back pain and its extinction with musculoskeletal physiotherapy. Phys Ther Rev 2008;13:57
  • Chong M, Bajwa Z. Diagnosis and treatment of neuropathic pain. J Pain Symptom Manage 2003;25:S4–S11
  • Schofferman J. Restoration of function: the missing link in pain medicine? Pain Med 2006;7: S159–S165
  • Freynhagen R, Rolke R, Baron R, et al. Pseudoradicular and radicular low-back pain – a disease continuum rather than different entities? Answers from quantitative sensory testing. Pain 2008;135:63–74
  • Eliav E,Herzberg U, Ruda M, Bennett G. Neuropathic pain from an experimental neuritis of the rat sciatic nerve. Pain 1999;83:169–182
  • Bove G, Ransil B, Lin H, Leem J. Inflammation induces ectopic mechanical sensitivity in axons of nociceptors innervating deep tissues. J Neurophysiol 2003;90:1049–1955
  • Chacur M, Milligan E, Gazda L, et al. A new model of sciatic inflammatory neuritis (SIN): induction of unilateral and bilateral mechanical allodynia following acute unilateral peri-sciatic immune activation in rats. Pain 2001;94:231–244
  • Sorkin L, Xiao W, Wagner R, Myers R. Tumor necrosis factoralpha induces ectopic activity in nociceptive primary afferent fibers. Neuroscience 1997;81:255–262
  • Dilley A, Lynn B, Pang S. Pressure and stretch mechanosensitivity of peripheral nerve fibres following local inflammation of the nerve trunk. Pain 2005;117:462–472
  • Cummins T, Sheets P, Waxman S. The roles of sodium channels in nociception: implications for mechanisms of pain. Pain 2007;131:243–257
  • Sindrup S, Jensen T. Are sodium channel blockers useless in peripheral neuropathic pain? Pain 2007;128:6–7
  • Granot R, Day R, Cohen M, et al. Targeted pharmacotherapy of evoked phenomena in neuropathic pain: a review of the current evidence. Pain Med 2007;8:48–64
  • Markman J, Dworkin R. Ion channel targets and treatment efficacy in neuropathic pain. J Pain 2006;7:S38–S47
  • Lekan HA, Carlton SM, Coggeshall R. Sprouting of A beta fibers into lamina II of the rat dorsal horn in peripheral neuropathy. Neurosci Lett 1996;208:147–150
  • Woolf C, Shortland P, Coggeshall R. Peripheral nerve injury triggers central sprouting of myelinated afferents. Nature 1992;355:75–78
  • Woolf C, Doubell T. The pathophysiology of chronic pain: increased sensitivity to low threshold A beta-fibre inputs. Curr Opin Neurobiol 1994;4:525–534
  • Lee BH, Yoon YW, Chung KS, Chung JM. Comparison of sympathetic sprouting in sensory ganglia in three animal models of neuropathic pain. Exp Brain Res 1998;120:432–438
  • Ramer M, Thompson S, McMahon S. Causes and consequences of sympathetic basket formation in dorsal root ganglia. Pain 1999;Supp 6: S111–S120
  • Dworkin R, O’Connor A, Backonja M, et al. Pharmacologic management of neuropathic pain: evidence based recommendations. Pain 2007;132:237–251
  • Watkins L, Maier S. Immune regulation of central nervous system functions: from sickness responses to pathological pain. J Internal Med 2005;257:139–155
  • Ji R-R, Kohno T, Moore K, Woolf C. Central sensitisation and long-term potentiation: do pain and memory share similar mechanisms? Trends Neurosci 2003;26:696–705
  • Kohno T, Ji R, Ito N, et al. Peripheral axonal injury results in reduced mu opioid receptor pre-and post-synaptic action in the spinal cord. Pain 2005;117:77–87
  • Wiesenfeld-Hallin Z, Xu X. The role of cholecystokinin in nociception, neuropathic pain and opiate tolerance. Regul Pept 1996;65:23–28
  • Moore K, Kohno T, Karchewski L, et al. Partial peripheral nerve injury promotes a selective loss of GABAergic inhibition in the superficial dorsal horn of the spinal cord. J Neurosci 2003;15:6724–6731
  • Baba H, Ji R-R, Kohno T, et al. Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission in the superficial dorsal horn. Mol Cell Neurosci 2003;24:818–830
  • Kawasaki Y, Kohno T, Zhuang Z-Y, et al. Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and src contribute to C-fiber-induced ERK activation and camp response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitisation. JNeurosci 2004;24:8310–8321
  • Sandkuhler J. Understanding LTP in pain pathways. Mol Pain 2007 http://www.molecularpain.com.content/3/1/9
  • Treede R-D, Klein T, Magerl W. Pain memory and central sensitisation in humans. In: Flor H, Kalso E, Dostrovsky J (Eds ) Proceedings of the 11th World Congress on Pain, 2006, Seattle: IASP Press, 23, pp 251–267
  • Woolf C, Salter M. Neuronal plasticity: increasing the gain in pain. Science 2000;288:1765–1768
  • Sandkuhler J, Chen J, Cheng G, Randic M. Low-frequency stimulation of afferent Ad-fibers induces long-term depression at primary afferent synapses with substantia gelatinosa neurons in the rat. J Neurosci 1997;17:6483–6491
  • Zieglgansberger W. Chronic pain: neuroplasticity in limbic structures. Pain in Europe IV, Congress of EFIC, Prague, Czech Republic, September 2003: 117 <www.kenes.com/efic2003>
  • Millecamps M, Centeno M, Berra H, et al. D-Cycloserine reduces neuropathic pain behavior through limbic NMDA-mediated circuitry. Pain 2007;132:108–123
  • Klein T, Magerl W, Nickel U, et al. Effects of the NMDA-receptor antagonist ketamine on perceptual correlates of long-term potentiation within the nociceptive system. Neuropharmacol. 2007;52:655–661
  • Lang S, Klein T, Magerl W, Treede R-D. Modality specific sensory changes in humans after the induction of long-term potentiation (LTP) in cutaneous nociceptive pathways. Pain 2007;128:254–263
  • Neugebauer V, Li W, Bird G, Han J. The amygdala and persistent pain. Neuroscientist 2004;3;221–234
  • Willis W. Long-term potentiation in spinothalamic neurons. Brain Res Rev 2002;40:202–214
  • Pertovaara A, Almeida A. Descending inhibitory systems. Handbook Clin Neurol, Pain 2006;81:179–192
  • Quirk G. Extinction: new excitement for an old phenomenon. Biol Psych 2006;60:317–318
  • Maren S. Building and burying fear memories in the brain. Neuroscientist 2005;11:89–99
  • Neugebauer V. Subcortical processing ofnociceptive information: basal ganglia and amygdala. Handbook Clin Neurol, Pain 2006;81:141–158
  • Moss P, Sluka K, Wright A. The initial effects of knee joint mobilization on osteoarthritic hyperalgesia. Man Ther 2007; 12:109–118
  • Fanselow M, Poulos A. The neuroscience of mammalian associative learning. Ann Rev Psychol 2005;56:207–234
  • Frankland P, Teixeira C. A pain in the ACC. Molecular Pain 2005 http://www.molecularpain.com.content/1/1/14
  • Crombez G, Van Damme S, Eccleston C. Hypervigilance to pain: an experimental and clinical analysis. Pain 2005;116:4–7
  • Eccleston C, Crombez G. Pain demands attention: a cognitive-affective model on the interruptive function of pain. Psychol Bull 1999;125:356–366
  • Povedano M, Gascon J, Galvez R, et al. Cognitive function impairments in patients with neuropathic pain under standard conditions of care. J Pain Symptom Manage 2007;33:78–89
  • Shin L, Rauch S, Pitman R. Amygdala, medial prefrontal cortex, and hippocampal function in PTSD. Ann N Y Acad Sci 2006;1071:67–79
  • Kreitler S, Niv D. Cognitive impairment in chronic pain. Pain: Clin Updates 2007;XV(4)
  • Veldhuijzen D, Kenemans J, van Wijck, et al. Processing capacity in chronic pain patients: a visual events-related potentials study. Pain 121 : 60–68
  • Heinricher M. Central processing of pain: modulation of nociception. In Justins D (Ed) Pain 2005 – An Updated Review: Refresher Course Syllabus. Seattle:IASP Press, 6, pp 49–57
  • Calejesan A, Kim S, Zhuo M. Descending facilitatory modulation of a behavioral nociceptive response by stimulation in the adult rat anterior cingulate cortex. Eur J Pain 2000;4:83–96
  • Price DD. Psychological and neural mechanisms of the affective dimensions of pain. Science 2000;288:1769–1772
  • Ren K, Dubner R. Descending modulation in persistent pain: an update. Pain 2002;100:1–6
  • Suzuki R, Rygh L, Dickenson A. Bad news from the brain; descending 5HT pathways that control spinal pain processing. Trends Pharmacol Sci 2004a;25:613–617
  • Suzuki R, Rahman W, Hunt S, Dickenson A. Descending facilitatory control of mechanically evoked responses is enhanced in deep dorsal horn neurones following peripheral nerve injury. Brain Res 2004b;1019:68–76
  • Burgess S, Gardell L, Osipov, et al. Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain. J Neurosci 2002;22:5129–5136
  • Gardell L, Vanderah T, Gardell S, et al. (2003) Enhanced evoked excitatory transmitter release in experimental neuropathy requires descending facilitation. J Neurosci 2003;23:8370–8379
  • Mechaly I, Bourane S, Piquemal D, et al. Gene profiling during development and after a peripheral nerve traumatism reveals genes specifically induced by injury in dorsal root ganglia. Mol Cell Neurosci 2006;32:217–229
  • Costigan M, Befort K, Karchewski I, et al. Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury. BMC Neurosci 2002;3:16–34
  • Rabert D, Xiao Y, Yiangou Y, et al. Plasticity of gene expression in injured human dorsal root ganglia revealed by GeneChip oligonucleotide microarrays. J Clin Neurosci 2004;11:289–299
  • Wang H, Sun H, Della Penna R, et al. Chronic neuropathic pain is accompanied by global changes in gene expression and shares pathobiology with neurodegenerative diseases. Neurosci 2002;114:529–546
  • Ueda H. Molecular mechanisms of neuropathic pain – phenotypic switch and initiation mechanisms. Pharmacol Therap 2006;109:57–77
  • Moalem G, Tracey D. Immune and inflammatory mechanisms in neuropathic pain. Brain Res Rev 2006;51:240–264
  • Inoue K. Neuropathic pain and purinergic receptors: involvement of microglia. Curr Anaesth Crit Care 2005;16:313–318
  • Apkarian A, Lavarello S, Randolf A, et al. Expression of IL-1b in supraspinal brain regions in rats with neuropathic pain. Neurosci Lett 2006;407:176–181
  • Apkarian A, Scholz J. Shared mechanisms between chronic pain and neurodegenerative disease. Drug Disc Today: Dis Mechan 2006;3:319–326
  • Yuan J, Yankner B. Apoptosis in the nervous system. Nature 2000;407:802–809
  • Maione S. Over-expression of pro-apoptotic genes and morphological changes in dorsal horn lamina II in a model ofneuropathic pain in rats. Eur J Pain 2006;10:S6 (19).
  • Siniscalco D, Fuccio C, Giordano C, et al. Role of reactive oxygen species and spinal cord apoptotic genes in the development of neuropathic pain. Pharmacol Res 2007;55:158–166
  • Scholz J, Broom D, Youn D-H, et al. Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibitions in lamina II of the dorsal horn after peripheral nerve injury. J Neurosci 2005;25:7317–7323
  • Haythornthwaite J, Benrud-Larson L. Psychological aspects of neuropathic pain. Clin J Pain 2000;16:S101-S105
  • Schmidt-Wilke T, Leinisch E, Ganssbauer B, et al. Affective components and intensity of pain correlate with structural differences in gray matter in chronic back patients. Pain 2006;125:89–97
  • Grachev I, Fredickson B, Apkarian A. Dissociating anxiety from pain: mapping the neuronal marker N-acetyl aspartate to perception distinguishes closely interrelated characteristics of chronic pain. Mol Psych 2001;6:256–258
  • Perkins F, Kehlet H. Chronic pain as an outcome of surgery: a review of predictive factors. Anesthesiol 2000;93:1123–1133
  • de Leon-Casasola O. Multimodal approaches to the management of neuropathic pain: the role of topical analgesia. J Pain Symptom Manage 2007;33:356–364

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