References
- Rosen G, Caparros B, Huvos AG, et al. Preoperative chemotherapy for osteogenic sarcoma. Selection of postoper-ative adjuvant chemotherapy based on the response of prima-ry tumor to preoperative chemotherapy. Cancer 1982; 49: 1221–1230.
- Rosen G. Preoperative (neoadjuvant) chemotherapy for osteogenic sarcoma: a ten year experience. Orthopaedics 1985; 8: 659–664.
- Winkler K, Beron G, Delling G, et al. Neoadjuvant chemotherapy of osteosarcoma: results of a randomized coop-erative trial (COSS-82) with salvage chemotherapy based on histologic tumor response. J Clin Oncol 1988; 6: 329–337.
- Saeter G, Alvegard TA, Elomaa I, Stenwig AE, Holmstrom T, Solheim OP. Treatment of osteosarcoma of the extremities with the T-10 protocol, with emphasis on the effects of preoperative chemotherapy with a single-agent high-dose methotrexate: a Scandinavian Sarcoma Group study. J Clin Oncol 1991; 9: 1766-1775.
- Bacci G, Picci P, Ferrari S, et al. Influence of adri-amycin dose in the outcome of patients with osteosarcoma treated with multidrug neoadjuvant chemotherapy: result of two sequential studies. J Chemother 1993; 5: 237–246.
- Provisor AJ, Ettinger II, Nachman JB, et al. Treatment of nonmetastatic osteosarcoma of the extremity with preoper-ative and postoperative chemotherapy: a report from the chil-dren's cancar group. J Clin Oncol 1997; 15: 76–84.
- Fuchs N, Bielack SS, Epler D, et al. Long-term results of the co-operative German-Austrian-Swiss osteosarcoma study group's protocol COSS-86 of intensive multidrug chemotherapy and surgery for osteosarcoma. Ann Oncol 1998; 9: 893–899.
- Saeter G, Wiebe T, Wiklund T, et al. Chemotherapy in osteosarcoma. The Scandinavian Sarcoma Group experience. Acta Orthop Scand 1999; 70: 74–82.
- Bacci G, Ferrari S, Berton' F, et al. Long-term Outcome for patients with nonmetastastic osteosarcoma of the extremi-ty treated at the Istituto Ortopedico Rizzoli according to the Istituto Ortopedico Rizzoli/Osteosarcoma-2 protocol: an updated report. J Clin Oncol 2000; 18: 4016-4027.
- Bacci G, Ferrari S, Delepine N, et al. Predictive factors of histologic response to primary chemotherapy in osteosarco-ma of the extremity: study of 272 patients preoperatively treated with high-dose methotrexate, doxorubicin, and cis-platin. J Clin Oncol 1998; 16: 658–663.
- Delepine N, Delepine G, Bacci G, Rosen G, Desbois JC. Influence of methotrexate dose intensity on outcome of patients with high grade osteogenic osteosarcoma. Cancer 1996; 78: 2127–2135.
- Chawla SP, Rosen G, Lowenbraun S, et al. Role of high dose ifosfamide in recurrent osteosarcoma. In: Proc Am Soc Clin Oncol 1990; 9: A1201.
- Patel SR, Vadhan-Raj, Papadopolous N, et al. High-dose ifosfamide in bone and soft tissue sarcomas: results of phase II and pilot studies - dose-response and schedule depen-dence. J Clin Oncol 1997; 15: 2378–2384.
- Rosen G, Niremberg G. Chemotherapy for osteogenic sarcoma: an investigative method, not a recipe. Cancer Treat Rep 1982; 4: 11–17.
- Enneking WF, Spanier S, Goodman MA. A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop 1980; 153: 106–120.
- Irrc' P, Bacci G, Campanacci M, et al. Histologic eval-uation of necrosis in osteosarcoma induced by chemotherapy. Cancer 1985; 56: 1515–1521.
- Huvos AG, Rosen G, Marcove RC. Pathologic aspects in 20 patients after treatment with chemotherapy, en block resection, and prosthetic bone replacement. Arch Pathol Lab Med 1977; 101: 14–18.
- Hryniuk W, Bush H. The importance of dose-intensity in chemotherapy of metastatic breast cancer. J Clin Oncol 1984; 2: 1281–1288.
- Ward WG, Mikaelian K, Dorey F, et al. Pulmonary metastases of stege IIB extremity osteosarcoma and subse-quent pulmonary metastases. J Clin Oncol 1994; 12: 1849–1858.
- Saeter G, Hole J, Stenwig AE, et al. Systemic relapse of patients with osteogenic sarcoma. Prognostic factors for long term survival. Cancer 1995; 75: 1084–1093.
- Pastorino U, Gasparini M, Tavecchio L, et al. The con-tribution of salvage surgery to the management of childhood osteosarcoma. J Clin Oncol 1991; 9: 1357–1362.
- Tabone MD, Kalifa C, Rodary C, et al. Osteosarcoma recurrences in pediatric patients previously treated with inten-sive chemotherapy. J Clin Oncol 1994; 12: 2614–2620.
- Bacci G, Ferrari S, Mercuri M, et al. Neoadjuvant chemotherapy for extremity osteosarcoma. Preliminary results of the Rizzoli's 4th study. Acta Oncol 1998; 37: 41–48.