Neoadjuvant Chemotherapy for High Grade Osteosarcoma of the Extremities: Long-Term Results for Patients Treated According to the Rizzoli IOR/OS-3b Protocol

REFERENCES

• Jaffe N, Frei E, Traggis D, et al. Adjuvant methotrexate and citrovorum factor treatment of osteosarcoma. N Eng J Med 1974; 29: 994–7.
   Web of Science ®Google Scholar
• Pratt CB, Shanks E, Hustu O, et al. Adjuvant multiple drug chemotherapy for osteosarcoma of the extremities. Cancer 1977; 39: 51–7.
   PubMed Web of Science ®Google Scholar
• Cortes EP, Holland JF, Wang JJ, et al. Amputation and adriamycin in primary osteosarcoma. N Eng J Med 1974; 291: 998–1000.
   PubMed Web of Science ®Google Scholar
• Fossati-Bellani F, Gasparini M, Gennari L, Fontanillas L, Bonadonna G. Adjuvant treatment with adriamycin in primary operable osteosarcoma. Cancer Treat Rep 1978; 62: 279–81.
   PubMedGoogle Scholar
• Ettinger LJ, Douglas HO, Higby DJ et al. Adjuvant chemotharapy and cis-diamminechlorplatinum (cisplatinum) in primary osteosarcoma. Cancer 1981; 47: 248–4.
   Google Scholar
• Campanacci M, Bacci G, Bertoni F, Picci P, Minutillo BA, Franceschi C. The treatment of osteosarcoma of the extremities: twenty years' experience at the Istituto Ortopedico Rizzoli. Cancer 1981; 48: 1569–81.
   PubMed Web of Science ®Google Scholar
• Eilber F, Giuliano A, Eckardt J, Patterson K, Moseley S, Goodnight J. Adjuvant chemotherapy for osteosarcoma: a randomized prospective trial. J Clin Oncol 1987; 5: 21–6.
   PubMed Web of Science ®Google Scholar
• Link MP, Goorin AM, Miser AW, et al. The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity. N Engl J Med 1986; 314: 1600–6.
   PubMed Web of Science ®Google Scholar
• Rosen G, Marcove RC, Caparros B, Nirenberg A, Kosloff C, Huvos AG. Primary osteogenic sarcoma: the ratio-nale for preoperative chemotherapy and delayed surgery. Cancer 1979; 43: 2163–77.
   PubMed Web of Science ®Google Scholar
• Winkler K, Beron G, Kotz R, et al. Neoadjuvant chemotherapy for Osteogenic sarcoma: Results of a Cooperative German/Austrian Study. J Clin Oncol 1984; 2: 617–624.
   PubMed Web of Science ®Google Scholar
• Jaffe N, Prudich J, Knapp J, et al. Treatment of primary osteosarcoma with intraarterial and intravenous high dose methotrexate. J Clin Oncol 1988; 3: 12–8.
   Google Scholar
• Winkler K, Beron G, Delling G, et al. Neoadjuvant chemotherapy of osteosarcoma: Results of a randomized Cooperative Trial (COSS-82) with salvage chemotherapy based on histological tumor response. J Clin Oncol 1988; 6: 329–37.
   PubMed Web of Science ®Google Scholar
• Benjamin RS, Chawla SP, Carrasco CH et al. Arterial infusion in the treatment of osteosarcoma. In: Recent con-cepts in sarcoma treatment. Ryan J and Baker L, eds. Boston: Kluver Acad Publ 1988: 269-74.
   Google Scholar
• Bramwell VHC, Burgers M, Sneath R, et al. A comparison of two short intensive adjuvant chemotherapy regimens in operable osteosarcoma of limbs in children and young adults: the first study of the European Osteosarcoma Intergroup. J Clin Oncol 1992; 10: 1579–91.
   PubMed Web of Science ®Google Scholar
• Smter G, Alvegard TA, Elomaa I et al. Treatment of osteosarcoma of the extremities with the T-10 protocol, with emphasis on the effects of preoperative chemotherapy with single-agent high-dose methotrexate: A Scandinavian Sarcoma Group Study. J Clin Oncol 1991; 9: 1766–75.
   Google Scholar
• Bacci G, Picci P, Ruggieri P, et al. Primary chemother-apy and delayed surgery (neoadjuvant chemotherapy) for osteosarcoma of the extremity. The Istituto Rizzoli experience in 127 patients treated preoperatively with intravenous methotrexate (high versus moderate doses) and intraarterial cisplatin. Cancer 1990; 65: 2539–53.
   Google Scholar
• Bacci G, Picci P, Ferrari S, et al. Primary chemothera-py and delayed surgery for non metastatic osteosarcoma of the extremity. Results in 164 patients preoperatively treated with high doses of methotrexate, followed by cisplatin and doxorubicin. Cancer 1993; 72: 1216–26.
   Google Scholar
• Ferrari S, Mercuri M, Picci P, et al. Nonmetastatic osteosarcoma of the extremity: results of a neoadjuvant chemotherapy protocol (IOR/OS-3) with high-dose methotrex-ate, intraarterial or intravenous cisplatin, doxorubicin, and sal-vage chemotherapy based on histologic tumor response. Tumori 1999; 85: 458–64.
   PubMed Web of Science ®Google Scholar
• Rosen G, Niremberg A. Chemotherapy for osteogenic sarcoma: an investigative method, not a recipe. Cancer Treat Rep 1982; 66: 1687–97.
   PubMedGoogle Scholar
• Enneking WF, Spanier S, Goodman MA. A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop 1980; 153: 106–20.
   PubMed Web of Science ®Google Scholar
• Picci P, Bacci G, Campanacci M, et al. Histologic eval-uation of necrosis in osteosarcoma induced by chemotherapy. Regional mapping of viable and nonviable tumor. Cancer 1985; 56: 1515–21.
   Google Scholar
• Enneking WF. Modification of the system for functional evaluation of surgical management of musculoskeletal oncolo-gy. New York: Churchill Livingstone 1987.
   Google Scholar
• Rosen G, Caparros B, Huvos AG, et al. Preoperative chemotherapy for osteogenic sarcoma: selection of postopera-tive adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy. Cancer 1982; 49: 1221–30.
   PubMed Web of Science ®Google Scholar
• Meyers PA, Heller G, Healey J, et al. Chemotherapy for nonmetastatic osteogenic sarcoma: The Memorial Sloan-Kettering experience. J Clin Oncol 1992; 10: 5–15.
   PubMed Web of Science ®Google Scholar
• Provisor AJ, Ettinger LJ, Nachman JB, et al. Treatment of nonmetastatic osteosarcoma of the extremity with preoperative and postoperative chemotherapy: a report from the Children's Cancer Group. J Clin Oncol 1997; 15: 76–84.
   PubMed Web of Science ®Google Scholar
• Fuchs N, Bielack SS, Epler D, et al. Long-term results of the co-operative German-Austrian-Swiss Osteosarcoma Study Group's protocol COSS-86 of intensive multidrug chemotherapy and surgery for osteosarcoma of the limbs. Ann Oncol 1998; 9: 893–99.
   PubMed Web of Science ®Google Scholar