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Antimicrobial Original Research Paper

Risk factors for colonization with ampicillin and high-level aminoglycoside-resistant enterococci during hospitalization in the ICU and the impact of prior antimicrobial exposure definition: a prospective cohort study

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References

  • Sievert DM, Ricks P, Edwards JR, Schneider A, Patel J, Srinivasan A, . Antimicrobial-resistant pathogens associated with healthcare-associated infections: summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009–2010. Infect Control Hosp Epidemiol. 2013;34(1):1–14.
  • Arias CA, Contreras GA, Murray BE. Management of multidrug-resistant enterococcal infections. Clin Microbiol Infect. 2010;16(6):555–62.
  • Safdar N, Maki DG. The commonality of risk factors for nosocomial colonization and infection with antimicrobial-resistant Staphylococcus aureus, enterococcus, Gram-negative bacilli, Clostridium difficile, and Candida. Ann Intern Med. 2002;136(11):834–44.
  • Monnet DL, Archibald LK, Phillips L, Tenover FC, McGowan JE Jr, Gaynes RP. Antimicrobial use and resistance in eight US hospitals: complexities of analysis and modeling. Intensive Care Antimicrobial Resistance Epidemiology Project and National Nosocomial Infections Surveillance System Hospitals. Infect Control Hosp Epidemiol. 1998;19(6):388–94.
  • Archibald L, Phillips L, Monnet D, McGowan JE Jr, Tenover F, Gaynes R. Antimicrobial resistance in isolates from inpatients and outpatients in the United States: increasing importance of the intensive care unit. Clin Infect Dis. 1997;24(2):211–5.
  • Austin DJ, Kristinsson KG, Anderson RM. The relationship between the volume of antimicrobial consumption in human communities and the frequency of resistance. Proc Natl Acad Sci USA. 1999;96(3):1152–6.
  • Hyle EP, Bilker WB, Gasink LB, Lautenbach E. Impact of different methods for describing the extent of prior antibiotic exposure on the association between antibiotic use and antibiotic-resistant infection. Infect Control Hosp Epidemiol. 2007;28(6):647–54.
  • Hyle EP, Gasink LB, Linkin DR, Bilker WB, Lautenbach E. Use of different thresholds of prior antimicrobial use in defining exposure: impact on the association between antimicrobial use and antimicrobial resistance. J Infect. 2007;55(5):414–8.
  • Turnidge J, Christiansen K. Antibiotic use and resistance–proving the obvious. Lancet. 2005;365(9459):548–9.
  • Rodriguez-Bano J, Ramirez E, Muniain MA, Santos J, Joyanes P, Gonzalez F, . Colonization by high-level aminoglycoside-resistant enterococci in intensive care unit patients: epidemiology and clinical relevance. J Hosp Infect. 2005;60(4):353–9.
  • Axelrod P, Talbot GH. Risk factors for acquisition of gentamicin-resistant enterococci. A multivariate analysis. Arch Intern Med. 1989;149(6):1397–401.
  • Handwerger S, Raucher B, Altarac D, Monka J, Marchione S, Singh KV, . Nosocomial outbreak due to Enterococcus faecium highly resistant to vancomycin, penicillin, and gentamicin. Clin Infect Dis. 1993;16(6):750–5.
  • Harthug S, Jureen R, Mohn SC, Digranes A, Simonsen GS, Sundsfjord A, . The prevalence of faecal carriage of ampicillin-resistant and high-level gentamicin-resistant enterococci among inpatients at 10 major Norwegian hospitals. J Hosp Infect. 2002;50(2):145–54.
  • Mohn SC, Harthug S, Langeland N. Outbreak of ampicillin-resistant Enterococcus faecium — risk factors for faecal colonisation. APMIS. 2000;108(4):296–302.
  • Torell E, Cars O, Hambraeus A. Ampicillin-resistant enterococci in a Swedish university hospital: nosocomial spread and risk factors for infection. Scand J Infect Dis. 2001;33(3):182–7.
  • Weinstein JW, Roe M, Towns M, Sanders L, Thorpe JJ, Corey GR, . Resistant enterococci: a prospective study of prevalence, incidence, and factors associated with colonization in a university hospital. Infect Control Hosp Epidemiol. 1996;17(1):36–41.
  • Wells VD, Wong ES, Murray BE, Coudron PE, Williams DS, Markowitz SM. Infections due to beta-lactamase-producing, high-level gentamicin-resistant Enterococcus faecalis. Ann Intern Med. 1992;116(4):285–92.
  • Fortun J, Coque TM, Martin-Davila P, Moreno L, Canton R, Loza E, . Risk factors associated with ampicillin resistance in patients with bacteraemia caused by Enterococcus faecium. J Antimicrob Chemother. 2002;50(6):1003–9.
  • Clinical and Laboratory Standards Institute (CLSI). Performance standards for antimicrobial susceptibility testing; 18th informational supplement (M100-S18) 2008. Wayne (PA): Clinical and Laboratory Standards Institute; 2008.
  • Murray BE, Singh KV, Heath JD, Sharma BR, Weinstock GM. Comparison of genomic DNAs of different enterococcal isolates using restriction endonucleases with infrequent recognition sites. J Clin Microbiol. 1990;28(9):2059–63.
  • Tenover FC, Arbeit RD, Goering RV, Mickelsen PA, Murray BE, Persing DH, . Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol. 1995;33(9):2233–9.
  • Zarrilli R, Tripodi MF, Di Popolo A, Fortunato R, Bagattini M, Crispino M, . Molecular epidemiology of high-level aminoglycoside-resistant enterococci isolated from patients in a university hospital in southern Italy. J Antimicrob Chemother. 2005;56(5):827–35.
  • R Development Core Team. R: a language and environment for statistical computing [document on the Internet]. Vienna: R Foundation for Statistical Computing; 2012 [updated 2012 Oct 26; cited 2012 Dec 16]. Available from: http://www.R-project.org
  • Caballero-Granado FJ, Cisneros JM, Luque R, Torres-Tortosa M, Gamboa F, Diez F, . Comparative study of bacteremias caused by Enterococcus spp. with and without high-level resistance to gentamicin. The Grupo Andaluz para el estudio de las Enfermedades Infecciosas. J Clin Microbiol. 1998;36(2):520–5.
  • McCarthy AE, Victor G, Ramotar K, Toye B. Risk factors for acquiring ampicillin-resistant enterococci and clinical outcomes at a Canadian tertiary-care hospital. J Clin Microbiol. 1994;32(11):2671–6.
  • Vigani AG, Oliveira AM, Bratfich OJ, Stucchi RS, Moretti ML. Clinical, epidemiological, and microbiological characteristics of bacteremia caused by high-level gentamicin-resistant Enterococcus faecalis. Braz J Med Biol Res. 2008;41(10):890–5.
  • Tenover FC, McGowan JE Jr. Reasons for the emergence of antibiotic resistance. Am J Med Sci. 1996;311(1):9–16.
  • Adembri C, Novelli A. Pharmacokinetic and pharmacodynamic parameters of antimicrobials: potential for providing dosing regimens that are less vulnerable to resistance. Clin Pharmacokinet. 2009;48(8):517–28.
  • Royston P, Altman DG, Sauerbrei W. Dichotomizing continuous predictors in multiple regression: a bad idea. Stat Med. 2006;25(1):127–41.
  • Papaparaskevas J, Vatopoulos A, Tassios PT, Avlami A, Legakis NJ, Kalapothaki V. Diversity among high-level aminoglycoside-resistant enterococci. J Antimicrob Chemother. 2000;45(3):277–83.
  • van Den Braak N, van Belkum A, Kreft D, te Witt R, Verbrugh HA, Endtz HP. The prevalence and clonal expansion of high-level gentamicin-resistant enterococci isolated from blood cultures in a Dutch university hospital. J Antimicrob Chemother. 1999;44(6):795–8.

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