148
Views
141
CrossRef citations to date
0
Altmetric
Experimental and Clinical Research

Inhibition of P-Glycoprotein Function and Expression by Kaempferol and Quercetin

Pages 86-95 | Published online: 18 Jul 2013

References

  • Endicott JA, Ling V. The biochemistry of P-glycopro-tein-mediated multidrug resistance. Annu Rev Biochem 1989; 58: 137–171.
  • Gottesman MM, Pastan I. The multidrug transporter, a double-edged sword. J Biol Chem 1988; 263 (25): 12163–12166.
  • Miller TP, Grogan TM, Dalton WS, Spier CM, Scheper RJ, Salmon SE. P-glycoprotein expression in malignant lym-phoma and reversal of clinical drug resistance with chemother-apy plus high-dose verapamil. J Clin Oncol 1991; 9 (1): 17–24.
  • Raderer M, Scheithauer W. Clinical trials of agents that reverse multidrug resistance. A literature review. Cancer 1993; 72 (12): 3553–3563.
  • Heim KE, Tagliaferro AR, Bobilya DJ. Flavonoid antiox-idants: chemistry, metabolism and structure-activity relation-ships. J Nutr Biochem 2002; 13 (10): 572–584.
  • Phang JM, Poore CM, Lopaczynska J, Yeh GC. Flavonol-stimulated efflux of 7,12-dimethylbenz(a)anthracene in multidrug-resistant breast cancer cells. Cancer Res 1993; 53 (24): 5977–5981.
  • Critchfield JW, Welsh CJ, Phang JM, Yeh GC. Modulation of adriamycin accumulation and efflux by flavonoids in HCT-15 colon cells. Activation of P-glycoprotein as a putative mechanism. Biochem Pharmacol 1994; 48 (7): 1437–1445.
  • Scambia G, Ranelletti FO, Panici PB et al. Quercetin potentiates the effect of adriamycin in a multidrug-resistant MCF-7 human breast-cancer cell line: P-glycoprotein as a pos-sible target. Cancer Chemother Pharmacol 1994; 34 (6): 459-464.
  • Shapiro AB, Ling V. Effect of quercetin on Hoechst 33342 transport by purified and reconstituted P-glycoprotein. Biochem Pharmacol 1997; 53 (4): 587–596.
  • Versantvoort CH, Schuurhuis CJ, Pinedo HM et al. Genistein modulates the decreased drug accumulation in non-P-glycoprotein mediated multidrug resistant tumour cells. Br J Cancer 1993; 68 (5): 939–946.
  • Castro AF, Altenberg GA. Inhibition of drug transport by genistein in multidrug-resistant cells expressing P-glycopro-tein. Biochem Pharmacol 1997; 53 (1): 89–93.
  • Mitsunaga Y, Takanaga H, Matsuo H et al. Effect of bioflavonoids on vincristine transport across blood-brain barri-er. Eur J Pharmacol 2000; 395 (3): 193–201.
  • Shen DW, Cardarelli C, Hwang J et al. Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins. J Biol Chem 1986; 261 (17): 7762–7770.
  • Ambudkar SV, Lelong IH, Zhang J, Cardarelli CO, Gottesman MM, Pastan I. Partial purification and reconstitu-tion of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis. Proc Natl Acad Sci USA 1992; 89 (18);8472-8476.
  • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxici-ty assays. J Immunol Meth 1983; 65(1-2):55–63.
  • Su WC, Chang SL, Chen TY, Chen JS, Tsao CJ. Comparison of in vitro growth-inhibitory activity of carboplatin and cisplatin on leukemic cells and hematopoietic progenitors: the myelosuppressive activity of carboplatin may be greater than its antileukemic effect. Jpn J Clin Oncol 2000; 30 (12): 562–567.
  • Khantamat O, Chaiwangyen W, Limtrakul P. Screening of flavonoids for their potential inhibitory effect on p-glycopro-tein activity in human cervical carcinoma cells. Chiang Mai Med Bull 2004; 43 (2): 45–56.
  • Bates SE, Lee JS, Dickstein B, Spolyar M, Fojo AT. Differential modulation of P-glycoprotein transport by protein kinase inhibition. Biochemistry 1993; 32 (35): 9156–9164.
  • Plouzek CA, Ciolino HP, Clarke R, Yeh GC. Inhibition of P-glycoprotein activity and reversal of multidrug resistance in vitro by rosemary extract. Eur J Cancer 1999; 35 (10): 1541–1545.
  • Nakata S, Sato J, Imai K, Yamanaka H, Ichinose Y. Epidemiological characteristics of prostate cancer in Gunma Prefecture, Japan. Gunma University Urological Oncology Study Group. Int J Urol 1995; 2 (3): 191–197.
  • Anuchapreeda S, Leechanachai P, Smith MM, Ambudkar SV, Limtrakul PN. Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells. Biochem Pharmacol 2002; 64 (4): 573–582.
  • Low' y OH, Rosebrough NJ, Lewis Farr A, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265–275.
  • Chu TM, Lin TH, Kawinski E. Detection of soluble P-glycoprotein in culture media and extracellular fluid. Biochem Biophys Res Commun 1994; 203: 506–512.
  • Mankhetkorn S, Dubru F, Hesschenbrouck J, Fiallo M, Garnier-Suillerot A. Relation among the resistance factor, kinetics of uptake, and kinetics of the P-glycoprotein-mediated efflux of doxorubicin, daunorubicin, 8-(S)-fluoroidarubicin, and idarubicin in multidrug-resistant K562 cells. Mol Pharmacol 1996; 49 (3): 532–539.
  • Limtrakul P, Anuchapreeda S, Bhudsuk D. Modulation of human multidrug- resistance MDR-1 gene by natural cur-cuminoids. BMC Cancer 2004; 4 (1): 13–21.
  • Shen DW, Fojo A, Chin JE et al. Human multidrug-resistant cell lines: increased mdrl expression can precede gene amplification. Science 1986; 232 (4750): 643–645.
  • Kioka N, Yamano Y, Komano T, Ueda K. Heat-shock responsive elements in the induction of the multidrug resis-tance gene (MDR1). FESS Lett 1992; 301 (1): 37–40.
  • Miyazaki M, Kohno K, Uchiumi T et al. Activation of human multidrug resistance-1 gene promoter in response to heat shock stress. Biochem Biophys Res Commun 1992; 187 (2): 677-684.
  • Kim SH, Yeo GS, Lim YS, Kang CD, Kim CM, Chung BS. Suppression of multidrug resistance via inhibition of heat shock factor by quercetin in MDR cells. Exp Mol Med 1998; 30 (2): 87–92.
  • Chieli E, Romiti N, Cervelli F, Tongiani R. Effects of flavonols on P-glycoprotein activity in cultured rat hepatocytes. Life Sci 1995; 57 (19): 1741–1751.
  • Volm K, Mattern J. Resistance mechanisms and their regulation in lung cancer. Crit Rev Oncogen 1996; 7: 227–244.
  • Dietel M. Whats new in cytostatic drug resistance and pathology. Pathol Res Pract 1991; 187 (7): 892–905.
  • Beck WT. Mechanisms of multidrug resistance in human tumor cells. The roles of P-glycoprotein, DNA topoiso-merase II, and other factors. Cancer Treat Rev 1990; 17 Suppl A:11-20.
  • Morrow CS, Cowan KH. Glutathione S-transferases and drug resistance. Cancer Cells 1990; 2 (1): 15–22.
  • Hammond JR, Johnstone RM, Gros P. Enhanced efflux of [3H]vinblastine from Chinese hamster ovary cells transfect-ed with a full-length complementary DNA clone for the mdrl gene. Cancer Res 1989; 49 (14): 3867–3871.
  • Hannun YA. Apoptosis and the dilemma of cancer chemotherapy. Blood 1997; 89 (6): 1845–1853.
  • Liu YY, Han TY, Giuliano AE, Cabot MC. Ceramide glycosylation potentiates cellular multidrug resistance. FASEB J 2001; 15 (3): 719–730.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.