References
- Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL. Human breast cancer: correlation of relapse and survival with amplification of Her-2/neu oncogene. Science 1987; 235: 177–182.
- Burgering B, Coffer P. Protein kinase B (c-Akt) in phos-phatidylinositol 3-kinase signal transduction. Nature 1995; 376: 559–602.
- Franke T, Yang S, Chan T et al. The protein kinase encoded by the Akt protooncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 1995; 81: 727–736.
- Kandel ES, Hay N. The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp Cell Res 1999; 253: 210–229.
- Tewey KM, Rowe TC, Yang L et al. Adriamycin-induced DNA damage mediated by mammalian DNA topoiso-merase II. Science 1984; 226: 466–468.
- Gewirtz DA. A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem Pharmacol 1999; 57: 727–741.
- Lim S-J, Lopez-Berestein G, Hung MC, Lupu R, Tani AM. Grb2 downregulation leads to Akt inactivation in hereg-ulin-stimulated and ErbB2-overexpressing breast cancer cells. Oncogene 2000; 19: 6271-6276.
- Tari AM, Lopez-Berestein G. Serum predominantly acti-vates MAPK and Akt kinases in EGFR and ErbB2 overex-pressing cells, respectively. Intl J Cancer 2000; 86: 295–297.
- Bargmann C, Hung M-C, Weinberg R. The neu onco-gene encodes an epidermal growth factor receptor-related protein. Nature 1986; 319: 226–234.
- Yamamoto T, Ikawa S, Akiyama T et al. Similarity of protein encoded by the human c-erbB2 gene to epidermal growth factor receptor. Nature 1986; 319: 230–234.
- Tari AM, Hung MC, Li K, Lopez-Berestein G. Growth inhibition in breast cancer cells by Grb2 down regulation is correlated with inactivation of mitogen-activated protein kinase in EGFR, but not in ErbB2 cells. Oncogene 1999; 18: 1325-1332.