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Acta Clinica Belgica
International Journal of Clinical and Laboratory Medicine
Volume 72, 2017 - Issue 3
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Case Report

Case report of a false positive result of the Xpert® MTB/RIF assay for rifampicin resistance in Mycobacterium tuberculosis complex

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Pages 195-197 | Received 26 May 2015, Accepted 03 Sep 2015, Published online: 10 Jun 2016

References

  • World Health Organization. Automated real-time nucleic acid amplification technology for rapid and simultaneous detection of tuberculosis and rifampicin resistance: Xpert® MTB/RIF assay for the diagnosis of pulmonary and extrapulmonary TB in adults and children; policy update. Geneva, Switzerland: WHO; 2013;. [WHO/HTM/TB/2013.14].
  • Mathys V, van de Vyvere M, de Droogh E, Soetaert K, Groenen G. False-positive rifampicin resistance on Xpert® MTB/RIF caused by a silent mutation in the rpoB gene. Int J Tuberc Lung Dis. 2014;18(10):1255–7.
  • Lawn SD, Nicol MP. Xpert® MTB/RIF assay: development, evaluation and implementation of a new rapid molecular diagnostic for tuberculosis and rifampicin resistance. Future Microbiol. 2011;6(9):1067–82.
  • Osman M, Simpson JA, Caldwell J, Bosman M, Nicol MP. GeneXpert MTB/RIF version G4 for identification of rifampicin-resistant tuberculosis in a programmatic setting. J Clin Microbiol. 2014;52(2):635–7.
  • Huh HJ, Jeong BH, Jeon K, Koh WJ, Ki CS, Lee NY. Performance evaluation of the Xpert® MTB/RIF assay according to its clinical application. BMC Infect Dis. 2014;14(1):589.

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