8
Views
4
CrossRef citations to date
0
Altmetric
Book Reviews

What Are the Real Causes of Cancer?

Pages 81-87 | Published online: 19 Jul 2013

Selected References

  • Gold LS, Slone TH, Manley NE, Ames BN. Misconceptions about the Causes of Cancer. Risk Controversy Series 3. Canada: The Fraser Institute, 2002, 141 pages.
  • Tomatis L, Melnick RL, Haseman J, Bar-rett JC, Huff J. Alleged misconceptions distort perceptions of environmental cancer risks. FASEB J. 2001 Jan; 15 (1): 195–203.
  • Tomatis L, Huff J, Hertz-Picciotto I, et al. Avoided and avoidable risks of cancer. Carcinogenesis. 1997 Jan;18: 97–105.
  • Huff J. Value, validity, and historical development of carcinogenesis studies for predicting and confirming carcino-genic risks to humans. In: Kitchin KT (ed). Carcinogenicity Testing, Predict-ing, 8c Interpreting Chemical Effects. New York: Marcel Dekker, 1999; chapter 2: 21-123.
  • NRC/NAS. Pesticides in the Diets of Infants and Children. Committee on Pesticides in the Diets of Infants and Children, National Research Council, NationalAcademy of Sciences, Washington, DC, 1993; 408 pages.
  • Davis DL. Natural anticarcinogens, car-cinogens, and changing patterns in cancer: some speculation. Environ Res. 1989 Dec;50 (2) :322–40.
  • Wattenberg LW, Hanley AB, Barany G, Sparnins VL, Lam LK, Fenwick GR. Inhibition of carcinogenesis by some minor dietary constituents. Princess Takamatsu Symp. 1985; 16: 193–203.
  • Rall DP. Laboratory animal tests and human cancer. Drug Metab Rev. 2000; 32: 119–28.
  • Huff” Long-term chemical carcinogen-esis bioassays predict human cancer hazards. Issues, controversies, and uncertainties. Ann NY Acad Sci. 1999; 895: 56–79.
  • Soffritti M, Belpoggi F, Minardi F, Maltoni C. Ramazzini Foundation cancer program: history and major projects, life-span carcinogenicity bioassay design, chemicals studied, and results. Ann NYAcad Sci. 2002; 982: 26–45.
  • Huff J. Chemicals studied and evaluated in long-term carcinogenesis bioassays by both the Ramazzini Foundation and the National Toxicology Program: in tribute to Cesare Maltoni and David Rall, Ann NYAcad Sci. 2002; 982: 208–30.
  • IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. International Agency for Research on Cancer, Lyons, France, 2005.
  • NTP 11th Report on Carcinogens (RoC), National Toxicology Program, ResearchTraingle Park, NC 2004.
  • EPA. Guidelines for Carcinogen Risk Assessment and Supplemental Guidance for Assessing Susceptibility from Early-Life Exposure to Carcinogens. Environmental Protection Agency, Washington, DC, 2005; 166 pages.
  • Tomatis L, Huff” Evolution of research on cancer etiology. Chapter 9: 189-201. In: Coleman WE, Tsongalis GJ (eds). The Molecular Basis of Human Cancer: Genomic Instability and Molecular Mutation in Neoplastic Transformation. Totowa, NJ: Humana, 2002.
  • Maronpot RR, Flake G, Huff J. Relevance of animal carcinogenesis findings to human cancer predictions and prevention. Toxicol Pathol. 2004;32 suppl 1: 40-8.
  • Tomatis L, Huff J. Evolution of cancer etiology and primary prevention. Environ Health Perspect. 2001; 109: A458–60.
  • Rall DP. Shoe-leather epidemiology-the footpads of mice and rats: animal tests in assessment of occupational risks. Mt Sinai J Med. 1994; 61: 504–8.
  • Tomatis 1., Aitio A, Wilbourn J, Shuker L. Human carcinogens so far identified. Jpn J Cancer Res, 1989; 80: 795–807
  • Huff J. Chemicals causally associated with cancers in humans and in laboratory animals: a perfect concordance. In: Waalkes MP, Ward JM (eds). Carcinogenesis. New York: Raven Press, 1994; chapter 2; 25-37.
  • Huff J, Rall DP. Relevance to humans of carcinogenesis results from laboratory animal toxicology studies, 433-440 8c 453-457. In: Last JM, Wallace RB (eds). Maxcy-Rosenau-Last's Public Health 8c Preventive Medicine. 13th ed. Norwalk, CT: Appleton 8c Lange, 1992; 1257 pages.
  • Huff J. Carcinogenesis results in animals predict cancer risks to humans. In: Wal-lace RB (ed). Maxcy-Rosenau-Last's Public Health 8c Preventive Medicine. 14th ed. Norwalk, CT: Appleton 8c Lange, 1998; 23: 543–50; 567-69.
  • Huff J. Known and attributed human carcinogens. In: Wallace RB (ed). Maxcy-Rosenau-Last's Public Health 8c Preventive Medicine. 15th ed. Norwalk, CT: Appleton & Lange, in press, 2006.
  • Tomatis L. The predictive value of rodent carcinogenicity tests in the eval-uation of human risks. Annu Rev Phar-macol Toxicol. 1979; 19: 511–30.
  • Huff J. Chemicals and cancer in humans: first evidence in experimental animals. Environ Health Perspect. 1993; 100: 201–10.
  • Huff J, Boyd J, Barrett JC. Hormonal carcinogenesis and environmental influ-ences: environmental influences. Progr Clin Biol Res. 1996; :1-XiX; 1-479.
  • Melnick R, Lucier G, Wolfe M, et al. Summary of the National Toxicology Program's report of the endocrine dis-ruptors low-dose peer review. Environ Health Perspect. 2002; 110: 427–31.
  • Haseman J, Melnick R, Tomatis L, Huff J. Carcinogenesis bioassays: study dura-tion and biological relevance. Food Chem Toxicol. 2001; 39: 73944.
  • Huff J. Carcinogenicity of bisphenol-A in Fischer rats and B6C3F1 mice. Odon-tology. 2001; 89: 12–20.
  • Huff J. Carcinogenicity of bisphenol A revisited. Toxicol Sci. 2002; 70: 281–3; author reply 283-4.
  • Huff J. Does exposure to bisphenol A represent a human health risk? Regul Toxicol Pharmacol. 2003; 37: 407–8.
  • Bucher JR. National Toxicology Pro-gram rodent bioassay: designs, interpretations, and scientific contributions. Ann NYAcad Sci. 2002; 982: 198–207.
  • Timms BG, Howdeshell KL, Barton L, Bradley S, Richter GA, vom Saal FS. Estrogenic chemicals in plastic and oral contraceptives disrupt development of the fetal mouse prostate and urethra. Proc Natl Acad Sci USA. 2005; 102: 70149.
  • Palmlund I. Exposure to a xenoestrogen before birth: the diethylstilbestrol expe-rience. J Psychosom Obstet Gynaecol. 1996; 17: 71–84.
  • Cairns J Jr. Absence of certainty is not synonymous with absence of risk. Envi-ron Health Perspect. 1999; 107: A56–7.
  • Epstein SS, Ashford NA, Blackwelder B, et al. The crisis in U.S. and international cancer policy. Int J. Health Serv. 2002; 32: 669–707.
  • Huff J. Industry influence on health and the environment fantasy, paranoia, real-ity? An insider's personal experience Int J Occup Environ Health. 2006; in press.
  • Huff J. Occupational Carcinogenesis: an international disgrace. Int J Occup Env-iron Health. 2006; in press.
  • Tomatis Lc Identification of carcino-genic agents and primary prevention of cancer. Ann NYAcad Sci. 2006;in press.
  • Schmahl D, Preussmann R, Berger MR. Causes of cancer-an alternative view to Doll and Peto (1981). Kiln Wochenschr. 1989; 67: 1169-73.
  • Schmahl D. Possibilities and limitations in cancer prevention. Naturwissen-schaften. 1988; 75: 334–40.
  • Maltoni C. The contribution of experi-mental [animal] studies to the control of industrial carcinogenesis. Appl Occup Environ Hyg. 1995; 10: 749–760.
  • Maltoni C, Soffritti M, Belpoggi F. The scientific and methodological bases of experimental studies for detecting and quantifying carcinogenic risks. Ann NY Acad Sci. 1999; 895: 10–26.
  • Huff J, Haseman J, Rall D. Scientific concepts, value, and significance of chemical carcinogenesis studies. Annu Rev Pharmacol Toxicol. 1991; 31: 621–52.
  • HuffJ, Hasemani Long-term chemical carcinogenesis experiments for identify-ing potential human cancer hazards: collective database of the National Cancer Institute and National Toxicol-ogy Program (1976-1991). Environ Health Perspect. 1991; 96: 23–31.
  • Tickner JA. Precautionary principle encourages policies that protect human health and the environment in the face of uncertain risks. Public Health Rep. 2002; 117: 493–7.
  • Fung VA, Barrett JC, Huff J. The car-cinogenesis bioassay in perspective: application in identifying human cancer hazards. Environ Health Per-spect. 1995; 103: 680–3.

Suggested Additional Reading

  • Axelson O, Balbus JM, Cohen G, et al. Re: Regulatory Toxicology and Pharmacol-ogy. Int J Occup Environ Health. 2003; 9: 386–9.
  • Habs M, Schmahl D. Combination effects in different organs in small rodents. In: Schmahl D (ed). Combination Effects in Chemicals Carcinogenesis. 1988: 75–92.
  • Huff J, Chan P, Nyska A. Is the human carcinogen arsenic carcinogenic to labora-tory animals? Toxicol Sci. 2000; 55: 17–23.
  • Huff J, Melnick R, Tomatis L, LaDou J, Teit-elbaum D. Trichloroethylene and can-cers in humans. Toxicology. 2004; 197: 185–7.
  • Huff J, Tomatis L. Re: Long-term toxicity and carcinogenicity study of cyclamate in nonhuman primates (Takayama et al. Toxicol Sci. 53, 33-9). Toxicol Sci. 2000; 57:186.
  • Huff J. IARC and the DEHP quagmire. Int J Occup Environ Health. 2003; 9: 402–4.
  • Huff J. IARC monographs, industry influ-ence, and upgrading, downgrading, and under-grading chemicals: a personal point of view. International Agency for Research on Cancer Int J Occup Environ Health. 2002; 8: 249–70.
  • Huff J. Sawmill chemicals and carcinogene-sis. Environ Health Perspect. 2001; 109: 209–12.
  • Johnson FM, Huff J. Bioassay bashing is bad science. Environ Health Perspect. 2002; 110: A736–7.
  • Melnick RL, Brody C, HuffJ. The IARC eval-uation of DEHP excludes key papers demonstrating carcinogenic effects. Int J Occup Environ Health. 2003c; 9: 400–2.
  • Melnick RL, Huff J. Testing toxic pesticides in humans: health risks with no health benefits. Environ Health Perspect. 2004; 112: A459–61.
  • Melnick RL, Kamel F, Huff J. Declaring chemicals “not carcinogenic to humans” requires validation, not speculation. Env-iron Health Perspect. 2003; 111: A203–4.
  • Melnick RL. Is permdsome proliferation an obligatory precursor step in the carcino-genicity of di (2-ethylhexyl) phthalate (DEHP)? Environ Health Perspect. 2001; 109: 437–42.
  • Melnick RL, Kohn MC. Possible mechanisms of induction of renal tubule cell neo-plasms in rats associated with alpha 2u-globulin: role of protein accumulation versus ligand delivery to the kidney. IARC Sci Publ. 1999; (147): 119-37.
  • Melnick RL. Introduction-workshop on characterizing the effects of endocrine disruptors on human health at environ-mental exposure levels. Environ Health Perspect. 1999;107 suppl 4: 603-4.
  • Melnick RL, Kohn MC, HuffJ. Weight of evi-dence versus weight of speculation to evaluate the alpha2u-globulin hypothe-sis. Environ Health Perspect. 1997; 105: 904-6. Odontology. 2001; 89: 12–20.
  • Schmahl D. Combination effects in chemi-cal carcinogenesis. New York: VCH Pub-lishers, 1988; 279 pages.
  • Thayer KA, Melnick R, Burns K, Davis D, Huff J. Fundamental flaws of hormesis for public health decisions. Environ Health Perspect. 2005; 113: 1271–6.
  • Tomatis L. Primary prevention of cancer in relation to science, sociocultural trends and economic pressures. Scand j Work Environ Health. 2005; 31: 227–32.
  • Tomatis L, HuffJ. Evidence of carcinogenic-ity of DDT in nonhuman primates. J Cancer Res Clin Oncol. 2000; 126: 246.
  • Van Larebeke NA, Birnbaum LS, Boogaerts MA, et al. Unrecognized or potential risk factors for childhood cancer. Int J Occup Environ Health. 2005; 11: 199–201.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.