Prevalence and antimicrobial resistance among Gram-negative pathogens in Saudi Arabia

References

• Giske CG, Monnet DL, Cars O, Carmeli Y. Clinical and economic impact of common multidrug-resistant Gram-negative bacilli. Antimicrob Agents Chemother. 2008;52:813–21.
   PubMed Web of Science ®Google Scholar
• Yezli S, Shibl AM, Livermore DM, Memish ZA. Antimicrobial resistance among Gram-positive pathogens in Saudi Arabia. J Chemother. 2012;24:125–36.
   PubMed Web of Science ®Google Scholar
• Yezli S, Memish ZA. Tuberculosis in Saudi Arabia: prevalence and antimicrobial resistance. J Chemother. 2012;24:1–5.
   PubMed Web of Science ®Google Scholar
• Yong D, Toleman MA, Giske CG, Cho HS, Sundman K, Lee K, et al. Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrob Agents Chemother. 2009;53:5046–54.
   PubMed Web of Science ®Google Scholar
• Abubakar I, Gautret P, Brunette GW, Blumberg L, Johnson D, Poumerol G, et al. Global perspectives for prevention of infectious diseases associated with mass gatherings. Lancet Infect Dis. 2012;12:66–74.
   PubMed Web of Science ®Google Scholar
• Memish ZA, Stephens GM, Steffen R, Ahmed QA. Emergence of medicine for mass gatherings: lessons from the Hajj. Lancet Infect Dis. 2012;12:56–65.
   PubMed Web of Science ®Google Scholar
• Salama OE. A study of nosocomial infection in a general hospital. J Egypt Public Health Assoc. 1996;71:31–46.
   PubMedGoogle Scholar
• Abussaud MJ. Prevalence of nosocomial infections in a Saudi Arabian teaching hospital. J Hosp Infect. 1991;17:235–8.
   PubMed Web of Science ®Google Scholar
• Al-Ghamdi S, El-Morsy F, Al-Mustafa ZH. Patterns of resistance to antibiotics at King Fahd Hospital of the University. J Family Community Med. 1999;6:43–50.
   PubMedGoogle Scholar
• Akhtar N, Alqurashi AM, Abu TM. In vitro ciprofloxacin resistance profiles among Gram-negative bacteria isolated from clinical specimens in a teaching hospital. J Pak Med Assoc. 2010;60:625–7.
   PubMed Web of Science ®Google Scholar
• Al-Ghamdi S, Gedebou M, Bilal NE. Nosocomial infections and misuse of antibiotics in a provincial community hospital, Saudi Arabia. J Hosp Infect. 2002;50:115–21.
   PubMed Web of Science ®Google Scholar
• Asghar AH. Frequency and antimicrobial susceptibility patterns of bacterial pathogens isolated from septicemic patients in Makkah hospitals. Saudi Med J. 2006;27:361–7.
   PubMed Web of Science ®Google Scholar
• Abussaud MJ. Incidence of wound infection in three different departments and the antibiotic sensitivity pattern of the isolates in a Saudi Arabian hospital. Acta Microbiol Immunol Hung. 1996;43:301–5.
   PubMedGoogle Scholar
• Twum-Danso K, Grant C, al-Suleiman SA, Abdel-Khader S, al-Awami MS, al-Breiki H, et al. Microbiology of postoperative wound infection: a prospective study of 1770 wounds. J Hosp Infect. 1992;21:29–37.
   PubMed Web of Science ®Google Scholar
• Qadri SM, Lee GC, Ueno Y, Burdette JM. Incidence of bacterial respiratory pathogens and their susceptibility to common antibacterial agents. J Natl Med Assoc. 1993;85:388–90.
   PubMed Web of Science ®Google Scholar
• Banjar HH. Clinical profile of Saudi children with bronchiectasis. Indian J Pediatr. 2007;74:149–52.
   PubMed Web of Science ®Google Scholar
• Al-Harthi AA, Al-Fifi SH. Antibiotic resistance pattern and empirical therapy for urinary tract infections in children. Saudi Med J. 2008;29:854–8.
   PubMed Web of Science ®Google Scholar
• Ahmad S, Ahmad F. Urinary tract infection at a specialist hospital in Saudi Arabia. Bangladesh Med Res Counc Bull. 1995;21:95–8.
   PubMedGoogle Scholar
• Al-Tawfiq JA, Anani AA. Antimicrobial susceptibility pattern of bacterial pathogens causing urinary tract infections in a Saudi Arabian hospital. Chemotherapy. 2009;55:127–31.
   PubMed Web of Science ®Google Scholar
• Al-Tawfiq JA, Abed MS. Prevalence and antimicrobial resistance of health care associated bloodstream infections at a general hospital in Saudi Arabia. Saudi Med J. 2009;30:1213–8.
   PubMed Web of Science ®Google Scholar
• Almuneef MA, Memish ZA, Balkhy HH, Hijazi O, Cunningham G, Francis C. Rate, risk factors and outcomes of catheter-related bloodstream infection in a paediatric intensive care unit in Saudi Arabia. J Hosp Infect. 2006;62:207–13.
   PubMed Web of Science ®Google Scholar
• Babay HA. Bacterial isolates from fatal cases of bloodstream infections at a university hospital in Central, Saudi Arabia. Saudi Med J. 2007;28:231–5.
   PubMed Web of Science ®Google Scholar
• Strateva T, Yordanov D. Pseudomonas aeruginosa – a phenomenon of bacterial resistance. J Med Microbiol. 2009;58:1133–48.
   PubMed Web of Science ®Google Scholar
• Lister PD, Wolter DJ, Hanson ND. Antibacterial-resistant Pseudomonas aeruginosa: clinical impact and complex regulation of chromosomally encoded resistance mechanisms. Clin Microbiol Rev. 2009;22:582–610.
   PubMed Web of Science ®Google Scholar
• Qadri SM, Ostrawski S, Johnson S, Flournoy DJ. Differences in antimicrobial susceptibilities of clinical isolates in Saudi Arabia and the United States. J Natl Med Assoc. 1987;79:433–7.
   PubMed Web of Science ®Google Scholar
• Qadri SM, Rizvi WH, Rahman SA, al-Dayel F, Flournoy DJ. Saudi Arabian-American differences in antimicrobial resistance of Escherichia, Klebsiella, and Pseudomonas. J Natl Med Assoc. 1989;81:1061–4.
   PubMed Web of Science ®Google Scholar
• Al-Tawfiq JA. Occurrence and antimicrobial resistance pattern of inpatient and outpatient isolates of Pseudomonas aeruginosa in a Saudi Arabian hospital: 1998–2003. Int J Infect Dis. 2007;11:109–14.
   PubMed Web of Science ®Google Scholar
• Qadri SM, Cunha BA, Ueno Y, Abumustafa F, Imambaccus H, Tullo DD, et al. Activity of cefepime against nosocomial blood culture isolates. J Antimicrob Chemother. 1995;36:531–6.
   PubMed Web of Science ®Google Scholar
• Babay HA. Antimicrobial resistance among clinical isolates of Pseudomonas aeruginosa from patients in a teaching hospital, Riyadh, Saudi Arabia, 2001–2005. Jpn J Infect Dis. 2007;60:123–5.
   PubMed Web of Science ®Google Scholar
• Al-Jasser AM, Elkhizzi NA. Antimicrobial susceptibility pattern of clinical isolates of Pseudomonas aeruginosa. Saudi Med J. 2004;25:780–4.
   PubMed Web of Science ®Google Scholar
• Saeed NK, Kambal AM, El-Khizzi NA. Antimicrobial-resistant bacteria in a general intensive care unit in Saudi Arabia. Saudi Med J. 2010;31:1341–9.
   PubMed Web of Science ®Google Scholar
• Tam VH, Gamez EA, Weston JS, Gerard LN, Larocco MT, Caeiro JP, et al. Outcomes of bacteremia due to Pseudomonas aeruginosa with reduced susceptibility to piperacillin-tazobactam: implications on the appropriateness of the resistance breakpoint. Clin Infect Dis. 2008;46:862–7.
   PubMed Web of Science ®Google Scholar
• Ahmad S, Ahmad F, Shawky M, Gugnani HC. Antibiotic sensitivity of isolates of Pseudomonas aeruginosa in Buraidah, Saudi Arabia. J Commun Dis. 1995;27:151–4.
   PubMedGoogle Scholar
• Kader AA, Kumar A, Dass SM. Antimicrobial resistance patterns of Gram-negative bacteria isolated from urine cultures at a general hospital. Saudi J Kidney Dis Transpl. 2004;15:135–9.
   PubMedGoogle Scholar
• Memish ZA, Shibl AM, Kambal AM, Ohaly YA, Ishaq A, Livermore DM. Antimicrobial resistance among non-fermenting Gram-negative bacteria in Saudi Arabia. J Antimicrob Chemother. 2012;67:1701–5.
   PubMed Web of Science ®Google Scholar
• Abo-Shadi MA, Al-Johani AA, Bahashwan AA. Antimicrobial resistance in pathogens causing pediatrics bloodstream infections in a Saudi hospital. Br Microbiol Res J. 2012;2:212–27.
   Google Scholar
• Eltahawy AT, Khalaf RM. Antibiotic resistance among Gram-negative non-fermentative bacteria at a teaching hospital in Saudi Arabia. J Chemother. 2001;13:260–4.
   PubMed Web of Science ®Google Scholar
• Begum NN, Al-Khattaf AS, Al-Mansouri SM, Yeboah EA, Kambal AM. A study of bacterial isolates from corneal specimens and their antibiotic resistance profile. Saudi Med J. 2006;27:41–5.
   PubMed Web of Science ®Google Scholar
• Chowdhury MN. Antibiotic sensitivity pattern; experience at University Hospital, Riyadh, Saudi Arabia. J Hyg Epidemiol Microbiol Immunol. 1991;35:289–301.
   PubMedGoogle Scholar
• Moaz A, Shannon K, Phillips I. Mechanisms of gentamicin resistance in Gram-negative bacilli in Riyadh, Kingdom of Saudi Arabia. J Antimicrob Chemother. 1989;24:689–98.
   PubMed Web of Science ®Google Scholar
• Al-Agamy MH, Shibl AM, Tawfik AF, Elkhizzi NA, Livermore DM. Extended-spectrum and metallo-beta-lactamases among ceftazidime-resistant Pseudomonas aeruginosa in Riyadh, Saudi Arabia. J Chemother. 2012;24:97–100.
   PubMed Web of Science ®Google Scholar
• Kader AA, Angamuthu K. Extended-spectrum beta-lactamases in urinary isolates of Escherichia coli, Klebsiella pneumoniae and other Gram-negative bacteria in a hospital in Eastern Province, Saudi Arabia. Saudi Med J. 2005;26:956–9.
   PubMed Web of Science ®Google Scholar
• Guerin F, Henegar C, Spiridon G, Launay O, Salmon-Ceron D, Poyart C. Bacterial prostatitis due to Pseudomonas aeruginosa harbouring the blaVIM-2 metallo-{beta}-lactamase gene from Saudi Arabia. J Antimicrob Chemother. 2005;56:601–2.
   PubMed Web of Science ®Google Scholar
• Cheer SM, Waugh J, Noble S. Inhaled tobramycin (TOBI): a review of its use in the management of Pseudomonas aeruginosa infections in patients with cystic fibrosis. Drugs. 2003;63:2501–20.
   PubMed Web of Science ®Google Scholar
• Poole K. Aminoglycoside resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2005;49:479–87.
   PubMed Web of Science ®Google Scholar
• Neuhauser MM, Weinstein RA, Rydman R, Danziger LH, Karam G, Quinn JP. Antibiotic resistance among Gram-negative bacilli in US intensive care units: implications for fluoroquinolone use. JAMA. 2003;289:885–8.
   PubMed Web of Science ®Google Scholar
• Lei YC, Wang HB, Sun ZY, Shen ZY. Susceptibility of 570 Pseudomonas aeruginosa strains to 11 antimicrobial agents and the mechanism of its resistance to fluoroquinolones. Zhonghua Yi Xue Za Zhi. 2003;83:403–7.
   PubMedGoogle Scholar
• Somily AM, Absar MM, Arshad MZ, Al Aska AI, Shakoor ZA, Fatani AJ, et al. Antimicrobial susceptibility patterns of multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii against carbapenems, colistin, and tigecycline. Saudi Med J. 2012;33:750–5.
   PubMed Web of Science ®Google Scholar
• Al Johani SM, Akhter J, Balkhy H, El-Saed A, Younan M, Memish Z. Prevalence of antimicrobial resistance among Gram-negative isolates in an adult intensive care unit at a tertiary care center in Saudi Arabia. Ann Saudi Med. 2010;30:364–9.
   PubMed Web of Science ®Google Scholar
• Kader AA, Kumar AK. Prevalence of extended spectrum beta-lactamase among multidrug resistant Gram-negative isolates from a general hospital in Saudi Arabia. Saudi Med J. 2004;25:570–4.
   PubMed Web of Science ®Google Scholar
• Perez F, Hujer AM, Hujer KM, Decker BK, Rather PN, Bonomo RA. Global challenge of multidrug-resistant Acinetobacter baumannii. Antimicrob Agents Chemother. 2007;51:3471–84.
   PubMed Web of Science ®Google Scholar
• Nordmann P. Acinetobacter baumannii, the nosocomial pathogen par excellence. Pathol Biol. 2004;52:301–3.
   PubMed Web of Science ®Google Scholar
• Gootz TD, Marra A. Acinetobacter baumannii: an emerging multidrug-resistant threat. Expert Rev Anti Infect Ther. 2008;6:309–25.
   PubMed Web of Science ®Google Scholar
• Montefour K, Frieden J, Hurst S, Helmich C, Headley D, Martin M, et al. Acinetobacter baumannii: an emerging multidrug-resistant pathogen in critical care. Crit Care Nurse. 2008;28:15–25.
   PubMed Web of Science ®Google Scholar
• Munoz-Price LS, Weinstein RA. Acinetobacter infection. N Engl J Med. 2008;358:1271–81.
   PubMed Web of Science ®Google Scholar
• Gordon NC, Wareham DW. Multidrug-resistant Acinetobacter baumannii: mechanisms of virulence and resistance. Int J Antimicrob Agents. 2010;35:219–26.
   PubMed Web of Science ®Google Scholar
• Jones A, Morgan D, Walsh A, Turton J, Livermore D, Pitt T, et al. Importation of multidrug-resistant Acinetobacter spp. infections with casualties from Iraq. Lancet Infect Dis. 2006;6:317–8.
   PubMed Web of Science ®Google Scholar
• Turton JF, Kaufmann ME, Gill MJ, Pike R, Scott PT, Fishbain J, et al. Comparison of Acinetobacter baumannii isolates from the United Kingdom and the United States that were associated with repatriated casualties of the Iraq conflict. J Clin Microbiol. 2006;44:2630–4.
   PubMed Web of Science ®Google Scholar
• Stuart TL, Mulvey M, Simor AE, Tien HC, Battad A, Taylor G, et al. Acinetobacter baumannii in casualties returning from Afghanistan. Can J Infect Control. 2007;22:152–4.
   PubMedGoogle Scholar
• Asghar AH, Faidah HS. Frequency and antimicrobial susceptibility of Gram-negative bacteria isolated from 2 hospitals in Makkah, Saudi Arabia. Saudi Med J. 2009;30:1017–23.
   PubMed Web of Science ®Google Scholar
• Mah MW, Memish ZA, Cunningham G, Bannatyne RM. Outbreak of Acinetobacter baumannii in an intensive care unit associated with tracheostomy. Am J Infect Control. 2001;29:284–8.
   PubMed Web of Science ®Google Scholar
• Manzar S. Outbreak of multidrug resistant Acinetobacter in the neonatal intensive care unit. Saudi Med J. 2004;25:961–3.
   PubMed Web of Science ®Google Scholar
• Al SN, Memish ZA, Cherfan A, Al SA. Post-neurosurgical meningitis due to multidrug-resistant Acinetobacter baumannii treated with intrathecal colistin: case report and review of the literature. J Chemother. 2006;18:554–8.
   PubMed Web of Science ®Google Scholar
• Bukhary Z, Mahmood W, Al-Khani A, Al-Abdely HM. Treatment of nosocomial meningitis due to a multidrug resistant Acinetobacter baumannii with intraventricular colistin. Saudi Med J. 2005;26:656–8.
   PubMed Web of Science ®Google Scholar
• Hamidian M, Hall RM. ISAba1 targets a specific position upstream of the intrinsic ampC gene of Acinetobacter baumannii leading to cephalosporin resistance. J Antimicrob Chemother. 2013;68:2682–3.
   PubMed Web of Science ®Google Scholar
• Al-Tawfiq JA, Mohandhas TX. Prevalence of antimicrobial resistance in Acinetobacter calcoaceticus–baumannii complex in a Saudi Arabian hospital. Infect Control Hosp Epidemiol. 2007;28:870–2.
   PubMed Web of Science ®Google Scholar
• Balkhy HH, Bawazeer MS, Kattan RF, Tamim HM, Al Johani SM, Aldughashem FA, et al. Epidemiology of Acinetobacter spp.-associated healthcare infections and colonization among children at a tertiary-care hospital in Saudi Arabia: a 6-year retrospective cohort study. Eur J Clin Microbiol Infect Dis. 2012;31:2645–51.
   PubMed Web of Science ®Google Scholar
• Alsultan AA, Evans BA, Elsayed EA, Al-Thawadi SI, Al-Taher AY, Amyes SG, et al. High frequency of carbapenem-resistant Acinetobacter baumannii in patients with diabetes mellitus in Saudi Arabia. J Med Microbiol. 2013;62:885–8.
   PubMed Web of Science ®Google Scholar
• Alsultan AA, Hamouda A, Evans BA, Amyes SG. Acinetobacter baumannii: emergence of four strains with novel bla(OXA-51-like) genes in patients with diabetes mellitus. J Chemother. 2009;21:290–5.
   PubMed Web of Science ®Google Scholar
• Brigante G, Migliavacca R, Bramati S, Motta E, Nucleo E, Manenti M, et al. Emergence and spread of a multidrug-resistant Acinetobacter baumannii clone producing both the carbapenemase OXA-23 and the 16S rRNA methylase ArmA. J Med Microbiol. 2012;61:653–61.
   PubMed Web of Science ®Google Scholar
• Baadani AM, Thawadi SI, El-Khizzi NA, Omrani AS. Prevalence of colistin and tigecycline resistance in Acinetobacter baumannii clinical isolates from 2 hospitals in Riyadh Region over a 2-year period. Saudi Med J. 2013;34:248–53.
   PubMed Web of Science ®Google Scholar
• Bilal NE, Gedebou M, Al-Ghamdi S. Endemic nosocomial infections and misuse of antibiotics in a maternity hospital in Saudi Arabia. APMIS. 2002;110:140–7.
   PubMed Web of Science ®Google Scholar
• Sabra SM, Abdel-Fattah MM. Epidemiological and microbiological profile of nosocomial infection in Taif hospitals, KSA (2010–2011). World J Med Sci. 2012;7:1–9.
   Google Scholar
• al-Orainey IO, al-Nasser MN, Saeed ES, Chowdhury MN. Nosocomial bacteraemia in a teaching hospital in Saudi Arabia. J Hosp Infect. 1989;14:201–7.
   PubMed Web of Science ®Google Scholar
• Babay HA, Twum-Danso K, Kambal AM, Al-Otaibi FE. Bloodstream infections in pediatric patients. Saudi Med J. 2005;26:1555–61.
   PubMed Web of Science ®Google Scholar
• Paterson DL. Resistance in Gram-negative bacteria: Enterobacteriaceae. Am J Infect Control. 2006;34:S20–8.
   PubMed Web of Science ®Google Scholar
• Rupp ME, Fey PD. Extended spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae: considerations for diagnosis, prevention and drug treatment. Drugs. 2003;63:353–65.
   PubMed Web of Science ®Google Scholar
• Carattoli A. Resistance plasmid families in Enterobacteriaceae. Antimicrob Agents Chemother. 2009;53:2227–38.
   PubMed Web of Science ®Google Scholar
• Tzouvelekis LS, Markogiannakis A, Psichogiou M, Tassios PT, Daikos GL. Carbapenemases in Klebsiella pneumoniae and other Enterobacteriaceae: an evolving crisis of global dimensions. Clin Microbiol Rev. 2012;25:682–707.
   PubMed Web of Science ®Google Scholar
• Daly MW, Riddle DJ, Ledeboer NA, Dunne WM, Ritchie DJ. Tigecycline for treatment of pneumonia and empyema caused by carbapenemase-producing Klebsiella pneumoniae. Pharmacotherapy. 2007;27:1052–7.
   PubMed Web of Science ®Google Scholar
• Elemam A, Rahimian J, Doymaz M. In vitro evaluation of antibiotic synergy for polymyxin B-resistant carbapenemase-producing Klebsiella pneumoniae. J Clin Microbiol. 2010;48:3558–62.
   PubMed Web of Science ®Google Scholar
• Arnold RS, Thom KA, Sharma S, Phillips M, Kristie JJ, Morgan DJ. Emergence of Klebsiella pneumoniae carbapenemase-producing bacteria. South Med J. 2011;104:40–5.
   PubMed Web of Science ®Google Scholar
• Livermore DM, Warner M, Mushtaq S, Doumith M, Zhang J, Woodford N. What remains against carbapenem-resistant Enterobacteriaceae? Evaluation of chloramphenicol, ciprofloxacin, colistin, fosfomycin, minocycline, nitrofurantoin, temocillin and tigecycline. Int J Antimicrob Agents. 2011;37:415–9.
   PubMed Web of Science ®Google Scholar
• Hooper DC. Clinical applications of quinolones. Biochim Biophys Acta. 1998;1400:45–61.
   PubMed Web of Science ®Google Scholar
• Carson C, Naber KG. Role of fluoroquinolones in the treatment of serious bacterial urinary tract infections. Drugs. 2004;64:1359–73.
   PubMed Web of Science ®Google Scholar
• Hooper DC, Wolfson JS. Bacterial resistance to the quinolone antimicrobial agents. Am J Med. 1989;87:17S–23S.
   Google Scholar
• Nordmann P, Poirel L. Emergence of plasmid-mediated resistance to quinolones in Enterobacteriaceae. J Antimicrob Chemother. 2005;56:463–9.
   PubMed Web of Science ®Google Scholar
• Livermore DM, Mushtaq S, Warner M, Zhang JC, Maharjan S, Doumith M, et al. Activity of aminoglycosides, including ACHN-490, against carbapenem-resistant Enterobacteriaceae isolates. J Antimicrob Chemother. 2011;66:48–53.
   PubMed Web of Science ®Google Scholar
• Al-Tawfiq JA. Increasing antibiotic resistance among isolates of Escherichia coli recovered from inpatients and outpatients in a Saudi Arabian hospital. Infect Control Hosp Epidemiol. 2006;27:748–53.
   PubMed Web of Science ®Google Scholar
• Al-Tawfiq JA, Antony A, Abed MS. Antimicrobial resistance rates of Enterobacter spp.: a seven-year surveillance study. Med Princ Pract. 2009;18:100–4.
   PubMed Web of Science ®Google Scholar
• Al-Tawfiq JA, Antony A. Antimicrobial resistance of Klebsiella pneumoniae in a Saudi Arabian hospital: results of a 6-year surveillance study, 1998–2003. J Infect Chemother. 2007;13:230–4.
   PubMedGoogle Scholar
• Panhotra BR, Saxena AK, Al-Ghamdi AM. Extended-spectrum beta-lactamase-producing Klebsiella pneumoniae hospital acquired bacteremia. Risk factors and clinical outcome. Saudi Med J. 2004;25:1871–6.
   PubMed Web of Science ®Google Scholar
• Balkhy HH, El-Saed A, Al Johani SM, Francis C, Al-Qahtani AA, Al-Ahdal MN, et al. The epidemiology of the first described carbapenem-resistant Klebsiella pneumoniae outbreak in a tertiary care hospital in Saudi Arabia: how far do we go? Eur J Clin Microbiol Infect Dis. 2012;31:1901–9.
   PubMed Web of Science ®Google Scholar
• Al-Agamy MH, Shibl AM, Elkhizzi NA, Meunier D, Turton JF, Livermore DM. Persistence of Klebsiella pneumoniae clones with OXA-48 or NDM carbapenemases causing bacteraemias in a Riyadh hospital. Diagn Microbiol Infect Dis. 2013;76:214–6.
   PubMed Web of Science ®Google Scholar
• Shibl A, Al-Agamy M, Memish Z, Senok A, Khader SA, Assiri A. The emergence of OXA-48- and NDM-1-positive Klebsiella pneumoniae in Riyadh, Saudi Arabia. Int J Infect Dis. 2013;17:e1130–3.
   PubMed Web of Science ®Google Scholar
• Hassan MI, Alkharsah KR, Alzahrani AJ, Obeid OE, Khamis AH, Diab A. Detection of extended spectrum beta-lactamases-producing isolates and effect of AmpC overlapping. J Infect Dev Ctries. 2013;7:618–29.
   PubMed Web of Science ®Google Scholar
• Ahmad S, Al-Juaid NF, Alenzi FQ, Mattar EH, Bakheet O. Prevalence, antibiotic susceptibility pattern and production of extended-spectrum beta-lactamases amongst clinical isolates of Klebsiella pneumoniae at Armed Forces Hospital in Saudi Arabia. J Coll Physicians Surg Pak. 2009;19:264–5.
   PubMed Web of Science ®Google Scholar
• Shibl AM, Al-Agamy MH, Khubnani H, Senok AC, Tawfik AF, Livermore DM. High prevalence of acquired quinolone-resistance genes among Enterobacteriaceae from Saudi Arabia with CTX-M-15 beta-lactamase. Diagn Microbiol Infect Dis. 2012;73:350–3.
   PubMed Web of Science ®Google Scholar
• Kader AA, Kumar A. Prevalence and antimicrobial susceptibility of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a general hospital. Ann Saudi Med. 2005;25:239–42.
   PubMed Web of Science ®Google Scholar
• Al-Otaibi FE, Bukhari EE. Clinical and laboratory profiles of urinary tract infections caused by extended-spectrum beta-lactamase-producing Escherichia coli in a tertiary care center in central Saudi Arabia. Saudi Med J. 2013;34:171–6.
   PubMed Web of Science ®Google Scholar
• Tawfik AF, Alswailem AM, Shibl AM, Al-Agamy MH. Prevalence and genetic characteristics of TEM, SHV, and CTX-M in clinical Klebsiella pneumoniae isolates from Saudi Arabia. Microb Drug Resist. 2011;17:383–8.
   PubMed Web of Science ®Google Scholar
• Al-Agamy MH, Shibl AM, Tawfik AF. Prevalence and molecular characterization of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in Riyadh, Saudi Arabia. Ann Saudi Med. 2009;29:253–7.
   PubMed Web of Science ®Google Scholar
• Khanfar HS, Bindayna KM, Senok AC, Botta GA. Extended spectrum beta-lactamases (ESBL) in Escherichia coli and Klebsiella pneumoniae: trends in the hospital and community settings. J Infect Dev Ctries. 2009;3:295–9.
   PubMed Web of Science ®Google Scholar
• El-Khizzi NA, Bakheshwain SM. Prevalence of extended-spectrum beta-lactamases among Enterobacteriaceae isolated from blood culture in a tertiary care hospital. Saudi Med J. 2006;27:37–40.
   PubMed Web of Science ®Google Scholar
• Babay HA. Detection of extended-spectrum b-lactamases in members of the family Enterobacteriaceae at a teaching hospital, Riyadh, Kingdom of Saudi Arabia. Saudi Med J. 2002;23:186–90.
   PubMed Web of Science ®Google Scholar
• ECDC. Antimicrobial resistance surveillance in Europe; 2012. http://www.ecdc.europa.eu/en/publications/Publications/antimicrobial-resistance-surveillance-europe-2012.pdf (accessed 2014 March 23).
   Google Scholar
• Denys GA, Callister SM, Dowzicky MJ. Antimicrobial susceptibility among Gram-negative isolates collected in the USA between 2005 and 2011 as part of the Tigecycline Evaluation and Surveillance Trial (T.E.S.T.). Ann Clin Microbiol Antimicrob. 2013;12:24.
   PubMed Web of Science ®Google Scholar
• Farrell DJ, Flamm RK, Sader HS, Jones RN. Antimicrobial activity of ceftolozane–tazobactam tested against Enterobacteriaceae and Pseudomonas aeruginosa with various resistance patterns isolated in U.S. Hospitals (2011–2012). Antimicrob Agents Chemother. 2013;57:6305–10.
   PubMed Web of Science ®Google Scholar
• Yezli S, Li H. Antibiotic resistance amongst healthcare-associated pathogens in China. Int J Antimicrob Agents. 2012;40:389–97.
   PubMed Web of Science ®Google Scholar
• Mendes RE, Mendoza M, Banga Singh KK, Castanheira M, Bell JM, Turnidge JD, et al. Regional resistance surveillance program results for 12 Asia-Pacific nations (2011). Antimicrob Agents Chemother. 2013;57:5721–6.
   PubMed Web of Science ®Google Scholar
• Jones RN, Guzman-Blanco M, Gales AC, Gallegos B, Castro AL, Martino MD, et al. Susceptibility rates in Latin American nations: report from a regional resistance surveillance program (2011). Braz J Infect Dis. 2013;17:672–81.
   PubMed Web of Science ®Google Scholar
• Shibl AM, Memish ZA, Kambal AM, Ohaly YA, Ishaq A, Senok AC, et al. National surveillance of antimicrobial resistance among Gram-positive bacteria in Saudi Arabia. J Chemother. 2013;26:13–8.
   PubMed Web of Science ®Google Scholar
• Gulf Cooperation Council – Centre for Infection Control. Infection prevention and control manual, 2nd edition; 2013. http://www.gdipc.org/GCC-ICM.html (accessed 2014 February 2).
   Google Scholar