91
Views
24
CrossRef citations to date
0
Altmetric
Original Article

Efficacy of vardenafil for the treatment of erectile dysfunction in men with hypertension:a meta-analysis of clinical trial data

, , , , &
Pages 2453-2460 | Accepted 02 Jul 2007, Published online: 28 Aug 2007

References

  • NIH Consensus Development Panel on Impotence. JAMA 1993;270:83–90
  • Seftel AD, Sun P, Swindle R. The prevalence of hypertension, hyperlipidemia, diabetes mellitus, and depression in men with erectile dysfunction. J Urol 2004;171:2341–5
  • Rosen RC, Fisher WA, Eardley I, et al. The multinational Men’s Attitudes to Life Events and Sexualtiy (MALES) study: I. Prevalence of erectile dysfunction and related health concerns in the general population. Curr Med Res Opin 2004;20:607–17
  • Burnett AL. Erectile dysfunction. J Urol 2006;175:S25–31
  • Lue TF. Erectile dysfunction. N Engl J Med 2000;342:1802–13
  • Francavilla S, Bocchio M, Pelliccione F, et al. Vascular aetiology of erectile dysfunction. Int J Androl 2005;28(Suppl 2):35–9
  • Papatsoris AG, Korantzopoulos PG. Hypertension, anti hypertensive therapy, and erectile dysfunction. Angiology 2006;57:47–52
  • Giuliano FA, Leriche A, Jaudinot EO, et al. Prevalence of erectile dysfunction among 7,689 patients with diabetes or hypertension, or both. Urology 2004;64:1196–201
  • Cameron A, Sun P, Lage M. Comorbid conditions in men with ED before and after ED diagnosis: a retrospective database study. Int J Impot Res 2006;18:375–81
  • Ponholzer A, Temml C, Mock K, et al. Prevalence and risk factors for erectile dysfunction in 2,869 men using a validated questionnaire. Eur Urol 2005;47:80–6
  • Rosen R, Shabsigh R, Berber M, et al. Efficacy and tolerability of vardenafil in men with mild depression and erectile dysfunction: the depression-related improvement with vardenafil for erectile response study. Am J Psychiatry 2006;163:79–87
  • Sun P, Swindle R. Are men with erectile dysfunction more likely to have hypertension than men without erectile dysfunction? A naturalistic national cohort study. J Urol 2005;174:244–8
  • Shabsigh R, Perelman MA, Lockhart DC, et al. Health issues of men: prevalence and correlates of erectile dysfunction. J Urol 2005;174:662–7
  • Fields LE, Burt VL, Cutler JA, et al. The burden of adult hypertension in the United States: 1999 to 2000 – a rising tide. Hypertension 2004;44:398–404
  • Makhsida N, Shah J, Yan G, et al. Hypogonadism and metabolic syndrome: implications for testosterone therapy. J Urol 2005;174:827–34
  • Middleton KR, Hing E. National hospital ambulatory medical care survey. 2004 outpatient department summary. Adv Data 2006;373:1–27
  • Grover SA, Lowensteyn I, Kaouache M, et al. The prevalence of erectile dysfunction in the primary care setting. Arch Intern Med 2006;166:213–19
  • Dunn KM, Croft PR, Hackett GI. Sexual problems: a study of the prevalence and need for health care in the general population. Fam Pract 1998;15:519–24
  • American Urology Association Erectile Dysfunction Guidelines 2006. Available at: http://www.auanet.org/guidelines/edmgmt.cfm. Accessed September 14, 2006
  • Berner MM, Kriston L, Harms A. Efficacy of PDE-5 inhibitors for erectile dysfunction. A comparative meta-analysis of fixed-dose regimen randomized controlled trials administering the Interna tional Index of Erectile Function in broad-spectrum populations. Int J Impot Res 2006;18: 229–35
  • Albuquerque DC, Miziara LJ, Saraiva JFK, et al. Efficacy, safety and tolerability of sildenafil in Brazilian hypertensive patients on multiple antihypertensive drugs. Int Braz J Urol 2005;31:342–55
  • Pickering TG, Shepherd AM, Puddey I, et al. Sildenafil citrate for erectile dysfunction in men receiving multiple antihypertensive agents. Am J Hypertens 2004;17:1135–42
  • Kloner RA, Brown M. Effect of sildenafil in patients with erectile dysfunction taking antihypertensive therapy. Am J Hypertens 2001;14:70–3
  • Kloner RA, Sadovsky R, Johnson EG, et al. Efficacy of tadalafil in the treatment of erectile dysfunction in hypertensive men on concomitant thiazide diuretic therapy. Int J Impot Res 2005;17:450–4
  • Valiquette L, Montorsi F, Auerbach S, for the Vardenafil Study Group. First-dose success with vardenafil in men with erectile dysfunction and associated comorbidities: RELY-1. Int J Clin Pract 2006;60: 1378–85
  • van Ahlen H, Wahle K, Kupper W, et al. Safety and efficacy of vardenafil, a selective phosphodiesterase 5 inhibitor, in patients with erectile dysfunction and arterial hypertension treated with multiple antihypertensives. J Sex Med 2005;2:856–64
  • Data on file, Study 10940, Bayer Healthcare
  • Data on file, Study 11139, Bayer Healthcare
  • Data on file, Study 11334, Bayer Healthcare
  • Data on file, Study 11561, Bayer Healthcare
  • Hatzichristou D, Montorsi F, Buvat J, et al, for the European Vardenafil Study Group. The efficacy and safety of flexible-dose vardenafil (Levitra®) in a broad population of European men. Eur Urol 2004;45:634–41
  • Carson CC, Hatzichristou DG, Carrier S, et al. Erectile response with vardenafil in sildenafil nonresponders: a multicenter, double-blind, 12-week, flexible-dose, placebo-controlled erectile dys function clinical trial. BJU Int 2004;94:1301–9
  • Fisher WA, Rosen RC, Mollen M, et al. Improving the sexual quality of life of couples affected by erectile dysfunction: a double-blind, randomized, placebo-controlled trial of vardenafil. J Sex Med 2005;2:699–708
  • Rosen RC, Riley A, Wagner G, et al. The International Index of Erectile Function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology 1997;46:822–30
  • Cappelleri JC, Rosen RC, Smith MS, et al. Diagnostic evaluation of the erectile function domain of the International Index of Erectile Function. Urology 1999;54:346–51
  • Broderick GA, Lue T. Evaluation and nonsurgical management of erectile dysfunction and priapism. In: Campbell’s Urology. Philadelphia, PA: Saunders, 2002
  • DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986;7:177–88
  • Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. BMJ 2003;327:557–60
  • Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med 2002;21:1539–58
  • Duval SJ, Tweedie RL. A non-parametric ‘trim and fill’ method of accounting for publication bias in meta-analysis. JASA 2000;95:89–98
  • Borenstein M, Hedges L, Higgins J, et al. Comprehensive Meta-analysis Version 2, Biostat, Englewood, NJ, 2005

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.