Antagonism of HSV-tk Transfection and Ganciclovir Treatment on Chemotherapeutic Drug Sensitivity

References

• Moolten FL. Tumor chemosensitivity conferred by insert-ed herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res 1986; 46 (10): 5276–5281.
   PubMed Web of Science ®Google Scholar
• Tomicic MT, Bey E, Wutzler P, Thust R, Kaina B. Comparative analysis of DNA breakage, chromosomal aberra-tions and apoptosis induced by the anti-herpes purine nucleo-side analogues aciclovir, ganciclovir and penciclovir. Mutat Res 2002; 505 (1-2): 1–11.
   PubMed Web of Science ®Google Scholar
• Tomicic MT, Thust R, Kaina B. Ganciclovir-induced apoptosis in HSV-1 thymidine kinase expressing cells: critical role of DNA breaks, Bcl-2 decline and caspase-9 activation. Oncogene 2002; 21 (14): 2141–2153.
   PubMed Web of Science ®Google Scholar
• van Dillen IJ, Mulder NH, Vaalburg W, de Vries EFJ, Hospers GAP. Influence of the bystander effect on HSV-tk/GCV gene therapy. A review. Curr Gene Ther 2002; 2 (3): 307–322.
   PubMedGoogle Scholar
• Wildner O, Morris JC, Vahanian NN, Ford H, Jr., Ramsey WJ, Blaese RM. Adenoviral vectors capable of repli-cation improve the efficacy of HSVtk/GCV suicide gene ther-apy of cancer. Gene Ther 1999; 6 (1): 57–62.
   PubMed Web of Science ®Google Scholar
• Robe PA, Princen F, Martin D et al. Pharmacological modulation of the bystander effect in the herpes simplex virus thymidine kinase/ganciclovir gene therapy system: effects of dibutyryl adenosine 3',5'-cyclic monophosphate, alpha-gly-cyrrhetinic acid, and cytosine arabinoside. Biochem Pharmacol 2000; 60 (2): 241-249.
   Google Scholar
• Touraine RL, Vahanian N, Ramsey WJ, Blaese RM. Enhancement of the herpes simplex virus thymidine kinase/ganciclovir bystander effect and its antitumor efficacy in vivo by pharmacologic manipulation of gap junctions. Hum Gene Ther 1998; 9 (16): 2385–2391.
   PubMed Web of Science ®Google Scholar
• Mesnil M, Yamasaki H. Bystander effect in herpes sim-plex virus-thymidine kinase/ganciclovir cancer gene therapy: role of gap-junctional intercellular communication. Cancer Res 2000; 60 (15): 3989–3999.
   PubMed Web of Science ®Google Scholar
• Freytag S, Paielli D, Wing M et al. Efficacy and toxicity of replication-competent adenovirus-mediated double suicide gene therapy in combination with radiation therapy in an orthotopic mouse prostate cancer model. Int J Radiat Oncol Biol Phys 2002; 54 (3): 873.
   Google Scholar
• Freytag SO, Khil M, Stricker H et al. Phase I study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancer. Cancer Res 2002; 62 (17): 4968–4976.
   Google Scholar
• Boucher PD, Ostruszka LJ, Shewach DS. Synergistic enhancement of herpes simplex virus thymidine kinase/ganci-clovir-mediated cytoxicity by hydroxyurea. Cancer Res 2000; 60 (6): 1631–1636.
   PubMed Web of Science ®Google Scholar
• Marini FC, III, Pan BF, Nelson JA, Lapeyre JN. The drug verapamil inhibits bystander killing but not cell suicide in thymidine kinase-ganciclovir prodrug-activated gene therapy. Cancer Gene Ther 1996; 3 (6): 405–412.
   PubMed Web of Science ®Google Scholar
• Tong X, Shine DH, Agoulnik I et al. Adenovirus medi-ated thymidine kinase gene therapy may enhance sensitivity of ovarian cancer cells to chemotherapeutic agents. Anticancer Res 1998; 18 (5A): 3421-3426.
   Google Scholar
• Rainov NG, Fels C, Droege JW, Schafer C, Kramm CM, Chou TC. Temozolomide enhances herpes simplex virus thymidine kinase/ganciclovir therapy of malignant glioma. Cancer Gene Ther 2001; 8 (9): 662–668.
   PubMed Web of Science ®Google Scholar
• Wildner O, Blaese RM, Morris JC. Synergy between the herpes simplex virus tk/ganciclovir prodrug suicide system and the topoisomerase I inhibitor topotecan. Hum Gene Ther 1999; 10 (16): 2679–2687.
   PubMed Web of Science ®Google Scholar
• Wildner O, Blaese RM, Candotti F. Enzyme prodrug gene therapy: synergistic use of the herpes simplex virus-cellu-lar thymidine kinase/ganciclovir system and thymidylate syn-thase inhibitors for the treatment of colon cancer. Cancer Res 1999; 59 (20): 5233–5238.
   PubMed Web of Science ®Google Scholar
• Nuessler V, Pogrebniak A, Pelka-Fleischer R, Boos K, Wilmanns W. Determination of thymidine phosphorylase activ-ity in leukemic blast cells by a high-performance liquid-chro-matographic assay. Chromatographia 2002; 49: 173–178.
   Web of Science ®Google Scholar
• Hospers GAP, Calogero A, van Waarde A et al. Monitoring of herpes simplex virus thymidine kinase enzyme activity using positron emission tomography. Cancer Res 2000; 60 (6): 1488–1491.
   Google Scholar
• Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248–254.
   PubMed Web of Science ®Google Scholar
• Berenbaum MC. What is synergy? Pharmacol Rev 1989; 41 (2): 93–141.
   PubMed Web of Science ®Google Scholar
• Beck WT. Topoisomerase inhibitors. In: Ratain MJ, Tempero M, Skosey C, eds. Outline of Oncology Therapeutics. W.B. Saunders Company, Philadelphia. 2001: 31-48.
   Google Scholar
• Dolan ME. DNA-binding agents. In: Ratain MJ, Tempero M, Skosey C, eds. Outline of Oncology Therapeutics. W.B. Saunders Company, Philadelphia. 2001: 1-20.
   Google Scholar
• Schilsky RL. Antimetabolites and their modulators. In: Ratain MJ, Tempero M, Skosey C, eds. Outline of Oncology Therapeutics. W.B. Saunders Company, Philadelphia. 2001: 49-66.
   Google Scholar
• Van Moorsel CJ, Smid K, Voorn DA, Bergman AM, Pinedo HM, Peters GJ. Effect of gemcitabine and cis-platinum combinations on ribonucleotide and deoxyribonucleotide pools in ovarian cancer cell lines. Int J Oncol 2003; 22 (1): 201–207
   PubMed Web of Science ®Google Scholar
• Wilkinson YA, McKenna PG. The effects of thymidine on deoxyribonucleotide pool levels, cytotoxicity and mutation induction in Friend mouse erythroleukaemia cells. Leuk Res 1989; 13 (7): 615–620.
   PubMed Web of Science ®Google Scholar
• Mineishi S, Nakahara S, Takebe N, Banerjee D, Zhao SC, Bertino JR. Co-expression of the herpes simplex virus thymidine kinase gene potentiates methotrexate resistance conferred by transfer of a mutated dihydrofolate reductase gene. Gene Ther 1997; 4 (6): 570–576.
   PubMed Web of Science ®Google Scholar
• Tomicic MT, Thust R, Sobol RW, Kaina B. DNA poly-merase beta mediates protection of mammalian cells against ganciclovir-induced cytotoxicity and DNA breakage. Cancer Res 2001; 61 (20): 7399–7403.
   PubMed Web of Science ®Google Scholar
• Grem JL, Danenberg KD, Behan K et al. Thymidine kinase, thymidylate synthase, and dihydropyrimidine dehydro-genase profiles of cell lines of the National Cancer Institute's Anticancer Drug Screen. Clin Cancer Res 2001; 7 (4): 999–1009.
   Google Scholar