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Original Articles

Absence of Carcinogenic Activity in Fischer Rats and B6C3F1 Mice Following 103-Week Inhalation Exposures to Toluene

Pages 138-146 | Published online: 19 Jul 2013

References

  • Ozokwelu ED. Toluene. In: Kirk-Othmer Encyclopedia of Chemical Technology. New York: John Wiley 8c Sons, 1997.
  • Belpoggi F, Soffritti M, Maltoni C. Methyl-tertiary-butyl ether (MTBE)-a gasoline additive-causes testicular and lympho-haematopoietic cancers in rats. Toxicol Ind Health. 1995; 11: 119–49.
  • Belpoggi F, Soffritti M, Filippini F, Maltoni C. Results of long-term experimental studies on the carcinogenicity of methyl tert-butyl ether. Ann NYAcad Sci. 1997 Dec 26; 837: 77–95.
  • Bird MG, Burleigh-Flayer HD, Chun JS, Douglas JF, Kneiss JJ, Andrews LS. Oncogenicity studies of inhaled methyl tertiary-butyl ether (MTBE) in CD-1 mice and F-344 rats. J Appl Toxicol. 1997;17, suppl 1:S45-S55.
  • Halprin J. Senate committee approves bill to phase out MTBE. Washington Post, 27 Sept 2001.
  • Chouaniere D, Wild P, Fontana JM, et al. Neurobehavioral dis-turbances arising from occupational toluene exposure. Am J Ind Med. 2002; 41: 77–88.
  • Henderson RF. Aromatic Hydrocarbons-Benzene and Other Alkylbenzenes. Toluene. In: Bingham E, Cohrssen B, Powell CH ( eds), Patty's Toxicology. New York: John Wiley & Sons, 2001.
  • Huff J, NTP Staff. Toxicology and Carcinogenesis Studies of Toluene (CAS No.108-88-3) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). NTP Tech Rept Series No. 371. National Toxicology Program, Research Triangle Park, NC, 1990.
  • Gibson JE, Hardisty JF. Chronic toxicity and oncogenicity bioas-say of inhaled toluene in Fischer-344 rats. Fundam Appl Toxi-col. 1983; 3: 315–9.
  • Maltoni C, Conti B, Cotti G, Belpoggi F. Experimental studies on benzene carcinogenicity at the Bologna Institute of Oncol-ogy: current results and ongoing research. Am J Ind Med. 1985; 7 (5-6) :415–46.
  • Maltoni C, Ciliberti A, Pinto C, Soffritti M, Belpoggi F, Menarini L. Results of long-term experimental carcinogenicity studies of the effects of gasoline, correlated fuels, and major gasoline aro-matics on rats. Ann NYAcad Sci. 1997 Dec 26; 837: 15–52.
  • Soffritti M, Belpoggi F, Maltoni C. Carcinogenicity in Sprague-Dawley rats following long-term oral administration of toluene in a life-span study. Eur J Oncol (in press, 2003).
  • Huff J. Design strategies, results and evaluations of long-term chemical carcinogenesis studies. Scand J Work Environ Health. 1992;18, suppl 1: 31-7.
  • Bucher JR. The National Toxicology Program rodent bioassay. Ann NYAcad Sci, 2002; 982: 198–207.
  • Huff JE, McConnell EE, Haseman JK, et al. Carcinogenesis stud-ies: results of 398 experiments on 104 chemicals from the U.S. National Toxicology Program. Ann NYAcad Sci. 1988; 534: 1–30.
  • Bucher JR. Doses in rodent cancer studies: sorting fact from fic-tion. Drug Metab Rev. 2000; 32: 153–63.
  • Yamaguchi H, Kidachi Y, Ryoyama K. Toluene at environmen-tally relevant low levels disrupts differentiation of astrocyte pre-cursor cells. Arch Environ Health. 2002; 57: 232–8.
  • Gerasimov MR, Ferrieri RA, Schiffer WK, et al. Study of brain uptake and biodistribution of (11C)toluene in non-human pri-mates and mice. Life Sci. 2002; 70: 2811-28.
  • Riegel AC, French ED. Abused inhalants and central reward pathways: electrophysiological and behavioral studies in the rat. Ann NYAcad Sci. 2002; 965: 281–91.
  • Huff JE, Haseman JK, DeMarini DM, et al. Multiple-site car-cinogenicity of benzene in Fischer 344 rats and B6C3F1 mice. Environ Health Perspect. 1989; 82: 125–63.
  • International Agency for Research on Cancer. Toluene. IARC Monogr Eval Carcinog Risks Hum. 1999;71 Pt 2: 829-64.
  • U.S. Environmental Protection Agency. Toluene in: Toxic Release Inventory (TRI) Chemicals. TRI On-site and Off-site Reported Releases (in Pounds), for Facilities in All Industries, for All Chemicals, U.S., 2000. http://www.epa.gov/cgi-bin/broker. 2003.
  • Pelclova D, Cerna M, Pastorkova A, et al. Study of the genotox-icity of toluene. Arch Environ Health. 2000; 55: 268–73.
  • Tsutsui T, Hayashi N, Maizumi H, Huff J, Barrett JC. Benzene-, catechol-, hydroquinone- and phenol-induced cell transforma-tion, gene mutations, chromosome aberrations, aneuploidy, sister chromatid exchanges and unscheduled DNA synthesis in Syrian hamster embryo cells. Mutat Res. 19973; 373: 113–23.
  • Huff JE, E,astin W, Roycroft J, Eustis SL, Haseman JK, Carcino-genesis studies of benzene, methyl benzene, and dimethyl ben-zenes. Ann NYAcad Sci. 1988; 534: 427–40
  • Huff J, Hejtmancik M, Eastin W. Carcinogenic activity of indus-trial grade mixed xylenes. Submitted.
  • Chan PC, Hasemani JK, Mahleri J, Aranyi C. Tumor induction in F344/N rats and B6C3F1 mice following inhalation exposure to ethylbenzene. Toxicol Lett. 1998 Sep 30; 99 (1): 23–32.
  • National Toxicology Program. Toxicology and Carcinogenesis Studies of Benzyl Alcohol (CAS No. 100-51-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP Tech Rept No 378. National Toxicology Program, Research Triangle Park, NC, 1989.
  • National Toxicology Program. Toxicology and Carcinogenesis Studies of Benzaldehyde (CAS No. 100-52-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP Tech Rept No 378. National Toxicology Program, Research Triangle Park, NC, 1990.
  • Hoel DG, Haseman JK, Hogan MD, Huff J, McConnell EE. The impact of toxicity on carcinogenicity studies: implications for risk assessment. Carcinogenesis. 1988; 9: 2045–52.
  • Huff J. Chemical toxicity and chemical carcinogenesis. Is there a causal connection? A comparative morphological evaluation of 1500 experiments. IARC Sci Publ. 1992; 116: 437–75.
  • Huff J. Absence of morphologic correlation between chemical toxicity and chemical carcinogenesis. Environ Health Perspect. 1993;101, suppl 5: 45-53.
  • Melnick RL, Huff J. Liver carcinogenesis is not a predicted out-come of chemically induced hepatocyte proliferation. Toxicol Ind Health. 1993; 9: 415–38.
  • Melnick RL. Does chemically induced hepatocyte proliferation predict liver carcinogenesis? FASEB J. 1992; 6 (9): 2698–706.
  • Huff J. Mechanisms, chemical carcinogenesis, and risk assess-ment: cell proliferation and cancer. Am J Ind Med. 1995; 27: 293–300.
  • Melnick RL, fluffJ, Barrett JC, Maronpot RR, Lucier G, Portier CJ. Cell proliferation and chemical carcinogenesis: a sympo-sium overview. Mol Carcinog. 1993; 7: 135–8.
  • Ward JM, Uno H, Kurata Y, Weghorst CM, Jang JJ. Cell prolifer-ation not associated with carcinogenesis in rodents and humans. Environ Health Perspect. 1993;101, suppl 5: 125-35.
  • Tomatis L. Cell proliferation and carcinogenesis: a brief history and current view based on an IARC workshop report. Interna-tional Agency for Research on Cancer. Environ Health Perspect 1993;101, suppl 5: 149-51.
  • Melnick RL, Roycmft JH, Hailey JR, Bucher JR, Huff J. Carcino-genic effects of inhaled non-fibrous poorly soluble particulates in rats and mice contradict lung particle overload, chronic pul-monary inflammation, and threshold hypotheses. Eur J Oncol. In press.
  • Huff J, Melnick RL. Chemical Carcinogenesis Bioassays: Critical for the sensible application of the precautionary principle for protecting public health. In memory: Cesare Maltoni, Norton Nelson, David Rall, Irving Selikoff. Eur J Oncol. In press.
  • Bucher JR, Huff J, Jokinen MP, Haseman JK, Stedham M, Cholakis JM. Inhalation of tetranitromethane causes nasal pas-sage irritation and pulmonary carcinogenesis in rodents. Cancer Lett. 1991; 57: 95–101.
  • Abdo KM, Grumbein S. Chou BJ, Herbert R. Toxicity and car-cinogenicity study in F344 rats following 2 years of whole-body exposure to naphthalene vapors. Inhal Toxicol. 2001; 13: 931–50.
  • Eustis SL, Hailey JR, Boorman GA, Haseman JK. The utility of multiple-section sampling in the histopathological evaluation of the kidney for carcinogenicity studies. Toxicol Pathol. 1994; 22: 457–72.
  • Rao GN. Diet and kidney diseases in rats. Toxicol Pathol. 2002; 30: 651–6.
  • Rao GN. New nonpurified diet (NTP-2000) for rodents in the National Toxicology Program's toxicology and carcinogenesis studies. J Nutr. 1997;127, 5 supp1: 842S-846S.
  • Rao GN. New diet (NTP-2000) for rats in the National Toxicol-ogy Program toxicity and carcinogenicity studies. Fundam Appl Toxicol. 1996; 32: 102–8.
  • Rao GN. Influence of diet on tumors of hormonal tissues. Progr Clin Biol Res. 1996; 394: 41–56.
  • Rao GN, Edmondson J, Elwell MR. Influence of dietary protein concentration on severity of nephropathy in Fischer-344 (F-344/N) rats. Toxicol Pathol. 1993; 21: 353–61.
  • Perera F, Brennan T, Fouts JR. Comment on the significance of positive carcinogenicity studies using gavage as the route of exposure. Environ Health Perspect. 1989; 79: 315–21.
  • Haseman JK, Tharrington EC, Huff JE, McConnell EE. Com-parison of site-specific and overall tumor incidence analyses for 81 recent National Toxicology Program carcinogenicity studies. Regal Toxicol Pharmacol. 198; 6: 155-70.
  • Haseman J, Melnick R, Tomatis L, Huff J. Carcinogenesis bioas-says: study duration and biological relevance. Food Chem Toxi-col. 2001; 39: 739–44.
  • Huff J. Chemicals studied and evaluated in long-term carcino-genesis bioassays by both the Ramazzini Foundation and by the National Toxicology Program. In tribute to Cesare Maltoni and David Rall. Ann NYAcad Sci. 2002; 982: 208–29.
  • Soffritti M, Belpoggi F, Minardi F, Maltoni C. Ramazzini Foun-dation cancer program: history and major products, life-span carcinogenicity bioassay design, chemicals studies, and results. Ann NYAcad Sci. 2002; 982: 26–45.
  • Huff J, Abdo K. Carcinogenicity of benzyl acetate in rodents via two exposure circumstances: oral intubation and feed. [ Submitted.]
  • Huff J. 1,2-Dibromoethane (ethylene dibromide). Environ Health Perspect. 1983; 47: 359–63.
  • IARC. Ethylene dibromide (1,2-dibromoethane). IARC Monogr Eval Carcinog Risks Hum. 1999;71, Pt 2: 641–69.
  • Maltoni C. Occupational carcinogenesis. Predictive value of carcinogenesis bioassays. Ann NYAcad Sci. 1976; 271: 431–43.
  • Maltoni C. Predictive carcinogenicity bioassays in industrial oncogenesis. Progr Biochem Pharmacol. 1978; 14: 47–56.
  • Maltoni C, Minardi F, Soffritti M, Lefemine G. Long-term car-cinogenicity bioassays on industrial chemicals and man-made mineral fibers, at the Bentivoglio (BT) laboratories of the Bologna Institute of Oncology: premises, programs, and results. Toxicol Ind Health. 1991; 7 (5-6): 63–94.
  • Maltoni C, Soffritti M, Belpoggi F. The scientific and method-ological bases of experimental studies for detecting and quanti-fying carcinogenic risks. Ann NYAcad Sci. 1999; 895: 10–26.
  • Maltoni C. The long-lasting legacy of industrial carcinogens: the lesson of asbestos. Irving J. Selikoff Memorial Lecture, 1995. Ann NYAcad Sci. 1997; 837: 570–86.
  • Maltoni C. The contribution of experimental (animal) studies to the control of industrial carcinogenesis. Appl Occup Environ Hyg. 1995; 10: 749–760.
  • Huff J. Long-term chemical carcinogenesis bioassays predict human cancer hazards. Issues, controversies, and uncertainties. Ann NYAcad Sci. 1999; 895: 56–79.
  • Huff J. Value, validity, and historical development of carcino-genesis studies for predicting and confirming carcin ogenic risks to humans. Chapter 2: 21-123. In: Kitchin KT (ed). Carcino-genicity Testing, Predicting, & Interpreting Chemical Effects, New York: Marcel Dekker, 1999.
  • Huff J. Chemical carcinogenesis bioassays, primary prevention, precautionary principles, and public health. Environ Health Perspect [submitted].
  • Huff J. Carcinogenicity of bisphenol-A in Fischer rats and B6C3F1 mice. Odontology. 2001r; 89 (1): 12–20.
  • Huff J. Carcinogenicity of bisphenol A: revisited. Toxicol Sci, 2002; 70: 281–4.
  • Huff J. Does exposure to bisphenol A represent a human health risk? Regal Toxicol Pharmacol. In press.
  • Wiebelt H, Becker N. Mortality in a cohort of toluene exposed employees (rotogravure printing plant workers). J Occup Envi-ron Med. 1999; 41: 1134–9.
  • Gerin M, Siemiatycki J, Desy M, Krewski D. Associations between several sites of cancer and occupational exposure to benzene, toluene, xylene, and styrene: results of a case-control study in Montreal. Am J Ind Med. 1998; 34: 14–4- 56.
  • Goldberg MS, Parent ME, Siemiatycki J, et al. A case-control study of the relationship between the risk of colon cancer in men and exposures to occupational agents. Am J Ind Med. 2001; 39: 531–46.

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