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Research Article

Safety of 25- and 50-mg capsules in the initiation of zonisamide therapy in patients with epilepsy: an uncontrolled, open-label study

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Pages 837-842 | Accepted 10 Mar 2004, Published online: 05 Apr 2004

References

  • Zonegran [package insert]. San Diego, Calif: Elan Pharmaceuticals, Inc; 2003
  • Schauf CL. Zonisamide enhances slow sodium inactivation in Myxicola. Brain Res 1987;413:185–8
  • Suzuki S, Kawakami K, Nishimura S, et al. Zonisamide blocks T-type calcium channel in cultured neurons of rat cerebral cortex. Epilepsy Res 1992;12:21–7
  • Zhu WT, Rogawski MA. Zonisamide depresses excitatory synaptic transmission by a presynaptic action [abstract]. Epilepsia 1999;7:245
  • Okada M, Hirano T, Kawata Y, et al. Biphasic effects of zonisamide on serotonergic system in rat hippocampus. Epilepsy Res 1999;34:187–97
  • Okada M, Kaneko S, Hirano T, et al. Effects of zonisamide on dopaminergic system. Epilepsy Res 1995;22:193–205
  • Komatsu M, Okamura Y, Hiramatsu M. Free radical scavenging activity of zonisamide and its inhibitory effect on lipid peroxide formation in iron-induced epileptogenic foci of rats. Neurosciences 1995;21:23–9
  • Mori A, Noda Y, Packer L. The anticonvulsant zonisamide scavenges free radicals. Epilepsy Res 1998;30:153–8
  • Endoh A, Kinno I, Kawai M, Hiramatsu M, Mori A. Effects of zonisamide on neurotransmitter in mouse brain. Neurosciences 1994;20:P173–6
  • Kawai M, Endoh A, Kinno I, et al. Effect of zonisamide on release of aspartic acid and gamma-aminobutyric acid from hippocampal slices of E1 mice. Neurosciences 1994;20:115–9
  • Schmidt D, Jacob R, Loiseau P, et al. Zonisamide for add-on treatment of refractory partial epilepsy: a European double-blind trial. Epilepsy Res 1993;15:67–73
  • Faught E, Ayala R, Montouris GG, Leppik IE. Randomized controlled trial of zonisamide for the treatment of refractory partial-onset seizures. Neurology 2001;57:1774–9
  • Sackellares JC, Ramsay RE, Wilder BJ, Browne TR III, Shellenberger K. Randomized, controlled clinical trial of zonisamide as adjunctive treatment for refractory partial seizures. Epilepsia: [in press]

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