Safety and efficacy of intravenous N‐acetylcysteine for acetaminophen overdose: analysis of the Hunter Area Toxicology Service (HATS) database

References

• Prescott L. Oral or intravenous N-acetylcysteine for acetaminophen poisoning? Ann Emerg Med 2005;45:409–13
   PubMed Web of Science ®Google Scholar
• Tsai CL, Chang WT, Weng TI, et al. A patient-tailored N-acetylcysteine protocol for acute acetaminophen intoxication. Clin Ther 2005;27:336–41
   PubMed Web of Science ®Google Scholar
• Nishida T, Matsura T, Nakada J, et al. Geranylgeranylacetone protects against acetaminophen-induced hepatotoxicity by inducing heat shock protein 70. Toxicology 2006;219:187–96
   PubMed Web of Science ®Google Scholar
• Larson AM, Polson J, Fontana RJ, et al. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology 2005;42:1364–72
   PubMed Web of Science ®Google Scholar
• Ayonrinde OT, Phelps GJ, Hurley JC, et al. Paracetamol overdose and hepatotoxicity at a regional Australian hospital: a 4-year experience. Intern Med J 2005;35:655–60
   PubMed Web of Science ®Google Scholar
• Davidson DG, Eastham WN. Acute liver necrosis following overdose of paracetamol. Br Med J 1966;2:497–9
   PubMed Web of Science ®Google Scholar
• Schmidt LE, Dalhoff K. Concomitant overdosing of other drugs in patients with paracetamol poisoning. Br J Clin Pharmacol 2002;53:535–41
   PubMed Web of Science ®Google Scholar
• Schiødt FV, Atillasoy E, Shakil AO, et al. Etiology and outcome for 295 patients with acute liver failure in the United States. Liver Transpl Surg 1999;5: 29–34
   Google Scholar
• Makin AJ, Wendon J, Williams R. A 7-year experience of severe acetaminophen-induced hepatotoxicity (1987–1993). Gastro enterology 1995;109: 1907–16
   Google Scholar
• Schmidt LE, Dalhoff K. Hyperamylasaemia and acute pancreatitis in paracetamol poisoning. Aliment Pharmacol Ther 2004;20:173–9
   PubMed Web of Science ®Google Scholar
• Whitcomb DC, Block GD. Association of acetaminophen hepatotoxicity with fasting and ethanol use. JAMA 1994;272:1845–50
   PubMed Web of Science ®Google Scholar
• Schmidt LE. Age and paracetamol self-poisoning. Gut 2005;54:686–90
   PubMed Web of Science ®Google Scholar
• Möling O, Cairon E, Rimenti G, et al. Severe hepatotoxicity after therapeutic doses of acetaminophen. Clin Ther 2006;28:755–60
   Google Scholar
• Bonkovsky HL, Kane RE, Jones DP, et al. Acute hepatic and renal toxicity from low doses of acetaminophen in the absence of alcohol abuse or malnutrition: evidence for increased susceptibility to drug toxicity due to cardiopulmonary and renal insufficiency. Hepatology 1994;19:1141–8
   PubMed Web of Science ®Google Scholar
• Schmidt LE, Dalhoff K. The impact of current tobacco use on the outcome of paracetamol poisoning. Aliment Pharmacol Ther 2003;18:979–85
   PubMed Web of Science ®Google Scholar
• Vitols S. Paracetamol hepatotoxicity at therapeutic doses. J Intern Med 2003;253:95–8
   PubMed Web of Science ®Google Scholar
• Critchley JA, Critchley LA, Anderson PJ, et al. Differences in the single-oral-dose pharmacokinetics and urinary excretion of paracetamol and its conjugates between Hong Kong Chinese and Caucasian subjects. J Clin Pharm Ther 2005;30:179–84
   PubMed Web of Science ®Google Scholar
• Critchley JA, Nimmo GR, Gregson CA, et al. Inter-subject and ethnic differences in paracetamol metabolism. Br J Clin Pharmacol 1986;22:649–57
   PubMed Web of Science ®Google Scholar
• American Academy of Pediatrics. Acetaminophen toxicity in children. Pediatrics 2001;108:1020–4
   PubMed Web of Science ®Google Scholar
• Jaeschke H, Knight TR, Bajt ML. The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity. Toxicol Lett 2003;144:279–88
   Google Scholar
• Prescott LF, Roscoe P, Wright N, et al. Plasma-paracetamol half-life and hepatic necrosis in patients with paracetamol overdosage. Lancet 1971;1:519–22
   PubMed Web of Science ®Google Scholar
• Cummings AJ, King ML, Martin BK. A kinetic study of drug elimination: the excretion of paracetamol and its metabolites in man. Br J Pharmacol Chemother 1967;29:150–7
   Google Scholar
• Josephy PD. The molecular toxicology of acetaminophen. Drug Metab Rev 2005;37:581–94
   PubMed Web of Science ®Google Scholar
• Flanagan RJ, Meredith TJ. Use of N-acetylcysteine in clinical toxicology. Am J Med 1991;91:131S–9
   Google Scholar
• Dabos KJ, Newsome PN, Parkinson JA, et al. A biochemical prognostic model of outcome in paracetamol-induced acute liver injury. Transplantation 2005;80:1712–7
   PubMed Web of Science ®Google Scholar
• James LP, Simpson PM, Farrar HC, et al. Cytokines and toxicity in acetaminophen overdose. J Clin Pharmacol 2005;45:1165–71
   PubMed Web of Science ®Google Scholar
• James LP, Farrar HC, Darville TL, et al. Elevation of serum interleukin 8 levels in acetaminophen overdose in children and adolescents. Clin Pharmacol Ther 2001;70:280–6
   PubMed Web of Science ®Google Scholar
• Prescott LF, Illingworth RN, Critchley JA, et al. Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning. Br Med J 1979;2:1097–100
   PubMed Web of Science ®Google Scholar
• Prescott LF. Treatment of severe acetaminophen poisoning with intravenous acetylcysteine. Arch Intern Med 1981;141:386–9
   PubMed Web of Science ®Google Scholar
• Rumack BH, Peterson RC, Koch GG, et al. Acetaminophen overdose. 662 cases with evaluation of oral acetylcysteine treatment. Arch Intern Med 1981;141: 380–5
   Google Scholar
• Smilkstein MJ, Knapp GL, Kulig KW, et al. Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985). N Engl J Med 1988;319:1557–62
   PubMed Web of Science ®Google Scholar
• Rumack BH, Peterson RG. Acetaminophen overdose: incidence, diagnosis, and management in 416 patients. Pediatrics 1978;62:898–903
   PubMed Web of Science ®Google Scholar
• Yip L, Dart RC, Hurlbut KM. Intravenous administration of oral N-acetylcysteine. Crit Care Med 1998;26:40–3
   PubMedGoogle Scholar
• Keays R, Harrison PM, Wendon JA, et al. Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial. BMJ 1991;303:1026–9
   PubMed Web of Science ®Google Scholar
• Harrison PM, Keays R, Bray GP, et al. Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of acetylcysteine. Lancet 1990;335:1572–3
   PubMed Web of Science ®Google Scholar
• Parker D, White JP, Paton D, et al. Safety of late acetylcysteine treatment in paracetamol poisoning. Hum Exp Toxicol 1990;9:25–7
   PubMed Web of Science ®Google Scholar
• Buckley NA, Whyte IM, O’Connell DL, et al. Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen (paracetamol) poisoning? J Toxicol Clin Toxicol 1999;37:759–67
   Google Scholar
• Whyte IM, Buckley NA, Dawson AH. Data collection in clinical toxicology: are there too many variables? J Toxicol Clin Toxicol 2002;40:223–30
   PubMed Web of Science ®Google Scholar
• Buckley NA, Whyte IM, Dawson AH, et al. Preformatted admission charts for poisoning admissions facilitate clinical assess ment and research. Ann Emerg Med 1999;34:476–82
   PubMed Web of Science ®Google Scholar
• Rumack BH, Matthew H. Acetaminophen poisoning and toxicity. Pediatrics 1975;55:871–6
   PubMed Web of Science ®Google Scholar
• Whyte IM, Buckley NA, Dawson AH. HyperTox Paracetamol (Acetaminophen) protocol. Available from http://www.hypertox.com. Newcastle, Australia: MediTox Pty Ltd, 2006 [Last accessed: August 03, 2007]
   Google Scholar
• Dawson AH, Henry DA, McEwen J. Adverse reactions to N-acetylcysteine during treatment for paracetamol poisoning. Med J Aust 1989;150:329–31
   Google Scholar
• Chan TY, Critchley JA. Adverse reactions to intravenous N-acetylcysteine in Chinese patients with paracetamol (acetaminophen) poisoning. Hum Exp Toxicol 1994;13:542–4
   PubMed Web of Science ®Google Scholar
• Mant TG, Tempowski JH, Volans GN, et al. Adverse reactions to acetylcysteine and effects of overdose. Br Med J (Clin Res Ed) 1984;289:217–9
   PubMed Web of Science ®Google Scholar
• Bailey B, McGuigan MA. Management of anaphylactoid reactions to intravenous N-acetylcysteine. Ann Emerg Med 1998;31:710–5
   PubMed Web of Science ®Google Scholar
• Kao LW, Kirk MA, Furbee RB, et al. What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning? Ann Emerg Med 2003;42:741–50
   PubMed Web of Science ®Google Scholar
• Reynard K, Riley A, Walker BE. Respiratory arrest after N-acetylcysteine for paracetamol overdose. Lancet 1992;340:675
   Google Scholar
• Appelboam AV, Dargan PI, Knighton J. Fatal anaphylactoid reaction to N-acetylcysteine: caution in patients with asthma. Emerg Med J 2002;19:594–5
   Google Scholar
• Black N. What observational studies can offer decision makers. Horm Res 1999;51(Suppl 1):44–9
   PubMedGoogle Scholar
• Black N. Why we need observational studies to evaluate the effectiveness of health care. Br Med J 1996;312:1215–8
   PubMed Web of Science ®Google Scholar