UPDATE ON THE TREATMENT OF PITUITARY ADENOMAS: FAMILIAL AND GENETIC CONSIDERATIONS

REFERENCES

• Ezzat S, Asa SL, Couldwell WT, el al. The prevalence of pituitary adenomas: a systematic review. Cancer 2004 Aug 1;101(3):613–9.
   PubMed Web of Science ®Google Scholar
• Davis JR, Farrell WE, Clayton RN. Pituitary tumours. Reproduc-tion 2001 Mar;121(3):363–7.1
   Google Scholar
• Daly AF, Rixhon M, Adam C, Dempegioti A, Tichomirowa MA, Beckers A. High prevalence of pituitary adenomas: a cross-sec-tional study in the province of Liege, Belgium.] din Endocrinol Metab 2006 Dec;91(12):4769–75.
   PubMed Web of Science ®Google Scholar
• Hemminki K, FörstiA, Ji J. Incidence and familial risks in pituitary adenoma and associated tumours. Endocr Relat Cancer 2007 Mar;14(1):103–9.
   Web of Science ®Google Scholar
• Asa SL, Ezzat S. Genetics and proteomics of pituitary tumours. Endocrine 2005 Oct;28(1):43–7.
   Google Scholar
• Agarwal SK, Lee Burns A, Sukhodolets KE, et al. Molecular pathol-ogy of the MEN1 gene. Ann N Y Acad Sci 2004; 1014:189–98.
   PubMed Web of Science ®Google Scholar
• Larsson C, Skogseid B, Oberg K, Nakamura Y, Nordenskjold M. Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma. Nature 1988 Mar 3;332(615485–7.
   Google Scholar
• Chandrasekharappa SC, Guru SC, Manickam P, el al. Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science 1997 Apr 18;276(5311):404–7.
   PubMed Web of Science ®Google Scholar
• Scacheri PC, Davis S, Odom DT, et at. Genome-wide analysis of menin binding provides insights into MEN1 tumourigenesis. PLoS Genet 2006 Apr;2(4):e51.
   Google Scholar
• Agarwal SK, Impey S, McWeeney S, et al. Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation. Neoplasia 2007 Feb;9(4101–7.
   Google Scholar
• Lemos MC, Thakker RV. Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the gene. Hum Mutat 2007 Aug 24; [Epub ahead of print].
   Web of Science ®Google Scholar
• Vergès B, Boureille F, Goudet P, el al. Pituitary disease in MEN type 1 (MEN1): data from the France-Belgium MEN1 multicenter study.] Clin Endocrinol Metab 2002 Feb;87(2):457–65.
   PubMed Web of Science ®Google Scholar
• Beckers A, Betea D, Valdes Socin H, Stevenaert A. The treatment of sporadic versus MEN1-related pituitary adenomas. J /nt Med 2003; 253: 599–605.
   Web of Science ®Google Scholar
• Zhuang Z, Ezzat SZ, Vortmeyer AO, et al. Mutations of the MEN1 tumour suppressor gene in pituitary tumours. Cancer Res 1997 Dec 15;57(24):5446–51.
   Web of Science ®Google Scholar
• Poncin J, Stevenaert A, Beckers A. Somatic MEN 1 gene mutation does not contribute significantly to sporadic pituitary tumou-rigenesis. Eur Endocrinol 1999 Jun;140(6):573–6.
   Web of Science ®Google Scholar
• Theodoropoulou M, Cavallari I, Barzon L, et al. Differential expres-sion of menin in sporadic pituitary adenomas. Endocr Relat Cancer 2004 Jun;11(2):333–44.
   PubMed Web of Science ®Google Scholar
• Beckers A, Abs R, Reyniers E, el al. Variable regions of chromo-some 11 loss in different pathological tissues of a patient with the multiple endocrine neoplasia type I syndrome.] Clin Endo-crinol Metab 1994 Nov;79(41498–502.
   Google Scholar
• Farid NR, Buehler S, Russell NA, Maroun FB, Allerdice P, Smyth HS. Prolactinomas in familial multiple endocrine neoplasia syndrome type I. Relationship to HLA and carcinoid tumours. Am' Med 1980 Dec;69(6):874–80.
   Web of Science ®Google Scholar
• Olufemi SE, Green JS, Manickam P, el al. Common ancestral mutation in the MEN1 gene is likely responsible for the prolac-tinoma variant of MEN1 (MEN1Burin) in four kindreds from Newfoundland. Hum Mutat 1998;11(4):264–9.
   Web of Science ®Google Scholar
• Brandi ML, Gagel RF, Angeli A, et al. Guidelines for diagnosis and therapy of MEN type 1 and type 2. J Clin Endocrinol Metab 2001; 86(12): 5658–71.
   PubMed Web of Science ®Google Scholar
• Boikos SA, Stratakis CA. Carney complex: the fi rst 20 years. Curr Opin Oncol 2007; 19: 24–9.
   PubMed Web of Science ®Google Scholar
• Casey M, Mah C, Merliss AD, et al. Identification of a novel genetic locus for familial cardiac myxomas and Carney complex. Circulation 1998; 98:2560–6.
   PubMed Web of Science ®Google Scholar
• Stratakis CA, Kirschner LS, Carney JA. Clinical and molecular features of the Carney complex: diagnostic criteria and recommendations for patient evaluation. J Clin Endocrinol Metab 2001; 86(9): 4041–6.
   PubMed Web of Science ®Google Scholar
• Stergiopoulos SG, Stratakis CA. Human tumours associated with Carney complex and germline PPKAR1A mutations: a protein kinase A disease! FEBS Letters 2003; 546: 59–64.
   PubMed Web of Science ®Google Scholar
• Kurtkaya-Yapicier O, Scheithauer BW, Carney JA, et al. Pituitary adenoma in Carney complex: an immunohistochemical, ultrastructural,and immunoelectron microscopic study. Ultrastruct Pathol 2002 Nov-Dec;26(6):345–53.
   Web of Science ®Google Scholar
• Kaltsas GA, Kola B, Borboli N, et al. Sequence analysis of the PRKAR1A gene in sporadic somatotroph and otherpituitary
   Google Scholar
• Fritz A, Walch A, Piotrowska K, et al. Recessive transmission of a multiple endocrine neoplasia syndrome in the rat. Cancer Res 2002 Jun 1;62(11):3048–51.
   Web of Science ®Google Scholar
• Pellegata NS, Quintanilla-Martinez L, Siggelkow H, et al. Germline mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans. Proc Natl Acad Sci USA 2006 Oct 17;103(42):15558–63.
   PubMed Web of Science ®Google Scholar
• Georgitsi M, Raitila A, Karhu A, et al. Germline CDKN1B/p27Kip1 mutation in multiple endocrine neoplasia. J Clin Endocrinol Metab 2007;92(8):3321–5.
   PubMed Web of Science ®Google Scholar
• Beckers A, Daly AF. The clinical, pathological, and genetic features of familial isolated pituitary adenomas. Eur J Endocrinol 2007 Oct;157(4):371–82.
   PubMed Web of Science ®Google Scholar
• Villa C, Magri F, Morbini P, et al. Silent Familial Isolated PituitaryAdenomas: Histopathological and Clinical Case Report. Endocr Pathol 2008 Mar 4 [Epub ahead of print].
   Web of Science ®Google Scholar
• Leontiou CA, Gueorguiev M, van der Spuy J, et al. The role of the AIP gene in familial and sporadic pituitary adenimas. J Clin Endocrinol Metab 2008 Apr 17 [Epub ahead of print].
   Web of Science ®Google Scholar
• Ciccarelli A, Daly AF, Beckers A. The epidemiology of prolacti-
   Google Scholar
• Vierimaa O, Georgitsi M, Lehtonen R, et al. Pituitary adenoma predisposition caused by germline mutations in the AIP gene. Science 2006;312(5777):1228–30.
   PubMed Web of Science ®Google Scholar
• lwata T, Yamada S, Mizusawa N, Golam HM, Sano T, Yoshimoto
   Google Scholar
• Toledo RA, Lourenco DM Jr, Liberman B, et al. Germline mutation in the aryl hydrocarbon receptor interacting protein gene in familial somatotropinoma. J Clin Endocrinol Metab. 2007 May;92(5):1934–7.
   PubMed Web of Science ®Google Scholar
• Yu R, Bonert V, Saporta I, Raffel LJ, Melmed S. AIP variants in sporadic pituitary adenomas. J Clin Endocrinol Metab 2006 Dec;91(12):5126–9.
   Web of Science ®Google Scholar
• Barlier A, Vanbellinghen JF, Daly AF, et al. Mutations in the aryl hydrocarbon receptor interacting protein gene are not highly prevalent among subjects with sporadic pituitary adenomas. ] Clin Endocrinol Metab 2007 May;92(5):1952–5. Epub 2007 Feb 13.
   Google Scholar
• Georgitsi M, Raitila A, Karhu A, et al. Molecular diagnosis of pituitary adenoma predisposition caused by aryl hydrocarbon receptor-interacting protein gene mutations. Proc NatlAcad Sci USA 2007 Mar 6;104(10):4101–5.
   PubMed Web of Science ®Google Scholar
• Georgitsi M, Karhu A, Winqvist R, et al. Mutation analysis of aryl hydrocarbon receptor interacting protein (AIP) gene in colorec-tal, breast, and prostate cancers. Br] Cancer 2007 Jan 29;96(2):352–6.
   Web of Science ®Google Scholar
• Petrulis JR, Perdew GH. The role of chaperone proteins in the aryl hydrocarbon receptor core complex. Chem Biol Interact 2002; 141(1-2):25–40.
   PubMed Web of Science ®Google Scholar
• Bell DR, Poland A. Binding of aryl hydrocarbon receptor (AhR) to AhR-interacting protein.The role of hsp90./ Biol Chem 2000; 275(46):36407–14.
   Web of Science ®Google Scholar
• Meyer BK, Petrulis JR, Perdew GH. Aryl hydrocarbon (Ah) recep-tor levels are selectively modulated by hsp90-associated im-mu nop hilin homolog XAP2. Cell Stress Chaperones 2000; 5(3):243–54.
   Web of Science ®Google Scholar
• Carver LA, LaPres JJ, Jain S, Dunham EE, Bradfield CA. Charac-terization of the Ah receptor-associated protein, ARA9. J Biol Chem 1998; 273(50):33580–7.
   Web of Science ®Google Scholar
• Meyer BK, Perdew GH. Characterization of the AhR-hsp90-XAP2 core complex and the role of the immunophilin-related protein XAP2 in AhR stabilization. Biochemistry 1999; 38(28):8907–17.
   PubMed Web of Science ®Google Scholar
• Bolger GB, Peden AH, Steele MR, et al. Attenuation of the activ-ity of the cAMP-specific phosphodiesterase PDE4A5 by interac-tion with the immunophilin XAP2.] Biol Chem 2003 Aug 29;278(35):33351–63.
   PubMed Web of Science ®Google Scholar
• de Oliveira SK, Hoffmeister M, Gambaryan S, Muller-Ester EW, Guimaraes JA, Smolenski AP. Phosphodiesterase 2A Forms a Complex with the Co-chaperone XAP2 and Regulates Nuclear Translocation of the Aryl Hydrocarbon Receptor.] Biol Chem 2007 May 4;282(18):13656–63.
   Web of Science ®Google Scholar
• Lin BC, Sullivan R, LeeY, Moran S, Glover E, Bradfield CA. Deletion of the aryl hydrocarbon receptor-associated protein 9 leads to cardiac malformation and embryonic lethality.JBiol Chem 2007 Dec 7;282(49):35924–32.
   Google Scholar
• Lin BC, Nguyen LP, Walisser JA, Bradfield CA. A Hypomorphic Allele of Aryl-hydrocarbon Receptor-associated-9 Produces a Phenocopy of the Ahr Null. Mol Pharmacol 2008 Jul 31. [Epub ahead of print]
   Web of Science ®Google Scholar
• Pesatori A, Baccarelli A, Consonni D, et al. Aryl hydrocarbon re-ceptor interacting protein and pituitary adenomas: a popula-tion-based study on subjects exposed to dioxin after the Seveso, Italy, accident. Eur J Endocrinol 2008 Sep 11. [Epub ahead of print]
   Web of Science ®Google Scholar
• Naves LA, Daly AF, Vanbellinghen JF, et al. Variable pathological and clinical features of a large Brazilian family harboring a mu-tation in the aryl hydrocarbon receptor-interacting protein gene. EurJ Endocrinol 2007 Oct;157(4):383–91.
   Web of Science ®Google Scholar
• Georgitsi M, Heliövaara E, Paschke R, et al. Large genomic dele-tions of aryl hydrocarbon receptor interacting protein (AIP) gene in pituitary adenoma predisposition.] Clin Endocrin Metab Epub July 15, 2008: doi:10.1210/jc.2008-1003.
   Google Scholar