48
Views
21
CrossRef citations to date
0
Altmetric
Research Article

The Effects of Single and Repeated Administration of Ebastine on Cognition and Psychomotor Performance in Comparison to Triprolidine and Placebo in Healthy Volunteers

&
Pages 273-281 | Published online: 26 Aug 2008

References

  • Howarth P. Assessment of antihistamine efficacy and potency. Determining the safety and efficacy of antihistamines. Presented at the Seventeenth Congress of the European Academy of Allergology and Clinical Immunology, Birmingham, UK, 1998
  • Hindmarch I, Shamsi Z. Antihistamines: models to assess sedative properties, assessment of sedation, safety and other side-effects. Clin Exp Allergy 1999;29(3):133–42
  • Shamsi Z, Hindmarch I. Sedation and antihistamines: a review of inter-drug differences using proportional impairment ratios. Hum Psy Clin Exp 2000;15(1):3–30
  • Volkerts ER, Van Willigenburg APP, Van Laar MW, Maes RA. Does cetirizine belong to the new generation of antihista-mines? An investigation into its acute and sub-chronic effects on highway driving, psychometric test performance and daytime sleepiness. Hum Psy Clin Exp 1992;7:227–38
  • Vermeeren A, Ramaekers JG, van Leeuwen CJ, O’Hanlon, JF. Residual effects on actual car driving of evening dosing of chlorpheniramine 8 and 12 mg when used with terfenadine 60 mg in the morning. Hum Psy Clin Exp 1998;13(2):79–86
  • Fairweather DB, Stanley N, Yoon J-S, Hindmarch I. The effects of fluoxetine and dothiepin on cognitive function in depressed patients in general practice. Hum Psy Clin Exp 1999;14:325–32
  • Simons FER. The therapeutic index of newer H1-receptor antagonists. Clin Exp Allergy 1994;24(8):707–23
  • Wiseman LR, Faulds D. Ebastine: A review of its pharmacological properties and clinical efficacy in the treatment of allergic disorders. Drugs 1996;51(2):260–77
  • Vincent J, Laminana R, Meredith PA. The pharmacokinetics, antihistamine and concentration–effect relationship of ebastine in healthy volunteers. Br J Clin Pharmacol 1988;26:497–502
  • Vincent J, Summer DJ, Reid JL. Ebastine: the effect of a new antihistamine on psychomotor performance and autonomic responses in healthy volunteers. Br J Clin Pharmacol 1988;26:503–8
  • Hopes H, Meuret G, Ungethum LG, Wiemann H. H1-receptor antagonists: placebo-controlled comparison of the acute effects of ebastine and clemastine on performance and EEG. Eur J Clin Pharmacol 1992;42:55–9
  • Aparicio S, Granel C, Randazzo L. Studies of non-sedative antihistamines (II): Assessment of its antihistaminic potency. Allergol Immunopathol Madr 1992;20:207–10
  • Matilla MJ, Kuitunen T, Pletan Y. Lack of pharmacodynamic and pharmacokinetic interactions of the antihistamine ebastine with ethanol in healthy subjects. Eur J Clin Pharmacol 1993;43:179–84
  • Azcona O, Barbanoj MJ, Gich I. Evaluation of CNS effects of repeated doses of ebastine and their interaction with alcohol in healthy subjects. J Psychopharmacol 1992 (Suppl book):Abstract 100, A25
  • Mattila MJ, Aranko K, Kuitunen T. Diazepam effects on performance of healthy subjects are not enhanced by treatment with the antihistamine ebastine. Br J Clin Pharmacol 1993;35:272–7
  • Barbanoj MJ, Torrent J, Azcona O. Psychomotor performance after different single oral doses of a new non-sedating antihistamine in healthy subjects. Rhône-Poulenc Rorer (Collegeville). Data on file
  • Rombaut NEI, Hindmarch I. Psychometric aspects of antihistamines: A review. Hum Psy Clin Exp 1994;157–69
  • Parkin C, Kerr JS, Hindmarch I. The effects of practice on choice reaction time and critical flicker fusion threshold. Hum Psy Clin Exp 1997;12:65–70
  • Curran S. Critical flicker fusion techniques in psychopharmacology. In: Hindmarch I, Stonier PD (Eds). Human Psychopharmacology: Measures and Methods, Volume 3. Chichester: Wiley, 1992
  • Hindmarch I. A 1–4 benzodiazepine, temazepam (K3917), its effect on some psychological parameters of sleep and behaviour. Arzneim. Forsch (Drug Research) 1975;25:1836–9
  • Woodworth RS, Schlosberg H. Experimental Psychology. London: Methuen, 1958
  • Hindmarch I. Critical flicker fusion frequency (CFF): The effects of psychotropic compounds. Phamacopsychiatria 1982;15(Suppl 1):44–8
  • Smith JM, Misiak H. H1-receptor antagonists. Critical flicker fusion frequency (CFF) and psychotropic drugs in normal human subjects: A review. Psychopharmacol 1976;47: 175–82
  • Hindmarch I. Psychomotor function and psychoactive drugs. Br J Clin Pharmacol 1980;10:189–209
  • Hindmarch I, Starmer GA, Mascord DJ, Kerr JS, Sherwood N. The effects of alcohol on the cognitive function of males and females and on skills relating to car driving. Hum Psy Clin Exp 1992;7:105–14
  • Hindmarch I, Psychometric aspects of antihistamines. Eur J Allergy Clin Immunol 1995;50:48–54
  • Sternberg S. High speed scanning in human memory. Science 1966;153:652–4
  • Hindmarch I, Gudgeon AC. The effects of clobazam and lorazepam on aspects of psychomotor performance and car handling ability. Br J Clin Pharmacol 1980;10:145
  • Parrott AC and Hindmarch I. The Leeds Sleep Evaluation Questionnaire in psychological investigations – a review. Psychopharmacology 1980;71:73–179
  • Bye CE, Claridge R, Peck AW, Plowman F. Evidence for tolerance to the central nervous effects of the histamine antagonist, triprolidine, in man. Eur J Clinical Pharmacol 1977;12:181–6
  • Brookhuis KA, de Vries G, de Waard D. Acute and subchronic effects of histamine (H1) receptor antagonist ebastine in 10, 20 and 30 mg dose, and triprolidine 10 mg on car driving performance. Br J Clin Pharmacol 1993;36:67–70
  • Cohen AF, Hamilton A, Philipson R, Peck AW. The acute effects of acrivastine, a new antihistamine compared with triprolidine on measures of CNS performance and subjective effects. Clin Pharm Ther 1985;38:381–6
  • Alford AC, Bhatti JZ, Rombaut NE, Curran S, Hindmarch I. A comparison of antihistamines using EEG and questionnaire based assessments. Med Sci Res 1989;17:421–3

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.