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Antimicrobial Original Research Papers

Recombinant murine IL-12 promotes a protective Th1/cellular response in Mongolian gerbils infected with Sporothrix schenckii

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References

  • Barros MB, de Almeida Paes R, Schubach AO. Sporothrix schenckii and sporotrichosis. Clin Microbiol Rev. 2011;24:633–54.
  • Galhardo MC, Silva MT, Lima MA, Nunes EP, Schettini LE, de Freitas RF, et al. Sporothrix schenckii in AIDS during immune reconstitution syndrome. J Neurol Neurosurg Psychiatry. 2010;81:696–9.
  • Carlos IZ, Sassá MF, da Graça Sgarbi DB, Placeres MC, Maia DC. Current research on the immune response to experimental sporotrichosis. Immunology. 2009;168:1–10.
  • Fernandes KS, Neto EH, Brito MM, Silva JS, Cunha FQ, Barja-Fidalgo C. Detrimental role of endogenous nitric oxide in host defence against Sporothrix schenckii. Immunology. 2008;123:469–79.
  • Sassá MF, Saturi AE, Souza LF, Ribeiro LC, Sgarbi DB, Carlos IZ. Response of macrophage Toll-like receptor 4 to a Sporothrix schenckii lipid extract during experimental sporotrichosis. Immunology. 2009;128:301–9.
  • Tachibana T, Matsuyama T, Mitsuyama M. Involvement of CD4+ T cells and macrophages in acquired protection against infection with Sporothrix schenckii in mice. Med Mycol. 1999;37:397–404.
  • Uenotsuchi T, Takeuchi S, Matsuda T, Urabe K, Koga T, Uchi H, et al. Differential induction of Th1-prone immunity by human dendritic cells activated with Sporothrix schenckii of cutaneous and visceral origins to determine their different virulence. Int Immunol. 2006;18:1637–46.
  • Maia DC, Sassá MF, Placeres MC, Carlos IZ. Influence of Th1/Th2 cytokines and nitric oxide in murine systemic infection induced by Sporothrix schenckii. Mycopathologia. 2006;161:11–9.
  • Hamza T, Barnett JB, Li B. Interleukin-12 a key immunoregulatory cytokine in infection applications. Int J Mol Sci. 2010;11:789–806.
  • O'Garra A, Murphy KM. From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce T(H)1 development. Nat Immunol. 2009;10:929–32.
  • Zhou P, Sieve MC, Tewari RP, Seder RA. Interleukin-12 modulates the protective immune responses in SCID mice infected with Histoplasma capsulatum. Infect Immun. 1997;65:936–42.
  • Magee DM, Cox RA. Interleukin-12 regulation of host defenses against Coccidioides immitis. Infect Immun. 1996;64:3609–13.
  • Hernández-Flores G, Gómez-Contreras PC, Domínguez-Rodríguez JR, Lerma-Díaz JM, Ortíz-Lazareno PC, Cervantes-Munguía R, et al. γ-Irradiation induced apoptosis in peritoneal macrophages by oxidative stress. Implications of antioxidants in caspase mitochondrial pathway. Anticancer Res. 2005;25:4091–100.
  • Fernandes KS, Coelho AL, Lopes Bezerra LM, Barja-Fidalgo C. Virulence of Sporothrix schenckii conidia and yeast cells, and their susceptibility to nitric oxide. Immunology. 2000;101:563–9.
  • Bravo-Cuellar A, Balercia G, Levesque JP, Liu XH, Osculati F, Orbach-Arbouys S. Enhanced activity of peritoneal cells after aclacinomycin injection: effect of pretreatment with superoxide dismutase on aclacinomycin-induced cytological alterations and antitumoral activity. Cancer Res. 1989;49:1578–86.
  • Flores-García A, Garibaldi-Becerra V, Barba-Barajas M, Velarde-Félix S, Fernandez-Argüelles R. Endogenous interleukin-12 regulates macrophage phagocytosis of Sporothrix schenckii. Rev Fac Cien Med (Quito). 2010;35:56–7.
  • Carlos IZ, Sgarbi DB, Santos GC, Placeres MC. Sporothrix schenckii lipid inhibits macrophage phagocytosis: involvement of nitric oxide and tumor necrosis factor-alpha. Scand J Immunol. 2003;57:214–20.
  • Kim JS, Kwon HY, Choi WH, Jeon CY, Kim JI, Kim J, et al. Phagocytosis of serum- and IgG-opsonized zymosan particles induces apoptosis through superoxide but not nitric oxide in macrophage J774A.1. Exp Mol Med. 2003;35:211–21.
  • Ramos-Zepeda R, González-Mendoza A. Metabolic activity of phagocytes in experimental sporotrichosis. Mycopathologia. 1986;93:109–12.
  • Kobayashi K, Kaneda K, Kasama T. Immunopathogenesis of delayed-type hypersensitivity. Microsc Res Tech. 2001;53:241–5.
  • Ruan S, McKinley L, Zheng M, Rudner X, D’Souza A, Kolls JK, et al. Interleukin-12 and host defense against murine Pneumocystis pneumonia. Infect Immun. 2008;76:2130–7.
  • Zhang CR, Lin JC, Xu WM, Li M, Ye HS, Cui WL, et al. Interleukin-12 and interleukin-2 alone or in combination against the infection in invasive pulmonary aspergillosis mouse model. Mycoses. 2013;56:117–22.
  • Lavigne LM, Schopf LR, Chung CL, Maylor R, Sypek JP. The role of recombinant murine IL-12 and IFN-γ in the pathogenesis of a murine systemic Candida albicans infection. J Immunol. 1998;160:284–92.
  • Sun K, Salmon SL, Lotz SA, Metzger DW. Interleukin-12 promotes gamma interferon-dependent neutrophil recruitment in the lung and improves protection against respiratory Streptococcus pneumoniae infection. Infect Immun. 2007;75:1196–202.
  • Liu Y, Egilmez NK, Russell MW. Enhancement of adaptive immunity to Neisseria gonorrhoeae by local intravaginal administration of microencapsulated interleukin 12. J Infect Dis. 2013;208:1821–9.
  • Lenzi R, Edwards R, June C, Seiden MV, Garcia ME, Rosenblum M, et al. Phase II study of intraperitoneal recombinant interleukin-12 (rhIL-12) in patients with peritoneal carcinomatosis (residual disease<1 cm) associated with ovarian cancer or primary peritoneal carcinoma. J Transl Med. 2007;5:66.
  • Hedlund J, Langer B, Konradsen HB, Ortqvist A. Negligible adjuvant effect for antibody responses and frequent adverse events associated with IL-12 treatment in humans vaccinated with pneumococcal polysaccharide. Vaccine. 2001;20:164–9.
  • De Luca, Zelante T, D’Angelo C, Zagarella S, Fallarino F, Spreca A, et al. IL-22 defines a novel immune pathway of antifungal resistance. Mucosal Immunol. 2010;3:361–73.
  • Zhang X, Zhang J, Huang H, Xue R, Hu X, Li M, et al. Taenia taeniaeformis in rat favors protracted skin lesions caused by Sporothrix schenckii infection: Dectin-1 and IL-17 are dispensable for clearance of this fungus. PLoS ONE. 2012;7:e52514.
  • Gaucher D, Chadee K. Molecular cloning of gerbil interleukin 12 and its expression as bioactive single-chain protein. Cytokine. 2001;14:177–83.
  • Crabtree JE, Court M, Aboshkiwa MA, Jeremy AHT, Dixon MF, Robinson PA. Gastric mucosal cytokine and epithelial cell responses to Helicobacter pylori infection in Mongolian gerbils. J Pathol. 2004;202:197–207.

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