305
Views
21
CrossRef citations to date
0
Altmetric
Research Articles

Lean tissue mass and energy expenditure are retained in hypogonadal men with spinal cord injury after discontinuation of testosterone replacement therapy

, , , &

References

  • Spungen AM, Adkins RH, Stewart CA, Wang J, Pierson RN Jr, Waters RL, et al. Factors influencing body composition in persons with spinal cord injury: a cross-sectional study. J Appl Physiol 2003;95(6):2398–407.
  • Mollinger LA, Spurr GB, Ghatit AZE, Barboriak JJ, Rooney CB, Davidoff DD, et al. Daily energy expenditure and basal metabolic rates of patients with spinal cord injury. Arch Phys Med Rehabil 1985;66(7):420–6.
  • Sedlock DA, Laventure SJ. Body composition and resting energy expenditure in long term spinal cord injury. Paraplegia 1990;28(7):448–54.
  • Buchholz AC, McGillivray CF, Pencharz PB. Differences in resting metabolic rate between paraplegic and able-bodied subjects are explained by differences in body composition. Am J Clin Nutr 2003;77(2):371–8.
  • Clark MJ, Schopp LH, Mazurek MO, Zaniletti I, Lammy AB, Martin TA, et al. Testosterone levels among men with spinal cord injury: relationship between time since injury and laboratory values. Am J Phys Med Rehabil 2008;87(9):758–67.
  • Huang TS, Wang YH, Chiang HS, Lien YN. Pituitary-testicular and pituitary-thyroid axes in spinal cord-injured males. Metabolism 1993;42(4):516–21.
  • Tsitouras PD, Zhong YG, Spungen AM, Bauman WA. Serum testosterone and growth hormone/insulin-like growth factor-I in adults with spinal cord injury. Horm Metab Res 1995;27(6):287–92.
  • Wang YH, Huang TS, Lien IN. Hormone changes in men with spinal cord injuries. Am J Phys Med Rehabil 1992;71(6):328–32.
  • Bauman WA, Spungen AM. Metabolic changes in persons after spinal cord injury. Phys Med Rehabil Clin N Am 2000;11(1):109–40.
  • Schopp LH, Clark M, Mazurek MO, Hagglund KJ, Acuff ME, Sherman AK, et al. Testosterone levels among men with spinal cord injury admitted to inpatient rehabilitation. Am J Phys Med Rehabil 2006;85(8):678–84; quiz 85–7.
  • Clark MJ, Petroski GF, Mazurek MO, Hagglund KJ, Sherman AK, Lammy AB, et al. Testosterone replacement therapy and motor function in men with spinal cord injury: a retrospective analysis. Am J Phys Med Rehabil 2008;87(4):281–4.
  • Bauman WA, La Fountaine MF, Spungen AM. Age-related prevalence of low testosterone in men with spinal cord injury. J Spinal Cord Med 2014;37(1):32–9.
  • Bauman WA, Spungen AM, Flanagan S, Zhong YG, Alexander LR, Tsitouras PD. Blunted growth hormone response to intravenous arginine in subjects with a spinal cord injury. Horm Metab Res 1994;26(3):152–6.
  • Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without the use of the preparative ultracentrifuge. Clin Chem 1972;18:499–502.
  • Gruenewald DA, Matsumoto AM. Testosterone supplementation therapy for older men: potential benefits and risks. J Am Geriatr Soc 2003;51(1):101–15; discussion 15.
  • Bauman WA, Cirnigliaro CM, La Fountaine MF, Jensen AM, Wecht JM, Kirshblum SC, et al. A small-scale clinical trial to determine the safety and efficacy of testosterone replacement therapy in hypogonadal men with spinal cord injury. Horm Metab Res 2011;43(8):574–9.
  • Sattler FR, Bhasin S, He J, Yarasheski K, Binder E, Todd Schroeder E, et al. Durability of the effects of testosterone and growth hormone supplementation in older community dwelling men: the HORMA trial. Clin Endocrinol 2011;75(1):103–11.
  • O'Connell MD, Roberts SA, Srinivas-Shankar U, Tajar A, Connolly MJ, Adams JE, et al. Do the effects of testosterone on muscle strength, physical function, body composition, and quality of life persist six months after treatment in intermediate-frail and frail elderly men? J Clin Endocrinol Metab 2011;96(2):454–8.
  • Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, Swerdloff RS, et al. Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2010;95(6):2536–59.
  • Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab 2001;86(2):724–31.
  • Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, Swerdloff RS, et al. Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2006;91(6):1995–2010.
  • Baim S, Binkley N, Bilezikian J, Kendler DL, Hans DB, Lewiecki EM, et al. Official positions of the international society for clinical densitometry and executive summary of the 2007 ISCD position development conference. J Clin Densitom 2008;11(1):75–91.
  • Bonnick SL, Johnston CC Jr, Kleerekoper M, Lindsay R, Miller P, Sherwood L, et al. Importance of precision in bone density measurements. J Clin Densitom 2001;4(2):105–10.
  • Harris JA BF. Biometric studies of basal metabolism in man. Publication no. 279. Washington, DC: Carnegie Institution of Washington; 1919.
  • Weir JB. New methods for calculating metabolic rate with special reference to protein metabolism. J Physiol 1949;109(1–2):1–9.
  • Consolazio CF, Johnson RE, Pecora LJ. Physiological measurement of metabolic function in man. New York: McGraw-Hill; 1963.
  • Holloszy J. Biochemical adaptations in muscle. J Biol Chem 1967;242(9):2278–82.
  • Wang C, Swerdloff RS, Iranmanesh A, Dobs A, Snyder PJ, Cunningham G, et al. Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadal men. J Clin Endocrinol Metab 2000;85(8):2839–53.
  • Wang C, Eyre DR, Clark R, Kleinberg D, Newman C, Iranmanesh A, et al. Sublingual testosterone replacement improves muscle mass and strength, decreases bone resorption, and increases bone formation markers in hypogonadal men – a clinical research center study. J Clin Endocrinol Metab 1996;81(10):3654–62.
  • Snyder PJ, Peachey H, Hannoush P, Berlin JA, Loh L, Lenrow DA, et al. Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age. J Clin Endocrinol Metab 1999;84(8):2647–53.
  • Brunton J, Bertolo R, Winthrop A, Atkinson S (eds.). Body composition by dual energy x-ray absorptiometry (DEXA) compared to chemical analysis of fat, lean, and bone mass in small piglets. in: International in Vivo Body Composition Conference; 1992; Houston, TX.
  • Spungen AM, Wang J, Pierson RN Jr, Bauman WA. Soft tissue body composition differences in monozygotic twins discordant for spinal cord injury. J Appl Physiol 2000;88(4):1310–5.
  • Gutai J, LaPorte R, Kuller L, Dai W, Falvo-Gerard L, Caggiula A. Plasma testosterone, high density lipoprotein cholesterol and other lipoprotein fractions. Am J Cardiol 1981;48(5):897–902.
  • Fernandez-Balsells MM, Murad MH, Lane M, Lampropulos JF, Albuquerque F, Mullan RJ, et al. Clinical review 1: adverse effects of testosterone therapy in adult men: a systematic review and meta-analysis. J Clin Endocrinol Metab 2010;95(6):2560–75.
  • Wahman K, Nash MS, Lewis JE, Seiger A, Levi R. Increased cardiovascular disease risk in Swedish persons with paraplegia: the Stockholm spinal cord injury study. J Rehabil Med 2010;42(5):489–92.
  • Orakzai SH, Orakzai RH, Ahmadi N, Agrawal N, Bauman WA, Yee F, et al. Measurement of coronary artery calcification by electron beam computerized tomography in persons with chronic spinal cord injury: evidence for increased atherosclerotic burden. Spinal Cord 2007;45(12):775–9.
  • Cragg JJ, Noonan VK, Dvorak M, Krassioukov A, Mancini GB, Borisoff JF. Spinal cord injury and type 2 diabetes: results from a population health survey. Neurology 2013;81(21):1864–8.
  • de Groot S, Post MW, Snoek GJ, Schuitemaker M, van der Woude LH. Longitudinal association between lifestyle and coronary heart disease risk factors among individuals with spinal cord injury. Spinal Cord 2013;51(4):314–8.
  • Bauman WA, Adkins RH, Spungen AM, Kemp BJ, Waters RL. The effect of residual neurological deficit on serum lipoproteins in individuals with chronic spinal cord injury. Spinal Cord 1998;36(1):13–7.
  • Morris PD, Channer KS. Testosterone and cardiovascular disease in men. Asian J Androl 2012;14(3):428–35.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.