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Research Article

Cardioprotective effects of trimetazidine: a review

Pages 661-672 | Accepted 10 Sep 2003, Published online: 22 Sep 2008

References

  • Berdeaux A, Colin P. Therapeutic perspectives in the treatment of stable angina. Therapie 2001;56(5):601–5
  • Pepine CJ, Abrams J, Marks RG, Morris JJ, Scheidt SS, Handberg E. Characteristics of a contemporary population with angina pectoris. TIDES Investigators. Am J Cardiol 1994;74(3):226–31
  • Kantor P, Lucien A, Kozak R, Lopaschuk G. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res 2000;86(5):580–8
  • Jackson G. Combination therapy in angina: a review of combined hemodynamic treatment and the role for combined hemodynamic and cardiac metabolic agents. Int J Clin Pract 2001;55(4):256–61
  • Detry JM, Sellier P, Pennaforte S, Cokkinos D, Dargie H, Mathes P. Trimetazidine: a new concept in the treatment of angina. Comparison with propranolol in patients with stable angina. Trimetazidine European Multicenter Study Group. Br J Clin Pharmacol 1994;37(3):279–88
  • Marzilli M. Clinical benefits of a metabolic approach in the management of coronary patients. Rev Port Cardiol 2000;19(Suppl 5):V25–30
  • Sellier P, Broustet JP. Efficacy at trough and safety of trimetazi-dine MR 35mg in patients with stable angina pectoris. Cardiovasc Drugs Ther 2001;15(Suppl):81
  • Brottier L, Barat JL, Combe C, et al. Therapeutic value of a cardioprotective agent in patients with severe ischemic cardiomyopathy. Eur Heart J 1990;11:207–12
  • Kober G, Pennaforte S, Buck T, Sievert H, Vallbracht C. Myocardial cytoprotection during percutaneous transluminal coronary angioplasty. Eur Heart J 1993;14(Suppl G):6–11
  • Tünerir B, Colak O, Alatas O, Besogul Y, Kural T, Aslan R. Measurement of troponin T to detect cardioprotective effect of trimetazidine during coronary artery bypass grafting. Ann Thorac Surg 1999;68(6):2173–6
  • Lu C. Dabrowski P, Fragasso G, Chierchia SL. Effects of trimetazidine on ischemic left ventricular dysfunction in patients with coronary artery disease. Am J Cardiol 1998;82(7):898–901
  • Belardinelli R. Trimetazidine and the contractile response of dys-functional myocardium in ischaemic cardiomyopathy. Rev Port Cardiol 2000;19(Suppl 5):V35–9
  • Wolff AA, Rotmensch HH, Stanley WC, Ferrari R. Metabolic approaches to the treatment of ischemic heart disease: the clinicians’ perspective. Heart Fail Rev 2002;7(2):187–203
  • Lopaschuk GD, Belke DD, Gamble J, Itoi I, Schönekess BO. Regulation of fatty acid oxidation in the mammalian heart in health and disease. Biochim Biophys Acta 1994;1213:263–76
  • Opie L. The mechanism of myocytes death in ischemia. Eur Heart J 1993;14(Suppl G):31–3
  • Stanley WC Partial fatty acid oxidation inhibitors for stable angina. Expert Opin Investig Drugs 2002;11(5):615–29
  • Stanley WC, Marzilli M. Metabolic therapy in the treatment of ischemic heart disease: the pharmacology of trimetazidine. Fund Clin Pharmacol 2003;17:133–45
  • Mody FV, Singh BN, Mohiuddin IH, Coyle KB, Buxton DB, Hansen HW, Sumida R, Schelbert HR. Trimetazidine-induced enhancement of myocardial glucose utilization in normal and ischemic myocardial tissue: an evaluation by positron emission tomography. Am J Cardiol 1998;82(5A):42–9K
  • El Banani H, Bernard M, Baetz D, Cabanes E, Cozzone P, Lucien A, Feuvray D. Changes in intracellular sodium and pH during ischaemia-reperfusion are attenuated by trimetazidine. Comparison between low-and zero-flow ischaemia. Cardiovasc Res 2000;47(4):688–96
  • Sentex E, Sergiel JP, Lucien A, Grynberg A. Trimetazidine increases phospholipid turnover in ventricular myocyte. Mol Cell Biochem 1997;175:153–62
  • Sentex E, Helies-Toussaint C, Rousseau D, Lucien A, Ferrary E, Grynberg A. Influence of trimetazidine on the synthesis of complex lipids in the heart and other target organs. Fundam Clin Pharmacol 2001;15(4):255–64
  • Tabbi-Anneni I, Lucien A, Grynberg A. Trimetazidine effect on phospholipids synthesis in ventricular myocyte: consequences in a-adrenergic signalling. Fund Clin Pharmacol 2003;17:51–9
  • Ruiz-Meana M, Garcia-Dorado D, Julia M, Gonzalez MA, Inserte J, Soler-Soler J. Pre-treatment with trimetazidine increases sarcolemmal mechanical resistance in reoxygenated myocytes. Cardiovasc Res 1996;32(3):587–92
  • Di Pasquale P, Lo Verso P, Bucca V, Cannizzaro S, Scalzo S, Maringhini G, Rizzo R, Paterna S. Effects of trimetazidine administration before thrombolysis in patients with anterior myocardial infarction: short-term and long-term results. Cardiovasc Drugs Ther 1999;13(5):423–8
  • Lagadic-Gossman D, Le Prigent K, Feuvray D. Effects of trimetazidine on pHi, regulation in the rat isolated ventricular myocyte. Br J Pharmacol 1996;117:831–8
  • Fantini E, Demaison L, Sentex E, Grynberg A, Athias P. Some biochemical aspects of the protective effect of trimetazidine on rat cardiomyocytes during hypoxia and reoxygenation. J Mol Cell Cardiol 1994;26:949–58
  • Williams FM, Tanda K, Kus M, Williams TJ. Trimetazidine inhibits neutrophil accumulation after myocardial ischaemia and reperfusion in rabbits. J Cardiovasc Pharmacol 1993;22(6):828–33
  • Belcher PR, Drake-Holland AJ, Hynd JW, Noble MI. Effects of trimetazidine on in vivo coronary arterial platelet thrombosis. Cardiovasc Drugs Ther 1993;7(1):149–57
  • Lavanchy N, Martin J, Rossi A. Anti-ischemic effects of trimetazidine: 31P NMR spectroscopy in the isolated rat heart. Arch Int Pharmacodyn Ther 1987;286: 97–110
  • Aussedat J, Ray A, Kay L, Verdys M, Harpey C, Rossi A. Improvement of long-term preservation of isolated arrested rat heart: beneficial effect of the antiischemic agent trimetazidine. J Cardiovasc Pharmacol 1993;21(1):128–35
  • Allibardi S, Chierchia SL, Margonato V, Merati G, Neri G, Dell’Antonio G, Samaja M. Effects of trimetazidine on metabolic and functional recovery of postischemic rat hearts. Cardiovasc Drugs Ther 1998;12(6):543–9
  • Boucher FR, Hearse DJ, Opie LH. Effects of trimetazidine on ischemic contracture in isolated perfused rat hearts. J Cardiovasc Pharmacol 1994;24(1):45–9
  • Drake-Holland AJ, Belcher PR, Hynd J, Noble MI. Infarct size in rabbits: a modified method illustrated by the effects of propranolol and trimetazidine. Basic Res Cardiol 1993;88(3):250–8
  • Guarnieri C, Finelli C, Zini M, Muscari C. Effects of trimetazi-dine on the calcium transport and oxidative phosphorylation of isolated rat heart mitochondria. Basic Res Cardiol 1997;92 (2):90–5
  • D’Hahan N, Taouil K, Janmot C, Morel JE. Effect of trimetazi-dine and verapamil on the cardiomyopathic hamster myosin phenotype. Br J Pharmacol 1998;123(4):611–16
  • Devynck MA, Le Quan Sang KH, Joulin Y, Mazeaud M. Inhibitory effect of trimetazidine on thrombin-induced aggregation and calcium entry into human platelets. J Cardiovasc Pharmacol 1994;23(3):401–7
  • Maupoil V, Rochette L, Tabard A, Clauser P, Harpey C. Direct measurement of free radical generation in isolated rat heart by electron paramagnetic resonance spectroscopy: effect of trimetazidine. Adv Exp Med Biol. 1990;264:373–6
  • Maridonneau-Parini I, Harpey C. Effects of trimetazidine on membrane damage induced by oxygen free radicals in human red cells. Br J Clin Pharmacol 1985;20:148–51
  • Pudil R, Pidrman V, Krejsek J, Gregor J, Tichy M, Andrys C, Drahosova M, Blaha V. The effect of trimetazidine on C-reactive protein, cytokines and adhesion molecules in the course of acute myocardial infarction. Acta Medica (Hradec Kralove) 2001;44(4):135–40
  • Willoughby SR, Chirkov YY, Kennedy JA, Murphy GA, Chirkova LP, Horowitz JD. Inhibition of long-chain fatty acid metabolism does not affect platelet aggregation responses. Eur J Pharmacol 1998;356(2–3):207–13
  • Shirahase H, Suzuki Y, Osumi S, Kakeya N, Kurahashi K. Inhibitory effects of trimetazidine dihydrochloride on aggregation, serotonin release and malondialdehyde production in rabbit platelets. Jpn J Pharmacol 1988;47(1):29–34
  • Desideri A, Celegon L, Metabolic management of ischemic heart disease: clinical data with trimetazidine. Am J Cardiol 1998;82 (5A):50–3K
  • Cross HR. Trimetazidine for stable angina pectoris. Expert Opin Pharmacother 2001;2(5):857–75
  • Jackson G. Stable angina: maximal medical therapy is not the same as optimal medical therapy. Int J Clin Pract 2000;54(6):351
  • Marzilli M, Klein W. Efficacy and tolerability of trimetazidine in stable angina: a metaanalysis of randomized, double-blind, controlled trials. Cor Artery Dis 2003;14:171–9
  • Sellier P. The effects of trimetazidine on ergometric parameters in exercise-induced angina: controlled multicenter double blind versus placebo study. Arch Mal Coeur Vaiss 1986;79:1331–6
  • Passeron J. Effectiveness of trimetazidine in stable effort angina due to chronic coronary insufficiency: a double-blind versus placebo study. Presse Med 1986;15:1775–8
  • Gallet M. Clinical effectiveness of trimetazidine in stable effort angina: a double blind versus placebo controlled study. Presse Med 1986;15:1779–82
  • Dalla-Volta S, Maraglino G, Della-Valentina P, Viena P, Desideri A. Comparison of trimetazidine with nifedipene in effort angina: a double-blind, crossover study. Cardiovasc Drugs Ther 1990;4:853–9
  • Levy S, Group of South of France Investigators. Combination therapy of trimetazidine with diltiazem in patients with coronary artery disease. Am J Cardiol 1995;76:12–16B
  • Manchanda SC, Krishnaswani S. Combination treatment with trimetazidine and diltiazem in stable angina pectoris. Heart 1997;78:353–7
  • Szwed H, Sadowski Z, Elikowski W, KoronKiewizc A, et al. Trimpol II: combination treatment of stable effort angina using trimetazidine and metoprolol: results of a randomised, double iblind, multicentre study. Eur Heart J 2001;22(2):2267–74
  • Piot C. Metabolic considerations in the treatment of coronary disease in diabetic patients. Diabetes Metab 2001;27(5 Pt 2):S25–9
  • Marzilli M. Management of ischemic heart disease in diabetic patients – is there a role for cardiac metabolic agents? Curr Med Res Opin 2001;17(3):153–8
  • Beygui F. Trimetazidine as adjunctive therapy to primary PTCA for acute myocardial infarction. Rev Port Cardiol 2000;19(Suppl 5):V31–4
  • Steg PG, Grollier G, Gallay P, et al. for the LIST Study Group. A randomized double-blind trial of intravenous trimetazidine as adjunctive therapy to primary angioplasty for acute myocardial infarction. Int J Cardiol 2001;77(2–3):263–73
  • Birand A, Kudaiberdieva GZ, Batyraliev TA, Akgul F, Usal A. Effects of trimetazidine on heart rate variability and left ventricular systolic performance in patients with coronary artery disease after percutaneous transluminal angioplasty. Angiology 1997;48(5):413–22
  • Polonski L, Dec I, Wojnar R, Wilczek K. Trimetazidine limits the effects of myocardial ischaemia during percutaneous coronary angioplasty. Curr Med Res Opin 2002;18(7):389–96
  • Triggiani M, Simeone F, Gallorini C, et al. Measurement of cardiac troponin T and myosin to detect perioperative myocardial damage during coronary surgery. Cardiovasc Surg 1994;2(4):441–5
  • Vedrinne JM, Vedrinne C, Bompard D, Lehot JJ, Boissel JP, Champsaur G. Myocardial protection during coronary artery bypass graft surgery: a randomized, double-blind, placebo-controlled study with trimetazidine. Anesth Analg 1996;82(4):712–18
  • Fabiani JN, Ponzio O, Emerit I, Massonet-Castel S, Paris M, Chevalier P, Jebara V, Carpentier A. Cardioprotective effect of trimetazidine during coronary artery graft surgery. J Cardiovasc Surg (Torino) 1992;33(4):486–91
  • Di Girolamo E, Potere F, Sabatini P, Leonzio L, Barsotti A. A 201Tl scintigraphic evidence of trimetazidine-mediated improvement of coronary microcirculation in patients with chronic stable angina. J Am Coll Cardiol 2000;35(Suppl A):409
  • Belardinelli R, Purcaro A. Effects of trimetazidine on the contractile response of chronically dysfunctional myocardium to low-dose dobutamine in ischaemic cardiomyopathy. Eur Heart J 2001;22(23):2164–70
  • The EMIP-FR Group. European Myocardial Infarction Project-Free Radicals. Effect of 48-h intravenous trimetazidine on short- and long-term outcomes of patients with acute myocardial infarction, with and without thrombolytic therapy; double-blind, placebo-controlled, randomized trial. Eur Heart J 2000;21(18):1537–46
  • Papadopoulos CL, Kanonidis IE, Kotridis PS, Papayannis IL, Savatis SC, Missopoulou-Kokka AI, Nikolaidis NK, Koukoulekidis GN, Sakadamis GC. The effect of trimetazidine on reperfusion arrhythmias in acute myocardial infarction. Int J Cardiol 1996;26;55(2):137–42
  • Kountouris E, Pappa E, Pappas K, Dimitroula V, Karanikis P, Tzimas T, Siogas K. Metabolic management of coronary heart disease: adjunctive treatment with trimetazidine decreases QT dispersion in patients with a first acute myocardial infarction. Cardiovasc Drugs Ther 2001;15(4):315–21
  • Ozdemir R, Tuncer C, Aladag M, et al. Effect of trimetazidine on late potentials after acute myocardial infarction. Cardiovasc Drugs Ther 1999;13(2):145–9
  • Ulgen MS, Akdemir O, Toprak N. The effects of trimetazidine on heart rate variability and signal-averaged electrocardiography in early period of acute myocardial infarction. Int J Cardiol 2001;77(2–3):255–62

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